Find 5 Star Hotels in Southeast Missouri, MO

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Check availability on Southeast Missouri 5 Star Hotels

Tonight
2 Mar - 3 Mar
Tomorrow
3 Mar - 4 Mar
Next weekend
7 Mar - 9 Mar
In two weeks
14 Mar - 16 Mar

Compare Southeast Missouri 5 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Drury Plaza Hotel Cape Girardeau Conference Center
Lobby

Drury Plaza Hotel Cape Girardeau Conference Center

3.0 star property
9.6 out of 10, Exceptional, (1004)
"The staff here are fabulous "
The price is AED 347
AED 391 total
includes taxes & fees
6 Mar - 7 Mar
Drury Plaza Hotel Cape Girardeau Conference Center
The Riverview
Grand Riverview Two Queen Room | Premium bedding, pillowtop beds, in-room safe, desk

The Riverview

3.5 star property
9.2 out of 10, Wonderful, (164)
"Very clean,big comfortable bed, coffee maker was nespresso and nasty need a regular coffee maker and nice bathroom but shower only had a half door so water went everywhere in the floor. But overall very nice hotel."
The price is AED 345
AED 389 total
includes taxes & fees
3 Mar - 4 Mar
The Riverview
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Exterior

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 star property
9.4 out of 10, Exceptional, (1003)
"So much around the hotel"
The price is AED 364
AED 410 total
includes taxes & fees
9 Mar - 10 Mar
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Silo Farm Haus- located in the heart of wine country!
Terrace/patio

Silo Farm Haus- located in the heart of wine country!

10.0 out of 10, Exceptional, (138)
"We truly enjoyed our weekend stay at this little hideaway. It was about 15 min drive to Farmington and Ste Gen. Several wineries close by. The craftsmanship of the building is amazing. The only thing that would have made it better would be a hot tub. "
The price is AED 878
AED 1,285 total
includes taxes & fees
4 Mar - 5 Mar
Silo Farm Haus- located in the heart of wine country!
Pear Tree Inn Cape Girardeau West
Lobby

Pear Tree Inn Cape Girardeau West

2.5 star property
9.0 out of 10, Wonderful, (1000)
"Itso"
The price is AED 231
AED 261 total
includes taxes & fees
9 Mar - 10 Mar
Pear Tree Inn Cape Girardeau West
Baymont Inn and Suites by Wyndham Farmington, MO
Business center

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 star property
8.0 out of 10, Very Good, (864)
"It's a better one in the area i heard"
The price is AED 197
AED 224 total
includes taxes & fees
30 Mar - 31 Mar
Baymont Inn and Suites by Wyndham Farmington, MO
Candlewood Suites Cape Girardeau by IHG
Exterior

Candlewood Suites Cape Girardeau by IHG

2.5 star property
8.2 out of 10, Very Good, (738)
"Room was nice. Really liked the kitchen area it had. Staff was very nice and helpful. Would stay again."
The price is AED 286
AED 343 total
includes taxes & fees
30 Mar - 31 Mar
Candlewood Suites Cape Girardeau by IHG
Days Inn and Suites by Wyndham Sikeston
1 bedroom, desk, laptop workspace, blackout drapes

Days Inn and Suites by Wyndham Sikeston

2.0 star property
7.2 out of 10, Good, (1006)
"This was a very nice place to stay. The property was older; however, it was newly renovated and super clean. Well, everything but the shower/tub combo. There was some kind of weird patch at the bottom of the tub, but it worked and the height of the shower head was great - a very tall person can actually stand underneath it. The staff wasn’t too friendly but the price was right, beds were comfy and again, clean and immaculate."
The price is AED 250
AED 285 total
includes taxes & fees
5 Mar - 6 Mar
Days Inn and Suites by Wyndham Sikeston
The Farmstead Hotel
Reception

The Farmstead Hotel

2.5 star property
8.8 out of 10, Excellent, (289)
"Love this property! Great place to stay! "
The price is AED 327
AED 372 total
includes taxes & fees
3 Mar - 4 Mar
The Farmstead Hotel
Motel 6 Poplar Bluff, MO
Blackout drapes, free WiFi, bed sheets

Motel 6 Poplar Bluff, MO

2.0 star property
8.0 out of 10, Very Good, (1003)
"I didn't realize it was a pet friendly facility. Not sure what was going on next door, but it sounded like they were keep an adult pig in the room. Oink! "
The price is AED 247
AED 260 total
includes taxes & fees
3 Mar - 4 Mar
Motel 6 Poplar Bluff, MO
Drury Inn & Suites Cape Girardeau
Business center

Drury Inn & Suites Cape Girardeau

3.0 star property
9.4 out of 10, Exceptional, (906)
"Quiet. Receptionist was very helpful, told us afternoon welcome was ending soon and we should join in before going to room."
The price is AED 347
AED 391 total
includes taxes & fees
9 Mar - 10 Mar
Drury Inn & Suites Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Property amenity

