Find hotels in Otay Mesa, San Diego from AED 257

  • Plan, book, stay with confidence

  • bex rewards loyalty icon
    Be picky
    Search almost a million properties worldwide
    payments icon
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    today icon
    Change your mind
    Book hotels with free cancellation

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating

Discover 4,586 Otay Mesa hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Quality Suites San Diego Otay Mesa

2.5 star property
7.2 out of 10, Good, (1004)
"Easy check in late at night"
The price is AED 357
AED 402 total
includes taxes & fees
6 Apr - 7 Apr
Quality Suites San Diego Otay Mesa

Sycuan Casino Resort

4.0 star property
9.2 out of 10, Wonderful, (1140)
"It was my first time coming here, and I will definitely come again!"
The price is AED 331
AED 408 total
includes taxes & fees
26 Mar - 27 Mar
Sycuan Casino Resort

Days Inn by Wyndham San Diego-East/El Cajon

2.0 star property
7.8 out of 10, Good, (1007)
"Breakfast was very basic! "
The price is AED 328
AED 361 total
includes taxes & fees
31 Mar - 1 Apr
Days Inn by Wyndham San Diego-East/El Cajon

Super 8 by Wyndham El Cajon/San Diego

2.0 star property
7.6 out of 10, Good, (1013)
"Clean room nice service"
The price is AED 311
AED 342 total
includes taxes & fees
26 Mar - 27 Mar
Super 8 by Wyndham El Cajon/San Diego

Best Western Plus La Mesa San Diego

2.5 star property
8.2 out of 10, Very Good, (1006)
"We reported damage to clothing from an iron which dropped rusty water on it. I was told the manager would ve in touch but never heard from him. "
The price is AED 423
AED 465 total
includes taxes & fees
20 Apr - 21 Apr
Best Western Plus La Mesa San Diego

SpringHill Suites by Marriott Chula Vista Eastlake

3.5 star property
9.6 out of 10, Exceptional, (278)
"Thank you for making my trip better. it's the little things that matter to like having water there to drink, and when you are tired from your trip that they are ready for you to check in."
The price is AED 643
AED 708 total
includes taxes & fees
6 Apr - 7 Apr
SpringHill Suites by Marriott Chula Vista Eastlake

Ayres Hotel San Diego South - Chula Vista

3.0 star property
9.8 out of 10, Exceptional, (1123)
"Excellent property, great complimentary breakfast and very nice staff"
The price is AED 621
AED 685 total
includes taxes & fees
16 Apr - 17 Apr
Ayres Hotel San Diego South - Chula Vista

Heritage Inn La Mesa

2.0 star property
6.4 out of 10, (1004)
"has a lot of bugs"
The price is AED 271
AED 299 total
includes taxes & fees
27 Mar - 28 Mar
Heritage Inn La Mesa

Lamplighter Inn & Suites at SDSU

2.5 star property
9.0 out of 10, Wonderful, (1073)
"Great little motel. Very clean and the location is great, especially if you’re visiting a student at sdsu. The only complaint is the water pressure. We were in room 106 and I think a baby’s pee would rinse you off faster. Otherwise a fantastic place. "
The price is AED 499
AED 552 total
includes taxes & fees
27 Mar - 28 Mar
Lamplighter Inn & Suites at SDSU

Best Western Chula Vista/Otay Valley Hotel

2.5 star property
7.8 out of 10, Good, (1356)
"👍"
The price is AED 403
AED 443 total
includes taxes & fees
6 Apr - 7 Apr
Best Western Chula Vista/Otay Valley Hotel

La Quinta Inn by Wyndham San Diego Chula Vista

2.5 star property
8.6 out of 10, Excellent, (1122)
"Friendly staff and clean facilities. "
The price is AED 426
AED 469 total
includes taxes & fees
13 Apr - 14 Apr
La Quinta Inn by Wyndham San Diego Chula Vista

Studio 6 Suites San Ysidro, CA -San Diego South Bay

2.5 star property
7.8 out of 10, Good, (940)
"Pretty nice , had no issues, easy check in and out "
The price is AED 257
AED 290 total
includes taxes & fees
26 Mar - 27 Mar
Studio 6 Suites San Ysidro, CA -San Diego South Bay

Valli Hi Motel

2.5 star property
8.2 out of 10, Very Good, (1003)
"I like this place it is comfortable and clean."
The price is AED 301
AED 338 total
includes taxes & fees
2 Apr - 3 Apr
Valli Hi Motel

Best Western Americana Inn

2.5 star property
8.8 out of 10, Excellent, (1070)
"Staff was friendly, the hotel and room are in good shape and clean. Our stay was uneventful and practical for our purposes."
The price is AED 418
AED 471 total
includes taxes & fees
31 Mar - 1 Apr
Best Western Americana Inn

Chula Vista Inn

2.5 star property
6.4 out of 10, (1006)
"Convert "
The price is AED 314
AED 345 total
includes taxes & fees
31 Mar - 1 Apr
Chula Vista Inn

Quality Inn San Diego South - Chula Vista

2.5 star property
7.6 out of 10, Good, (892)
"It is quite"
The price is AED 281
AED 309 total
includes taxes & fees
13 Apr - 14 Apr
Quality Inn San Diego South - Chula Vista

Days Inn by Wyndham Chula Vista/San Diego

2.0 star property
6.2 out of 10, (886)
"Clean and friendly "
The price is AED 290
AED 320 total
includes taxes & fees
22 Apr - 23 Apr
Days Inn by Wyndham Chula Vista/San Diego

Hotel Palmeras Chula Vista

2.0 star property
7.0 out of 10, Good, (1727)
"Nice place to stay my only issue was my door was jammed but everything else was fine"
The price is AED 262
AED 288 total
includes taxes & fees
26 Mar - 27 Mar
Hotel Palmeras Chula Vista

Hercor Hotel - Urban Boutique

3.0 star property
8.6 out of 10, Excellent, (1127)
"Great place."
The price is AED 396
AED 436 total
includes taxes & fees
7 Apr - 8 Apr
Hercor Hotel - Urban Boutique

Howard Johnson by Wyndham National City/San Diego South

2.0 star property
7.2 out of 10, Good, (1007)
"Good place"
The price is AED 294
AED 324 total
includes taxes & fees
26 Mar - 27 Mar
Howard Johnson by Wyndham National City/San Diego South
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Don't see what you're looking for?
See all available properties in Otay Mesa
Save an average of 15% on thousands of hotels when you're signed in

Frequently asked questions

What's it like in Otay Mesa?

Otay Mesa is a neighborhood that travelers like for its beaches, restaurants, and shopping.

Where is the best hotel for a stay in Otay Mesa?

Based on Expedia customer reviews, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is the highest ranked property in Otay Mesa. This hotel offers free breakfast and an outdoor pool. Another top choice in the area is Quality Suites San Diego Otay Mesa.

How many hotels will I be able to find in the Otay Mesa area?

Expedia has 5 Otay Mesa hotels and other accommodations, and one might make a good home base for venturing out into the greater San Diego area.

If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?

Yes! The majority of hotel reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a non-refundable reservation, you might still have the option to cancel and receive a refund within a 24-hour period of booking. Put your dates in and click on "Search", then you can use the "fully refundable" filter to view the best deals available in Otay Mesa.

Where can I learn more about changing or cancelling my trip to Otay Mesa?

To find more details about changing or cancelling your trip to Otay Mesa, go to https://www.expedia.com/service/.

What is there to do in this San Diego neighborhood?

A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana, and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.