Photo by Ryan Coleman

Find hotels in Sikeston, MO from AED 215

  • Plan, book, stay with confidence

  • bex rewards loyalty icon
    Be picky
    Search almost a million properties worldwide
    payments icon
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    today icon
    Change your mind
    Book hotels with free cancellation

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating

Compare 247 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Drury Plaza Hotel Cape Girardeau Conference Center

3.0 star property
9.6 out of 10, Exceptional, (1000)
"We stayed here to rest as we drove from Northern Illinois to New Orleans. We were pleasantly surprised at how nice this hotel is. Extremely clean, comfortable and spacious. All of the staff was very friendly and helpful. The free breakfast was phenomenal. Many choices and delicious. Highly recommend this hotel! "
The price is AED 364
AED 410 total
includes taxes & fees
26 Jan - 27 Jan
Drury Plaza Hotel Cape Girardeau Conference Center

Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel

2.5 star property
9.4 out of 10, Exceptional, (1000)
"Very spacious room holiday inn is our go to!"
The price is AED 364
AED 410 total
includes taxes & fees
9 Feb - 10 Feb
Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel

Pear Tree Inn Cape Girardeau West

2.5 star property
9.0 out of 10, Wonderful, (1000)
"Wonderful Stay "
The price is AED 231
AED 261 total
includes taxes & fees
18 Feb - 19 Feb
Pear Tree Inn Cape Girardeau West

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

2.5 star property
8.8 out of 10, Excellent, (493)
"Jaydon deserves a raise great young man quality professional!"
The price is AED 287
AED 311 total
includes taxes & fees
18 Feb - 19 Feb
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Days Inn and Suites by Wyndham Sikeston

2.0 star property
7.2 out of 10, Good, (1002)
"Quick trip. Just needed a stopover. Comfy beds clean room "
The price is AED 231
AED 263 total
includes taxes & fees
26 Jan - 27 Jan
Days Inn and Suites by Wyndham Sikeston

The Riverview

3.5 star property
9.2 out of 10, Wonderful, (126)
"Beautiful hotel, but there was only an Expression machine for coffee and my husband only likes regular coffee. "
The price is AED 356
AED 402 total
includes taxes & fees
27 Jan - 28 Jan
The Riverview

Drury Inn & Suites Cape Girardeau

3.0 star property
9.4 out of 10, Exceptional, (874)
"We had a nice stay thank you"
The price is AED 347
AED 392 total
includes taxes & fees
26 Jan - 27 Jan
Drury Inn & Suites Cape Girardeau

Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel

2.5 star property
8.6 out of 10, Excellent, (389)
"Great"
The price is AED 415
AED 470 total
includes taxes & fees
9 Feb - 10 Feb
Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel

Candlewood Suites Cape Girardeau, an IHG Hotel

2.5 star property
8.2 out of 10, Very Good, (719)
"Loved it"
The price is AED 301
AED 360 total
includes taxes & fees
30 Jan - 31 Jan
Candlewood Suites Cape Girardeau, an IHG Hotel

Drury Inn & Suites Jackson MO

3.0 star property
9.6 out of 10, Exceptional, (1003)
"Great!"
The price is AED 331
AED 349 total
includes taxes & fees
26 Jan - 27 Jan
Drury Inn & Suites Jackson MO

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 star property
9.0 out of 10, Wonderful, (1003)
"Staff was very friendly and helpful "
The price is AED 215
AED 242 total
includes taxes & fees
9 Feb - 10 Feb
Pear Tree Inn Cape Girardeau Near the Medical Center

Best Western Plus Sikeston

2.5 star property
8.4 out of 10, Very Good, (1002)
"Good place to stay, should add fried egg to their breakfast menu to make it excellent."
The price is AED 314
AED 358 total
includes taxes & fees
26 Jan - 27 Jan
Best Western Plus Sikeston

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

2.5 star property
8.4 out of 10, Very Good, (620)
"Only reasons I wasn't fond of the property was no elevator to 2nd floor, and the overuse of floral scent in the halls and lobby. I had to open the window for a little while to make the room breathable. Otherwise, the room and property were very clean, the staff friendly."
The price is AED 237
AED 270 total
includes taxes & fees
23 Jan - 24 Jan
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Comfort Inn & Suites Sikeston I-55

2.5 star property
8.4 out of 10, Very Good, (233)
"Nice spacious rooms. Beds were very comfortable. Quiet place."
The price is AED 327
AED 373 total
includes taxes & fees
26 Jan - 27 Jan
Comfort Inn & Suites Sikeston I-55

Courtyard by Marriott Cape Girardeau Downtown

3.0 star property
9.6 out of 10, Exceptional, (393)
"Beautiful historic preservation "
The price is AED 426
AED 483 total
includes taxes & fees
9 Feb - 10 Feb
Courtyard by Marriott Cape Girardeau Downtown

Hampton Inn Cape Girardeau I 55 East

2.5 star property
9.6 out of 10, Exceptional, (686)
"Clean, friendly, and great place"
The price is AED 403
AED 454 total
includes taxes & fees
2 Feb - 3 Feb
Hampton Inn Cape Girardeau I 55 East

