Find Family Hotels in Big Pine Key, FL
Change your mind
Book hotels with free cancellation
Be picky
Search almost a million properties worldwide
Check availability on Big Pine Key Family Hotels
Compare Big Pine Key Family Hotels room rates, reviews, and availability. Most hotels are fully refundable.

Deer Run Bed & Breakfast
Deer Run Bed & Breakfast
8.0 out of 10, Very Good, (1)

Old Wooden Bridge Resort and Marina
Old Wooden Bridge Resort and Marina
8.6 out of 10, Excellent, (235)
The price is AED 511
AED 1,447 total
includes taxes & fees
18 May - 19 May

Sunshine Key RV Resort & Marina
Sunshine Key RV Resort & Marina
8.8 out of 10, Excellent, (146)

Ed & Ellen's Lodging Big Pine Key
Ed & Ellen's Lodging Big Pine Key
7.0 out of 10, Good, (26)
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find out more about Big Pine Key
Find out more about Big Pine Key
Recent reviews of Big Pine Key hotels
Recent reviews of Big Pine Key hotels

Tranquility Bay Beachfront Hotel and Resort
5/5 Excellent
Great family stay with little kids
"Beautiful place with plenty of room for a family. Lots to do on site, kids loved the pool and beach areas. Onsite restaurants were as to be expected at a resort type property. It was nice having the space of an air bnb, but the amenities of a resort. Would’ve enjoyed a nice cleaning one day during our visit. Cleaners only came the first morning after check in (before we needed anything) and never again during our stay. Other than that, everything was great. We’d go back for sure. Loved being right next door to the turtle hospital!"
A verified traveler stayed at Tranquility Bay Beachfront Hotel and Resort
Posted 1 day ago
Explore a world of travel with Expedia
Explore a world of travel with Expedia
More Hotel Options in Big Pine Key
- Adventure Hotels in Big Pine Key
- Beach Hotels in Big Pine Key
- Cheap Hotels in Big Pine Key
- Hotel Wedding Venues in Big Pine Key
- Hotel with a Concierge in Big Pine Key
- Hotels with Free Parking in Big Pine Key
- Hotels with Hot Tubs in Big Pine Key
- Hotels with WiFi in Big Pine Key
- Hotels with a Pool in Big Pine Key
- Pet-friendly Hotels in Big Pine Key
- Resorts & Hotels with Spas in Big Pine Key
- Romantic Hotels in Big Pine Key
- Shopping Hotels in Big Pine Key
- Ski Hotels in Big Pine Key
More Accommodation Types in Big Pine Key
- Vacation Homes in Florida
- Condo Rentals in Florida
- Apartments in Florida
- Villas in Florida
- Cottages in Florida
- Resorts in Florida
- Aparthotels in Florida
- Motels in Florida
- Guest Houses in Florida
- Cabin Rentals in Florida
- B&B in Florida
- Houseboats in Florida
- Town Houses in Florida
- RV Parks in Florida
- Farmstay in Florida
- Condo Resorts in Florida
- Lodges in Florida
- Hostels in Florida
- Chalets in Florida
- Residences in Florida
- Holiday Park Resorts in Florida
- Inns in Florida
- Country Houses in Florida
Big Pine Key Hotels by Star Rating
Explore more hotels
- Rainbow Bend Resort
- Delightful Aqualodge! Cabana Club Access!
- Hampton Inn Marathon - Florida Keys
- Kingsail Resort
- Parmer's Resort
- Captain Pips Marina & Hideaway
- Glunz Ocean Beach Hotel & Resort
- Looe Key Reef Resort
- Yacht Haven Marina
- Sugarloaf Key Hotel at KOA Resort
- Sugar Loaf Lodge
- Tropical Cottages
- Skipjack Resort & Marina
- Gulf View Waterfront Resort
- Floating Sea Cove Resort & Marina
- Cabins at Bonefish Bay
- Aqua Lodges at 47th Street Gulfside
- Bonefish Bay Motel
- Knight's Key Suites
- Aqua Lodge Rentals At Coconut Cay