Find hotels in Cairo, IL from AED 234
- Plan, book, stay with confidence
Be picky
Search almost a million properties worldwide
Change your mind
Book hotels with free cancellation
Check prices for these dates
Compare 24 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Quality Inn Cairo I-57
Quality Inn Cairo I-57
6.6 out of 10, (247)
The price is AED 312
AED 346 total
includes taxes & fees
25 Mar - 26 Mar

La Center Motel
La Center Motel
7.6 out of 10, Good, (13)
The price is AED 239
AED 275 total
includes taxes & fees
25 Mar - 26 Mar

Regency Inn
Regency Inn
The price is AED 350
AED 389 total
includes taxes & fees
25 Mar - 26 Mar

Eagle Inn Charleston
Eagle Inn Charleston
6.8 out of 10, (95)
The price is AED 234
AED 260 total
includes taxes & fees
25 Mar - 26 Mar

Super 8 by Wyndham Charleston/Sikeston East MO
Super 8 by Wyndham Charleston/Sikeston East MO
6.6 out of 10, (547)
The price is AED 241
AED 268 total
includes taxes & fees
6 Apr - 7 Apr

Quality Inn Charleston - Sikeston
Quality Inn Charleston - Sikeston
6.8 out of 10, (374)
The price is AED 262
AED 290 total
includes taxes & fees
20 Apr - 21 Apr
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Learn more about Cairo
Escape to quaint Cairo! Enjoy its ruins, history, and food.
More cheap stays in Cairo
More cheap stays in Cairo

Super 8 by Wyndham Charleston/Sikeston East MO
310 S Story St, Charleston, MO
The price is AED 241 per night from Apr 6 to Apr 7
AED 241
AED 268 total
includes taxes & fees
6 Apr - 7 Apr
6.6/10 (546 reviews)
Stay near popular Cairo attractions
Stay near popular Cairo attractions
Fort Defiance State Park
4/5(14 reviews)
You can take time to visit Fort Defiance State Park during your travels to Cairo. Stroll along the riverfront or visit the churches while you're in the area.
Recent reviews of Cairo hotels
Recent reviews of Cairo hotels

Quality Inn Charleston - Sikeston
5/5 Excellent
"Staff were very friendly. Room was spacious and well designed."
A verified traveler stayed at Quality Inn Charleston - Sikeston
Posted 7 days ago
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Stay near popular Cairo attractions
- Hotels near Fort Defiance State Park
- Hotels near Shawnee National Forest
- Hotels near Mississippi River
- Hotels near Ohio River
- Hotels near Columbus-Belmont State Park
- Hotels near Henry N Barkhausen Cache River Wetlands Center
- Hotels near Mound City National Cemetery
- Hotels near Ballard Wildlife Management Area
- Hotels near Shawnee Community College
- Hotels near Ullin City Hall
- Hotels near Front Street Studio & Art Gallery
More Accommodation Types in Cairo
Cairo Hotels by Brand
Other Hotels near Cairo, Illinois
- Paducah Hotels
- Cape Girardeau Hotels
- Sikeston Hotels
- Southern Illinois Hotels
- Anna Hotels
- Central United States Hotels
- Charleston Hotels
- Western Kentucky Hotels
- Southeast Missouri Hotels
- Jonesboro Hotels
- The South Hotels
- Dongola Hotels
- Kevil Hotels
- La Center Hotels
- East Prairie Hotels
- Clinton Hotels
- Karnak Hotels
- Bardwell Hotels
- Ullin Hotels
Explore more hotels
- Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286
- Upscale & Quiet Paducah Retreat on 15 Acres!
- Charming Home just minutes from Interstate and Mall
- La Center Motel
- Charming 3-bedroom house near ball park in quiet neighborhood
- Upscale & Quiet Paducah Retreat on 15 Acres!
- Perfect Hunter's/Writer's Cabin
- Beautiful newly renovated farm house overlooking 5 acre lake. ****New Rates ***
- Solar Eclipse Festival at our Campground at Benton Speedway. April 6-8th 2024.
- Solar Eclipse Festival Campground at Benton Speedway. April 6-8th 2024.