Quality Inn

2.5 star property
7.0 out of 10, Good, (536)
"It was very nice"
The price is AED 223
AED 252 total
includes taxes & fees
18 Feb - 19 Feb
Quality Inn

Pear Tree Inn Sikeston

2.5 star property
9.4 out of 10, Exceptional, (1004)
"Wonderful"
The price is AED 281
AED 323 total
includes taxes & fees
31 Jan - 1 Feb
Pear Tree Inn Sikeston

Fairfield Inn & Suites by Marriott Cape Girardeau

2.5 star property
9.2 out of 10, Wonderful, (74)
"Clean, quiet "
The price is AED 327
AED 369 total
includes taxes & fees
26 Jan - 27 Jan
Fairfield Inn & Suites by Marriott Cape Girardeau

Comfort Suites Jackson-Cape Girardeau

2.5 star property
8.2 out of 10, Very Good, (678)
"good breakfast, great service, front desk worker was very helpful, even carried bags to and from vehicle for me. Overall Great Place to stay"
The price is AED 290
AED 314 total
includes taxes & fees
23 Jan - 24 Jan
Comfort Suites Jackson-Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Don't see what you're looking for?
See all available properties in Sikeston
Save an average of 15% on thousands of hotels when you're signed in

Frequently asked questions

Where is the best place to stay in Sikeston?

Drury Inn & Suites Sikeston, MO is ranked highly by Expedia customers. This hotel offers free breakfast and an outdoor pool. Other top choices based on reviews include Pear Tree Inn Sikeston and Hampton Inn Sikeston. See all available top hotels, or vacation rentals in Sikeston.

What are some of the best vacation rentals in Sikeston?

Notting Hill Cottage: This vacation home rental outside of Sikeston offers a patio, a private yard, and a barbecue grill to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include a dishwasher, a fridge, and a stovetop. You and your friends and family can relax into your vacation with amenities like a spa tub. See all vacation rentals in Sikeston.

If I need to cancel my hotel reservation in Sikeston, will I receive a refund?

Yes! You'll find that most hotel bookings are fully refundable as long as you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a reservation that's non-refundable, it might still be possible to cancel it and get a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Sikeston.

Where can I learn more about changing or cancelling my trip to Sikeston?

For more details about changing or cancelling your trip to Sikeston, head over to our customer service page.

What's the best budget-friendly hotel in Sikeston?

Based on reviews, Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) is a popular hotel for our travelers who want a more economical choice, and features free breakfast and free WiFi. View all budget hotels in Sikeston.

What's the best hotel for a family vacation in Sikeston?

Drury Inn & Suites Sikeston, MO is a hotel with an outdoor pool and free parking, and it's a top choice on Expedia for families. Pear Tree Inn Sikeston is another good choice for your stay with the kids. Kids of all ages will also enjoy a visit to The Book Bug. Find more child-friendly accommodations in Sikeston.

What is the top LGBTQ-friendly hotel in Sikeston?

Drury Inn & Suites Sikeston, MO is a top LGBTQ-friendly hotel, and features free breakfast and free WiFi. Pear Tree Inn Sikeston and Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel are two other good options for your vacation.

What's the best pet-friendly accommodation in Sikeston?

Drury Inn & Suites Sikeston, MO is a top hotel for people traveling with their pets, and offers an indoor pool and free WiFi for its human guests. Other good options for you and your pet's trip include Pear Tree Inn Sikeston and Days Inn and Suites by Wyndham Sikeston. See more pet-friendly hotel accommodations in Sikeston.

Where is the best hotel to stay close to Central Park?

Hampton Inn Sikeston is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an indoor pool. It's located just a short 1 mi (1.6 km) from Central Park. Another good option is Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel, located just 0.9 mi (1.5 km) away.

What about the best place to stay close to Sikeston Depot Museum?

One of the top choices for your stay is Pear Tree Inn Sikeston, located 3.1 mi (5 km) from Sikeston Depot Museum, and this hotel offers free breakfast and an outdoor pool. Hampton Inn Sikeston and Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel are two other good options within a few miles.

What are some accommodations with pools in Sikeston?

Best Western Plus Sikeston is a top hotel with a pool, free full breakfast, and free parking. View all hotels with pools in Sikeston.

What's the best place to stay near Barkley Regional Airport (PAH)?

Drury Inn & Suites Paducah is one of the top choices for your stay and is a popular 3-star hotel featuring free breakfast and an indoor pool. It's located 4.7 mi (7.6 km) from Barkley Regional Airport. Other choices close to the airport include La Quinta Inn & Suites by Wyndham Paducah and Baymont by Wyndham Paducah.

What is staying in Sikeston like?

Families will find kid-friendly activities in Sikeston, and visitors give high marks for the top-notch restaurants and shopping. This welcoming city also attracts tourists with its riverfront and university setting. In Sikeston, there are 15 hotels and other accommodations to choose from. Find out more about Sikeston.

What are the top places to visit in Sikeston?

Favorite places to visit include The Book Bug, Central Park, and Sikeston Depot Museum. Additionally, you might want to add Boot Heel Golf Club to your itinerary. Check out what more to see and do in Expedia's Sikeston guide.

What's the seasonal weather like in Sikeston?

The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Sikeston is 60 inches.