Find hotels in Southeast Missouri, MO from AED 191
- Plan, book, stay with confidence
Be picky
Search almost a million properties worldwide
Change your mind
Book hotels with free cancellation
Go beyond your typical stay in Southeast Missouri
Cabin
Pet friendly
Check prices for these dates
Compare 552 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference Center
9.6 out of 10, Exceptional, (1003)
The price is AED 347
AED 392 total
includes taxes & fees
30 Mar - 31 Mar

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
9.4 out of 10, Exceptional, (623)
The price is AED 511
AED 584 total
includes taxes & fees
6 Apr - 7 Apr

Pear Tree Inn Sikeston
Pear Tree Inn Sikeston
9.4 out of 10, Exceptional, (1009)
The price is AED 312
AED 359 total
includes taxes & fees
23 Mar - 24 Mar

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
9.0 out of 10, Wonderful, (517)
The price is AED 303
AED 328 total
includes taxes & fees
23 Mar - 24 Mar

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
9.4 out of 10, Exceptional, (1001)
The price is AED 378
AED 427 total
includes taxes & fees
6 Apr - 7 Apr

Holiday Inn Express & Suites Perryville by IHG
Holiday Inn Express & Suites Perryville by IHG
9.4 out of 10, Exceptional, (447)
The price is AED 378
AED 433 total
includes taxes & fees
6 Apr - 7 Apr
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Great weekend hotel deals in Southeast Missouri, MO
Showing deals for:Mar 28 - Mar 30
Image gallery for La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Jackson
9.0/10Wonderful (517 reviews)
15% off
Price is AED 515
per night
AED 1,115 total
includes taxes & fees
Save an average of 15% on thousands of hotels when you're signed in
Learn more about Southeast Missouri
Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from K Bridge Recreation Area to Lake Wappapello State Park.

More cheap stays in Southeast Missouri
More cheap stays in Southeast Missouri

Motel 6 Poplar Bluff, MO
4101 Highway 67 N, Poplar Bluff, MO
The price is AED 247 per night from Mar 25 to Mar 26
AED 247
AED 260 total
includes taxes & fees
25 Mar - 26 Mar
7.8/10 Good! (1,000 reviews)
Hotels in Southeast Missouri with star-rating
Hotels in Southeast Missouri with star-rating

4 Star Hotels
1 properties
Stay near popular Southeast Missouri attractions
Stay near popular Southeast Missouri attractions

Elephant Rocks State Park
5/5(13 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
Recent reviews of Southeast Missouri hotels
Recent reviews of Southeast Missouri hotels

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
5/5 Excellent
"Well kept & clean. Good value for money. Standard breakfast items well presented. Room was good size with a better than average mattress & pillows. Will definitely stay there again."
A verified traveler stayed at La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Posted 21 hours ago
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Hotels in Southeast Missouri Neighborhoods
Stay near popular Southeast Missouri attractions
- Hotels near Elephant Rocks State Park
- Hotels near Johnson's Shut-ins State Park
- Hotels near Southeast Missouri State University
- Hotels near Ozark National Scenic Riverways
- Hotels near Lake Wappapello
- Hotels near Echo Bluff State Park
- Hotels near Isle Casino Cape Girardeau
- Hotels near Bonne Terre Mine
- Hotels near Big Spring
- Hotels near Century Casino Caruthersville
- Hotels near Alley Spring & Mill
- Hotels near Taum Sauk Mountain State Park
- Hotels near Current River State Park
- Hotels near Sainte Genevieve Winery
- Hotels near Rocky Falls
- Hotels near Akers Ferry
- Hotels near Crown Valley Winery
- Hotels near Black River Coliseum
- Hotels near Riverfront Bridge Park
- Hotels near K Bridge Recreation Area
More Hotel Options in Southeast Missouri
- Adults Only Resorts & Hotels in Southeast Missouri
- Adventure Hotels in Southeast Missouri
- Business Hotels in Southeast Missouri
- Casinos in Southeast Missouri
- Cheap Hotels in Southeast Missouri
- Family Hotels in Southeast Missouri
- Golf Hotels in Southeast Missouri
- Historic Hotels in Southeast Missouri
- Hotel Wedding Venues in Southeast Missouri
- Hotel with a Concierge in Southeast Missouri
- Hotels with Bars in Southeast Missouri
- Hotels with Free Parking in Southeast Missouri
- Hotels with Hot Tubs in Southeast Missouri
- Hotels with Waterslides in Southeast Missouri
- Hotels with WiFi in Southeast Missouri
- Hotels with a Pool in Southeast Missouri
- Hotels with an Indoor Pool in Southeast Missouri
- Hotels with smoking rooms in Southeast Missouri
- Luxury Hotels in Southeast Missouri
- Pet-friendly Hotels in Southeast Missouri
- Resorts & Hotels with Spas in Southeast Missouri
- Romantic Hotels in Southeast Missouri
- Shopping Hotels in Southeast Missouri
- Ski Hotels in Southeast Missouri
- Winery Hotels in Southeast Missouri
More Accommodation Types in Southeast Missouri
- Vacation Homes in Southeast Missouri
- Cabin Rentals in Southeast Missouri
- Cottages in Southeast Missouri
- Apartments in Southeast Missouri
- Motels in Southeast Missouri
- Farmstay in Southeast Missouri
- RV Parks in Southeast Missouri
- Condo Rentals in Southeast Missouri
- Lodges in Southeast Missouri
- Aparthotels in Southeast Missouri
- B&B in Southeast Missouri
- Villas in Southeast Missouri
Hotels near Southeast Missouri Airports
Southeast Missouri Hotels by Brand
Other Hotels near Southeast Missouri, Missouri
- Chesterfield Hotels
- Cape Girardeau Hotels
- Carbondale Hotels
- Sikeston Hotels
- Poplar Bluff Hotels
- Fenton Hotels
- Ozarks Hotels
- Ste Genevieve Hotels
- Farmington Hotels
- Richmond Heights Hotels
- Eminence Hotels
- Kirkwood Hotels
- East St. Louis Hotels
- Arnold Hotels
- Brentwood Hotels
- Southern Illinois Hotels
- West Plains Hotels
- Wildwood Hotels
- Festus Hotels
- Eureka Hotels
Explore more hotels
- Candlewood Suites Cape Girardeau by IHG
- Pear Tree Inn Sikeston
- New Orleans Inn Portageville
- Courtyard by Marriott Cape Girardeau Downtown
- Pear Tree Inn Cape Girardeau Near the Medical Center
- Drury Inn & Suites Cape Girardeau
- Drury Inn & Suites Sikeston, MO
- Best Western Plus Sikeston
- Fairfield Inn & Suites by Marriott Cape Girardeau
- La Quinta Inn & Suites by Wyndham Festus - St. Louis South
- Comfort Inn Festus - St Louis South
- Drury Inn & Suites Hayti Caruthersville