Photo by Ryan Coleman

Find hotels in Sikeston, MO from AED 248

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Compare 258 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Drury Plaza Hotel Cape Girardeau Conference Center

3.0 star property
9.6 out of 10, Exceptional, (1008)
"The Drury was excellent. The room was sapcious and very clean. Breakfast in the morning was great. Easy access to the interstate."
The price is AED 347
AED 392 total
includes taxes & fees
30 Mar - 31 Mar
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Inn & Suites Jackson MO

3.0 star property
9.6 out of 10, Exceptional, (1004)
"This place is top notch! Free dinner, drinks, breakfast... giant rooms! Ciean and quiet. "
The price is AED 331
AED 349 total
includes taxes & fees
30 Mar - 31 Mar
Drury Inn & Suites Jackson MO

The Riverview

3.5 star property
9.2 out of 10, Wonderful, (194)
"Very nice "
The price is AED 345
AED 390 total
includes taxes & fees
26 Mar - 27 Mar
The Riverview

Tru By Hilton Cape Girardeau

2.5 star property
10.0 out of 10, Exceptional, (2)
The price is AED 372
AED 423 total
includes taxes & fees
6 Apr - 7 Apr
Tru By Hilton Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

2.5 star property
9.0 out of 10, Wonderful, (519)
"We love this hotel. We stay here every time we visit our daughter at SEMO."
The price is AED 303
AED 328 total
includes taxes & fees
26 Mar - 27 Mar
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 star property
9.0 out of 10, Wonderful, (1004)
"It was small room but was okay "
The price is AED 248
AED 280 total
includes taxes & fees
30 Mar - 31 Mar
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau West

2.5 star property
9.0 out of 10, Wonderful, (1008)
"This hotel was sooo much nicer than our other hotel stay and at the same price. Can't complain on the price, cleanliness or the customer service we received here. We did have an issue with the location of the entrance, we came in at night at to our opinion the lighting and signage could be better."
The price is AED 281
AED 317 total
includes taxes & fees
30 Mar - 31 Mar
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Sikeston

2.5 star property
9.4 out of 10, Exceptional, (1016)
"Very nice hotel. Except when we went to the hot tub, there was a bowel movement in the water. Didn't notice till we got out. Reported to hotel staff."
The price is AED 314
AED 361 total
includes taxes & fees
30 Mar - 31 Mar
Pear Tree Inn Sikeston

Drury Inn & Suites Cape Girardeau

3.0 star property
9.4 out of 10, Exceptional, (910)
"Staff was polite and very helpful and attentive. Will stay here the next time I’m passing through."
The price is AED 347
AED 392 total
includes taxes & fees
30 Mar - 31 Mar
Drury Inn & Suites Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau

2.5 star property
9.4 out of 10, Exceptional, (94)
"Very clean and updated"
The price is AED 342
AED 385 total
includes taxes & fees
30 Mar - 31 Mar
Fairfield Inn & Suites by Marriott Cape Girardeau

Drury Inn & Suites Sikeston, MO

3.0 star property
9.4 out of 10, Exceptional, (1007)
"Our stay was amazing as always "
The price is AED 364
AED 418 total
includes taxes & fees
30 Mar - 31 Mar
Drury Inn & Suites Sikeston, MO

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 star property
9.4 out of 10, Exceptional, (1004)
"Very clean, great location especially while traveling (gas stations/stores/restaurants) parking was also very convenient. The breakfast in the morning was free with many options. Dining area was also clean and I saw staff cleaning just about everywhere on every surface on our way to check out. Would stay again. "
The price is AED 378
AED 427 total
includes taxes & fees
6 Apr - 7 Apr
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Courtyard by Marriott Cape Girardeau Downtown

3.0 star property
9.6 out of 10, Exceptional, (404)
"Had a great visit to Cape. Lovely place to stay the night. Convenient to shoppin, food and fun!"
The price is AED 459
AED 520 total
includes taxes & fees
6 Apr - 7 Apr
Courtyard by Marriott Cape Girardeau Downtown

Hampton Inn Cape Girardeau I 55 East

2.5 star property
9.6 out of 10, Exceptional, (695)
"Quick check in, friendly service and clean room. The price point was also very reasonable "
The price is AED 403
AED 454 total
includes taxes & fees
6 Apr - 7 Apr
Hampton Inn Cape Girardeau I 55 East

Hampton Inn Sikeston

2.5 star property
8.8 out of 10, Excellent, (325)
"Friendly staff, comfortable beds, spacious room (313). "
The price is AED 403
AED 456 total
includes taxes & fees
30 Mar - 31 Mar
Hampton Inn Sikeston

Candlewood Suites Cape Girardeau by IHG

2.5 star property
8.2 out of 10, Very Good, (748)
"The appliances in the room are a nice touch "
The price is AED 301
AED 360 total
includes taxes & fees
30 Mar - 31 Mar
Candlewood Suites Cape Girardeau by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

2.5 star property
8.6 out of 10, Excellent, (399)
"Clean "
The price is AED 450
AED 510 total
includes taxes & fees
30 Mar - 31 Mar
Holiday Inn Express & Suites Sikeston Southwest by IHG

Comfort Suites Jackson-Cape Girardeau

2.5 star property
8.2 out of 10, Very Good, (692)
"Room looked great when we got there. There was a few things that needed attention. I left them a note."
The price is AED 309
AED 334 total
includes taxes & fees
27 Mar - 28 Mar
Comfort Suites Jackson-Cape Girardeau

Best Western Plus Sikeston

2.5 star property
8.4 out of 10, Very Good, (1003)
"liked the person that checked us in came and showed us how to get tv on "
The price is AED 333
AED 380 total
includes taxes & fees
6 Apr - 7 Apr
Best Western Plus Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Sikeston and related destinations

Explore Sikeston: its food, riverfront, museums, and more!

