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Find Family Hotels in Cape Girardeau, MO

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Check availability on Cape Girardeau Family Hotels

Compare Cape Girardeau Family Hotels room rates, reviews, and availability. Most hotels are fully refundable.

Drury Inn & Suites Cape Girardeau
Business center

Drury Inn & Suites Cape Girardeau

3.0 star property
9.4 out of 10, Exceptional, (917)
"5 Stars is not enough for all of the staff on duty April 4th, 2025. These folks are a SOLID 11! There was a genuine tornado approaching and they made sure all the lodgers were in safe spaces and appraised of what was going on. There was no hesitation of what to do, where to go and all was calm. Luckily, all was good. Oh yeah the dinner & breakfast was great the place was clean and our room was fantastic. Value was excellent. Allen B."
The price is AED 347
AED 392 total
includes taxes & fees
18 Apr - 19 Apr
Drury Inn & Suites Cape Girardeau
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Exterior

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 star property
9.4 out of 10, Exceptional, (1002)
"Will definitely stay there again!!"
The price is AED 378
AED 427 total
includes taxes & fees
4 May - 5 May
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Pear Tree Inn Cape Girardeau Near the Medical Center
Seasonal outdoor pool

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 star property
9.0 out of 10, Wonderful, (1004)
"It was small room but was okay "
The price is AED 248
AED 280 total
includes taxes & fees
14 Apr - 15 Apr
Pear Tree Inn Cape Girardeau Near the Medical Center
Historical 'Kage House' Short Term Rental located in "Old Town Cape"
Property grounds

Historical 'Kage House' Short Term Rental located in "Old Town Cape"

10.0 out of 10, Exceptional, (212)
"There couldn’t be a better location for going out on the riverfront in Cape Girardeau. It is well set up with beautiful furniture and all the kitchen supplies you would need. Highly recommend. "
Historical 'Kage House' Short Term Rental located in "Old Town Cape"
Hampton Inn Cape Girardeau I 55 East
Courtyard

Hampton Inn Cape Girardeau I 55 East

2.5 star property
9.6 out of 10, Exceptional, (700)
"It was clean and the beds were actually very comfortable. They never refilled the conditioner in the shower but that was the only complaint. "
The price is AED 408
AED 460 total
includes taxes & fees
18 Apr - 19 Apr
Hampton Inn Cape Girardeau I 55 East
Pear Tree Inn Cape Girardeau West
Lobby

Pear Tree Inn Cape Girardeau West

2.5 star property
9.0 out of 10, Wonderful, (1000)
"Everything was amazing..The clerk was super nice, the room was neat and clean how i like..I would stay at this hotel wherever I need a quick get away to relax."
The price is AED 264
AED 298 total
includes taxes & fees
14 Apr - 15 Apr
Pear Tree Inn Cape Girardeau West
Candlewood Suites Cape Girardeau by IHG
Exterior

Candlewood Suites Cape Girardeau by IHG

2.5 star property
8.2 out of 10, Very Good, (762)
"Very nice place to stay and friendly people"
The price is AED 301
AED 360 total
includes taxes & fees
27 Apr - 28 Apr
Candlewood Suites Cape Girardeau by IHG
Quality Inn
Lobby

Quality Inn

2.5 star property
7.0 out of 10, Good, (562)
"It was okay"
The price is AED 258
AED 291 total
includes taxes & fees
23 Apr - 24 Apr
Quality Inn
Drury Plaza Hotel Cape Girardeau Conference Center
Lobby

Drury Plaza Hotel Cape Girardeau Conference Center

3.0 star property
9.6 out of 10, Exceptional, (1001)
"We stay here several times a year and it’s always a wonderful time. All of the staff go above and beyond and we are always very comfortable "
The price is AED 347
AED 392 total
includes taxes & fees
14 Apr - 15 Apr
Drury Plaza Hotel Cape Girardeau Conference Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

What's Cape Girardeau like for family-friendly vacations?
You might want to consider the historic destination of Cape Girardeau if you’ve been thinking about a trip for the whole family. The restaurants here makes this an attractive vacation spot for families. Fly into Cape Girardeau, MO (CGI-Cape Girardeau Municipal), which is the closest airport, or Cairo, IL (CIR-Cairo Regional), which is located 23.4 mi (37.6 km) from the city center.
What's the best accommodation for a family vacation to Cape Girardeau?
Drury Plaza Hotel Cape Girardeau Conference Center is a hotel with an indoor pool and a restaurant, and it’s a top choice on Expedia for families. Other good options for your family trip include Pear Tree Inn Cape Girardeau West and Pear Tree Inn Cape Girardeau Near the Medical Center.
How many family-friendly hotels are there in Cape Girardeau?
Expedia has 12 family-friendly hotels and other accommodations in Cape Girardeau.
When's the best time to book a family-friendly vacation in Cape Girardeau?
The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 40°F. Average annual precipitation for Cape Girardeau is 59 inches.
What's there to see and do with your family in Cape Girardeau?
While you and your family are visiting Cape Girardeau, you might want to check out some kid-friendly attractions such as Show Me Center, Shawnee National Forest, and Cape Splash Family Aquatic Center. Make sure you have lots of time for activities like Cape Girardeau Conservation Nature Center and Lazy L Safari Park.