Find hotels in Otay Mesa, San Diego from AED 264

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Check prices for these dates

Tonight
14 Apr - 15 Apr
Tomorrow
15 Apr - 16 Apr
This weekend
18 Apr - 20 Apr
Next weekend
25 Apr - 27 Apr

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Discover 4,583 Otay Mesa hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Exterior

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2.5 star property
7.6 out of 10, Good, (1415)
"The best hotel ever! It’s a must stay. "
The price is AED 485
AED 546 total
includes taxes & fees
20 Apr - 21 Apr
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Quality Suites San Diego Otay Mesa
Outdoor pool

Quality Suites San Diego Otay Mesa

2.5 star property
7.2 out of 10, Good, (1004)
"location was ok. location is close to cbx"
The price is AED 360
AED 405 total
includes taxes & fees
27 Apr - 28 Apr
Quality Suites San Diego Otay Mesa
Sycuan Casino Resort
3 outdoor pools, cabanas (surcharge), pool umbrellas

Sycuan Casino Resort

4.0 star property
9.2 out of 10, Wonderful, (1175)
"Great place to get away close to home and do some gambling. "
The price is AED 353
AED 432 total
includes taxes & fees
20 Apr - 21 Apr
Sycuan Casino Resort
Days Inn by Wyndham San Diego-East/El Cajon
Standard Room, 1 King Bed, Smoking | Desk, laptop workspace, iron/ironing board, free WiFi

Days Inn by Wyndham San Diego-East/El Cajon

2.0 star property
7.6 out of 10, Good, (1006)
"Staff was friendly, room clean and breakfast adequate. Lots of parking spaces."
The price is AED 309
AED 341 total
includes taxes & fees
20 Apr - 21 Apr
Days Inn by Wyndham San Diego-East/El Cajon
Super 8 by Wyndham El Cajon/San Diego
Lobby

Super 8 by Wyndham El Cajon/San Diego

2.0 star property
7.6 out of 10, Good, (1006)
"Good hotel in terms of cleanliness, the staff are very friendly, close to the markets, and the room service is good 👍"
The price is AED 311
AED 342 total
includes taxes & fees
15 Apr - 16 Apr
Super 8 by Wyndham El Cajon/San Diego
Best Western Plus La Mesa San Diego
Lobby

Best Western Plus La Mesa San Diego

2.5 star property
8.2 out of 10, Very Good, (1007)
" Easy to get in"
The price is AED 408
AED 449 total
includes taxes & fees
20 Apr - 21 Apr
Best Western Plus La Mesa San Diego
SpringHill Suites by Marriott Chula Vista Eastlake
Suite, 1 King Bed, Patio, Poolside | View from room

SpringHill Suites by Marriott Chula Vista Eastlake

3.5 star property
9.6 out of 10, Exceptional, (301)
"I really enjoyed my stay at SpringHill Suites. The property was clean, modern, and well-maintained — exactly what I was hoping for. The room was comfortable and stylish, with everything I needed for a relaxing stay. The location was another big plus — it’s conveniently situated near great restaurants, shops, and other local spots, making it easy to explore the area without needing to go far. Staff were friendly and efficient, and the overall atmosphere was calm and welcoming. I’d definitely...
The price is AED 643
AED 708 total
includes taxes & fees
18 Apr - 19 Apr
SpringHill Suites by Marriott Chula Vista Eastlake
Ayres Hotel San Diego South - Chula Vista
Lobby lounge

Ayres Hotel San Diego South - Chula Vista

3.0 star property
9.8 out of 10, Exceptional, (1107)
"Wonderful stay! Omelette station! Large room with sofa! Easy parking! Right off interstate! Nice spa! Great stay! Keep up the good work. "
The price is AED 572
AED 630 total
includes taxes & fees
20 Apr - 21 Apr
Ayres Hotel San Diego South - Chula Vista
Heritage Inn La Mesa
Outdoor pool, pool umbrellas, sun loungers

Heritage Inn La Mesa

2.0 star property
6.6 out of 10, (1015)
"Quiet & close to shopping."
The price is AED 281
AED 310 total
includes taxes & fees
16 Apr - 17 Apr
Heritage Inn La Mesa
Lamplighter Inn & Suites at SDSU
Outdoor pool, pool umbrellas, sun loungers

Lamplighter Inn & Suites at SDSU

2.5 star property
9.0 out of 10, Wonderful, (1104)
"Great area. Check in was easy and the staff was so nice. Clean and comfortable room. "
The price is AED 530
AED 586 total
includes taxes & fees
16 Apr - 17 Apr
Lamplighter Inn & Suites at SDSU
Best Western Chula Vista/Otay Valley Hotel
Lobby

