Photo by Ryan Coleman

Find hotels in Sikeston, MO from AED 246

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Compare 258 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3.0 star property
9.0 out of 10, Wonderful, (529)
"Nice"
The price is AED 303
AED 328 total
includes taxes & fees
10 Apr - 11 Apr
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 star property
9.4 out of 10, Exceptional, (1002)
"We enjoyed our stay both times on our vacation to New Orleans."
The price is AED 378
AED 427 total
includes taxes & fees
4 May - 5 May
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

The Riverview

3.5 star property
9.2 out of 10, Wonderful, (222)
"Very nice place "
The price is AED 354
AED 399 total
includes taxes & fees
23 Apr - 24 Apr
The Riverview

Drury Plaza Hotel Cape Girardeau Conference Center

3.0 star property
9.6 out of 10, Exceptional, (1001)
"It was a great hotel and the staff were very helpful to us with our kids at breakfast time. The kids loved getting popcorn from the staff after a long day of driving."
The price is AED 347
AED 392 total
includes taxes & fees
13 Apr - 14 Apr
Drury Plaza Hotel Cape Girardeau Conference Center

Tru By Hilton Cape Girardeau

2.5 star property
9.6 out of 10, Exceptional, (4)
"New hotel. very nice."
The price is AED 372
AED 423 total
includes taxes & fees
20 Apr - 21 Apr
Tru By Hilton Cape Girardeau

Drury Inn & Suites Cape Girardeau

3.0 star property
9.4 out of 10, Exceptional, (916)
"5 Stars is not enough for all of the staff on duty April 4th, 2025. These folks are a SOLID 11! There was a genuine tornado approaching and they made sure all the lodgers were in safe spaces and appraised of what was going on. There was no hesitation of what to do, where to go and all was calm. Luckily, all was good. Oh yeah the dinner & breakfast was great the place was clean and our room was fantastic. Value was excellent. Allen B."
The price is AED 347
AED 392 total
includes taxes & fees
18 Apr - 19 Apr
Drury Inn & Suites Cape Girardeau

Pear Tree Inn Cape Girardeau West

2.5 star property
9.0 out of 10, Wonderful, (1000)
"Everything was amazing..The clerk was super nice, the room was neat and clean how i like..I would stay at this hotel wherever I need a quick get away to relax."
The price is AED 264
AED 298 total
includes taxes & fees
13 Apr - 14 Apr
Pear Tree Inn Cape Girardeau West

Fairfield Inn & Suites by Marriott Cape Girardeau

2.5 star property
9.4 out of 10, Exceptional, (97)
"Very clean and updated"
The price is AED 342
AED 385 total
includes taxes & fees
17 Apr - 18 Apr
Fairfield Inn & Suites by Marriott Cape Girardeau

Pear Tree Inn Sikeston

2.5 star property
9.4 out of 10, Exceptional, (1004)
"Clean hotel. Friendly staff"
The price is AED 314
AED 361 total
includes taxes & fees
14 Apr - 15 Apr
Pear Tree Inn Sikeston

Hampton Inn Cape Girardeau I 55 East

2.5 star property
9.6 out of 10, Exceptional, (699)
"It was clean and the beds were actually very comfortable. They never refilled the conditioner in the shower but that was the only complaint. "
The price is AED 403
AED 454 total
includes taxes & fees
20 Apr - 21 Apr
Hampton Inn Cape Girardeau I 55 East

Drury Inn & Suites Jackson MO

3.0 star property
9.6 out of 10, Exceptional, (1003)
"Very accommodating and friendly staff! Helpful with stressful travelers😊 Great breakfast and evening kick back snacks and drinks!"
The price is AED 331
AED 349 total
includes taxes & fees
13 Apr - 14 Apr
Drury Inn & Suites Jackson MO

Drury Inn & Suites Sikeston, MO

3.0 star property
9.4 out of 10, Exceptional, (1001)
"We have stayed in many drury inn and suites in a variety of cities/towns and this was the best! Friendly people, great suite for a room, great breakfast. "
The price is AED 364
AED 418 total
includes taxes & fees
20 Apr - 21 Apr
Drury Inn & Suites Sikeston, MO

Courtyard by Marriott Cape Girardeau Downtown

3.0 star property
9.6 out of 10, Exceptional, (408)
"Amazing "
The price is AED 511
AED 579 total
includes taxes & fees
13 Apr - 14 Apr
Courtyard by Marriott Cape Girardeau Downtown

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 star property
9.0 out of 10, Wonderful, (1003)
"It was small room but was okay "
The price is AED 248
AED 280 total
includes taxes & fees
13 Apr - 14 Apr
Pear Tree Inn Cape Girardeau Near the Medical Center

Hampton Inn Sikeston

2.5 star property
8.8 out of 10, Excellent, (327)
"Friendly staff, comfortable beds, spacious room (313). "
The price is AED 403
AED 456 total
includes taxes & fees
17 Apr - 18 Apr
Hampton Inn Sikeston

Comfort Suites Jackson-Cape Girardeau

2.5 star property
8.2 out of 10, Very Good, (697)
"V"
The price is AED 342
AED 370 total
includes taxes & fees
10 Apr - 11 Apr
Comfort Suites Jackson-Cape Girardeau

Best Western Plus Sikeston

2.5 star property
8.4 out of 10, Very Good, (1002)
"The gentleman at the front desk was super nice , friendly and just fun when we checked in , we had a quick overnight stay in town ! Pool was clean nice and warm , the next morning breakfast was nice clean and stocked and the young lady cleaning and keeping it full was very friendly also , plus we were able to have are Yorkie in room at a reasonable charge "
The price is AED 315
AED 359 total
includes taxes & fees
15 Apr - 16 Apr
Best Western Plus Sikeston

