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Check prices for these dates

Next weekend
28 Feb - 2 Mar
In two weeks
7 Mar - 9 Mar
In one month
21 Mar - 23 Mar
In two months
18 Apr - 20 Apr

Compare 143 Vacation Homes in Southeast Missouri with updated reviews, rates, and availability.

Quaint, Beautiful Home next to SEMO and Hospital
Living area

Quaint, Beautiful Home next to SEMO and Hospital

9.8 out of 10, Exceptional, (32)
"This property is on a very quiet street in a great location that is close to everything including the volleyball tournament I attended over the weekend. The gas fireplace was nice. The bed and bedding were comfortable. Everything was smooth and easy. Would stay again. "
Quaint, Beautiful Home next to SEMO and Hospital
Shawnee Creek Hideaway - Close to Eminence and the Jacks Fork River!
Dining

Shawnee Creek Hideaway - Close to Eminence and the Jacks Fork River!

10.0 out of 10, Exceptional, (60)
"We chose this property for our 1st Christmas away from home. I traveled with my husband, 3 kids aged 10-17, and 2 dogs. Walking in the first thing we saw was the beautiful Christmas tree and the decorated screened in porch. The home was very clean and had everything we could possibly need. The furniture was comfy and there were plenty of places for everyone to sit and relax. The bedrooms were spacious. The closets provided more than enough space to hang the clothes we brought with us. These...
Shawnee Creek Hideaway - Close to Eminence and the Jacks Fork River!
Gabouri Place ~ Completely Renovated Victorian in Ste. Genevieve's Historic Dist
New Summer 2018

Gabouri Place ~ Completely Renovated Victorian in Ste. Genevieve's Historic Dist

10.0 out of 10, Exceptional, (164)
"Nice location, clean and inviting."
Gabouri Place ~ Completely Renovated Victorian in Ste. Genevieve's Historic Dist
Whole house, secluded getaway near Alley Springs, Eminence , Missouri.
Exterior

Whole house, secluded getaway near Alley Springs, Eminence , Missouri.

10.0 out of 10, Exceptional, (2)
"This location was a perfect place for a large family gathering. There was adequate space for a couple of families to stay overnight! Close to Harvey’s canoe/raft rentals! The host was very helpful!"
Whole house, secluded getaway near Alley Springs, Eminence , Missouri.
Cozy 1.5 story bungalow in downtown Ste. Genevieve!
Interior

Cozy 1.5 story bungalow in downtown Ste. Genevieve!

9.8 out of 10, Exceptional, (11)
"Spent one night, explored St Genevieve. We had everything needed and host was most accommodating. The upstairs bedroom has low clearance but not an issue for us. "
Cozy 1.5 story bungalow in downtown Ste. Genevieve!
Come stay at The White House. Old World Charm in fabulous Farmington
Exterior

Come stay at The White House. Old World Charm in fabulous Farmington

2.0 star property
9.8 out of 10, Exceptional, (8)
"We stayed here for 1 week and had a wonderful time. The home is convenient to stores and is a very family friendly home and area to stay. "
The price is AED 477
AED 948 total
includes taxes & fees
20 Feb - 21 Feb
Come stay at The White House. Old World Charm in fabulous Farmington
Missouri Castle w/ Private Lake, Pool & 100 Acres!
Saint Mary Vacation Rental | 7BR | 3.5BA | 6,800 Sq Ft | Steps Required

Missouri Castle w/ Private Lake, Pool & 100 Acres!

10.0 out of 10, Exceptional, (3)
"My family of 14 people needed a place for all of us to stay for the holidays. The twin turrets was a great fit for what we needed. Everyone had their own bed, the bathrooms took a little time to get showers scheduled, since there are only 2 showers, but it worked out. The home was fun to explore inside and out. We went for some walks on the trails, enjoyed watching the ducks and geese, or just looking out at the lake. So peaceful! "
Missouri Castle w/ Private Lake, Pool & 100 Acres!
Tiny Houses of French Village
Front of property

Tiny Houses of French Village

2.5 star property
10.0 out of 10, Exceptional, (2)
"Charming property with a space for everything and everything in its place. Would not hesitate to recommend or stay again."
The price is AED 907
AED 1,344 total
includes taxes & fees
20 Feb - 21 Feb
Tiny Houses of French Village
Bluebird Meadows with In-ground Pool and Hot Tub! 125 ACRES TO EXPLORE
Pool

Bluebird Meadows with In-ground Pool and Hot Tub! 125 ACRES TO EXPLORE

10.0 out of 10, Exceptional, (59)
"Nice farmhouse in the country."
Bluebird Meadows with In-ground Pool and Hot Tub! 125 ACRES TO EXPLORE
The Cabin on Current River with Private Gravel Bar!!
Kitchen View

The Cabin on Current River with Private Gravel Bar!!

8.6 out of 10, Excellent, (25)
"Due to a situation beyond the property owners control we weren’t able to stay at the original cabin but they acted quickly and moved us to another. Great service and we had a great time. "
The Cabin on Current River with Private Gravel Bar!!
"Brickyard" Remodeled 1920's Dutch Colonial Revival in Downtown Cape Girardeau
There is on-street parking directly in front of the house.

