Find hotels in Southern Illinois, IL from AED 197
- Plan, book, stay with confidence
Be picky
Search almost a million properties worldwide
Change your mind
Book hotels with free cancellation
Go beyond your typical stay in Southern Illinois
Cabin
Check prices for these dates
Compare 975 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Drury Plaza Hotel Mt. Vernon
Drury Plaza Hotel Mt. Vernon
9.6 out of 10, Exceptional, (1287)
The price is AED 331
AED 374 total
includes taxes & fees
19 Apr - 20 Apr

La Quinta Inn & Suites by Wyndham Effingham
La Quinta Inn & Suites by Wyndham Effingham
9.0 out of 10, Wonderful, (1004)
The price is AED 387
AED 434 total
includes taxes & fees
20 Apr - 21 Apr

Country Inn & Suites by Radisson, Effingham, IL
Country Inn & Suites by Radisson, Effingham, IL
8.8 out of 10, Excellent, (1003)
The price is AED 359
AED 398 total
includes taxes & fees
14 Apr - 15 Apr

Comfort Suites Mount Vernon
Comfort Suites Mount Vernon
8.8 out of 10, Excellent, (1006)
The price is AED 400
AED 452 total
includes taxes & fees
14 Apr - 15 Apr

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
9.4 out of 10, Exceptional, (422)
The price is AED 422
AED 469 total
includes taxes & fees
27 Apr - 28 Apr

Holiday Inn Express And Suites Effingham by IHG
Holiday Inn Express And Suites Effingham by IHG
9.4 out of 10, Exceptional, (1001)
The price is AED 444
AED 498 total
includes taxes & fees
20 Apr - 21 Apr
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Great weekend hotel deals in Southern Illinois, IL
Showing deals for:Apr 25 - Apr 27
Image gallery for Makanda Inn

Makanda Inn
Makanda
10/10Exceptional (29 reviews)
11% off
Price is AED 892
per night
AED 2,034 total
includes taxes & fees
Save an average of 15% on thousands of hotels when you're signed in
Learn more about Southern Illinois
Discover the culture and history of this region shaped by indigenous and pioneering communities and spend time in its peaceful, picturesque landscapes.

Photo by Southernmost Illinois Tourism Bureau
Open Photo by Southernmost Illinois Tourism Bureau
Where to stay in Southern Illinois
Where to stay in Southern Illinois
Find the best Southern Illinois areas and neighborhoods for the activities you enjoy most. Learn more about Southern Illinois

Eastport
If you're spending some time in Eastport, Gateway Conference Center and Splash City Family Waterpark are top sights worth seeing.
More cheap stays in Southern Illinois
More cheap stays in Southern Illinois

Super 8 by Wyndham O'Fallon
1100 Eastgate Dr, O'Fallon, IL
The price is AED 197 per night from Apr 27 to Apr 28
AED 197
AED 226 total
includes taxes & fees
27 Apr - 28 Apr
7.6/10 Good! (1,004 reviews)
Hotels in Southern Illinois with star-rating
Hotels in Southern Illinois with star-rating

4 Star Hotels
4 properties
Stay near popular Southern Illinois attractions
Stay near popular Southern Illinois attractions

Southern Illinois University
4.5/5(173 reviews)
Take a campus tour or just explore the area of Southern Illinois University, during your trip to Carbondale. Check out the shops and top-notch restaurants in this family-friendly area.
Recent reviews of Southern Illinois hotels
Recent reviews of Southern Illinois hotels

