Photo by Ryan Coleman

Search Vacation Homes in Sikeston

    calendar shield illustration
    Change your mind
    Book hotels with free cancellation
    deals illustration
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    bed illustration
    Be picky
    Search almost a million properties worldwide

Check prices for these dates

Next weekend
In two weeks
In one month
In two months

Compare 76 Vacation Homes in Sikeston with updated reviews, rates, and availability.

Serenity South -- Gardens, River-Views, and Refreshing Space

10.0 out of 10, Exceptional, (130)
"When looking for a VRBO for our daughter's college visit, we knew the perfect place to stay! This is our second stay at Serenity South and it was just as incredible as the first visit. Clean, inviting and cozy. Thanks Jo for another beautiful stay."
The price is AED 551
AED 900 total
includes taxes & fees
19 May - 20 May
Serenity South -- Gardens, River-Views, and Refreshing Space

Notting Hill Cottage

9.6 out of 10, Exceptional, (308)
"We stayed 4 days with our pup who enjoyed the fenced in yard! Despite the rainy weather for half of our trip we were comfortable in the house. It had everything we needed to cook and relax. Utlized the hot tub a few days as well as hiked neary Giant City and Ferne Cliff. "
Notting Hill Cottage

Beautiful location in the secluded woods

9.8 out of 10, Exceptional, (26)
"Absolutely beautiful property! We loved staying at the lodge so much and will definitely be coming back. Such a great location, beautiful views. We have nothing but great things to say about our stay. The host was very responsive and helpful. Such a great experience! Adult, kids and doggy approved of this awesome place!"
The price is AED 422
AED 694 total
includes taxes & fees
6 May - 7 May
Beautiful location in the secluded woods

* On the Wine Trail * Hot Tub * Wi-Fi *

9.8 out of 10, Exceptional, (225)
"Property was just as described! Very centrally located on the wine trail and had everything we needed! "
* On the Wine Trail * Hot Tub * Wi-Fi *

Wine Trail, Cozy Cabin plus hot tub

10.0 out of 10, Exceptional, (92)
"We had a great stay despite the rainy weather. The house was cozy and clean. We enjoyed staying in and using the hot tub. Great experience. "
Wine Trail, Cozy Cabin plus hot tub

* Best Location on the Wine Trail! * Hiking Trail 1 min away * Wi-Fi *

10.0 out of 10, Exceptional, (91)
"This place was perfect for our Shawnee National Forest Adventure. We were there early in the week so the local things we liked were not open. Great Value, but loses a star for dirty front windows, no dishwasher and no ceiling fans."
* Best Location on the Wine Trail! * Hiking Trail 1 min away * Wi-Fi *

Minutes from WineTrail, Giant City, Shawnee Forest - Daily Deer Viewing - Rural

10.0 out of 10, Exceptional, (115)
"My husband and I stayed with our dog at this property and had a wonderful time! We have been to the trail many times during peak season, but decided we wanted to do something a little more lowkey and bring our dog. We spent quite a bit of time in the house, reading, watching TV cooking, and all of the amenities that we needed were there. Communication with the property owner, Steve, was also very easy and he was very responsive.Would recommend this cozy home! "
Minutes from WineTrail, Giant City, Shawnee Forest - Daily Deer Viewing - Rural

Brick Estate with pool in Quiet Carbondale Neighborhood

9.4 out of 10, Exceptional, (85)
"We enjoyed our stay here very much. The home is large yet cozy and located in a lovely quiet neighborhood. Perfect for visiting local family and friends!"
Brick Estate with pool in Quiet Carbondale Neighborhood

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

8.8 out of 10, Excellent, (28)
"all was so nice and we enjoyed our stay. grandkids and us loved having pool table and card games and all the peace and quiet there. thank u again for contacting me and giving us address. we appreciated that very much. "
The price is AED 551
AED 862 total
includes taxes & fees
27 Apr - 28 Apr
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

8.0 out of 10, Very Good, (1)
"The house has a very eclectic decor, but fun. We were a group of 10 ladies and had a great time. Thank you "
The price is AED 1,098
AED 1,738 total
includes taxes & fees
27 Apr - 28 Apr
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

Dexter Homestead. Very Cozy & NEW Remodel !