Best Western Chula Vista/Otay Valley Hotel

2.5 star property
7.8 out of 10, Good, (1384)
"Everyone was so attentive loves it "
The price is AED 403
AED 443 total
includes taxes & fees
20 Apr - 21 Apr
Best Western Chula Vista/Otay Valley Hotel
La Quinta Inn by Wyndham San Diego Chula Vista
Exterior

La Quinta Inn by Wyndham San Diego Chula Vista

3.0 star property
8.6 out of 10, Excellent, (1146)
"Served our accommodation needs"
The price is AED 415
AED 457 total
includes taxes & fees
27 Apr - 28 Apr
La Quinta Inn by Wyndham San Diego Chula Vista
Studio 6 Suites San Ysidro, CA -San Diego South Bay
Boating

Studio 6 Suites San Ysidro, CA -San Diego South Bay

2.5 star property
7.8 out of 10, Good, (970)
"Clean and quiet."
The price is AED 286
AED 323 total
includes taxes & fees
15 Apr - 16 Apr
Studio 6 Suites San Ysidro, CA -San Diego South Bay
Valli Hi Motel
Desk, blackout drapes, soundproofing, free WiFi

Valli Hi Motel

2.5 star property
8.2 out of 10, Very Good, (1001)
"The area is busy and crowded. It's an old city near Camp Pendleton. The hotel itself was nice though. I used Uber eats when I needed anything from town. Just made my stay a bit more relaxing not having to drive in that town. "
The price is AED 311
AED 350 total
includes taxes & fees
15 Apr - 16 Apr
Valli Hi Motel
Best Western Americana Inn
Pillowtop beds, in-room safe, desk, laptop workspace

Best Western Americana Inn

2.5 star property
8.8 out of 10, Excellent, (1072)
"Ok. Good"
The price is AED 417
AED 469 total
includes taxes & fees
11 May - 12 May
Best Western Americana Inn
Chula Vista Inn
Exterior

Chula Vista Inn

2.5 star property
6.4 out of 10, (1007)
"Good environment"
The price is AED 304
AED 335 total
includes taxes & fees
20 Apr - 21 Apr
Chula Vista Inn
Quality Inn San Diego South - Chula Vista
Coffee service

Quality Inn San Diego South - Chula Vista

2.5 star property
7.6 out of 10, Good, (911)
"Better than most "
The price is AED 281
AED 309 total
includes taxes & fees
20 Apr - 21 Apr
Quality Inn San Diego South - Chula Vista
Days Inn by Wyndham Chula Vista/San Diego
Lobby

Days Inn by Wyndham Chula Vista/San Diego

2.0 star property
6.2 out of 10, (905)
"Clean room, everything was great"
The price is AED 328
AED 361 total
includes taxes & fees
15 Apr - 16 Apr
Days Inn by Wyndham Chula Vista/San Diego
Hotel Palmeras Chula Vista
Standard Room, 2 Queen Beds, Non Smoking | Desk, blackout drapes, iron/ironing board, free WiFi

Hotel Palmeras Chula Vista

2.0 star property
7.0 out of 10, Good, (1727)
"Our go to hotel in Chula Vista, affordable when compared to other places. "
The price is AED 264
AED 291 total
includes taxes & fees
20 Apr - 21 Apr
Hotel Palmeras Chula Vista
Hercor Hotel - Urban Boutique
Daily continental breakfast (USD 13.49 per person)

Hercor Hotel - Urban Boutique

3.0 star property
8.6 out of 10, Excellent, (1150)
"Room was clean , front staff was very nice "
The price is AED 415
AED 457 total
includes taxes & fees
28 Apr - 29 Apr
Hercor Hotel - Urban Boutique
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

What's it like in Otay Mesa?

Otay Mesa is a neighborhood that travelers like for its beaches, restaurants, and shopping.

Where is the best hotel for a stay in Otay Mesa?

Based on Expedia customer reviews, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is the highest ranked property in Otay Mesa. This hotel offers free breakfast and an outdoor pool. Another top choice in the area is Quality Suites San Diego Otay Mesa.

How many hotels will I be able to find in the Otay Mesa area?

Expedia has 5 Otay Mesa hotels and other accommodations, and one might make a good home base for venturing out into the greater San Diego area.

If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?

Yes! The majority of hotel reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a non-refundable reservation, you might still have the option to cancel and receive a refund within a 24-hour period of booking. Put your dates in and click on "Search", then you can use the "fully refundable" filter to view the best deals available in Otay Mesa.

Where can I learn more about changing or cancelling my trip to Otay Mesa?

To find more details about changing or cancelling your trip to Otay Mesa, go to https://www.expedia.com/service/.

What is there to do in this San Diego neighborhood?

A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana, and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.