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Compare 144 Vacation Homes in Southeast Missouri with updated reviews, rates, and availability.

Quaint, Beautiful Home next to SEMO and Hospital
Living area

Quaint, Beautiful Home next to SEMO and Hospital

9.8 out of 10, Exceptional, (28)
"Great weekend getaway with the girls for attending the local craft fairs. Quiet location with plenty of space for everyone. "
Quaint, Beautiful Home next to SEMO and Hospital
Whole house, secluded getaway near Alley Springs, Eminence , Missouri.
Exterior

Whole house, secluded getaway near Alley Springs, Eminence , Missouri.

10.0 out of 10, Exceptional, (2)
"This location was a perfect place for a large family gathering. There was adequate space for a couple of families to stay overnight! Close to Harvey’s canoe/raft rentals! The host was very helpful!"
Whole house, secluded getaway near Alley Springs, Eminence , Missouri.
Cozy Three bedroom home in Central Farmington
Living Room

Cozy Three bedroom home in Central Farmington

9.6 out of 10, Exceptional, (17)
"We came into town for opening weekend of deer season and need a convenient place to stay. We found this listing and reserved the home for the weekend. The home was clean and very welcoming and met all of our expectations. The owner was very accommodating and eager to help however needed. We enjoyed our stay!"
The price is AED 441
AED 961 total
includes taxes & fees
10 Jan - 11 Jan
Cozy Three bedroom home in Central Farmington
Home Sweet Home, Spacious Sunroom & Fun Deck!
Sunroom sitting & lounging area. TV, DVD & VHS

Home Sweet Home, Spacious Sunroom & Fun Deck!

10.0 out of 10, Exceptional, (57)
"This house was adorable! Loved the sun room!! It felt like home! Very clean. Works definitely start again!"
Home Sweet Home, Spacious Sunroom & Fun Deck!
Gabouri Place ~ Completely Renovated Victorian in Ste. Genevieve's Historic Dist
New Summer 2018

Gabouri Place ~ Completely Renovated Victorian in Ste. Genevieve's Historic Dist

10.0 out of 10, Exceptional, (164)
"We come here annually and love the memories made in this home to kick off the holidays! "
Gabouri Place ~ Completely Renovated Victorian in Ste. Genevieve's Historic Dist
Come stay at The White House. Old World Charm in fabulous Farmington
Exterior

Come stay at The White House. Old World Charm in fabulous Farmington

2.0 star property
9.8 out of 10, Exceptional, (7)
"Needed a place to stay while visiting and this place worked out great. Plenty of room and no issues. "
The price is AED 477
AED 962 total
includes taxes & fees
10 Jan - 11 Jan
Come stay at The White House. Old World Charm in fabulous Farmington
The Cabin on Current River with Private Gravel Bar!!
Kitchen View

The Cabin on Current River with Private Gravel Bar!!

8.6 out of 10, Excellent, (25)
"Due to a situation beyond the property owners control we weren’t able to stay at the original cabin but they acted quickly and moved us to another. Great service and we had a great time. "
The Cabin on Current River with Private Gravel Bar!!
Bluebird Meadows with In-ground Pool and Hot Tub! 125 ACRES TO EXPLORE
Pool

Bluebird Meadows with In-ground Pool and Hot Tub! 125 ACRES TO EXPLORE

10.0 out of 10, Exceptional, (58)
"Our family rented Bluebird Meadows for a weekend get away. We had a great time all three days. Place was everything we were hoping. "
Bluebird Meadows with In-ground Pool and Hot Tub! 125 ACRES TO EXPLORE
Newly renovated early 1900’s farmhouse
Bathroom

Newly renovated early 1900’s farmhouse

10.0 out of 10, Exceptional, (14)
"This old farmhouse has been spectacularly renovated. Hearts feel right at home when you enter here. Such a wonderful place for resting, relaxing and rejuvenating the spirit. Marsha is the most amazing hostess, who creates the most picture perfect experience for guests who enter her home. If you love peace and quiet, this charmer is the perfect retreat for you. "
Newly renovated early 1900’s farmhouse
Missouri Castle w/ Private Lake, Pool & 100 Acres!
Saint Mary Vacation Rental | 7BR | 3.5BA | 6,800 Sq Ft | Steps Required

Missouri Castle w/ Private Lake, Pool & 100 Acres!

10.0 out of 10, Exceptional, (3)
"Our group stayed here after a larger family reunion at Trout Lodge, YMCA. The place was great with something to do for everyone. Having a private, CLEAN pool for the family is amazing. We hiked around and boated around the lake, made s’mores by a campfire, played pool and darts and board games and grilled meals. This house lets you do it all and has the space to visit family and also have alone time. I’d love to come back."
Missouri Castle w/ Private Lake, Pool & 100 Acres!
Tiny Houses of French Village
Front of property

Tiny Houses of French Village

2.5 star property
10.0 out of 10, Exceptional, (2)
"Charming property with a space for everything and everything in its place. Would not hesitate to recommend or stay again."
The price is AED 907
AED 1,344 total
includes taxes & fees
12 Jan - 13 Jan
Tiny Houses of French Village
Enjoy a charming 1860s newly renovated home!!

