Otay Mesa, CA

San Diego

Popular places to visit

San Diego Zoo featuring landscape views, zoo animals and a pond

San Diego Zoo

Why not visit the animals who live at San Diego Zoo and see why this is a favorite attraction in San Diego? Stroll along the area's seaside or experience its acclaimed art scene.

San Diego Zoo
San Diego Convention Center

San Diego Convention Center

During your trip, find out what's happening at San Diego Convention Center, a top convention center in San Diego. Experience the area's acclaimed art scene and entertainment choices.

San Diego Convention Center
Mission Bay featuring a sandy beach

Mission Bay

Explore the great outdoors at Mission Bay, a popular spot to commune with nature in San Diego. Stroll along the seaside in this family-friendly area, or check out its top-notch restaurants.

Mission Bay
Bayside Skyride at Sea World, San Diego, CA

SeaWorld

Make time to visit the sea life at SeaWorld and find out why this is a popular attraction in San Diego. Discover the beautiful sunsets and top-notch restaurants in this walkable area.

SeaWorld
Balboa Park which includes a pond

Balboa Park

Explore the great outdoors with a trip to Balboa Park, a popular green space in San Diego. Discover the area's top-notch restaurants and its acclaimed art scene.

Balboa Park
Mission Beach featuring tropical scenes, street scenes and a beach

Mission Beach

Nothing says vacation like spending a lazy day at Mission Beach, a popular beach in San Diego. Stroll along the seaside or discover the area's sunsets.

Mission Beach

Otay Mesa Hotel Deals

Paradise Point Resort & Spa
Paradise Point Resort & Spa
4 out of 5
1404 Vacation Rd, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is AED 656 per night from Dec 30 to Dec 31
AED 656
AED 922 total
includes taxes & fees
30 Dec - 31 Dec
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
8.4/10 Very Good! (1,963 reviews)
"Awesome spot for price 🙏"

Reviewed on 19 December 2024

Paradise Point Resort & Spa
Manchester Grand Hyatt San Diego
Manchester Grand Hyatt San Diego
4 out of 5
1 Market Pl, San Diego, CA
The price is AED 621 per night from Dec 23 to Dec 24
AED 621
AED 874 total
includes taxes & fees
23 Dec - 24 Dec
Book a stay at this eco-certified hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the bar in our reviews. ...
8.8/10 Excellent! (2,778 reviews)
"Good in general"

Reviewed on 17 December 2024

Manchester Grand Hyatt San Diego
Wyndham San Diego Bayside
Wyndham San Diego Bayside
4 out of 5
1355 N Harbor Drive, San Diego, CA
The price is AED 559 per night from Jan 2 to Jan 3
AED 559
AED 630 total
includes taxes & fees
2 Jan - 3 January 2025
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.2/10 Very Good! (5,536 reviews)
"The Bayview is nine and it is close to the city center."

Reviewed on 20 December 2024

Wyndham San Diego Bayside
The Dana on Mission Bay
The Dana on Mission Bay
3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
The price is AED 547 per night from Jan 1 to Jan 2
AED 547
AED 617 total
includes taxes & fees
1 Jan - 2 January 2025
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 spa tubs. Our guests praise the pool and the restaurant in ...
8.6/10 Excellent! (2,946 reviews)
"A very good clean, friendly place to stay For sure we will use it next time we’re in San Diego"

Reviewed on 20 December 2024

The Dana on Mission Bay
Wyndham Garden San Diego Near SeaWorld
Wyndham Garden San Diego Near SeaWorld
3 out of 5
3737 Sports Arena Blvd, San Diego, CA
The price is AED 364 per night from Dec 23 to Dec 24
AED 364
AED 410 total
includes taxes & fees
23 Dec - 24 Dec
Stay at this 3-star business-friendly hotel in San Diego. Enjoy free WiFi, parking (surcharge), and a 24-hour front desk. Our guests praise the helpful staff ...
7.2/10 Good! (3,643 reviews)
"They charge me $20 dollars a day for parking, this is ridiculous, this area it’s not Disneyland"

Reviewed on 20 December 2024

Wyndham Garden San Diego Near SeaWorld
Comfort Inn Sea World Area
Comfort Inn Sea World Area
3.5 out of 5
3880 Greenwood St, San Diego, CA
The price is AED 364 per night from Jan 2 to Jan 3
AED 364
AED 409 total
includes taxes & fees
2 Jan - 3 January 2025
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.4/10 Very Good! (1,274 reviews)
Great hotel overall
"Room was clean, comfortable, seemed safe, good breakfast, staff was nice, and housekeeping was great."

Reviewed on 20 December 2024

Comfort Inn Sea World Area
See all 4,456 properties in Otay Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighborhoods around Otay Mesa

Lake Murray in San Diego

Mid-City

If you're spending time in Mid-City, check out sights like Viejas Arena or San Diego State University Art Gallery and hop on the metro to see more the city at SDSU Transit Center Station or Alvarado Station.

Mid-City
Gaslamp Quarter showing signage, night scenes and street scenes

Gaslamp Quarter

Downtown San Diego's historic district boasts Victorian-era buildings, now housing vibrant restaurants, shops, and entertainment venues. Stroll from Broadway to Harbor Drive, and 4th to 6th Avenue, admiring the newly installed gaslamps at Market Street.

Gaslamp Quarter
US Grant Hotel

Downtown San Diego

4.5/5(8,497 area reviews)

Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.

Downtown San Diego
Try the tamale eggs Benedict!

North Park

4/5(78 area reviews)

North Park is well-liked for its restaurants. You can also take some time to explore sights in the surrounding area like San Diego Zoo and Balboa Park.

North Park
Little Italy

Little Italy

Little Italy is popular for its captivating waterfront views. Explore top sights like Waterfront Park and Maritime Museum of San Diego, and you can get around town on the metro at County Center - Little Italy Station.

Little Italy
Loads of Loafs

Hillcrest

3.5/5(53 area reviews)

Visitors to Hillcrest enjoy its restaurants, and if you want to do some exploring, Marston House is worth a stop.

Hillcrest

Otay Mesa, CA

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