Search Vacation Homes in Southeast Missouri

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Check prices for these dates

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2 May - 4 May
In two weeks
9 May - 11 May
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23 May - 25 May
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20 Jun - 22 Jun

Compare 171 Vacation Homes in Southeast Missouri with updated reviews, rates, and availability.

Serenity South -- Gardens, River-Views, and Refreshing Space
Fridge, microwave, oven, stovetop

Serenity South -- Gardens, River-Views, and Refreshing Space

10.0 out of 10, Exceptional, (130)
"Great place."
The price is AED 551
AED 892 total
includes taxes & fees
4 May - 5 May
Serenity South -- Gardens, River-Views, and Refreshing Space
The Sutton House 2 blocks from Main Street & Courthouse Square
Exterior

The Sutton House 2 blocks from Main Street & Courthouse Square

10.0 out of 10, Exceptional, (23)
"Beautiful stately home in peaceful neighborhood close to Elephant Rock and Johnston Shut Ins. Highly recommended! "
The price is AED 489
AED 635 total
includes taxes & fees
30 Apr - 1 May
The Sutton House 2 blocks from Main Street & Courthouse Square
"Little Brick House on Main (1865)”
Interior

"Little Brick House on Main (1865)”

10.0 out of 10, Exceptional, (41)
"We absolutely LOVED staying in this adorable cottage!! We will definitely be going back in the future!"
The price is AED 485
AED 632 total
includes taxes & fees
28 Apr - 29 Apr
"Little Brick House on Main (1865)”
Cozy Three bedroom home in Central Farmington
Fridge, microwave, oven, stovetop

Cozy Three bedroom home in Central Farmington

9.6 out of 10, Exceptional, (22)
"We stayed for 3 nights it was small n cozy but the bedrooms actually were pretty big. The kitchen was very nice and fully stocked with anything you would need to make a meal. It was warm but the bedrooms all had nice ceiling fans. We were very happy with are stay n would stay there again."
The price is AED 441
AED 950 total
includes taxes & fees
28 Apr - 29 Apr
Cozy Three bedroom home in Central Farmington
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Exterior

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

8.8 out of 10, Excellent, (28)
"Not bad but Hot tub was not accessible and the hotwater in the 2nd bedroom had no hot water."
The price is AED 551
AED 865 total
includes taxes & fees
28 Apr - 29 Apr
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Shawnee Creek Hideaway - Close to Eminence and the Jacks Fork River!
Miscellaneous

Shawnee Creek Hideaway - Close to Eminence and the Jacks Fork River!

10.0 out of 10, Exceptional, (60)
"Great property. Everything as advertised. Had a great quiet stay and the Christmas tree was a really nice touch. Will definitely book again for future trip "
Shawnee Creek Hideaway - Close to Eminence and the Jacks Fork River!
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
Exterior

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

8.0 out of 10, Very Good, (1)
"The house has a very eclectic decor, but fun. We were a group of 10 ladies and had a great time. Thank you "
The price is AED 1,098
AED 1,738 total
includes taxes & fees
28 Apr - 29 Apr
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
Wren’s Hideaway Sleeps 8 Historic downtown neighborhood Charming & Relaxing
Exterior

Wren’s Hideaway Sleeps 8 Historic downtown neighborhood Charming & Relaxing

10.0 out of 10, Exceptional, (20)
"Would stay here again!"
Wren’s Hideaway Sleeps 8 Historic downtown neighborhood Charming & Relaxing
Whole house, secluded getaway near Alley Springs, Eminence , Missouri.
Exterior

Whole house, secluded getaway near Alley Springs, Eminence , Missouri.

10.0 out of 10, Exceptional, (3)
"Beautiful property,, frogs sang at night and the birds in the day."
Whole house, secluded getaway near Alley Springs, Eminence , Missouri.
Dexter Homestead. Very Cozy & NEW Remodel !
Smart TV, fireplace, stereo

Dexter Homestead. Very Cozy & NEW Remodel !

