Photo by Ryan Coleman
Find Luxury Hotels in Sikeston, MO
- Plan, book, stay with confidence
Be picky
Search almost a million properties worldwide
Change your mind
Book hotels with free cancellation
Check availability on Sikeston Luxury Hotels
Compare Sikeston Luxury Hotels room rates, reviews, and availability. Most hotels are fully refundable.

Days Inn and Suites by Wyndham Sikeston
Days Inn and Suites by Wyndham Sikeston
7.2 out of 10, Good, (1003)
The price is AED 281
AED 320 total
includes taxes & fees
17 Mar - 18 Mar

Historical 'Kage House' Short Term Rental located in "Old Town Cape"
Historical 'Kage House' Short Term Rental located in "Old Town Cape"
10.0 out of 10, Exceptional, (209)

Pear Tree Inn Cape Girardeau Near the Medical Center
Pear Tree Inn Cape Girardeau Near the Medical Center
9.0 out of 10, Wonderful, (1002)
The price is AED 248
AED 280 total
includes taxes & fees
18 Mar - 19 Mar

Quality Inn
Quality Inn
7.0 out of 10, Good, (554)
The price is AED 246
AED 278 total
includes taxes & fees
16 Mar - 17 Mar

Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MO
9.4 out of 10, Exceptional, (1002)
The price is AED 364
AED 418 total
includes taxes & fees
30 Mar - 31 Mar

Drury Inn & Suites Cape Girardeau
Drury Inn & Suites Cape Girardeau
9.4 out of 10, Exceptional, (908)
The price is AED 347
AED 391 total
includes taxes & fees
23 Mar - 24 Mar
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find out more about Sikeston
Find out more about Sikeston
Recent reviews of Sikeston hotels
Recent reviews of Sikeston hotels

Days Inn and Suites by Wyndham Sikeston
5/5 Excellent
"Having the suite, really makes it much more comfortable
I would like to see them making the bed as regular as the towell check"
A verified traveler stayed at Days Inn and Suites by Wyndham Sikeston
Posted 3 days ago

Drury Inn & Suites Sikeston, MO
5/5 Excellent
"I was hoping to use my One Cash $ but could not figure out how to do it. "
A verified traveler stayed at Drury Inn & Suites Sikeston, MO
Posted 5 days ago
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Find More Hotels near Sikeston
More Hotel Options in Sikeston
- Adults Only Resorts & Hotels in Sikeston
- Adventure Hotels in Sikeston
- Business Hotels in Sikeston
- Casinos in Sikeston
- Cheap Hotels in Sikeston
- Family Hotels in Sikeston
- Golf Hotels in Sikeston
- Historic Hotels in Sikeston
- Hotel Wedding Venues in Sikeston
- Hotels with Bars in Sikeston
- Hotels with Free Parking in Sikeston
- Hotels with Hot Tubs in Sikeston
- Hotels with WiFi in Sikeston
- Hotels with a Pool in Sikeston
- Hotels with an Indoor Pool in Sikeston
- Hotels with smoking rooms in Sikeston
- Pet-friendly Hotels in Sikeston
- Resorts & Hotels with Spas in Sikeston
- Romantic Hotels in Sikeston
- Shopping Hotels in Sikeston
- Winery Hotels in Sikeston
More Accommodation Types in Sikeston
- Vacation Homes in Missouri
- Condo Rentals in Missouri
- Apartments in Missouri
- Cabin Rentals in Missouri
- Cottages in Missouri
- Motels in Missouri
- Resorts in Missouri
- Chalets in Missouri
- Lodges in Missouri
- Villas in Missouri
- B&B in Missouri
- Farmstay in Missouri
- Aparthotels in Missouri
- RV Parks in Missouri
- Guest Houses in Missouri
- Inns in Missouri
- Condo Resorts in Missouri
- Hostels in Missouri
- Houseboats in Missouri
- Residences in Missouri
Hotels near popular Sikeston Attractions
- Hotels near Boot Heel Golf Club
- Hotels near Sikeston Depot Museum
- Hotels near The Book Bug
- Hotels near Central Park
- Hotels near Shawnee National Forest
- Hotels near Mississippi River
- Hotels near Ohio River
- Hotels near Southeast Missouri State University
- Hotels near Riverfront Bridge Park
- Hotels near Riverfront Park
Sikeston Hotels by Star Rating
Explore more hotels
- The Riverview
- Drury Plaza Hotel Cape Girardeau Conference Center
- Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
- Pear Tree Inn Cape Girardeau West
- La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
- Candlewood Suites Cape Girardeau by IHG
- Courtyard by Marriott Cape Girardeau Downtown
- Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
- Pear Tree Inn Cape Girardeau Near the Medical Center
- Drury Inn & Suites Cape Girardeau
- Fairfield Inn & Suites by Marriott Cape Girardeau
- Quality Inn
- Drury Inn & Suites Jackson MO
- Holiday Inn Express & Suites Perryville by IHG
- Rest, Relax and Renew. Our log cabin experience awaits your arrival.
- New cabin in the woods with private hot tub
- Beautiful location in the secluded woods
- Brand new cabin in the woods with hot tub 1/2 mile from Starview Winery
- Hampton Inn Cape Girardeau I 55 East
- Town House Inn Cape Giradreau