Photo by Skyy
Find Adults Only Resorts & Hotels in Cape Girardeau, MO
- Plan, book, stay with confidence
Be picky
Search almost a million properties worldwide
Change your mind
Book hotels with free cancellation
Check availability on Cape Girardeau Adults Only Resorts & Hotels
Pick from Cape Girardeau Adults Only Resorts & Hotels and compare room rates, reviews, and availability. Most hotels are fully refundable.
Find out more about Cape Girardeau
Find out more about Cape Girardeau
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Find More Hotels near Cape Girardeau
More Hotel Options in Cape Girardeau
- Adventure Hotels in Cape Girardeau
- Business Hotels in Cape Girardeau
- Casinos in Cape Girardeau
- Cheap Hotels in Cape Girardeau
- Family Hotels in Cape Girardeau
- Historic Hotels in Cape Girardeau
- Hotel Wedding Venues in Cape Girardeau
- Hotels with Bars in Cape Girardeau
- Hotels with Free Parking in Cape Girardeau
- Hotels with Hot Tubs in Cape Girardeau
- Hotels with WiFi in Cape Girardeau
- Hotels with a Pool in Cape Girardeau
- Hotels with an Indoor Pool in Cape Girardeau
- Hotels with smoking rooms in Cape Girardeau
- Luxury Hotels in Cape Girardeau
- Pet-friendly Hotels in Cape Girardeau
- Resorts & Hotels with Spas in Cape Girardeau
- Romantic Hotels in Cape Girardeau
- Shopping Hotels in Cape Girardeau
- Winery Hotels in Cape Girardeau
More Accommodation Types in Cape Girardeau
- Condo Rentals in Missouri
- Vacation Homes in Missouri
- Apartments in Missouri
- Cabin Rentals in Missouri
- Cottages in Missouri
- Motels in Missouri
- Resorts in Missouri
- Chalets in Missouri
- Lodges in Missouri
- Villas in Missouri
- B&B in Missouri
- Farmstay in Missouri
- RV Parks in Missouri
- Aparthotels in Missouri
- Guest Houses in Missouri
- Inns in Missouri
- Condo Resorts in Missouri
- Hostels in Missouri
- Houseboats in Missouri
- Residences in Missouri
Hotels near popular Cape Girardeau Attractions
- Hotels near Southeast Missouri State University
- Hotels near Isle Casino Cape Girardeau
- Hotels near Riverfront Bridge Park
- Hotels near Riverfront Park
- Hotels near eDen Spa & Salon
- Hotels near Cape Rock Park
- Hotels near Cape Girardeau Conservation Nature Center
- Hotels near Hunter Valley Winery
- Hotels near Fort D Historic Site
- Hotels near Cape Splash Family Aquatic Center
Cape Girardeau Hotels by Star Rating
Explore more hotels
- Quality Inn
- Fairfield Inn & Suites by Marriott Cape Girardeau
- Town House Inn Cape Giradreau
- 4-acre Home with Multiple Decks: Pool Table, Putt-Putt, 4 miles to Downtown
- Serenity South -- Gardens, River-Views, and Refreshing Space
- Little Blue Cottage on Spanish
- Charming Secluded Getaway Cabin within minutes of amenities
- Loft Apartment Across From Semo University Houch Field House. Walk To Events
- Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO
- The Twisted Sassafras Treehouse
- Charming 2-Story- C.1847 - River Views - Fast Wifi
- River Town Retreat near SEMO
- Quaint, Beautiful Home next to SEMO and Hospital
- Downtown 4BR with 2 King Beds! Walking distance to SEMO and the River Front.
- La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
- Hotel 7 Inn Anna
- New cabin in the woods with private hot tub
- Comfort Suites Jackson-Cape Girardeau
- Rest, Relax and Renew. Our log cabin experience awaits your arrival.
- Drury Inn & Suites Jackson MO