"Brickyard" Remodeled 1920's Dutch Colonial Revival in Downtown Cape Girardeau

10.0 out of 10, Exceptional, (13)
"Chip was fantastic and went above and beyond to get us acquainted with the property! Fantastic weekend in a beautiful home with family and friends!"
"Brickyard" Remodeled 1920's Dutch Colonial Revival in Downtown Cape Girardeau
Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi
Exterior

Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi

10.0 out of 10, Exceptional, (5)
"A large and comfortable house with cool historical details and just about everything you need to have a great, easy, smooth-running vacation. Great location for downtown exploring."
Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi
Ste Genevieve Home on 17 Acres, Near Wineries!
Ste Genevieve Vacation Rental | 5BR | 4BA | 1,980 Sq Ft | Stairs Required

Ste Genevieve Home on 17 Acres, Near Wineries!

9.8 out of 10, Exceptional, (7)
"We stayed at this property for my birthday weekend and it was fabulous! We cooked several meals and the kitchen had EVERYTHING! The house is nestled in the woods, with beautiful surroundings and the house is so cozy. I would definitely stay here again!"
Ste Genevieve Home on 17 Acres, Near Wineries!
Historic Victorian close to amazing hiking - pet friendly!
Exterior

Historic Victorian close to amazing hiking - pet friendly!

9.4 out of 10, Exceptional, (3)
"The house was well kept and comfortable. The host was very reaponsive and helpful during my stay. "
The price is AED 331
AED 551 total
includes taxes & fees
25 Feb - 26 Feb
Historic Victorian close to amazing hiking - pet friendly!
Black River Retreat 5 Minutes from Jeff’s Canoe Rental /K Bridge
Exterior

Black River Retreat 5 Minutes from Jeff’s Canoe Rental /K Bridge

10.0 out of 10, Exceptional, (12)
"Great accommodations for a family, lots of room. No wifi, tho."
Black River Retreat 5 Minutes from Jeff’s Canoe Rental /K Bridge
2 Bedroom Home less than 2 miles to Jacks Fork River
Living area

2 Bedroom Home less than 2 miles to Jacks Fork River

10.0 out of 10, Exceptional, (18)
"Thank you for sharing your beautiful home! Everything about it was perfect. We loved the fur mattresses and the quiet secluded yard. Everything was so clean. Everything we needed was there. Thank you;we would highly recommend!"
2 Bedroom Home less than 2 miles to Jacks Fork River
Just A Stone's Throw Cabin from Eminence, Jacks Fork, & Cross County Trail Ride

Just A Stone's Throw Cabin from Eminence, Jacks Fork, & Cross County Trail Ride

9.0 out of 10, Wonderful, (10)
"It was nice to be able to pull right up to the entrance of the property and walk through the door with no stairs. For a one bedroom one bathroom apartment everything was very spacious and accommodating. We especially picked this because of the king size bed. We were not able to utilize some of the outdoor space, but I imagine it would be really nice to do so. We did however enjoy the wonderful gliders /on the front porch. The owner did a great job on the decor and the furniture is very...
Just A Stone's Throw Cabin from Eminence, Jacks Fork, & Cross County Trail Ride
Sunshine Shack at Clearwater Lake (sleeps 6)
Terrace/patio

Sunshine Shack at Clearwater Lake (sleeps 6)

8.8 out of 10, Excellent, (10)
"Loved staying a week at Sunshine Shack. The screened in deck is perfect to watch the deer at dusk."
Sunshine Shack at Clearwater Lake (sleeps 6)
Charming and spacious 3-bedroom home in Farmington, close to everything.
Living area

Charming and spacious 3-bedroom home in Farmington, close to everything.

Charming and spacious 3-bedroom home in Farmington, close to everything.
RIVER FRONT HOUSE
Outdoor dining

RIVER FRONT HOUSE

9.6 out of 10, Exceptional, (38)
"Nice place. Would stay again."
RIVER FRONT HOUSE
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Other property types in Southeast Missouri

Holiday Inn Club Vacations Timber Creek Resort at De Soto
Exterior

Holiday Inn Club Vacations Timber Creek Resort at De Soto

3.5 star property
9.4 out of 10, Exceptional, (139)
"Many things to do if you don't want to go anywhere. Close to shopping, restaurant. "
The price is AED 584
AED 673 total
includes taxes & fees
20 Feb - 21 Feb
Holiday Inn Club Vacations Timber Creek Resort at De Soto
Postcard Cabins St. Francois
Exterior

Postcard Cabins St. Francois

2.0 star property
10.0 out of 10, Exceptional, (2)
"This place made me look like a rockstar to my wife. I surprised her with a V day getaway. The cabin was awesome. We loved the view of nature from the large window. I made dinner reservations nearby at the weingarten vineyard. The hiking trail along the creek was fun. We ate breakfast right down the road at Kozy. For our final night I cooked steaks over the open fire"
The price is AED 264
AED 285 total
includes taxes & fees
5 Mar - 6 Mar
Postcard Cabins St. Francois
Serenity South -- Gardens, River-Views, and Refreshing Space
Exterior

Serenity South -- Gardens, River-Views, and Refreshing Space

10.0 out of 10, Exceptional, (126)
"This is an older home (1920’s?) with so much charm. It’s exceptionally well cared for - the floors are clean and in excellent condition, the walls are clean, paint job is beautiful, etc. The air is clean (no smell of mold) bathroom fans work, etc! In short, one of the best maintained rentals we’ve stayed in. The beds are comfy. Oh - and the landscaping is also beautiful! It is winter - would love to see the gardens in the spring. Jo was easy to contact, check in was easy. The trains do run 1...
The price is AED 551
AED 896 total
includes taxes & fees
23 Feb - 24 Feb
Serenity South -- Gardens, River-Views, and Refreshing Space
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.