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Compare hotels near Cairo Regional airport with room rates, reviews, and updated availability. Most hotels are fully refundable.

Quality Inn Cairo I-57
Quality Inn Cairo I-57
6.6 out of 10, (247)
The price is AED 312
AED 346 total
includes taxes & fees
25 Mar - 26 Mar

Eagle Inn Charleston
Eagle Inn Charleston
6.8 out of 10, (95)
The price is AED 234
AED 260 total
includes taxes & fees
25 Mar - 26 Mar

Super 8 by Wyndham Charleston/Sikeston East MO
Super 8 by Wyndham Charleston/Sikeston East MO
6.6 out of 10, (547)
The price is AED 241
AED 268 total
includes taxes & fees
6 Apr - 7 Apr
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Recent reviews of Cairo Regional hotels
Recent reviews of Cairo Regional hotels

Best Western Plus Sikeston
5/5 Excellent
"liked the person that checked us in came and showed us how to get tv on "
A verified traveler stayed at Best Western Plus Sikeston
Posted 17 hours ago
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Hotels Close to Nearby Airports
Hotels near popular Cairo Attractions
- Shawnee National Forest
- Mississippi River
- Ohio River
- Southeast Missouri State University
- Isle Casino Cape Girardeau
- Riverfront Bridge Park
- Cape Rock Park
- Columbus-Belmont State Park
- Riverfront Park
- Henry N Barkhausen Cache River Wetlands Center
- Fort D Historic Site
- eDen Spa & Salon
- The Book Bug
- Mound City National Cemetery
- Fort Defiance State Park
- Boot Heel Golf Club
- Ballard Wildlife Management Area
- Shawnee Community College
- Sikeston Depot Museum
- Ullin City Hall
Hotel options around Cairo Regional
- Charming 3-bedroom house near ball park in quiet neighborhood
- Days Inn and Suites by Wyndham Sikeston
- The Riverview
- Pear Tree Inn Sikeston
- Best Western Plus Sikeston
- Drury Inn & Suites Sikeston, MO
- Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
- Country Yard Inn and Suite
- Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286
- Comfort Inn & Suites Sikeston I-55
- Charming cottage overlooking Lake Acre
- Super 8 by Wyndham Sikeston/Miner Area
- Charming Home just minutes from Interstate and Mall
- Courtyard by Marriott Cape Girardeau Downtown
- Building at Cape Girardeau Regional Airport
- Next door to Wildlife Mgmt Area. Full kitchen, washer/dryer.
- Charming 3-bedroom house with WiFi and AC in beautiful Joppa.
- Serenity South -- Gardens, River-Views, and Refreshing Space
- Hampton Inn Sikeston
- River's Dawn - Modernized Historic Home - River Views - King Bed - Fast Wifi