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

2.5 star property
9.0 out of 10, Wonderful, (509)
"We had a short one night stay due to weather and it was overall a good stay! The microwave in our room didn't work! And the bathroom was dirty had to clean it before we used it!"
The price is AED 300
AED 324 total
includes taxes & fees
16 Mar - 17 Mar
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Fairfield Inn & Suites by Marriott Cape Girardeau
Lobby

Fairfield Inn & Suites by Marriott Cape Girardeau

2.5 star property
9.4 out of 10, Exceptional, (84)
"We had an early check-out on a Sunday, so we thought we would miss the breakfast offerings. The staff allowed us early access to it so we could grab some grub and be on our way. We were very thankful for their efforts to fuel us up before our long trip home."
The price is AED 340
AED 384 total
includes taxes & fees
9 Mar - 10 Mar
Fairfield Inn & Suites by Marriott Cape Girardeau
Quality Inn
Lobby

Quality Inn

2.5 star property
7.0 out of 10, Good, (551)
"Property management very polite, the facility has all the amenities I need "
The price is AED 246
AED 278 total
includes taxes & fees
3 Mar - 4 Mar
Quality Inn
Courtyard by Marriott Cape Girardeau Downtown
Lobby

Courtyard by Marriott Cape Girardeau Downtown

3.0 star property
9.6 out of 10, Exceptional, (399)
"It is a great hotel. Jist need more parking thay is closer to door or more doors to access from back parking lot."
The price is AED 459
AED 520 total
includes taxes & fees
16 Mar - 17 Mar
Courtyard by Marriott Cape Girardeau Downtown
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
Lobby

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

2.5 star property
8.0 out of 10, Very Good, (756)
"This was a very nice place to stay. Very clean."
The price is AED 362
AED 414 total
includes taxes & fees
2 Apr - 3 Apr
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
Pear Tree Inn Cape Girardeau Near the Medical Center
Seasonal outdoor pool

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 star property
9.0 out of 10, Wonderful, (1003)
"The front desk staff was excellent!!..very friendly & helpful!..will definitely stay again!"
The price is AED 215
AED 242 total
includes taxes & fees
16 Mar - 17 Mar
Pear Tree Inn Cape Girardeau Near the Medical Center
Fairfield Inn & Suites by Marriott Poplar Bluff
Lobby

Fairfield Inn & Suites by Marriott Poplar Bluff

2.5 star property
9.4 out of 10, Exceptional, (694)
"Clean, spacious and comfortable room"
The price is AED 371
AED 419 total
includes taxes & fees
6 Mar - 7 Mar
Fairfield Inn & Suites by Marriott Poplar Bluff
Drury Inn & Suites Jackson MO
Lobby

Drury Inn & Suites Jackson MO

3.0 star property
9.6 out of 10, Exceptional, (1003)
"Always a nice breakfast and happy hour. Room and pool area very well kept. MOST of staff were very friendly! Large dogs in room next to us and weren't made aware dogs were allowed on this property. I am allergic to large hairy dogs."
The price is AED 331
AED 349 total
includes taxes & fees
6 Mar - 7 Mar
Drury Inn & Suites Jackson MO
Pear Tree Inn Sikeston
Lobby

Pear Tree Inn Sikeston

2.5 star property
9.4 out of 10, Exceptional, (1006)
"Staff: Amazing service. Friendly. Helpful. Cheery. Room: Cozy. Clean. Bed was comfy! Pillows were a dream to sleep on. It's nice having the sink separate from the bathroom. No one wants to be in the bathroom when your spouse is doing number 2. LOL. Breakfast: Delicious! We enjoyed coming down and having a hot breakfast (eggs, sausage, you can make your own waffles, fruit, yogurt, toast, bagels). Fitness Center: Small room w/ a treadmill available. I was a bit bummed there were no weights or...
The price is AED 281
AED 323 total
includes taxes & fees
7 Mar - 8 Mar
Pear Tree Inn Sikeston
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Southeast Missouri?
How much you pay for a 5-star hotel in Southeast Missouri depends on factors like when you want to go and the length of your trip. A top tip for scoring the best deal? Use our pricing filters to check out all of the available accommodations for your preferred dates.

  • Search for the lowest price per night

What makes a hotel 5 stars in Southeast Missouri?
Flawless guest service is at the heart of every 5-star hotel in Southeast Missouri. From the minute you step through the door, staff are at your beck and call, whether recommending activities and tours or providing in-room beauty treatments. Additionally, hotels have to offer superior conveniences to be entitled to a 5-star rating. These can include luxury baths, an on-site spa, swimming pools, fine dining kitchens and knowledgeable concierge.
Are there any 5-star all-inclusive resorts in Southeast Missouri?
Our filter tool is the easiest way to find exactly what you’re looking for. Check the “All inclusive” and “5-star” boxes to show the finest properties in Southeast Missouri where your meals, room, activities and entertainment are included in the upfront price. At these escapes, your trip is absolute indulgence from the moment you arrive.
Are there any 5-star vacation rentals in Southeast Missouri?
Although there aren’t any 5-star vacation rentals in Southeast Missouri on our site, we have a range of escapes that promise an unforgettable getaway. Discover one that suits your style by searching our vacation rentals in Southeast Missouri.