8.0 out of 10, Very Good, (23)
"I've stayed here many times. The remodel is great. Reserved for 10 days, had to leave 2 days early. Ill be back!"
The price is AED 364
AED 765 total
includes taxes & fees
12 May - 13 May
Dexter Homestead. Very Cozy & NEW Remodel !

Private lake, beach & hot tub, romantic getaway or family vaca

10.0 out of 10, Exceptional, (23)
"We had a funeral in Poplar Bluff and needed a place to stay. This worked well for our family for the few days we stayed. "
Private lake, beach & hot tub, romantic getaway or family vaca

'The Lakehouse' Lovely Wappapello Country Home!

9.8 out of 10, Exceptional, (16)
"Traveled with my two daughters (teens) to visit my mom. The house was perfect for hanging around and visiting with family. Well stocked and good communication from the host. "
'The Lakehouse' Lovely Wappapello Country Home!

Charming 2-bedroom house in delightful Jackson with AC, WiFi

10.0 out of 10, Exceptional, (4)
"Very clean and spacious. Well decorated and stocked with every you might need away from home. Will definitely stay here again."
Charming 2-bedroom house in delightful Jackson with AC, WiFi

Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi

10.0 out of 10, Exceptional, (5)
"A large and comfortable house with cool historical details and just about everything you need to have a great, easy, smooth-running vacation. Great location for downtown exploring."
Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi

Quaint, Beautiful Home next to SEMO and Hospital

9.8 out of 10, Exceptional, (34)
"The home had everything we needed for a relaxing weekend! Owner responded promptly and everything was as it was listed!"
Quaint, Beautiful Home next to SEMO and Hospital

Welcome campers, hikers, fishermen, girls' weekend wine getaways!!

2.0 star property
10.0 out of 10, Exceptional, (9)
"It was exactly what we were looking for and exceeded our expectations. We plan to be back! The hosts were wonderful! "
The price is AED 735
AED 907 total
includes taxes & fees
29 Apr - 30 Apr
Welcome campers, hikers, fishermen, girls' weekend wine getaways!!

"Brickyard" Remodeled 1920's Dutch Colonial Revival in Downtown Cape Girardeau

10.0 out of 10, Exceptional, (14)
"Chip was an excellent host, always available to provide tips about restaurants and answer any questions about the property. Property was in great condition and would not hesitate to recommend."
"Brickyard" Remodeled 1920's Dutch Colonial Revival in Downtown Cape Girardeau

Embers of Murphysboro - 5 Star Cabin Sleeps up to 12 - GREAT AMMENITIES!

10.0 out of 10, Exceptional, (10)
"The property exceeded all of our expectations. We couldn’t have asked for better hosts. "
Embers of Murphysboro - 5 Star Cabin Sleeps up to 12 - GREAT AMMENITIES!

StarView Vineyards Winery Retreat

10.0 out of 10, Exceptional, (33)
"The house was clean and nicely updated. There was plenty of room for us. The area is easily accessible to activities. "
StarView Vineyards Winery Retreat
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Don't see what you're looking for?
See all available properties in Sikeston
Save an average of 15% on thousands of hotels when you're signed in

Other property types in Sikeston

New cabin in the woods with private hot tub

10.0 out of 10, Exceptional, (110)
"Great clean cabin in the woods with hot tub clean and nice"
New cabin in the woods with private hot tub

Beautiful location in the secluded woods

9.8 out of 10, Exceptional, (26)
"Absolutely beautiful property! We loved staying at the lodge so much and will definitely be coming back. Such a great location, beautiful views. We have nothing but great things to say about our stay. The host was very responsive and helpful. Such a great experience! Adult, kids and doggy approved of this awesome place!"
The price is AED 422
AED 694 total
includes taxes & fees
6 May - 7 May
Beautiful location in the secluded woods

Rest, Relax and Renew. Our log cabin experience awaits your arrival.

10.0 out of 10, Exceptional, (378)
"Overall very nice place. Host were great and easy to contact. "
The price is AED 430
AED 762 total
includes taxes & fees
5 May - 6 May
Rest, Relax and Renew. Our log cabin experience awaits your arrival.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.