Find 4 Star Hotels in Southeast Missouri, MO

  • Plan, book, stay with confidence

    • bex rewards loyalty icon
    Be picky
    Search almost a million properties worldwide
    payments icon
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    Sign in
    today icon
    Change your mind
    Book hotels with free cancellation

Compare Southeast Missouri 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Urban Lofts
Property grounds

Urban Lofts

4.0 star property
Urban Lofts
Old Caledonian Bed and Breakfast
Front of property

Old Caledonian Bed and Breakfast

4.0 star property
9.8 out of 10, Exceptional, (30)
"This is a beautiful property, and the hosts (Jon and Penny) are wonderful. Jon is a chef who prepares really tasty vegan meals. Highly recommended for a weekend getaway!"
Old Caledonian Bed and Breakfast
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Frequently asked questions

How much does it cost to stay in a 4-star hotel in Southeast Missouri?
To book a 4-star hotel in Southeast Missouri that matches your budget, take advantage of Expedia’s handy search filters. Browse the available options during your chosen dates and use our pricing filter to set your limit. You can also list your results by the cheapest stay first.

  • Search for the lowest price

What's the difference between 5-star and 4-star hotels in Southeast Missouri?
Treat yourself to refined living during your Southeast Missouri vacation by choosing a 4-star hotel. As well as featuring upmarket surroundings, these retreats are typically packed with amenities, including complimentary bathrobes, large beds and more. A 5-star hotel will go above and beyond to make your trip an even more lavish and memorable one. 24-hour front desk, on-site spas and gourmet dining are a few of the superior services and conveniences you’ll likely have access to.
Does Southeast Missouri have any 4-star all-inclusive resorts?
Use our “All inclusive” filter to find your next escape in Southeast Missouri where just about everything is taken care of, from your accommodations to your food, entertainment and activities. We can also help you find standard 4-star stays in and around this sought-after destination.
What are the top 4-star apartments in Southeast Missouri?
You’ll feel at home at Urban Lofts in Perryville, Southeast Missouri. Our 4-star apartments offer the freedom and convenience to fully immerse yourself in the local atmosphere, while ensuring you have all the necessary comforts for an unforgettable stay.