Find Resorts & Hotels with Spas in Southeast Missouri, MO
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Compare Southeast Missouri Resorts & Hotels with Spas room rates, reviews, and availability. Most hotels are fully refundable.

Pear Tree Inn Sikeston
Pear Tree Inn Sikeston
9.4 out of 10, Exceptional, (1006)
The price is AED 314
AED 361 total
includes taxes & fees
11 May - 12 May

Drury Inn & Suites Hayti Caruthersville
Drury Inn & Suites Hayti Caruthersville
9.4 out of 10, Exceptional, (1003)
The price is AED 364
AED 414 total
includes taxes & fees
8 May - 9 May

Super 8 by Wyndham Perryville
Super 8 by Wyndham Perryville
8.4 out of 10, Very Good, (852)
The price is AED 269
AED 307 total
includes taxes & fees
12 May - 13 May

Hampton Inn Cape Girardeau I 55 East
Hampton Inn Cape Girardeau I 55 East
9.6 out of 10, Exceptional, (707)
The price is AED 403
AED 454 total
includes taxes & fees
11 May - 12 May

Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MO
9.6 out of 10, Exceptional, (1004)
The price is AED 331
AED 349 total
includes taxes & fees
12 May - 13 May

Pear Tree Inn Cape Girardeau West
Pear Tree Inn Cape Girardeau West
9.0 out of 10, Wonderful, (1002)
The price is AED 264
AED 298 total
includes taxes & fees
11 May - 12 May

Drury Inn & Suites Cape Girardeau
Drury Inn & Suites Cape Girardeau
9.4 out of 10, Exceptional, (925)
The price is AED 347
AED 392 total
includes taxes & fees
1 Jun - 2 Jun

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
8.4 out of 10, Very Good, (652)
The price is AED 277
AED 316 total
includes taxes & fees
5 May - 6 May
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find out more about Southeast Missouri
Find out more about Southeast Missouri
Recent reviews of Southeast Missouri hotels
Recent reviews of Southeast Missouri hotels

Drury Plaza Hotel Cape Girardeau Conference Center
5/5 Excellent
"It was very clean, staff was friendly, and wonderful breakfast."
A verified traveler stayed at Drury Plaza Hotel Cape Girardeau Conference Center
Posted 2 days ago
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- Historic Hotels in Southeast Missouri
- Hotel Wedding Venues in Southeast Missouri
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- Hotels with smoking rooms in Southeast Missouri
- Luxury Hotels in Southeast Missouri
- Pet-friendly Hotels in Southeast Missouri
- Romantic Hotels in Southeast Missouri
- Shopping Hotels in Southeast Missouri
- Ski Hotels in Southeast Missouri
- Winery Hotels in Southeast Missouri
Hotels near popular Southeast Missouri Attractions
- Hotels near Elephant Rocks State Park
- Hotels near Johnson's Shut-ins State Park
- Hotels near Ozark National Scenic Riverways
- Hotels near Southeast Missouri State University
- Hotels near Echo Bluff State Park
- Hotels near Lake Wappapello
- Hotels near Isle Casino Cape Girardeau
- Hotels near Big Spring
- Hotels near Current River State Park
- Hotels near K Bridge Recreation Area
Southeast Missouri Hotels by Star Rating
Explore more hotels
- Drury Inn & Suites Jackson MO
- Best Western Plus Sikeston
- Pear Tree Inn Cape Girardeau Near the Medical Center
- Drury Inn & Suites Cape Girardeau
- Comfort Inn Festus - St Louis South
- Days Inn and Suites by Wyndham Sikeston
- Drury Inn & Suites Sikeston, MO
- Drury Inn & Suites Hayti Caruthersville
- La Quinta Inn & Suites by Wyndham Festus - St. Louis South
- Holiday Inn Express & Suites Perryville by IHG
- Quality Inn
- Hampton Inn Sikeston
- Super 8 by Wyndham Farmington
- Pear Tree Inn Cape Girardeau West
- Courtyard by Marriott Cape Girardeau Downtown
- Super 8 by Wyndham Bonne Terre
- Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
- Fairfield Inn & Suites by Marriott Cape Girardeau
- Holiday Inn Poplar Bluff by IHG
- Tru By Hilton Cape Girardeau