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Find Resorts & Hotels with Spas in Cape Girardeau, MO

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Check availability on Cape Girardeau Resorts & Hotels with Spas

Tonight
8 Apr - 9 Apr
Tomorrow
9 Apr - 10 Apr
This weekend
11 Apr - 13 Apr
Next weekend
18 Apr - 20 Apr

Compare Cape Girardeau Resorts & Hotels with Spas room rates, reviews, and availability. Most hotels are fully refundable.

Hampton Inn Cape Girardeau I 55 East
Courtyard

Hampton Inn Cape Girardeau I 55 East

2.5 star property
9.6 out of 10, Exceptional, (699)
"It was clean and the beds were actually very comfortable. They never refilled the conditioner in the shower but that was the only complaint. "
The price is AED 403
AED 454 total
includes taxes & fees
20 Apr - 21 Apr
Hampton Inn Cape Girardeau I 55 East
Pear Tree Inn Cape Girardeau West
Lobby

Pear Tree Inn Cape Girardeau West

2.5 star property
9.0 out of 10, Wonderful, (1000)
"Everything was amazing..The clerk was super nice, the room was neat and clean how i like..I would stay at this hotel wherever I need a quick get away to relax."
The price is AED 264
AED 298 total
includes taxes & fees
13 Apr - 14 Apr
Pear Tree Inn Cape Girardeau West
Drury Inn & Suites Cape Girardeau
Business center

Drury Inn & Suites Cape Girardeau

3.0 star property
9.4 out of 10, Exceptional, (916)
"5 Stars is not enough for all of the staff on duty April 4th, 2025. These folks are a SOLID 11! There was a genuine tornado approaching and they made sure all the lodgers were in safe spaces and appraised of what was going on. There was no hesitation of what to do, where to go and all was calm. Luckily, all was good. Oh yeah the dinner & breakfast was great the place was clean and our room was fantastic. Value was excellent. Allen B."
The price is AED 297
AED 336 total
includes taxes & fees
19 Apr - 20 Apr
Drury Inn & Suites Cape Girardeau
Drury Plaza Hotel Cape Girardeau Conference Center
Lobby

Drury Plaza Hotel Cape Girardeau Conference Center

3.0 star property
9.6 out of 10, Exceptional, (1000)
"It was a great hotel and the staff were very helpful to us with our kids at breakfast time. The kids loved getting popcorn from the staff after a long day of driving."
The price is AED 347
AED 392 total
includes taxes & fees
13 Apr - 14 Apr
Drury Plaza Hotel Cape Girardeau Conference Center
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Exterior

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 star property
9.4 out of 10, Exceptional, (1000)
"We enjoyed our stay both times on our vacation to New Orleans."
The price is AED 378
AED 427 total
includes taxes & fees
4 May - 5 May
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Candlewood Suites Cape Girardeau by IHG
Exterior

Candlewood Suites Cape Girardeau by IHG

2.5 star property
8.2 out of 10, Very Good, (761)
"The only problem we had was parking. Several people parked in the middle of two spots. A truck and trailer were taking up 6 spots and several spots had trailers and work equipment. They told us we could park in the gravel lot beside the hotel. I would think that is where the trailers and big trucks should park."
The price is AED 301
AED 360 total
includes taxes & fees
18 Apr - 19 Apr
Candlewood Suites Cape Girardeau by IHG
Pear Tree Inn Cape Girardeau Near the Medical Center
Seasonal outdoor pool

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 star property
9.0 out of 10, Wonderful, (1001)
"It was small room but was okay "
The price is AED 248
AED 280 total
includes taxes & fees
13 Apr - 14 Apr
Pear Tree Inn Cape Girardeau Near the Medical Center
Town House Inn Cape Giradreau
Desk, free WiFi

Town House Inn Cape Giradreau

2.5 star property
6.0 out of 10, (178)
"NA"
The price is AED 231
AED 270 total
includes taxes & fees
9 Apr - 10 Apr
Town House Inn Cape Giradreau
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Exterior

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

8.8 out of 10, Excellent, (27)
"Amazing property that we simply didn't stay long enough to enjoy in its completeness. Billiards and Putt-Putt on entry, so attractive that we started playing before we even unpacked! I'm very artsy interior, and lots of room and outdoor fire pit, multiple decks, and an in-ground pool. The home is even on the grounds, an event venue. Probably a wonderful combination for them! Would enjoy returning, but for a longer stay will you could enjoy all with the property had to offer! Highly recommend it"
The price is AED 551
AED 862 total
includes taxes & fees
9 Apr - 10 Apr
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Serenity South -- Gardens, River-Views, and Refreshing Space
Fridge, microwave, oven, stovetop

Serenity South -- Gardens, River-Views, and Refreshing Space

10.0 out of 10, Exceptional, (129)
"When looking for a VRBO for our daughter's college visit, we knew the perfect place to stay! This is our second stay at Serenity South and it was just as incredible as the first visit. Clean, inviting and cozy. Thanks Jo for another beautiful stay."
The price is AED 551
AED 900 total
includes taxes & fees
9 Apr - 10 Apr
Serenity South -- Gardens, River-Views, and Refreshing Space
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Looking for a spa hotel in Cape Girardeau?
Treat yourself to some pampering and book a hotel with a spa. Travelers recommend the gourmet restaurants in Cape Girardeau. Enjoy the historical sites and riverfront during your vacation. Hotels with spas are a great way to break away from your routine and add a layer of luxury to your weekend away.
What is the best spa hotel in Cape Girardeau?
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG is a top spa hotel featuring a pool and a fitness center.
How many spa hotels will I find in Cape Girardeau?
Among Expedia’s 58 accommodation options in Cape Girardeau, there is 1 spa hotel.
What's there to see and do in Cape Girardeau?
Experience all that Cape Girardeau has to offer when you visit Isle Casino Cape Girardeau, Show Me Center, and Hunter Valley Winery. If you have a bit of extra time while you’re in the area, you might want to check out Trail of Tears State Park and Shawnee National Forest.
What is a Cape Girardeau spa hotel?
Spa hotels in Cape Girardeau have full on-site spas offering services such as massages and a choice of body treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are great for rest, rejuvenation, and relaxation.