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Compare 64 Vacation Homes in Sikeston with updated reviews, rates, and availability.

Serenity South -- Gardens, River-Views, and Refreshing Space

10.0 out of 10, Exceptional, (128)
"We had a wonderful time at Serenity South! The house is quiet and very clean, in walking distance of fantastic shops and fun places to eat. We look forward to returning next year!"
The price is AED 551
AED 900 total
includes taxes & fees
17 Mar - 18 Mar
Serenity South -- Gardens, River-Views, and Refreshing Space

Beautiful location in the secluded woods

9.8 out of 10, Exceptional, (23)
"This was a great house for us! We were able to bring our dog, she’s old, the house had only a few steps for her to get in and out. The property was flat with lots of space for her to roam. There’s lots of hiking trails near and the area is beautiful! The house isn’t fancy, but it was very homey and comfort. We really enjoyed our long weekend there!"
The price is AED 422
AED 683 total
includes taxes & fees
17 Mar - 18 Mar
Beautiful location in the secluded woods

"Brickyard" Remodeled 1920's Dutch Colonial Revival in Downtown Cape Girardeau

10.0 out of 10, Exceptional, (13)
"Chip was fantastic and went above and beyond to get us acquainted with the property! Fantastic weekend in a beautiful home with family and friends!"
"Brickyard" Remodeled 1920's Dutch Colonial Revival in Downtown Cape Girardeau

Wine Trail, Cozy Cabin plus hot tub

10.0 out of 10, Exceptional, (86)
"Really nice little place in the middle of nowhere but also close to hiking spots and wineries. Very clean and just the right size for our small family. We especially enjoyed the hot tub and seeing all of the stars at night. Lovely owners and good communication. Easy to check in and out."
Wine Trail, Cozy Cabin plus hot tub

* Best Location on the Wine Trail! * Hiking Trail 1 min away * Wi-Fi *

10.0 out of 10, Exceptional, (88)
"Girls trip "
The price is AED 878
AED 1,096 total
includes taxes & fees
12 Apr - 13 Apr
* Best Location on the Wine Trail! * Hiking Trail 1 min away * Wi-Fi *

Notting Hill Cottage

9.6 out of 10, Exceptional, (304)
"We stayed here previously but it was under different ownership. The new owners have done a great job of making it really comfortable. It was a perfect spot for us to visit family and have our own space close by."
Notting Hill Cottage

Charming 2-bedroom house in delightful Jackson with AC, WiFi

10.0 out of 10, Exceptional, (3)
"We had 4 of us for a 2 night stay. The property is clean, everything looked fresh and welcoming. The house is located about a mile off of hwy 61, so is close to fuel, restaurants, etc. We enjoyed the quiet surroundings."
Charming 2-bedroom house in delightful Jackson with AC, WiFi

Spacious 2 BR, 1 1/2 baths, hot tub, pool table, outside room, full kitchen

9.8 out of 10, Exceptional, (141)
"We loved our stay here! Myself and a few friends came to hike in this beautiful area of Illinois. This VRBO is as lovely as it appears in the photos and description! Kathy is a delightful lady who was very helpful to us, and the home is set up with everything you’ll need, and with such intentional and thoughtful hospitality. We enjoyed relaxing in the hot tub, playing games, and eating delicious food prepared in the spacious kitchen. We ask agreed we would definitely recommend this VRBO to...
Spacious 2 BR, 1 1/2 baths, hot tub, pool table, outside room, full kitchen

Brick Estate with pool in Quiet Carbondale Neighborhood

9.4 out of 10, Exceptional, (84)
"We enjoyed our stay here very much. The home is large yet cozy and located in a lovely quiet neighborhood. Perfect for visiting local family and friends!"
Brick Estate with pool in Quiet Carbondale Neighborhood

* On the Wine Trail * Hot Tub * Wi-Fi *

9.8 out of 10, Exceptional, (219)
"Thank you for your hospitality and quick assistance to any need. The apartment was cozy, clean and comfortable. We enjoy very much our stay and would love to be back for sure."
* On the Wine Trail * Hot Tub * Wi-Fi *

Private lake, beach & hot tub, romantic getaway or family vaca

10.0 out of 10, Exceptional, (23)
"We had a funeral in Poplar Bluff and needed a place to stay. This worked well for our family for the few days we stayed. "
Private lake, beach & hot tub, romantic getaway or family vaca

Betty's Vineyard House - On the Shawnee Wine Trail - Walk to/from the Winery!

