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Find Casinos in Sikeston, MO

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Check availability on Sikeston Casinos

Compare Sikeston Casinos room rates, reviews, and availability. Most hotels are fully refundable.

Town House Inn Cape Giradreau
Desk, free WiFi

Town House Inn Cape Giradreau

2.5 star property
6.0 out of 10, (178)
"NA"
The price is AED 231
AED 270 total
includes taxes & fees
14 Apr - 15 Apr
Town House Inn Cape Giradreau
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Exterior

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 star property
9.4 out of 10, Exceptional, (1002)
"Will definitely stay there again!!"
The price is AED 378
AED 427 total
includes taxes & fees
4 May - 5 May
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Pear Tree Inn Cape Girardeau Near the Medical Center
Seasonal outdoor pool

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 star property
9.0 out of 10, Wonderful, (1005)
"Absolutely wonderful friendly people great location very clean! I love it "
The price is AED 248
AED 280 total
includes taxes & fees
17 Apr - 18 Apr
Pear Tree Inn Cape Girardeau Near the Medical Center
Candlewood Suites Cape Girardeau by IHG
Exterior

Candlewood Suites Cape Girardeau by IHG

2.5 star property
8.2 out of 10, Very Good, (765)
"Very nice place to stay and friendly people"
The price is AED 301
AED 360 total
includes taxes & fees
20 Apr - 21 Apr
Candlewood Suites Cape Girardeau by IHG
Pear Tree Inn Cape Girardeau West
Lobby

Pear Tree Inn Cape Girardeau West

2.5 star property
9.0 out of 10, Wonderful, (1004)
"Nicr"
The price is AED 264
AED 298 total
includes taxes & fees
17 Apr - 18 Apr
Pear Tree Inn Cape Girardeau West
Drury Inn & Suites Cape Girardeau
Business center

Drury Inn & Suites Cape Girardeau

3.0 star property
9.4 out of 10, Exceptional, (917)
"5 Stars is not enough for all of the staff on duty April 4th, 2025. These folks are a SOLID 11! There was a genuine tornado approaching and they made sure all the lodgers were in safe spaces and appraised of what was going on. There was no hesitation of what to do, where to go and all was calm. Luckily, all was good. Oh yeah the dinner & breakfast was great the place was clean and our room was fantastic. Value was excellent. Allen B."
The price is AED 347
AED 392 total
includes taxes & fees
18 Apr - 19 Apr
Drury Inn & Suites Cape Girardeau
Quality Inn
Lobby

Quality Inn

2.5 star property
7.0 out of 10, Good, (563)
"It was okay"
The price is AED 246
AED 278 total
includes taxes & fees
14 Apr - 15 Apr
Quality Inn
Comfort Suites Jackson-Cape Girardeau
Lobby

Comfort Suites Jackson-Cape Girardeau

2.5 star property
8.2 out of 10, Very Good, (698)
"V"
The price is AED 356
AED 386 total
includes taxes & fees
14 Apr - 15 Apr
Comfort Suites Jackson-Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Searching for casino hotels in Sikeston?
Tourists speak highly of the family-friendly activities, shopping, and local cuisine.
How many hotels that are good for gaming can I expect to find in Sikeston?
You won’t need a stroke of luck to find something that suits with one of Expedia’s 15 casino hotels in Sikeston.
When should I take my casino trip to Sikeston?
You might spend a lot of your vacation inside, but if you want to see more of the area, looking at local weather trends is a good idea. The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Sikeston is 60 inches.
What is there to do in Sikeston?
If you’re interested in local cultural spots, you can check out Sikeston Depot Museum and Front Street Studio & Art Gallery. Nature enthusiasts will appreciate the riverfront, and places to get outdoors include Big Oak Tree State Park, Shawnee National Forest, and Mississippi River. If you’re looking for more to see and do, you can add Central Park and The Book Bug to your list.
What are my transportation options for my casino getaway to Sikeston?
Here are some transportation options in Sikeston: You can arrange a flight to the nearest airport, which is Cairo, IL (CIR-Cairo Regional), 23.8 mi (38.3 km) from the city center. If you’d like to explore around the area, you may want a rental car for your journey.