Candlewood Suites Cape Girardeau by IHG

2.5 star property
8.2 out of 10, Very Good, (762)
"Very nice place to stay and friendly people"
The price is AED 301
AED 360 total
includes taxes & fees
27 Apr - 28 Apr
Candlewood Suites Cape Girardeau by IHG

Quality Inn

2.5 star property
7.0 out of 10, Good, (562)
"It was okay"
The price is AED 246
AED 278 total
includes taxes & fees
10 Apr - 11 Apr
Quality Inn

Days Inn and Suites by Wyndham Sikeston

2.0 star property
7.2 out of 10, Good, (1001)
"Everything was good for a guick one night stay. Nothing fancy but there were 5 of us and plenty of room. Breakfast not great but just enough choices for 3 adults and 2 kids. Only problem was pull out sofa bed was broken but it was big enough to just sleep on top. For the price it was good. I would recommend. "
The price is AED 297
AED 338 total
includes taxes & fees
13 Apr - 14 Apr
Days Inn and Suites by Wyndham Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Sikeston and related destinations

Explore Sikeston: its food, riverfront, university life, and more!

The best restaurant I have EVER been to! Hands down!!!
Photo by Ryan Coleman
Open Photo by Ryan Coleman

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Photo by Jess. LongestBusRide
Open Photo by Jess. LongestBusRide

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A frosted malt, fries and a double hamburger from Kewpee Hamburgers.

Of the five remaining Kewpee restaurants, three of them can be found in Lima, OH.

Kewpee hamburgers started in 1923 and this iconic location in downtown Lima opened in 1928.

A Kewpee location in Kalamazoo, MI, near where Wendy's founder Dave Thomas grew up, is said to have inspired him with their square hamburgers and thick shakes.
Photo by throwingsofas
Open Photo by throwingsofas

Frequently asked questions

Where is the best place to stay in Sikeston?

Drury Inn & Suites Sikeston, MO is ranked highly by Expedia customers. This hotel offers free breakfast and an outdoor pool. Other top choices based on reviews include Pear Tree Inn Sikeston and Hampton Inn Sikeston. See all available top hotels, or vacation rentals in Sikeston.

What are some of the best vacation rentals in Sikeston?

Beautiful location in the secluded woods : This vacation home rental outside of Sikeston offers a fireplace, a patio, and a barbecue grill to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. Kick off your shoes and enjoy yourself with a garden and a selection of games. See all vacation rentals in Sikeston.

If I need to cancel my hotel reservation in Sikeston, will I receive a refund?

Yes! You'll find that most hotel bookings are fully refundable as long as you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a reservation that's non-refundable, it might still be possible to cancel it and get a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Sikeston.

Where can I learn more about changing or cancelling my trip to Sikeston?

For more details about changing or cancelling your trip to Sikeston, head over to our customer service page.

What's the best budget-friendly hotel in Sikeston?

Based on reviews, Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) is a popular hotel for our travelers who want a more economical choice, and features free breakfast and free WiFi. View all budget hotels in Sikeston.

What's the best hotel for a family vacation in Sikeston?

Pear Tree Inn Sikeston is a hotel with an outdoor pool and free breakfast, and it's a top choice on Expedia for families. Drury Inn & Suites Sikeston, MO is another good choice for your stay with the kids. Kids of all ages will also enjoy a visit to The Book Bug. Find more child-friendly accommodations in Sikeston.

What is the top LGBTQ-friendly hotel in Sikeston?

Pear Tree Inn Sikeston is a top LGBTQ-friendly hotel, and features free breakfast and free WiFi. Drury Inn & Suites Sikeston, MO and Hampton Inn Sikeston are two other good options for your vacation.

What's the best pet-friendly accommodation in Sikeston?

Pear Tree Inn Sikeston is a top hotel for people traveling with their pets, and offers an indoor pool and free WiFi for its human guests. Other good options for you and your pet's trip include Drury Inn & Suites Sikeston, MO and Days Inn and Suites by Wyndham Sikeston. See more pet-friendly hotel accommodations in Sikeston.

Where is the best hotel to stay close to Central Park?

Hampton Inn Sikeston is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an indoor pool. It's located just a short 1 mi (1.6 km) from Central Park. Another good option is Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel, located just 0.9 mi (1.5 km) away.

What about the best place to stay close to Sikeston Depot Museum?

One of the top choices for your stay is Pear Tree Inn Sikeston, located 3.1 mi (5 km) from Sikeston Depot Museum, and this hotel offers free breakfast and an outdoor pool. Hampton Inn Sikeston and Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel are two other good options within a few miles.

What are some accommodations with pools in Sikeston?

Best Western Plus Sikeston is a top hotel with a pool, free full breakfast, and free parking. View all hotels with pools in Sikeston.

What's the best place to stay near Barkley Regional Airport (PAH)?

Drury Inn & Suites Paducah is one of the top choices for your stay and is a popular 3-star hotel featuring free breakfast and an indoor pool. It's located 4.7 mi (7.6 km) from Barkley Regional Airport. Other choices close to the airport include La Quinta Inn & Suites by Wyndham Paducah and Baymont by Wyndham Paducah.

What is staying in Sikeston like?

Families will find kid-friendly activities in Sikeston, and visitors give high marks for the top-notch restaurants and shopping. This welcoming city also attracts tourists with its riverfront and university setting. In Sikeston, there are 15 hotels and other accommodations to choose from. Find out more about Sikeston.

What are the top places to visit in Sikeston?

Favorite places to visit include Central Park, The Book Bug, and Sikeston Depot Museum. Additionally, you might want to add Boot Heel Golf Club to your itinerary. Check out what more to see and do in Expedia's Sikeston guide.

What's the seasonal weather like in Sikeston?

The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Sikeston is 60 inches.