10.0 out of 10, Exceptional, (72)
"Beth was really a great host! She communicated with us very well and even checked with us while we were there to see if we needed anything else. We will definitely come back. The house was darling and everything was as described. Thank you for a great weekend!!"
Betty's Vineyard House - On the Shawnee Wine Trail - Walk to/from the Winery!

Minutes from WineTrail, Giant City, Shawnee Forest - Daily Deer Viewing - Rural

10.0 out of 10, Exceptional, (115)
"My husband and I stayed with our dog at this property and had a wonderful time! We have been to the trail many times during peak season, but decided we wanted to do something a little more lowkey and bring our dog. We spent quite a bit of time in the house, reading, watching TV cooking, and all of the amenities that we needed were there. Communication with the property owner, Steve, was also very easy and he was very responsive.Would recommend this cozy home! "
Minutes from WineTrail, Giant City, Shawnee Forest - Daily Deer Viewing - Rural

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

The price is AED 1,098
AED 1,738 total
includes taxes & fees
23 Mar - 24 Mar
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

8.8 out of 10, Excellent, (27)
"Amazing property that we simply didn't stay long enough to enjoy in its completeness. Billiards and Putt-Putt on entry, so attractive that we started playing before we even unpacked! I'm very artsy interior, and lots of room and outdoor fire pit, multiple decks, and an in-ground pool. The home is even on the grounds, an event venue. Probably a wonderful combination for them! Would enjoy returning, but for a longer stay will you could enjoy all with the property had to offer! Highly recommend it"
The price is AED 551
AED 869 total
includes taxes & fees
23 Mar - 24 Mar
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

Spacious 3 bedroom, 2 full baths, hot tub, fireplace, full kitchen, outside deck

9.8 out of 10, Exceptional, (14)
"Cozy, cute place. The hot tub was excellent. So close to town. Would recommend."
Spacious 3 bedroom, 2 full baths, hot tub, fireplace, full kitchen, outside deck

Attention hunters! Deer Camp, Duck Camp nestled in the Shawnee Forest.

2.0 star property
10.0 out of 10, Exceptional, (7)
"This place is just what we needed for our snow goose hunting camp! Place was clean and tidy and even had a pool table that made for hours of fun! Host went above and beyond to be helpful and was excellent with communication and was even kind enough to bring us some snow goose summer sausage (which was delicious)! I wouldn't hesitate to stay here again and would recommend it to anyone!!!"
The price is AED 735
AED 907 total
includes taxes & fees
19 Mar - 20 Mar
Attention hunters! Deer Camp, Duck Camp nestled in the Shawnee Forest.

'The Lakehouse' Lovely Wappapello Country Home!

9.6 out of 10, Exceptional, (15)
"This place worked out perfect for our group of snow goose hunters."
'The Lakehouse' Lovely Wappapello Country Home!

Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi

10.0 out of 10, Exceptional, (5)
"A large and comfortable house with cool historical details and just about everything you need to have a great, easy, smooth-running vacation. Great location for downtown exploring."
Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi

Quaint, Beautiful Home next to SEMO and Hospital

9.8 out of 10, Exceptional, (32)
"This property is on a very quiet street in a great location that is close to everything including the volleyball tournament I attended over the weekend. The gas fireplace was nice. The bed and bedding were comfortable. Everything was smooth and easy. Would stay again. "
Quaint, Beautiful Home next to SEMO and Hospital
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Other property types in Sikeston

Beautiful location in the secluded woods

9.8 out of 10, Exceptional, (23)
"This was a great house for us! We were able to bring our dog, she’s old, the house had only a few steps for her to get in and out. The property was flat with lots of space for her to roam. There’s lots of hiking trails near and the area is beautiful! The house isn’t fancy, but it was very homey and comfort. We really enjoyed our long weekend there!"
The price is AED 422
AED 683 total
includes taxes & fees
17 Mar - 18 Mar
Beautiful location in the secluded woods

New cabin in the woods with private hot tub

10.0 out of 10, Exceptional, (104)
"Perfect property for a couples getaway. The kitchen had everything we needed. The beds were soft and clean. Very centrally located to get to the different wineries. Loved the hot tub!! I would stay here again."
New cabin in the woods with private hot tub

Rest, Relax and Renew. Our log cabin experience awaits your arrival.

10.0 out of 10, Exceptional, (374)
"This was our second stay at this quiet out of the way cabin. Will most definitely return!"
The price is AED 430
AED 754 total
includes taxes & fees
17 Mar - 18 Mar
Rest, Relax and Renew. Our log cabin experience awaits your arrival.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.