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Compare 80 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Days Inn and Suites by Wyndham Sikeston
Days Inn and Suites by Wyndham Sikeston
7.2 out of 10, Good, (1002)
The price is AED 297
AED 338 total
includes taxes & fees
20 Apr - 21 Apr

Hampton Inn Sikeston
Hampton Inn Sikeston
8.8 out of 10, Excellent, (330)
The price is AED 403
AED 456 total
includes taxes & fees
20 Apr - 21 Apr

Holiday Inn Express & Suites Sikeston Southwest by IHG
Holiday Inn Express & Suites Sikeston Southwest by IHG
8.6 out of 10, Excellent, (400)
The price is AED 450
AED 510 total
includes taxes & fees
20 Apr - 21 Apr

Best Western Plus Sikeston
Best Western Plus Sikeston
8.4 out of 10, Very Good, (1002)
The price is AED 328
AED 374 total
includes taxes & fees
20 Apr - 21 Apr

Pear Tree Inn Sikeston
Pear Tree Inn Sikeston
9.4 out of 10, Exceptional, (1007)
The price is AED 314
AED 361 total
includes taxes & fees
16 Apr - 17 Apr

Comfort Inn & Suites Sikeston I-55
Comfort Inn & Suites Sikeston I-55
8.4 out of 10, Very Good, (249)
The price is AED 340
AED 388 total
includes taxes & fees
4 May - 5 May
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Learn more about East Prairie
Explore attractions like Big Oak Tree State Park and Mississippi River as you discover things to see and do in East Prairie.
More cheap stays in East Prairie
More cheap stays in East Prairie

Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr, Sikeston, MO
The price is AED 297 per night from Apr 20 to Apr 21
AED 297
AED 338 total
includes taxes & fees
20 Apr - 21 Apr
7.2/10 Good! (992 reviews)
Hotels in East Prairie with star-rating
Hotels in East Prairie with star-rating

3 Star Hotels
3 properties

2 Star Hotels
28 properties
Stay near popular East Prairie attractions
Stay near popular East Prairie attractions
Big Oak Tree State Park
4.5/5(3 reviews)
You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.
Recent reviews of East Prairie hotels
Recent reviews of East Prairie hotels

Pear Tree Inn Sikeston
5/5 Excellent
"This hotel is very comfortable clean and staff goes out of their way to be friendly!!!! I love staying at this hotel!"
A verified traveler stayed at Pear Tree Inn Sikeston
Posted 2 days ago
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Stay near popular East Prairie attractions
- Hotels near Big Oak Tree State Park
- Hotels near Mississippi River
- Hotels near Ohio River
- Hotels near Reelfoot Lake State Park
- Hotels near Discovery Park of America
- Hotels near Columbus-Belmont State Park
- Hotels near Union City Masquerade Theatre
- Hotels near The Book Bug
- Hotels near Campbell's Point
- Hotels near Fort Defiance State Park
- Hotels near New Madrid Historical Museum
- Hotels near Marston Community Center
- Hotels near Central Park
- Hotels near Graham Park
- Hotels near Sikeston Depot Museum
- Hotels near River Ridge Winery
More Accommodation Types in East Prairie
East Prairie Hotels by Brand
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- The South Hotels
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- Central United States Hotels
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- Country Hearth Inn & Suites Union City
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- Sleep Inn
- Super 8 By Wyndham Marston
- Super 8 by Wyndham Charleston/Sikeston East MO
- Hampton Inn Union City
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- Lake House scales and duck
- Lakeside View Lodge overlooking beautiful Reelfoot Lake