8.0 out of 10, Very Good, (23)
"Plenty of room to move about. Quiet neighborhood. Host took care of all our needs."
The price is AED 364
AED 765 total
includes taxes & fees
12 May - 13 May
Dexter Homestead. Very Cozy & NEW Remodel !
Pet-Friendly Downtown Ironton minutes away Elephant Rocks, Johnson Shut-ins
Property grounds

Pet-Friendly Downtown Ironton minutes away Elephant Rocks, Johnson Shut-ins

10.0 out of 10, Exceptional, (29)
"Stayed in ironton for one night loved the decorations and host was easy to interact with even offered the garage for use to keep the bikes in. Would definitely recommend to anyone looking so a nice quiet getaway!"
The price is AED 437
AED 815 total
includes taxes & fees
28 Apr - 29 Apr
Pet-Friendly Downtown Ironton minutes away Elephant Rocks, Johnson Shut-ins
Newly remodeled house close to downtown and minutes away from golf courses
Terrace/patio

Newly remodeled house close to downtown and minutes away from golf courses

2.0 star property
9.8 out of 10, Exceptional, (15)
"Enjoyed our stay. House provides all essentials in kitchen and bathroom. Very clean. Outside curb appeal does not reflect the inside. Would stay there again."
The price is AED 360
AED 696 total
includes taxes & fees
4 May - 5 May
Newly remodeled house close to downtown and minutes away from golf courses
Cute town house with fenced backyard
Fridge, microwave, oven, stovetop

Cute town house with fenced backyard

9.6 out of 10, Exceptional, (13)
"We stayed here while visiting family nearby. It met our needs. "
The price is AED 350
AED 921 total
includes taxes & fees
28 Apr - 29 Apr
Cute town house with fenced backyard
Private lake, beach & hot tub, romantic getaway or family vaca
Private kitchen

Private lake, beach & hot tub, romantic getaway or family vaca

10.0 out of 10, Exceptional, (23)
"Love the peace. "
Private lake, beach & hot tub, romantic getaway or family vaca
Bluebird Meadows with In-ground Pool and Hot Tub! 125 ACRES TO EXPLORE
Outdoor pool

Bluebird Meadows with In-ground Pool and Hot Tub! 125 ACRES TO EXPLORE

10.0 out of 10, Exceptional, (59)
"Nice farmhouse in the country."
Bluebird Meadows with In-ground Pool and Hot Tub! 125 ACRES TO EXPLORE
Unbeatable convenience in amazing Eminence!
Private kitchen

Unbeatable convenience in amazing Eminence!

Unbeatable convenience in amazing Eminence!
'The Lakehouse' Lovely Wappapello Country Home!
Miscellaneous

'The Lakehouse' Lovely Wappapello Country Home!

9.8 out of 10, Exceptional, (16)
"Home was as describe and we enjoyed a memorable stay."
'The Lakehouse' Lovely Wappapello Country Home!
Charming 2-bedroom house in delightful Jackson with AC, WiFi
Fridge, microwave, oven, stovetop

Charming 2-bedroom house in delightful Jackson with AC, WiFi

10.0 out of 10, Exceptional, (4)
"Nice clean property second stay."
Charming 2-bedroom house in delightful Jackson with AC, WiFi
Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi
Fridge, microwave, oven, stovetop

Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi

10.0 out of 10, Exceptional, (5)
"A large and comfortable house with cool historical details and just about everything you need to have a great, easy, smooth-running vacation. Great location for downtown exploring."
Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi
Historic Victorian close to amazing hiking - pet friendly!
Interior

Historic Victorian close to amazing hiking - pet friendly!

8.8 out of 10, Excellent, (6)
"Cute & clean home! Property manager was so easy to communicate with and super friendly!! We will be coming back!!"
Historic Victorian close to amazing hiking - pet friendly!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Other property types in Southeast Missouri

Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG
Exterior

Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG

3.5 star property
9.4 out of 10, Exceptional, (141)
"Beautiful property. Lots to do with the kids. Would be happy to come back when I have more time to spend there. "
The price is AED 584
AED 673 total
includes taxes & fees
30 Apr - 1 May
Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG
Postcard Cabins St. Francois
Terrace/patio

Postcard Cabins St. Francois

2.0 star property
10.0 out of 10, Exceptional, (4)
"We really enjoyed our stay here. It was a little confusing to find our cabin at first. The cabin was very clean and not outdated in style. It was very quiet and nice for relaxing! I wish there was a tv in the cabin for more entertainment!"
The price is AED 331
AED 494 total
includes taxes & fees
12 May - 13 May
Postcard Cabins St. Francois
Springside Cottage in beautiful Eminence. Great outdoor space - NEW Hot tub!
Fridge, microwave, oven, stovetop

Springside Cottage in beautiful Eminence. Great outdoor space - NEW Hot tub!

10.0 out of 10, Exceptional, (2)
"My fiancè and I had a lovely time staying at this cute little cottage. The location is perfect. It's tucked away but close enough to all there is to see and do in Eminence. The hot tub in the patio with the tv was so cool. I definitely would stay here again!"
The price is AED 698
AED 823 total
includes taxes & fees
29 Apr - 30 Apr
Springside Cottage in beautiful Eminence. Great outdoor space - NEW Hot tub!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.