Find 4 Star Hotels in Otay Mesa, CA from AED 459
- Plan, book, stay with confidence
Be picky
Search almost a million properties worldwide
Change your mind
Book hotels with free cancellation
Check availability on Otay Mesa 4 Star Hotels
Compare Otay Mesa 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

San Diego Marriott Gaslamp Quarter
San Diego Marriott Gaslamp Quarter
8.6 out of 10, Excellent, (1324)
The price is AED 804
AED 907 total
includes taxes & fees
7 Mar - 8 Mar

Hyatt Regency Mission Bay Spa and Marina
Hyatt Regency Mission Bay Spa and Marina
8.4 out of 10, Very Good, (1451)
The price is AED 621
AED 861 total
includes taxes & fees
9 Mar - 10 Mar

Sheraton San Diego Resort
Sheraton San Diego Resort
8.0 out of 10, Very Good, (2566)
The price is AED 621
AED 849 total
includes taxes & fees
7 Mar - 8 Mar

Omni San Diego Hotel
Omni San Diego Hotel
9.0 out of 10, Wonderful, (1845)
The price is AED 644
AED 887 total
includes taxes & fees
16 Mar - 17 Mar

Manchester Grand Hyatt San Diego
Manchester Grand Hyatt San Diego
9.0 out of 10, Wonderful, (2810)
The price is AED 694
AED 957 total
includes taxes & fees
6 Mar - 7 Mar

Hotel Indigo San Diego-Gaslamp Quarter by IHG
Hotel Indigo San Diego-Gaslamp Quarter by IHG
8.6 out of 10, Excellent, (1004)
The price is AED 731
AED 956 total
includes taxes & fees
16 Mar - 17 Mar

Loews Coronado Bay Resort
Loews Coronado Bay Resort
8.8 out of 10, Excellent, (1005)
The price is AED 768
AED 1,020 total
includes taxes & fees
28 Feb - 1 Mar

Wyndham San Diego Bayside
Wyndham San Diego Bayside
8.2 out of 10, Very Good, (5620)
The price is AED 590
AED 665 total
includes taxes & fees
16 Mar - 17 Mar
Save an average of 15% on thousands of hotels when you're signed in
Explore similar 5-star hotels
Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Otay Mesa.

Pendry San Diego
550 J Street, San Diego, CA
The price is AED 1,010 per night from Mar 9 to Mar 10
AED 1,010
AED 1,326 total
includes taxes & fees
9 Mar - 10 Mar
9.2/10 Wonderful! (1,002 reviews)
Still don't see what you're looking for?
See all properties in Otay Mesa.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Recent reviews of Otay Mesa hotels
Recent reviews of Otay Mesa hotels

Wyndham San Diego Bayside
5/5 Excellent
"I liked everything. Pretty much I was expecting. Thank you "
A verified traveler stayed at Wyndham San Diego Bayside
Posted 7 hours ago
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Otay Mesa Hotels by Star Rating
Stay near popular Otay Mesa attractions
- Hotels near San Diego Zoo
- Hotels near San Diego Convention Center
- Hotels near Mission Bay
- Hotels near San Ysidro Border Crossing
- Hotels near Balboa Park
- Hotels near Mission Beach
- Hotels near Petco Park
- Hotels near San Diego State University
- Hotels near Hotel Circle
- Hotels near Marine Corps Recruit Depot
- Hotels near Naval Base San Diego
- Hotels near USS Midway Museum
- Hotels near Hotel del Coronado
- Hotels near Port of San Diego
- Hotels near Coronado Beach
- Hotels near University of San Diego
- Hotels near B Street Cruise Ship Terminal
- Hotels near Mission Beach Boardwalk
- Hotels near Seaport Village
- Hotels near Las Americas Premium Outlets
More Hotel Options in Otay Mesa
- Beach Hotels in Otay Mesa
- Business Hotels in Otay Mesa
- Casinos in Otay Mesa
- Cheap Hotels in Otay Mesa
- Family Hotels in Otay Mesa
- Golf Hotels in Otay Mesa
- Historic Hotels in Otay Mesa
- Hotels with Free Parking in Otay Mesa
- Hotels with Hot Tubs in Otay Mesa
- Hotels with WiFi in Otay Mesa
- Hotels with a Pool in Otay Mesa
- Hotels with smoking rooms in Otay Mesa
- Luxury Hotels in Otay Mesa
- Resorts & Hotels with Spas in Otay Mesa
- Shopping Hotels in Otay Mesa
- Winery Hotels in Otay Mesa
Explore more hotels
- Lafayette Hotel & Club
- Kings Inn San Diego
- The Sofia Hotel
- The Horton Grand, Downtown/Gaslamp Quarter
- Bay Club Hotel & Marina
- Hilton San Diego Bayfront
- Paradise Point Resort & Spa
- Manchester Grand Hyatt San Diego
- Best Western Plus Marina Gateway Hotel
- San Diego Mission Bay Resort
- AC Hotel by Marriott San Diego Downtown Gaslamp Quarter
- Legacy Resort Hotel & Spa
- Marriott Marquis San Diego Marina
- Wyndham Garden San Diego Near SeaWorld
- Days Inn by Wyndham San Diego Hotel Circle
- Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
- Bahia Resort Hotel
- Alma San Diego Downtown, a Tribute Portfolio Hotel
- The Westin San Diego Bayview
- Margaritaville Hotel San Diego Gaslamp Quarter