Find Resorts & Hotels with Spas in Southeast Missouri, MO

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Check availability on Southeast Missouri Resorts & Hotels with Spas

Compare Southeast Missouri Resorts & Hotels with Spas room rates, reviews, and availability. Most hotels are fully refundable.

Pear Tree Inn Sikeston

2.5 star property
9.4 out of 10, Exceptional, (1006)
"This hotel is very comfortable clean and staff goes out of their way to be friendly!!!! I love staying at this hotel!"
The price is AED 314
AED 361 total
includes taxes & fees
15 Apr - 16 Apr
Pear Tree Inn Sikeston

Drury Inn & Suites Hayti Caruthersville

3.0 star property
9.4 out of 10, Exceptional, (1001)
"Clean rooms"
The price is AED 397
AED 452 total
includes taxes & fees
20 Apr - 21 Apr
Drury Inn & Suites Hayti Caruthersville

Super 8 by Wyndham Perryville

2.0 star property
8.4 out of 10, Very Good, (844)
"The staff was very friendly and the guy at the front desk was helpful with ever thing we asked about hotel was nice clean and quiet. Thus was my second time staying at this same hotel"
The price is AED 253
AED 289 total
includes taxes & fees
5 May - 6 May
Super 8 by Wyndham Perryville

Hampton Inn Cape Girardeau I 55 East

2.5 star property
9.6 out of 10, Exceptional, (700)
"Great experience "
The price is AED 403
AED 455 total
includes taxes & fees
19 Apr - 20 Apr
Hampton Inn Cape Girardeau I 55 East

Drury Inn & Suites Jackson MO

3.0 star property
9.6 out of 10, Exceptional, (1003)
"Very accommodating and friendly staff! Helpful with stressful travelers😊 Great breakfast and evening kick back snacks and drinks!"
The price is AED 331
AED 349 total
includes taxes & fees
16 Apr - 17 Apr
Drury Inn & Suites Jackson MO

Pear Tree Inn Cape Girardeau West

2.5 star property
9.0 out of 10, Wonderful, (1001)
"Nicr"
The price is AED 264
AED 298 total
includes taxes & fees
16 Apr - 17 Apr
Pear Tree Inn Cape Girardeau West

Drury Inn & Suites Cape Girardeau

3.0 star property
9.4 out of 10, Exceptional, (917)
"5 Stars is not enough for all of the staff on duty April 4th, 2025. These folks are a SOLID 11! There was a genuine tornado approaching and they made sure all the lodgers were in safe spaces and appraised of what was going on. There was no hesitation of what to do, where to go and all was calm. Luckily, all was good. Oh yeah the dinner & breakfast was great the place was clean and our room was fantastic. Value was excellent. Allen B."
The price is AED 347
AED 392 total
includes taxes & fees
18 Apr - 19 Apr
Drury Inn & Suites Cape Girardeau

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

2.5 star property
8.4 out of 10, Very Good, (645)
"Easy check-in, clean queen non smoking room. Absolutely worth the price. The continental breakfast was weak. The oj machine serves orange water and the raisin bran was exceptionally old. So much so that the raisins were hard as pebbles; not kidding. "
The price is AED 277
AED 316 total
includes taxes & fees
13 Apr - 14 Apr
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Hampton Inn Sikeston

2.5 star property
8.8 out of 10, Excellent, (329)
"Friendly staff, comfortable beds, spacious room (313). "
The price is AED 403
AED 456 total
includes taxes & fees
17 Apr - 18 Apr
Hampton Inn Sikeston

Drury Plaza Hotel Cape Girardeau Conference Center

3.0 star property
9.6 out of 10, Exceptional, (1004)
"We stay here several times a year and it’s always a wonderful time. All of the staff go above and beyond and we are always very comfortable "
The price is AED 347
AED 392 total
includes taxes & fees
16 Apr - 17 Apr
Drury Plaza Hotel Cape Girardeau Conference Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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