Photo by Ryan Coleman

Find Luxury Hotels in Sikeston, MO

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Pick from 7 Sikeston Luxury Hotels and compare room rates, reviews, and availability. Most hotels are fully refundable.

Days Inn and Suites by Wyndham Sikeston
Room
Days Inn and Suites by Wyndham Sikeston
2.0 star property
7.2 out of 10, Good, (1001)
"T"
The price is AED 231
AED 258 total
includes taxes & fees
18 Nov - 19 Nov
Days Inn and Suites by Wyndham Sikeston
Pear Tree Inn Cape Girardeau Near the Medical Center
Exterior
Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 star property
9.0 out of 10, Wonderful, (1003)
"Breakfast was not what we expected…. It was no better than some cheaper hotels I have stayed at!!!! Waffles and cereal was basically the choices you had!"
The price is AED 218
AED 246 total
includes taxes & fees
24 Nov - 25 Nov
Pear Tree Inn Cape Girardeau Near the Medical Center
Quality Inn
Exterior
Quality Inn
2.5 star property
7.0 out of 10, Good, (516)
"We really enjoyed our 2 day stay there. Staff nice, rooms clean, parking was easy. My only complaint was breakfast. There could/should have had a better selection. Overall....a great stay. "
The price is AED 224
AED 253 total
includes taxes & fees
17 Nov - 18 Nov
Quality Inn
Drury Inn & Suites Sikeston, MO
Pool
Drury Inn & Suites Sikeston, MO
3.0 star property
9.4 out of 10, Exceptional, (1001)
"Very impressed with the customer service!"
The price is AED 364
AED 418 total
includes taxes & fees
24 Nov - 25 Nov
Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Cape Girardeau
Exterior
Drury Inn & Suites Cape Girardeau
3.0 star property
9.4 out of 10, Exceptional, (813)
"Great"
The price is AED 314
AED 354 total
includes taxes & fees
22 Nov - 23 Nov
Drury Inn & Suites Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Are you looking for a luxury hotel for your stay in Sikeston?
Use Expedia and let us help you arrange a flight to Cairo, IL (CIR-Cairo Regional) airport or Cape Girardeau, MO (CGI-Cape Girardeau Municipal) airport, and then select from different places to stay that will deliver the luxury you want. Amenities are important when you plan a trip, so we make it easy to find what you want to make your stay relaxing and comfortable. If you want an upscale hotel with a spa, an indoor pool, or luxury bedding, Expedia can assist you in finding the best luxury hotel experience that Sikeston has to offer. During your visit, you might want to enjoy the shopping which Sikeston is known for.
How many luxury hotels will I find in Sikeston?
Lie in the lap of luxury during your getaway to Sikeston in one of Expedia’s 5 luxury hotels.
When can I expect good weather in Sikeston?
Planning for the weather is a good way to make your trip to Sikeston relaxing and enjoyable, especially when you’re splurging. The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Sikeston is 60 inches.
What's there to see and do in Sikeston?
Experience Sikeston with a stop at The Book Bug, Sikeston Depot Museum, and Boot Heel Golf Club. If you have a little extra time during your trip, you might want to make a stop at Central Park and Front Street Studio & Art Gallery.