Find 4 Star Hotels in Southeast Missouri, MO
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Compare Southeast Missouri 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.
Urban Lofts
Urban Lofts
Old Caledonian Bed and Breakfast
Old Caledonian Bed and Breakfast
9.8 out of 10, Exceptional, (30)
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Southeast Missouri Hotels by Star Rating
Hotels in Southeast Missouri Neighborhoods
Stay near popular Southeast Missouri attractions
- Hotels near Elephant Rocks State Park
- Hotels near Southeast Missouri State University
- Hotels near Ozark National Scenic Riverways
- Hotels near Johnson's Shut-ins State Park
- Hotels near Isle Casino Cape Girardeau
- Hotels near Echo Bluff State Park
- Hotels near Century Casino Caruthersville
- Hotels near Lake Wappapello
- Hotels near Taum Sauk Mountain State Park
- Hotels near Big Spring
- Hotels near Riverfront Bridge Park
- Hotels near Sainte Genevieve Winery
- Hotels near Crown Valley Winery
- Hotels near National Shrine of Our Lady of the Miraculous Medal
- Hotels near Black River Coliseum
- Hotels near Bonne Terre Mine
- Hotels near Current River State Park
- Hotels near Alley Spring & Mill
- Hotels near Riverfront Park
More Hotel Options in Southeast Missouri
- Adults Only Resorts & Hotels in Southeast Missouri
- Adventure Hotels in Southeast Missouri
- Business Hotels in Southeast Missouri
- Casinos in Southeast Missouri
- Cheap Hotels in Southeast Missouri
- Family Hotels in Southeast Missouri
- Golf Hotels in Southeast Missouri
- Historic Hotels in Southeast Missouri
- Hotel Wedding Venues in Southeast Missouri
- Hotel with a Concierge in Southeast Missouri
- Hotels with Bars in Southeast Missouri
- Hotels with Free Parking in Southeast Missouri
- Hotels with Hot Tubs in Southeast Missouri
- Hotels with Waterslides in Southeast Missouri
- Hotels with WiFi in Southeast Missouri
- Hotels with a Pool in Southeast Missouri
- Hotels with an Indoor Pool in Southeast Missouri
- Hotels with smoking rooms in Southeast Missouri
- Luxury Hotels in Southeast Missouri
- Pet-friendly Hotels in Southeast Missouri
- Resorts & Hotels with Spas in Southeast Missouri
- Romantic Hotels in Southeast Missouri
- Shopping Hotels in Southeast Missouri
- Ski Hotels in Southeast Missouri
- Winery Hotels in Southeast Missouri
More Accommodation Types in Southeast Missouri
- Vacation Homes in Southeast Missouri
- Cabin Rentals in Southeast Missouri
- Cottages in Southeast Missouri
- Apartments in Southeast Missouri
- Motels in Southeast Missouri
- Farmstay in Southeast Missouri
- RV Parks in Southeast Missouri
- Condo Rentals in Southeast Missouri
- Lodges in Southeast Missouri
- Aparthotels in Southeast Missouri
- B&B in Southeast Missouri
- Resorts in Southeast Missouri
- Villas in Southeast Missouri
Explore more hotels
- Silo Farm Haus- located in the heart of wine country!
- The Riverview
- Days Inn and Suites by Wyndham Sikeston
- Candlewood Suites Cape Girardeau, an IHG Hotel
- Drury Inn & Suites Hayti Caruthersville
- Courtyard by Marriott Cape Girardeau Downtown
- La Quinta Inn & Suites by Wyndham Festus - St. Louis South
- The Farmstead Hotel
- Fairfield Inn & Suites by Marriott Poplar Bluff
- New Orleans Inn Portageville
- Hampton Inn Poplar Bluff
- Quality Inn
- Holiday Inn Express & Suites Perryville, an IHG Hotel
- Hampton Inn Cape Girardeau I 55 East
- Drury Inn & Suites Poplar Bluff
- Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS, an IHG Hotel
- Best Western Plus Sikeston
- Super 8 by Wyndham Perryville
- Holiday Inn Poplar Bluff, an IHG Hotel
- Comfort Inn Festus - St Louis South