Find Resorts & Hotels with Spas in Southeast Missouri, MO
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Compare Southeast Missouri Resorts & Hotels with Spas room rates, reviews, and availability. Most hotels are fully refundable.

Pear Tree Inn Sikeston
Pear Tree Inn Sikeston
9.4 out of 10, Exceptional, (1006)
The price is AED 314
AED 361 total
includes taxes & fees
10 Apr - 11 Apr

Drury Inn & Suites Hayti Caruthersville
Drury Inn & Suites Hayti Caruthersville
9.4 out of 10, Exceptional, (1006)
The price is AED 397
AED 452 total
includes taxes & fees
13 Apr - 14 Apr

Super 8 by Wyndham Perryville
Super 8 by Wyndham Perryville
8.4 out of 10, Very Good, (840)
The price is AED 253
AED 289 total
includes taxes & fees
4 May - 5 May

Hampton Inn Cape Girardeau I 55 East
Hampton Inn Cape Girardeau I 55 East
9.6 out of 10, Exceptional, (699)
The price is AED 403
AED 454 total
includes taxes & fees
13 Apr - 14 Apr

Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MO
9.6 out of 10, Exceptional, (1004)
The price is AED 331
AED 349 total
includes taxes & fees
10 Apr - 11 Apr

Pear Tree Inn Cape Girardeau West
Pear Tree Inn Cape Girardeau West
9.0 out of 10, Wonderful, (1006)
The price is AED 264
AED 298 total
includes taxes & fees
5 May - 6 May

Drury Inn & Suites Cape Girardeau
Drury Inn & Suites Cape Girardeau
9.4 out of 10, Exceptional, (916)
The price is AED 347
AED 392 total
includes taxes & fees
27 Apr - 28 Apr

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
8.4 out of 10, Very Good, (644)
The price is AED 277
AED 316 total
includes taxes & fees
7 Apr - 8 Apr
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find out more about Southeast Missouri
Find out more about Southeast Missouri
Recent reviews of Southeast Missouri hotels
Recent reviews of Southeast Missouri hotels

Drury Plaza Hotel Cape Girardeau Conference Center
5/5 Excellent
Great roadtrip hotel
"It was a great hotel and the staff were very helpful to us with our kids at breakfast time. The kids loved getting popcorn from the staff after a long day of driving."
A verified traveler stayed at Drury Plaza Hotel Cape Girardeau Conference Center
Posted 2 days ago
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Hotels near popular Southeast Missouri Attractions
- Hotels near Elephant Rocks State Park
- Hotels near Johnson's Shut-ins State Park
- Hotels near Southeast Missouri State University
- Hotels near Ozark National Scenic Riverways
- Hotels near Lake Wappapello
- Hotels near Echo Bluff State Park
- Hotels near Isle Casino Cape Girardeau
- Hotels near Big Spring
- Hotels near Alley Spring & Mill
- Hotels near Century Casino Caruthersville
Southeast Missouri Hotels by Star Rating
Explore more hotels
- Pear Tree Inn Cape Girardeau Near the Medical Center
- Best Western Plus Sikeston
- Drury Inn & Suites Sikeston, MO
- Candlewood Suites Cape Girardeau by IHG
- Drury Inn & Suites Cape Girardeau
- La Quinta Inn & Suites by Wyndham Festus - St. Louis South
- Super 8 by Wyndham Perryville
- Quality Inn
- Hampton Inn Sikeston
- Comfort Inn Festus - St Louis South
- Drury Inn & Suites Hayti Caruthersville
- Drury Inn & Suites Jackson MO
- Days Inn and Suites by Wyndham Sikeston
- Courtyard by Marriott Cape Girardeau Downtown
- Fairfield Inn & Suites by Marriott Cape Girardeau
- New Orleans Inn Portageville
- Town House Inn Cape Giradreau
- Holiday Inn Express & Suites Perryville by IHG
- Comfort Inn Poplar Bluff North
- Holiday Inn Poplar Bluff by IHG