Enjoy a charming 1860s newly renovated home!!

8.2 out of 10, Very Good, (13)
"Traveling with a large family is never easy, but this rental made us feel at home. Full kitchen for cooking, dining area to seat everyone, huge tv, great wi-fi, washer and dryer, fun backyard to make s’mores, and beds upstairs to sleep all our kids. We would stay here again!"
The price is AED 496
AED 988 total
includes taxes & fees
10 Jan - 11 Jan
Enjoy a charming 1860s newly renovated home!!
Cozy town house - 3 Queen beds
Living area

Cozy town house - 3 Queen beds

9.8 out of 10, Exceptional, (10)
"We had a great stay! Thank you! "
The price is AED 345
AED 618 total
includes taxes & fees
13 Jan - 14 Jan
Cozy town house - 3 Queen beds
Cozy Haven Little Hidden Gem Sleeps 4
Cozy Haven Guest House Couples /family, Friends Gatherings.

Cozy Haven Little Hidden Gem Sleeps 4

10.0 out of 10, Exceptional, (38)
"It was relaxing and peaceful."
Cozy Haven Little Hidden Gem Sleeps 4
Shawnee Creek Hideaway - Close to Eminence and the Jacks Fork River!
Dining

Shawnee Creek Hideaway - Close to Eminence and the Jacks Fork River!

10.0 out of 10, Exceptional, (60)
"Exactly as liste very nice accommodations and centrally located for lots of outdoor activities thanks George for your hospitality "
Shawnee Creek Hideaway - Close to Eminence and the Jacks Fork River!
2 Bedroom Home less than 2 miles to Jacks Fork River
Living area

2 Bedroom Home less than 2 miles to Jacks Fork River

10.0 out of 10, Exceptional, (18)
"Thank you for sharing your beautiful home! Everything about it was perfect. We loved the fur mattresses and the quiet secluded yard. Everything was so clean. Everything we needed was there. Thank you;we would highly recommend!"
2 Bedroom Home less than 2 miles to Jacks Fork River
Black River Retreat 5 Minutes from Jeff’s Canoe Rental /K Bridge
Exterior

Black River Retreat 5 Minutes from Jeff’s Canoe Rental /K Bridge

10.0 out of 10, Exceptional, (12)
"Great accommodations for a family, lots of room. No wifi, tho."
Black River Retreat 5 Minutes from Jeff’s Canoe Rental /K Bridge
"Brickyard" Remodeled 1920's Dutch Colonial Revival in Downtown Cape Girardeau
There is on-street parking directly in front of the house.

"Brickyard" Remodeled 1920's Dutch Colonial Revival in Downtown Cape Girardeau

10.0 out of 10, Exceptional, (11)
"Was in town working a convention, family stayed here more than I did but they enjoyed their time there. Property is next to local park, the split door made it great to have open for a breeze and keep an eye on the kids. Beds were comfy and everyone had a great time. Our host, Chip, was friendly and informative on the history of the property, kids loved meeting with him and "Busy" his 4 legged friend."
"Brickyard" Remodeled 1920's Dutch Colonial Revival in Downtown Cape Girardeau
Sunshine Shack at Clearwater Lake (sleeps 6)
Terrace/patio

Sunshine Shack at Clearwater Lake (sleeps 6)

8.8 out of 10, Excellent, (10)
"Loved staying a week at Sunshine Shack. The screened in deck is perfect to watch the deer at dusk."
Sunshine Shack at Clearwater Lake (sleeps 6)
Historic Victorian close to amazing hiking - pet friendly!
Exterior

Historic Victorian close to amazing hiking - pet friendly!

9.0 out of 10, Wonderful, (2)
"Cute & clean home! Property manager was so easy to communicate with and super friendly!! We will be coming back!!"
Historic Victorian close to amazing hiking - pet friendly!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Other property types in Southeast Missouri

Holiday Inn Club Vacations Timber Creek Resort at De Soto, an IHG Hotel
Exterior

Holiday Inn Club Vacations Timber Creek Resort at De Soto, an IHG Hotel

3.5 star property
9.4 out of 10, Exceptional, (139)
"Many things to do if you don't want to go anywhere. Close to shopping, restaurant. "
The price is AED 584
AED 673 total
includes taxes & fees
13 Jan - 14 Jan
Holiday Inn Club Vacations Timber Creek Resort at De Soto, an IHG Hotel
Secluded Ozarks Tiny House cabin in Eminence, MO
Exterior

Secluded Ozarks Tiny House cabin in Eminence, MO

9.6 out of 10, Exceptional, (90)
"Very clean accommodations. Very secluded location. Private, peaceful, and quiet. Very relaxing environment. We found it to be a very good central location for going out and exploring the trails."
Secluded Ozarks Tiny House cabin in Eminence, MO
Quaint, Beautiful Home next to SEMO and Hospital
Living area

Quaint, Beautiful Home next to SEMO and Hospital

9.8 out of 10, Exceptional, (28)
"Great weekend getaway with the girls for attending the local craft fairs. Quiet location with plenty of space for everyone. "
Quaint, Beautiful Home next to SEMO and Hospital
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.