Find Resorts & Hotels with Spas in San Luis Obispo, CA

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Pick from 15 San Luis Obispo Resorts & Hotels with Spas and compare room rates, reviews, and availability. Most hotels are fully refundable.

Quality Suites Downtown San Luis Obispo
3.0 star property
9.4 out of 10, Exceptional, (1008)
"Staff was friendly and helpful. Enjoyed the happy hour and bbq. About a half mile to the Fremont Theater. Our door was a little tricky to open but no big deal."
The price is AED 350
AED 464 total
includes taxes & fees
8 Dec - 9 Dec
Quality Suites Downtown San Luis Obispo
Hotel San Luis Obispo
4.5 star property
9.4 out of 10, Exceptional, (439)
"Great property "
The price is AED 1,319
AED 1,497 total
includes taxes & fees
1 Dec - 2 Dec
Hotel San Luis Obispo
University Inn
2.0 star property
8.2 out of 10, Very Good, (971)
"The room was average. There was Construction in the works. Our bathroom ceiling has been patched up & the floor hadn't been mopped for awhile, a white hand towel turned black after wiping up spilt water. Our refrig hummed us to sleep. Location was great & the over all service was very good. "
The price is AED 272
AED 406 total
includes taxes & fees
24 Nov - 25 Nov
University Inn
Madonna Inn
3.5 star property
9.2 out of 10, Wonderful, (1080)
"Loved the infinity pool and hot tub! The bar was fun and the bartenders were experienced. We saw and got to pet some horses outside of our room one morning! 10/10 trip."
The price is AED 433
AED 607 total
includes taxes & fees
4 Dec - 5 Dec
Madonna Inn
La Quinta Inn & Suites by Wyndham San Luis Obispo Downtown
3.0 star property
9.0 out of 10, Wonderful, (1314)
"Clean and quiet. Lighting could be improved with more ceiling illumination"
The price is AED 384
AED 436 total
includes taxes & fees
8 Dec - 9 Dec
La Quinta Inn & Suites by Wyndham San Luis Obispo Downtown
Vagabond Inn San Luis Obispo
2.0 star property
8.4 out of 10, Very Good, (1041)
"It’s a decent hotel. Nothing fancy for sure. Somewhat outdated. "
The price is AED 290
AED 366 total
includes taxes & fees
24 Nov - 25 Nov
Vagabond Inn San Luis Obispo
Mission Inn San Luis Obispo
2.0 star property
7.8 out of 10, Good, (772)
"Great stay, perfect for what we needed."
The price is AED 253
AED 329 total
includes taxes & fees
24 Nov - 25 Nov
Mission Inn San Luis Obispo
HOTEL CERRO, Autograph Collection
4.0 star property
9.2 out of 10, Wonderful, (424)
"Love how clean and neat the hotel is. My door and window to the patio weren’t working—I was not able to open it, other than that, love the layout and decors. Was not fond of the light above my head, the opening between the sinks.—I couldn’t figure out where all the light switches were at to turn off some of the lights. Lol Over all, very nice and would definitely go back."
The price is AED 757
AED 958 total
includes taxes & fees
2 Dec - 3 Dec
HOTEL CERRO, Autograph Collection
Motel 6 San Luis Obispo, CA - South
2.0 star property
8.2 out of 10, Very Good, (1001)
"Clean & quiet"
The price is AED 294
AED 334 total
includes taxes & fees
1 Dec - 2 Dec
Motel 6 San Luis Obispo, CA - South
Best Western Plus Royal Oak Hotel
2.5 star property
8.6 out of 10, Excellent, (1001)
"Thank Rosa was great customer service "
The price is AED 422
AED 471 total
includes taxes & fees
8 Dec - 9 Dec
Best Western Plus Royal Oak Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Looking for a spa hotel in San Luis Obispo?
Book one of our lush spa hotels and pamper yourself from the moment you arrive. Travelers love the wineries and restaurants in San Luis Obispo. Enjoy the art galleries and beaches during your vacation. Hotels with spas are the perfect way to take a break from your daily routine and add a layer of luxury to your holiday.
What is the best spa hotel in San Luis Obispo?
Madonna Inn is a top spa hotel featuring a fitness center, tennis courts, a bar, and an outdoor pool. Spend an afternoon at The Spa at Madonna Inn. where you’ll find facials, body scrubs, and Swedish massages and more. Other popular spa hotels in San Luis Obispo include HOTEL CERRO, Autograph Collection and Hotel San Luis Obispo.
How many spa hotels will I find in San Luis Obispo?
Among Expedia’s 216 accommodation options in San Luis Obispo, there are 3 spa hotels.
What's there to see and do in San Luis Obispo?
Enjoy all that San Luis Obispo has to offer and visit Fremont Theater, Downtown SLO Farmers’ Market, and San Luis Obispo Superior Court. If you have extra time while you’re in the area, you might want to see Bubblegum Alley and Mission San Luis Obispo de Tolosa.
What is a San Luis Obispo spa hotel?
Spa hotels in San Luis Obispo provide lodging and have a full on-site spa which offers services like therapies and beauty treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation, and relaxation.