Find Resorts & Hotels with Spas in Big Pine Key, FL

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Compare Big Pine Key Resorts & Hotels with Spas room rates, reviews, and availability. Most hotels are fully refundable.

Old Wooden Bridge Resort and Marina

2.5 star property
8.4 out of 10, Very Good, (170)
"The check was very smooth; everyone friendly and helpful with local suggestions. Location was great! Nice and quiet"
The price is AED 474
AED 900 total
includes taxes & fees
23 Dec - 24 Dec
Old Wooden Bridge Resort and Marina

Deer Run Bed & Breakfast

2.5 star property
8.0 out of 10, Very Good, (1)
"Loved it. Beautiful property."
Deer Run Bed & Breakfast

Tropical Caribbean Wonderland

9.2 out of 10, Wonderful, (77)
"The camper was clean and easy to find. There’s a bath/shower house 2campsites away. We enjoyed our stay."
Tropical Caribbean Wonderland

Banana Republics - Located in Paradise

Banana Republics - Located in Paradise

Aquafina Big Pine Key Fishing & Boating Paradise

9.2 out of 10, Wonderful, (7)
"The property was amazing. The house, canal and boat lift made our fishing and boating a breeze. I hope they're house is available next time were visiting. Also with any issues that came up which were not too many they were always available to answer questions. "
Aquafina Big Pine Key Fishing & Boating Paradise

Newly Remodeled Corner House on the Water

10.0 out of 10, Exceptional, (1)
"we stayed the month of febuary. We really enjoyed the property"
Newly Remodeled Corner House on the Water

The most setup home in BPK TIKI HUT,POOL ,GRILL ,CANAL FRONT, FREE UNLIMITED ICE

9.2 out of 10, Wonderful, (5)
"Of you like to kayak, SUP, fish the shallows and explore mangroves, this is the house for you. House was exactly as described. Great cave pool level for my teens and plenty of room upstairs. The outside area is fantastic and the owner very responsive when contacted with questions etc. Only thing we missed was a dining area big enough for a sit down meal. Overall we loved the space and would come back."
The most setup home in BPK TIKI HUT,POOL ,GRILL ,CANAL FRONT, FREE UNLIMITED ICE

Keys To The Kingdom! Private Oceanfront Retreat with Beach and Pool

Keys To The Kingdom! Private Oceanfront Retreat with Beach and Pool

Big Pine Key Waterfront Home: Boating, Sunrises, Sunsets; Relax in Paradise!

10.0 out of 10, Exceptional, (31)
"After over a decade of staying in Big Pine Key every summer, this property was by far the best. The views were absolutely stunning. The location was spectacular. So close to everything we needed. All the stores, shops, restaurants, bait shops, etc. Just a couple miles up the road if that. Diana was an amazing host and all-around kind person to communicate with. All correspondences between us were very prompt and helpful. As this was our first experience renting with VRBO, she made the whole...
Big Pine Key Waterfront Home: Boating, Sunrises, Sunsets; Relax in Paradise!

Manatee Watch | Gorgeous pool, 5 bedrooms, easy ocean access on Big Pine Key

10.0 out of 10, Exceptional, (2)
"Very nice house with way more room than we actually needed. Great pool and spa with access to the open water. Saw a manatee in the canal which was a bonus"
Manatee Watch | Gorgeous pool, 5 bedrooms, easy ocean access on Big Pine Key
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Looking for a spa hotel in Big Pine Key?
Treat yourself to some time in a luxurious spa hotel and you won’t regret it. Check out the beaches in Big Pine Key - worth a picture or two! Be sure to enjoy activities like kayaking and snorkeling during your stay. Hotels with spas are the perfect way to break away from your routine and add a layer of luxury to your vacation.
How many spa hotels will I find in Big Pine Key?
Among Expedia’s 88 accommodation options in Big Pine Key, there are 2 spa hotels.
What's there to see and do in Big Pine Key?
Enjoy all that Big Pine Key has to offer and visit Calusa Beach, Bahia Honda State Park, and Florida Keys Beaches. If you have extra time while you’re in the area, you might want to see Big Pine Key Flea Market and Coupon Bight Aquatic Preserve.
What is a Big Pine Key spa hotel?
Spa hotels in Big Pine Key provide lodging and have an on-site spa offering services such as massages and body treatments. Some also offer in-room treatments. Spa hotels are a must if you want to give yourself an extra treat while on vacation.