Photo by Skyy
Find Luxury Hotels in Cape Girardeau, MO
- Plan, book, stay with confidence
Be picky
Search almost a million properties worldwide
Change your mind
Book hotels with free cancellation
Check availability on Cape Girardeau Luxury Hotels
Pick from 4 Cape Girardeau Luxury Hotels and compare room rates, reviews, and availability. Most hotels are fully refundable.
Pear Tree Inn Cape Girardeau Near the Medical Center
Pear Tree Inn Cape Girardeau Near the Medical Center
9.0 out of 10, Wonderful, (1008)
The price is AED 215
AED 242 total
includes taxes & fees
16 Dec - 17 Dec
Quality Inn
Quality Inn
7.0 out of 10, Good, (517)
The price is AED 224
AED 253 total
includes taxes & fees
27 Nov - 28 Nov
Drury Inn & Suites Cape Girardeau
Drury Inn & Suites Cape Girardeau
9.4 out of 10, Exceptional, (818)
The price is AED 347
AED 392 total
includes taxes & fees
1 Dec - 2 Dec
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find out more about Cape Girardeau
Find out more about Cape Girardeau
Recent reviews of Cape Girardeau hotels
Recent reviews of Cape Girardeau hotels
5/5 Excellent
Comfy
"Clean and bed was comfy! Nice looking hotel and very friendly staff!"
A verified traveler stayed at Drury Inn & Suites Cape Girardeau
Posted 1 day ago
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Find More Hotels near Cape Girardeau
More Hotel Options in Cape Girardeau
- Adults Only Resorts & Hotels in Cape Girardeau
- Adventure Hotels in Cape Girardeau
- Business Hotels in Cape Girardeau
- Casinos in Cape Girardeau
- Cheap Hotels in Cape Girardeau
- Family Hotels in Cape Girardeau
- Historic Hotels in Cape Girardeau
- Hotel Wedding Venues in Cape Girardeau
- Hotels with Bars in Cape Girardeau
- Hotels with Free Parking in Cape Girardeau
- Hotels with Hot Tubs in Cape Girardeau
- Hotels with WiFi in Cape Girardeau
- Hotels with a Pool in Cape Girardeau
- Hotels with an Indoor Pool in Cape Girardeau
- Hotels with smoking rooms in Cape Girardeau
- Pet-friendly Hotels in Cape Girardeau
- Resorts & Hotels with Spas in Cape Girardeau
- Romantic Hotels in Cape Girardeau
- Shopping Hotels in Cape Girardeau
- Winery Hotels in Cape Girardeau
More Accommodation Types in Cape Girardeau
- Vacation Homes in Missouri
- Condo Rentals in Missouri
- Apartments in Missouri
- Cabin Rentals in Missouri
- Cottages in Missouri
- Motels in Missouri
- Resorts in Missouri
- Chalets in Missouri
- Lodges in Missouri
- Villas in Missouri
- B&B in Missouri
- Farmstay in Missouri
- Aparthotels in Missouri
- RV Parks in Missouri
- Guest Houses in Missouri
- Inns in Missouri
- Condo Resorts in Missouri
- Hostels in Missouri
- Houseboats in Missouri
- Residences in Missouri
Hotels near popular Cape Girardeau Attractions
- Hotels near Southeast Missouri State University
- Hotels near Isle Casino Cape Girardeau
- Hotels near Riverfront Bridge Park
- Hotels near Riverfront Park
- Hotels near eDen Spa & Salon
- Hotels near Cape Rock Park
- Hotels near Cape Girardeau Conservation Nature Center
- Hotels near Hunter Valley Winery
- Hotels near Fort D Historic Site
- Hotels near Cape Splash Family Aquatic Center
Cape Girardeau Hotels by Star Rating
Explore more hotels
- Quality Inn
- Fairfield Inn & Suites by Marriott Cape Girardeau
- Town House Inn Cape Giradreau
- 4-acre Home with Multiple Decks: Pool Table, Putt-Putt, 4 miles to Downtown
- Serenity South -- Gardens, River-Views, and Refreshing Space
- Little Blue Cottage on Spanish
- Charming Secluded Getaway Cabin within minutes of amenities
- Loft Apartment Across From Semo University Houch Field House. Walk To Events
- Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO
- The Twisted Sassafras Treehouse
- Charming 2-Story- C.1847 - River Views - Fast Wifi
- River Town Retreat near SEMO
- Quaint, Beautiful Home next to SEMO and Hospital
- Downtown 4BR with 2 King Beds! Walking distance to SEMO and the River Front.
- La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
- Hotel 7 Inn Anna
- New cabin in the woods with private hot tub
- Comfort Suites Jackson-Cape Girardeau
- Rest, Relax and Renew. Our log cabin experience awaits your arrival.
- Drury Inn & Suites Jackson MO