Baymont by Wyndham Marion
5/5 Excellent
"Great experince here, from the friendly staff, as well as the property bring very clean and well maintained "
A verified traveler stayed at Baymont by Wyndham Marion
Posted 2 days ago
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Hotels in Southern Illinois Neighborhoods
Stay near popular Southern Illinois attractions
- Hotels near Shawnee National Forest
- Hotels near Southern Illinois University
- Hotels near Harrah's Metropolis
- Hotels near Garden of the Gods Recreation Area
- Hotels near Lake of Egypt
- Hotels near Rend Lake
- Hotels near Giant City State Park
- Hotels near O'Fallon Family Sports Park
- Hotels near Scott Air Force Base
- Hotels near World Wide Technology Raceway
- Hotels near Cahokia Mounds State Historic Site
- Hotels near Carlyle Lake
- Hotels near Lake Sara
- Hotels near Superman Statue
- Hotels near DuQuoin State Fairgrounds
- Hotels near Marion Cultural and Civic Center
- Hotels near The Edge
- Hotels near Gateway Conference Center
- Hotels near McKendree University
- Hotels near Cave in Rock State Park
More Hotel Options in Southern Illinois
- Adults Only Resorts & Hotels in Southern Illinois
- Adventure Hotels in Southern Illinois
- Beach Hotels in Southern Illinois
- Business Hotels in Southern Illinois
- Casinos in Southern Illinois
- Cheap Hotels in Southern Illinois
- Family Hotels in Southern Illinois
- Golf Hotels in Southern Illinois
- Green Hotels in Southern Illinois
- Historic Hotels in Southern Illinois
- Hotel Wedding Venues in Southern Illinois
- Hotel with a Concierge in Southern Illinois
- Hotels with Bars in Southern Illinois
- Hotels with Early Check-in in Southern Illinois
- Hotels with Free Parking in Southern Illinois
- Hotels with Hot Tubs in Southern Illinois
- Hotels with WiFi in Southern Illinois
- Hotels with a Pool in Southern Illinois
- Hotels with an Indoor Pool in Southern Illinois
- Hotels with smoking rooms in Southern Illinois
- Luxury Hotels in Southern Illinois
- Pet-friendly Hotels in Southern Illinois
- Resorts & Hotels with Spas in Southern Illinois
- Romantic Hotels in Southern Illinois
- Scuba Diving in Southern Illinois
- Shopping Hotels in Southern Illinois
- Ski Hotels in Southern Illinois
- Waterpark Hotels in Southern Illinois
- Winery Hotels in Southern Illinois
More Accommodation Types in Southern Illinois
- Vacation Homes in Southern Illinois
- Cabin Rentals in Southern Illinois
- Apartments in Southern Illinois
- Motels in Southern Illinois
- Cottages in Southern Illinois
- Aparthotels in Southern Illinois
- RV Parks in Southern Illinois
- Farmstay in Southern Illinois
- B&B in Southern Illinois
- Condo Rentals in Southern Illinois
- Lodges in Southern Illinois
- Guest Houses in Southern Illinois
- Villas in Southern Illinois
- Chalets in Southern Illinois
- Resorts in Southern Illinois
Hotels near Southern Illinois Airports
- St. Louis Downtown Airport Hotels
- Mount Vernon Outland Airport Hotels
- MidAmerica-St. Louis Airport Hotels
- Southern Illinois Airport Hotels
- Williamson County Regional Airport Hotels
- Vandalia Municipal Airport Hotels
- Lawrenceville-Vincennes Intl. Airport Hotels
- Coles County Memorial Airport Hotels
- Cairo Regional Airport Hotels
Southern Illinois Hotels by Brand
Other Hotels near Southern Illinois, Illinois
- St. Charles Hotels
- Evansville Hotels
- Paducah Hotels
- Maryland Heights Hotels
- Chesterfield Hotels
- Terre Haute Hotels
- Cape Girardeau Hotels
- Effingham Hotels
- Marion Hotels
- Carbondale Hotels
- O'Fallon Hotels
- Mount Vernon Hotels
- Decatur Hotels
- Fairview Heights Hotels
- Hazelwood Hotels
- Collinsville Hotels
- Sikeston Hotels
- Fenton Hotels
- Farmington Hotels
- Edwardsville Hotels
Explore more hotels
- Drury Inn & Suites St. Louis Fairview Heights
- Red Lion Inn & Suites Caseyville
- Comfort Suites Fairview Heights
- Country Inn & Suites by Radisson, Effingham, IL
- Walker's Bluff Casino Resort
- Super 8 by Wyndham Troy IL/St. Louis Area
- Quality Inn O'Fallon IL - St. Louis
- Days Inn by Wyndham Collinsville/St. Louis
- Baymont by Wyndham Effingham
- Holiday Inn Express Troy by IHG
- Best Western Plus Pontoon Beach
- Super 8 by Wyndham Fairview Heights-St. Louis