The best restaurant I have EVER been to! Hands down!!!
Photo by Ryan Coleman
Open Photo by Ryan Coleman

Explore the historic buildings and museums of this delightful South Carolina city that’s also known for its nature trails and outdoor pursuits.

Once a Mexican migrant settlement, this Californian town is located on the edge of one of the most important wetland regions in North America.

Great food! Big burritos, delicious tacos. Outdoor seating only.
Photo by Jess. LongestBusRide
Open Photo by Jess. LongestBusRide

Experience romantic Olive Branch: its food, entertainment, live music, and more!

Lima awaits: its university life, food, cathedral, and more!

A frosted malt, fries and a double hamburger from Kewpee Hamburgers.

Of the five remaining Kewpee restaurants, three of them can be found in Lima, OH.

Kewpee hamburgers started in 1923 and this iconic location in downtown Lima opened in 1928.

A Kewpee location in Kalamazoo, MI, near where Wendy's founder Dave Thomas grew up, is said to have inspired him with their square hamburgers and thick shakes.
Photo by throwingsofas
Open Photo by throwingsofas

Frequently asked questions

Where is the best place to stay in Sikeston?

Drury Inn & Suites Sikeston, MO is ranked highly by Expedia customers. This hotel offers free breakfast and an outdoor pool. Other top choices based on reviews include Pear Tree Inn Sikeston and Hampton Inn Sikeston. See all available top hotels, or vacation rentals in Sikeston.

What are some of the best vacation rentals in Sikeston?

Beautiful location in the secluded woods : This vacation home rental outside of Sikeston offers a fireplace, a patio, and a barbecue grill to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. Kick off your shoes and enjoy yourself with a garden and a selection of games. See all vacation rentals in Sikeston.

If I need to cancel my hotel reservation in Sikeston, will I receive a refund?

Yes! You'll find that most hotel bookings are fully refundable as long as you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a reservation that's non-refundable, it might still be possible to cancel it and get a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Sikeston.

Where can I learn more about changing or cancelling my trip to Sikeston?

For more details about changing or cancelling your trip to Sikeston, head over to our customer service page.

What's the best budget-friendly hotel in Sikeston?

Based on reviews, Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) is a popular hotel for our travelers who want a more economical choice, and features free breakfast and free WiFi. View all budget hotels in Sikeston.

What's the best hotel for a family vacation in Sikeston?

Pear Tree Inn Sikeston is a hotel with an outdoor pool and free breakfast, and it's a top choice on Expedia for families. Drury Inn & Suites Sikeston, MO is another good choice for your stay with the kids. Kids of all ages will also enjoy a visit to The Book Bug. Find more child-friendly accommodations in Sikeston.

What is the top LGBTQ-friendly hotel in Sikeston?

Pear Tree Inn Sikeston is a top LGBTQ-friendly hotel, and features free breakfast and free WiFi. Drury Inn & Suites Sikeston, MO and Holiday Inn Express & Suites Sikeston Southwest by IHG are two other good options for your vacation.

What's the best pet-friendly accommodation in Sikeston?

Pear Tree Inn Sikeston is a top hotel for people traveling with their pets, and offers an indoor pool and free WiFi for its human guests. Other good options for you and your pet's trip include Drury Inn & Suites Sikeston, MO and Days Inn and Suites by Wyndham Sikeston. See more pet-friendly hotel accommodations in Sikeston.

Where is the best hotel to stay close to Central Park?

Hampton Inn Sikeston is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an indoor pool. It's located just a short 1 mi (1.6 km) from Central Park. Another good option is Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel, located just 0.9 mi (1.5 km) away.

What about the best place to stay close to Sikeston Depot Museum?

One of the top choices for your stay is Pear Tree Inn Sikeston, located 3.1 mi (5 km) from Sikeston Depot Museum, and this hotel offers free breakfast and an outdoor pool. Hampton Inn Sikeston and Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel are two other good options within a few miles.

What are some accommodations with pools in Sikeston?

Best Western Plus Sikeston is a top hotel with a pool, free full breakfast, and free parking. View all hotels with pools in Sikeston.

What's the best place to stay near Barkley Regional Airport (PAH)?

Drury Inn & Suites Paducah is one of the top choices for your stay and is a popular 3-star hotel featuring free breakfast and an indoor pool. It's located 4.7 mi (7.6 km) from Barkley Regional Airport. Other choices close to the airport include La Quinta Inn & Suites by Wyndham Paducah and Baymont by Wyndham Paducah.

What is staying in Sikeston like?

Families will find kid-friendly activities in Sikeston, and visitors give high marks for the top-notch restaurants and shopping. This welcoming city also attracts tourists with its riverfront and university setting. In Sikeston, there are 15 hotels and other accommodations to choose from. Find out more about Sikeston.

What are the top places to visit in Sikeston?

Favorite places to visit include Sikeston Depot Museum, Boot Heel Golf Club, and The Book Bug. Additionally, you might want to add Central Park to your itinerary. Check out what more to see and do in Expedia's Sikeston guide.

What's the seasonal weather like in Sikeston?

The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Sikeston is 60 inches.