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Find Resorts & Hotels with Spas in Cape Girardeau, MO

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Check availability on Cape Girardeau Resorts & Hotels with Spas

Tonight
2 May - 3 May
Tomorrow
3 May - 4 May
This weekend
2 May - 4 May
Next weekend
9 May - 11 May

Compare Cape Girardeau Resorts & Hotels with Spas room rates, reviews, and availability. Most hotels are fully refundable.

Hampton Inn Cape Girardeau I 55 East
Courtyard

Hampton Inn Cape Girardeau I 55 East

2.5 star property
9.6 out of 10, Exceptional, (705)
"We stay here each time we go around Missouri "
The price is AED 403
AED 454 total
includes taxes & fees
18 May - 19 May
Hampton Inn Cape Girardeau I 55 East
Pear Tree Inn Cape Girardeau West
Lobby

Pear Tree Inn Cape Girardeau West

2.5 star property
9.0 out of 10, Wonderful, (1001)
"Nice place, would stay here again "
The price is AED 264
AED 298 total
includes taxes & fees
14 May - 15 May
Pear Tree Inn Cape Girardeau West
Drury Inn & Suites Cape Girardeau
Business center

Drury Inn & Suites Cape Girardeau

3.0 star property
9.4 out of 10, Exceptional, (925)
"Always The best hotel "
The price is AED 347
AED 392 total
includes taxes & fees
1 Jun - 2 Jun
Drury Inn & Suites Cape Girardeau
Drury Plaza Hotel Cape Girardeau Conference Center
Lobby

Drury Plaza Hotel Cape Girardeau Conference Center

3.0 star property
9.6 out of 10, Exceptional, (1003)
"Great stay!!"
The price is AED 331
AED 373 total
includes taxes & fees
7 May - 8 May
Drury Plaza Hotel Cape Girardeau Conference Center
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Exterior

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 star property
9.4 out of 10, Exceptional, (1001)
"Will definitely stay there again!!"
The price is AED 364
AED 410 total
includes taxes & fees
1 Jun - 2 Jun
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Candlewood Suites Cape Girardeau by IHG
Exterior

Candlewood Suites Cape Girardeau by IHG

2.5 star property
8.2 out of 10, Very Good, (776)
"Was clean and comfortable "
The price is AED 301
AED 360 total
includes taxes & fees
18 May - 19 May
Candlewood Suites Cape Girardeau by IHG
Pear Tree Inn Cape Girardeau Near the Medical Center
Seasonal outdoor pool

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 star property
9.0 out of 10, Wonderful, (1002)
"Continental breakfast where the hostess made the waffles for you; friendly staff."
The price is AED 215
AED 242 total
includes taxes & fees
6 May - 7 May
Pear Tree Inn Cape Girardeau Near the Medical Center
Town House Inn Cape Giradreau
Desk, free WiFi

Town House Inn Cape Giradreau

2.5 star property
6.0 out of 10, (181)
"Easy to get in and out "
The price is AED 231
AED 270 total
includes taxes & fees
4 May - 5 May
Town House Inn Cape Giradreau
Serenity South -- Gardens, River-Views, and Refreshing Space
Fridge, microwave, oven, stovetop

Serenity South -- Gardens, River-Views, and Refreshing Space

10.0 out of 10, Exceptional, (130)
"Great place."
The price is AED 551
AED 889 total
includes taxes & fees
4 May - 5 May
Serenity South -- Gardens, River-Views, and Refreshing Space
The Twisted Sassafras Treehouse
Terrace/patio

The Twisted Sassafras Treehouse

10.0 out of 10, Exceptional, (13)
"Stayed here for our 5 year anniversary as a weekend getaway and it was perfect! This property is perfect for a couples retreat and I couldn't recommend it more. Everything was very clean and the hosts were super accommodating considering it was a special occasion. We can't wait to come back again! "
The price is AED 841
AED 1,222 total
includes taxes & fees
13 May - 14 May
The Twisted Sassafras Treehouse
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Looking for a spa hotel in Cape Girardeau?
Treat yourself to some pampering and book a hotel with a spa. Travelers recommend the gourmet restaurants in Cape Girardeau. Enjoy the historical sites and riverfront during your vacation. Hotels with spas are a great way to break away from your routine and add a layer of luxury to your weekend away.
What is the best spa hotel in Cape Girardeau?
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG is a top spa hotel featuring a pool and a fitness center.
How many spa hotels will I find in Cape Girardeau?
Among Expedia’s 58 accommodation options in Cape Girardeau, there is 1 spa hotel.
What's there to see and do in Cape Girardeau?
Experience all that Cape Girardeau has to offer when you visit Isle Casino Cape Girardeau, Show Me Center, and Cape Splash Family Aquatic Center. If you have a bit of extra time while you’re in the area, you might want to check out Hunter Valley Winery and Trail of Tears State Park.
What is a Cape Girardeau spa hotel?
Spa hotels in Cape Girardeau have full on-site spas offering services such as massages and a choice of body treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are great for rest, rejuvenation, and relaxation.