Find 4 Star Hotels in Southeast Missouri, MO
- Plan, book, stay with confidence
Be picky
Search almost a million properties worldwide
Change your mind
Book hotels with free cancellation
Check availability on Southeast Missouri 4 Star Hotels
Compare Southeast Missouri 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.
Urban Lofts
Urban Lofts
Old Caledonian Bed and Breakfast
Old Caledonian Bed and Breakfast
9.8 out of 10, Exceptional, (30)
Save an average of 15% on thousands of hotels when you're signed in
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Southeast Missouri Hotels by Star Rating
Hotels in Southeast Missouri Neighborhoods
Stay near popular Southeast Missouri attractions
- Hotels near Elephant Rocks State Park
- Hotels near Southeast Missouri State University
- Hotels near Ozark National Scenic Riverways
- Hotels near Isle Casino Cape Girardeau
- Hotels near Lake Wappapello
- Hotels near Johnson's Shut-ins State Park
- Hotels near Century Casino Caruthersville
- Hotels near Echo Bluff State Park
- Hotels near Big Spring
- Hotels near Taum Sauk Mountain State Park
- Hotels near Sainte Genevieve Winery
- Hotels near The Book Bug
- Hotels near Black River Coliseum
- Hotels near Riverfront Park
- Hotels near Bonne Terre Mine
- Hotels near St. Francois State Park
- Hotels near Big River
- Hotels near Current River State Park
- Hotels near National Shrine of Our Lady of the Miraculous Medal
More Hotel Options in Southeast Missouri
- Adults Only Resorts & Hotels in Southeast Missouri
- Adventure Hotels in Southeast Missouri
- Business Hotels in Southeast Missouri
- Casinos in Southeast Missouri
- Cheap Hotels in Southeast Missouri
- Family Hotels in Southeast Missouri
- Golf Hotels in Southeast Missouri
- Historic Hotels in Southeast Missouri
- Hotel Wedding Venues in Southeast Missouri
- Hotel with a Concierge in Southeast Missouri
- Hotels with Bars in Southeast Missouri
- Hotels with Free Parking in Southeast Missouri
- Hotels with Hot Tubs in Southeast Missouri
- Hotels with Waterslides in Southeast Missouri
- Hotels with WiFi in Southeast Missouri
- Hotels with a Pool in Southeast Missouri
- Hotels with an Indoor Pool in Southeast Missouri
- Hotels with smoking rooms in Southeast Missouri
- Luxury Hotels in Southeast Missouri
- Pet-friendly Hotels in Southeast Missouri
- Resorts & Hotels with Spas in Southeast Missouri
- Romantic Hotels in Southeast Missouri
- Shopping Hotels in Southeast Missouri
- Ski Hotels in Southeast Missouri
- Winery Hotels in Southeast Missouri
More Accommodation Types in Southeast Missouri
- Vacation Homes in Southeast Missouri
- Cabin Rentals in Southeast Missouri
- Cottages in Southeast Missouri
- Apartments in Southeast Missouri
- Motels in Southeast Missouri
- Farmstay in Southeast Missouri
- RV Parks in Southeast Missouri
- Condo Rentals in Southeast Missouri
- Lodges in Southeast Missouri
- Aparthotels in Southeast Missouri
- B&B in Southeast Missouri
- Villas in Southeast Missouri
Explore more hotels
- La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
- Silo Farm Haus- located in the heart of wine country!
- Pear Tree Inn Cape Girardeau Near the Medical Center
- Pear Tree Inn Sikeston
- La Quinta Inn & Suites by Wyndham Festus - St. Louis South
- Fairfield Inn & Suites by Marriott Poplar Bluff
- New Orleans Inn Portageville
- Drury Inn & Suites Hayti Caruthersville
- Drury Inn & Suites Poplar Bluff
- Courtyard by Marriott Cape Girardeau Downtown
- The Farmstead Hotel
- Quality Inn
- Hampton Inn Poplar Bluff
- Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS, an IHG Hotel
- Drury Inn & Suites Jackson MO
- Fairfield Inn & Suites by Marriott Cape Girardeau
- Best Western Plus Sikeston
- Holiday Inn Express & Suites Perryville, an IHG Hotel
- Super 8 by Wyndham Perryville
- Hampton Inn Cape Girardeau I 55 East