Photo by Ryan Coleman

Find Luxury Hotels in Sikeston, MO

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Compare Sikeston Luxury Hotels room rates, reviews, and availability. Most hotels are fully refundable.

Days Inn and Suites by Wyndham Sikeston
Room

Days Inn and Suites by Wyndham Sikeston

2.0 star property
7.2 out of 10, Good, (1001)
"Nice and clean very friendly "
The price is AED 231
AED 263 total
includes taxes & fees
5 Jan - 6 January 2025
Days Inn and Suites by Wyndham Sikeston
Pear Tree Inn Cape Girardeau Near the Medical Center
Exterior

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 star property
9.0 out of 10, Wonderful, (1001)
"They allowed us to checkin early and we got a much needed nap after a long drive. "
The price is AED 215
AED 242 total
includes taxes & fees
8 Jan - 9 January 2025
Pear Tree Inn Cape Girardeau Near the Medical Center
Quality Inn
Exterior

Quality Inn

2.5 star property
7.0 out of 10, Good, (526)
"Yes"
The price is AED 217
AED 244 total
includes taxes & fees
1 Jan - 2 January 2025
Quality Inn
Drury Inn & Suites Sikeston, MO
Pool

Drury Inn & Suites Sikeston, MO

3.0 star property
9.4 out of 10, Exceptional, (1001)
"Nice sized room. Very clean and quiet."
The price is AED 364
AED 418 total
includes taxes & fees
31 Jan - 1 February 2025
Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Cape Girardeau
Exterior

Drury Inn & Suites Cape Girardeau

3.0 star property
9.4 out of 10, Exceptional, (853)
"Loved our stay here, the staff was extremely friendly and helpful. Really made it feel like you were home. Room was clean and the 5:30 kickback made the stay such a great deal"
The price is AED 347
AED 392 total
includes taxes & fees
7 Jan - 8 January 2025
Drury Inn & Suites Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Are you looking for a luxury hotel for your stay in Sikeston?
Use Expedia and let us help you arrange a flight to Cairo, IL (CIR-Cairo Regional) airport or Cape Girardeau, MO (CGI-Cape Girardeau Municipal) airport, and then select from different places to stay that will deliver the luxury you want. Amenities are important when you plan a trip, so we make it easy to find what you want to make your stay relaxing and comfortable. If you want an upscale hotel with a spa, an indoor pool, or luxury bedding, Expedia can assist you in finding the best luxury hotel experience that Sikeston has to offer. During your visit, you might want to enjoy the shopping which Sikeston is known for.
How many luxury hotels will I find in Sikeston?
Lie in the lap of luxury during your getaway to Sikeston in one of Expedia’s 5 luxury hotels.
When can I expect good weather in Sikeston?
Planning for the weather is a good way to make your trip to Sikeston relaxing and enjoyable, especially when you’re splurging. The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Sikeston is 60 inches.
What's there to see and do in Sikeston?
Experience Sikeston with a stop at The Book Bug, Sikeston Depot Museum, and Central Park. If you have a little extra time during your trip, you might want to make a stop at Hunter-Dawson State Historic Site and Boot Heel Golf Club.