Find 4 Star Hotels in Southeast Missouri, MO
Change your mind
Book hotels with free cancellation
Be picky
Search almost a million properties worldwide
Check availability on Southeast Missouri 4 Star Hotels
Compare Southeast Missouri 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.
Urban Lofts
Urban Lofts
Save an average of 15% on thousands of hotels when you're signed in
Learn more about Southeast Missouri
Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from Sam A. Baker State Park to K Bridge Recreation Area.
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Southeast Missouri Hotels by Star Rating
Hotels in Southeast Missouri Neighborhoods
Stay near popular Southeast Missouri attractions
- Hotels near Elephant Rocks State Park
- Hotels near Johnson's Shut-ins State Park
- Hotels near Ozark National Scenic Riverways
- Hotels near Southeast Missouri State University
- Hotels near Echo Bluff State Park
- Hotels near Lake Wappapello
- Hotels near Isle Casino Cape Girardeau
- Hotels near Big Spring
- Hotels near Current River State Park
- Hotels near Alley Spring & Mill
- Hotels near K Bridge Recreation Area
- Hotels near Century Casino Caruthersville
- Hotels near Rocky Falls
- Hotels near Taum Sauk Mountain State Park
- Hotels near Akers Ferry
- Hotels near Bonne Terre Mine
- Hotels near Crown Valley Winery
- Hotels near Sainte Genevieve Winery
- Hotels near Black River Coliseum
- Hotels near Round Spring Cave
More Hotel Options in Southeast Missouri
- Adults Only Resorts & Hotels in Southeast Missouri
- Adventure Hotels in Southeast Missouri
- Business Hotels in Southeast Missouri
- Casinos in Southeast Missouri
- Cheap Hotels in Southeast Missouri
- Family Hotels in Southeast Missouri
- Golf Hotels in Southeast Missouri
- Historic Hotels in Southeast Missouri
- Hotel Wedding Venues in Southeast Missouri
- Hotel with a Concierge in Southeast Missouri
- Hotels with Bars in Southeast Missouri
- Hotels with Free Parking in Southeast Missouri
- Hotels with Hot Tubs in Southeast Missouri
- Hotels with Waterslides in Southeast Missouri
- Hotels with WiFi in Southeast Missouri
- Hotels with a Pool in Southeast Missouri
- Hotels with an Indoor Pool in Southeast Missouri
- Hotels with smoking rooms in Southeast Missouri
- Luxury Hotels in Southeast Missouri
- Pet-friendly Hotels in Southeast Missouri
- Resorts & Hotels with Spas in Southeast Missouri
- Romantic Hotels in Southeast Missouri
- Shopping Hotels in Southeast Missouri
- Ski Hotels in Southeast Missouri
- Winery Hotels in Southeast Missouri
More Accommodation Types in
- Vacation Homes in Southeast Missouri
- Cabin Rentals in Southeast Missouri
- Cottages in Southeast Missouri
- Apartments in Southeast Missouri
- Motels in Southeast Missouri
- Farmstay in Southeast Missouri
- RV Parks in Southeast Missouri
- Lodges in Southeast Missouri
- Condo Rentals in Southeast Missouri
- Aparthotels in Southeast Missouri
- B&B in Southeast Missouri
- Villas in Southeast Missouri
Explore more hotels
- Pear Tree Inn Cape Girardeau Near the Medical Center
- Best Western Plus Sikeston
- Drury Inn & Suites Jackson MO
- Pear Tree Inn Cape Girardeau West
- Comfort Inn Festus - St Louis South
- Days Inn and Suites by Wyndham Sikeston
- Holiday Inn Express & Suites Perryville by IHG
- Drury Inn & Suites Cape Girardeau
- Drury Inn & Suites Hayti Caruthersville
- Drury Inn & Suites Sikeston, MO
- Quality Inn
- Super 8 by Wyndham Farmington
- Super 8 by Wyndham Bonne Terre
- Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
- Courtyard by Marriott Cape Girardeau Downtown
- Fairfield Inn & Suites by Marriott Cape Girardeau
- Holiday Inn Poplar Bluff by IHG
- Hampton Inn Sikeston
- La Quinta Inn & Suites by Wyndham Festus - St. Louis South
- Silo Farm Haus- located in the heart of wine country!