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Find Luxury Hotels in Cape Girardeau, MO

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Pick from 4 Cape Girardeau Luxury Hotels and compare room rates, reviews, and availability. Most hotels are fully refundable.

Pear Tree Inn Cape Girardeau Near the Medical Center
Exterior
Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 star property
9.0 out of 10, Wonderful, (1003)
"I cannot say enough things about the entire staff. Everyone from the front desk personnel to the breakfast attendants to housekeeping were so friendly, efficient, and obviously happy in their jobs. Drury Inn should be very proud."
The price is AED 218
AED 246 total
includes taxes & fees
10 Nov - 11 Nov
Pear Tree Inn Cape Girardeau Near the Medical Center
Quality Inn
Exterior
Quality Inn
2.5 star property
7.0 out of 10, Good, (513)
"We really enjoyed our 2 day stay there. Staff nice, rooms clean, parking was easy. My only complaint was breakfast. There could/should have had a better selection. Overall....a great stay. "
The price is AED 224
AED 253 total
includes taxes & fees
6 Nov - 7 Nov
Quality Inn
Drury Inn & Suites Cape Girardeau
Exterior
Drury Inn & Suites Cape Girardeau
3.0 star property
9.4 out of 10, Exceptional, (811)
"Wonderful"
The price is AED 364
AED 410 total
includes taxes & fees
10 Nov - 11 Nov
Drury Inn & Suites Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Are you searching for the perfect hotel for your luxury getaway to Cape Girardeau?
Use Expedia to arrange your flight to Cape Girardeau, MO (CGI-Cape Girardeau Municipal) airport or Cairo, IL (CIR-Cairo Regional) airport, and then select from a variety of places to stay that will deliver the luxury you want. Amenities are important when you plan a vacation, so we make it easy to get what you’d like to make your stay relaxing and comfortable. If you want an upscale hotel that has fine dining, a spa, or several swimming pools, Expedia can help you find the best luxury hotel experience that Cape Girardeau offers. During your visit, you might want to enjoy the university which Cape Girardeau is known for.
How many luxury hotels will I find in Cape Girardeau?
Lie in the lap of luxury during your getaway to Cape Girardeau in one of Expedia’s 6 luxury hotels.
What's the best time to vacation in Cape Girardeau?
Planning for the weather is an important factor for making your trip to Cape Girardeau a success, especially when you’re splurging. The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 40°F. Average annual precipitation for Cape Girardeau is 59 inches.
What's there to see and do in Cape Girardeau?
Enjoy all that Cape Girardeau has to offer and visit Isle Casino Cape Girardeau, Riverfront Bridge Park, and Show Me Center. If you have a bit of extra time while you’re in the area, you might want to check out Cape Splash Family Aquatic Center and Hunter Valley Winery.