Find 5 Star Hotels in Big Pine Key, FL from AED 1,465
- Plan, book, stay with confidence
Be picky
Search almost a million properties worldwide
Change your mind
Book hotels with free cancellation
Check availability on Big Pine Key 5 Star Hotels
Compare Big Pine Key 5 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Barnacle Resort
Barnacle Resort
8.0 out of 10, Very Good, (24)
The price is AED 793
AED 984 total
includes taxes & fees
12 Mar - 13 Mar

Deer Run Bed & Breakfast
Deer Run Bed & Breakfast
8.0 out of 10, Very Good, (1)

Beautiful Family Big Pine Retreat! Short drive to Key West!
Beautiful Family Big Pine Retreat! Short drive to Key West!
Save an average of 15% on thousands of hotels when you're signed in
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Big Pine Key Hotels by Star Rating
Stay near popular Big Pine Key attractions
- Hotels near National Key Deer Refuge Visitor Center
- Hotels near Key West Visitors Center
- Hotels near Big Pine Key Flea Market
- Hotels near Coupon Bight Aquatic Preserve
- Hotels near Blue Hole
- Hotels near Veterans Memorial Park & Beach
- Hotels near Sombrero Beach
- Hotels near Seven Mile Bridge
- Hotels near Curry Hammock State Park
- Hotels near Sunset Park Beach
More Hotel Options in Big Pine Key
- Adventure Hotels in Big Pine Key
- Beach Hotels in Big Pine Key
- Cheap Hotels in Big Pine Key
- Family Hotels in Big Pine Key
- Hotel Wedding Venues in Big Pine Key
- Hotel with a Concierge in Big Pine Key
- Hotels with Free Parking in Big Pine Key
- Hotels with Hot Tubs in Big Pine Key
- Hotels with WiFi in Big Pine Key
- Hotels with a Pool in Big Pine Key
- Pet-friendly Hotels in Big Pine Key
- Resorts & Hotels with Spas in Big Pine Key
- Romantic Hotels in Big Pine Key
- Shopping Hotels in Big Pine Key
- Ski Hotels in Big Pine Key
More Accommodation Types in Big Pine Key
- Vacation Homes in Big Pine Key
- Condo Rentals in Big Pine Key
- Apartments in Big Pine Key
- Cottages in Big Pine Key
- Villas in Big Pine Key
- Resorts in Big Pine Key
- RV Parks in Big Pine Key
- B&B in Big Pine Key
- Houseboats in Big Pine Key
- Motels in Big Pine Key
- Cabin Rentals in Big Pine Key
- Aparthotels in Big Pine Key
- Lodges in Big Pine Key
Explore more hotels
- Courtyard by Marriott Faro Blanco Resort
- Tranquility Bay Beachfront Hotel and Resort
- Kingsail Resort
- Captain Pips Marina & Hideaway
- Skipjack Resort & Marina
- Looe Key Reef Resort
- Parmer's Resort
- Sugarloaf Key Hotel at KOA Resort
- Hampton Inn Marathon - Florida Keys
- Rainbow Bend Resort
- Sugar Loaf Lodge
- Yacht Haven Marina
- Bonefish Bay Motel
- Floating Sea Cove Resort & Marina
- Tropical Cottages
- Delightful Aqualodge! Cabana Club Access!
- Glunz Ocean Beach Hotel & Resort
- Grassy Flats Resort & Beach Club
- Gulf View Waterfront Resort
- Aqua Lodge Rentals At Coconut Cay