Find hotels in Charleston, MO from AED 231
- Plan, book, stay with confidence
Be picky
Search almost a million properties worldwide
Change your mind
Book hotels with free cancellation
Check prices for these dates
Compare 90 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Quality Inn Charleston - Sikeston
Quality Inn Charleston - Sikeston
6.8 out of 10, (375)
The price is AED 282
AED 313 total
includes taxes & fees
20 Apr - 21 Apr

Super 8 by Wyndham Charleston/Sikeston East MO
Super 8 by Wyndham Charleston/Sikeston East MO
6.6 out of 10, (548)
The price is AED 241
AED 268 total
includes taxes & fees
13 Apr - 14 Apr

Eagle Inn Charleston
Eagle Inn Charleston
6.8 out of 10, (95)
The price is AED 234
AED 260 total
includes taxes & fees
7 Apr - 8 Apr

La Center Motel
La Center Motel
7.6 out of 10, Good, (13)
The price is AED 239
AED 275 total
includes taxes & fees
7 Apr - 8 Apr

Regency Inn
Regency Inn
The price is AED 350
AED 389 total
includes taxes & fees
7 Apr - 8 Apr

Quality Inn Cairo I-57
Quality Inn Cairo I-57
6.6 out of 10, (249)
The price is AED 312
AED 346 total
includes taxes & fees
7 Apr - 8 Apr
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Learn more about Charleston
Quaint Charleston is calling! Discover its opera, entertainment, churches, and more.
More cheap stays in Charleston
More cheap stays in Charleston

Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr, Sikeston, MO
The price is AED 281 per night from Apr 8 to Apr 9
AED 281
AED 320 total
includes taxes & fees
8 Apr - 9 Apr
7.2/10 Good! (1,000 reviews)
Recent reviews of Charleston hotels
Recent reviews of Charleston hotels

Drury Inn & Suites Cape Girardeau
5/5 Excellent
"5 Stars is not enough for all of the staff on duty April 4th, 2025. These folks are a SOLID 11! There was a genuine tornado approaching and they made sure all the lodgers were in safe spaces and appraised of what was going on. There was no hesitation of what to do, where to go and all was calm. Luckily, all was good.
Oh yeah the dinner & breakfast was great the place was clean and our room was fantastic. Value was excellent.
Allen B."
A verified traveler stayed at Drury Inn & Suites Cape Girardeau
Posted 1 day ago
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Stay near popular Charleston attractions
- Hotels near Shawnee National Forest
- Hotels near Mississippi River
- Hotels near Ohio River
- Hotels near Southeast Missouri State University
- Hotels near Isle Casino Cape Girardeau
- Hotels near Riverfront Bridge Park
- Hotels near Riverfront Park
- Hotels near Columbus-Belmont State Park
- Hotels near Cape Rock Park
- Hotels near Big Oak Tree State Park
- Hotels near Cape Splash Family Aquatic Center
- Hotels near Mound City National Cemetery
- Hotels near eDen Spa & Salon
- Hotels near The Book Bug
- Hotels near Fort D Historic Site
- Hotels near New Madrid Historical Museum
- Hotels near Fort Defiance State Park
- Hotels near Central Park
- Hotels near Ullin City Hall
- Hotels near River Ridge Winery
More Hotel Options in Charleston
- Business Hotels in Charleston
- Cheap Hotels in Charleston
- Family Hotels in Charleston
- Hotels with Bars in Charleston
- Hotels with Free Parking in Charleston
- Hotels with WiFi in Charleston
- Hotels with a Pool in Charleston
- Hotels with smoking rooms in Charleston
- Pet-friendly Hotels in Charleston
- Resorts & Hotels with Spas in Charleston
More Accommodation Types in Charleston
Charleston Hotels by Brand
Other Hotels near Charleston, Missouri
- Paducah Hotels
- Cape Girardeau Hotels
- Sikeston Hotels
- Ozarks Hotels
- Southern Illinois Hotels
- Union City Hotels
- Southeastern United States Hotels
- Mayfield Hotels
- Tiptonville Hotels
- Western Kentucky Hotels
- Cairo Hotels
- Western Tennessee Hotels
- Fulton Hotels
- Southeast Missouri Hotels
- Jonesboro Hotels
- New Madrid Hotels
- The South Hotels
- Dongola Hotels
- Central United States Hotels
- Kevil Hotels
Explore more hotels
- Drury Inn & Suites Sikeston, MO
- Candlewood Suites Cape Girardeau by IHG
- Drury Inn & Suites Cape Girardeau
- Hampton Inn Sikeston
- Days Inn and Suites by Wyndham Sikeston
- Courtyard by Marriott Cape Girardeau Downtown
- Fairfield Inn & Suites by Marriott Cape Girardeau
- Town House Inn Cape Giradreau
- Hampton Inn Cape Girardeau I 55 East
- Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
- Holiday Inn Express & Suites Sikeston Southwest by IHG
- Comfort Inn & Suites Sikeston I-55