Photo by Linda Cronan

Find hotels in Medical Center District, San Antonio from AED 279

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Discover 4,218 Medical Center District hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Riverwalk Plaza
Lobby

Riverwalk Plaza

4.0 star property
8.2 out of 10, Very Good, (4467)
"Nice staff, easy walk to main attractions, safe."
The price is AED 340
AED 402 total
includes taxes & fees
3 Jan - 4 January 2025
Riverwalk Plaza
Drury Plaza Hotel San Antonio Riverwalk
Exterior

Drury Plaza Hotel San Antonio Riverwalk

3.0 star property
9.4 out of 10, Exceptional, (3015)
"Loved the old world charm of the lobby and elevator banks; complimentary breakfast, bites and drinks were great; seemed to be on the quieter side of the riverwalk which was awesome. "
The price is AED 441
AED 521 total
includes taxes & fees
12 Jan - 13 January 2025
Drury Plaza Hotel San Antonio Riverwalk
Menger Hotel
Lobby

Menger Hotel

3.5 star property
9.0 out of 10, Wonderful, (3156)
"Was a historical hotel. Very close to the Alamo and close to river walk. Housekeeping was sparse every 4 days and was supposed to be on request, but when I did request on day 3 they didnt come."
The price is AED 449
AED 538 total
includes taxes & fees
16 Jan - 17 January 2025
Menger Hotel
Omni La Mansion del Rio
Terrace/patio

Omni La Mansion del Rio

4.0 star property
9.4 out of 10, Exceptional, (2409)
"Acogedor "
The price is AED 629
AED 755 total
includes taxes & fees
19 Jan - 20 January 2025
Omni La Mansion del Rio
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
Pool

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

3.0 star property
7.8 out of 10, Good, (3337)
"Close yo Riverwalk."
The price is AED 309
AED 551 total
includes taxes & fees
1 Jan - 2 January 2025
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
Hotel Contessa
Living area

Hotel Contessa

4.0 star property
9.0 out of 10, Wonderful, (2986)
"This was the most hospitable and friendly hotel we have stayed at in our travels. It is in a quieter area of the riverwalk which was nice. Our dogs were welcomed and loved on the whole time we were there. The room is soundproof and a perfect size/layout for a family. The drinks at the bar are delicious and nice to have a comfortable place to relax and rest between outings. The whole staff is by far the friendliest and most helpful of any hotel we have ever encountered. We had a wonderful...
The price is AED 572
AED 734 total
includes taxes & fees
7 Jan - 8 January 2025
Hotel Contessa
Hyatt Regency San Antonio Riverwalk
Pool

Hyatt Regency San Antonio Riverwalk

4.0 star property
9.0 out of 10, Wonderful, (1671)
"Great hotel"
The price is AED 496
AED 716 total
includes taxes & fees
20 Jan - 21 January 2025
Hyatt Regency San Antonio Riverwalk
La Quinta Inn & Suites by Wyndham San Antonio Downtown
Exterior

La Quinta Inn & Suites by Wyndham San Antonio Downtown

2.5 star property
8.8 out of 10, Excellent, (2578)
"We enjoyed our stay here, the location was so convenient to everywhere we wanted to go. The service was great, the housekeeping kept our room clean and refreshed. The breakfast each morning was hot and the selection was wonderful. We will for sure stay here on our next visit."
The price is AED 303
AED 358 total
includes taxes & fees
6 Jan - 7 January 2025
La Quinta Inn & Suites by Wyndham San Antonio Downtown
Hotel Valencia Riverwalk
Exterior

Hotel Valencia Riverwalk

4.5 star property
9.4 out of 10, Exceptional, (1861)
"I like the convenience of being downtown. I didn’t like that we hear the party going on outside"
The price is AED 588
AED 762 total
includes taxes & fees
19 Jan - 20 January 2025
Hotel Valencia Riverwalk
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
Front of property

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

2.5 star property
8.6 out of 10, Excellent, (2164)
"the facility was very nice. Staff was very friendly, except, when asking housekeeping staff a question, they seemed to be mostly Spanish speaking and did not understand me. Desk staff was marvelous, especially Marcella and the staff on her day off. They gave me directions to the nearest grocery store. unfortunately, they do not serve hot cocoa, but fortunately, I brought my own. the room was nicely clean, but the mattress is rather too soft and probably should be replaced soon. They need...
The price is AED 326
AED 386 total
includes taxes & fees
1 Jan - 2 January 2025
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
Hyatt Place San Antonio - Riverwalk
Room

Hyatt Place San Antonio - Riverwalk

3.0 star property
8.8 out of 10, Excellent, (1068)
"My son and I were in town for a wedding and the staff was so friendly and personable. They made great suggestions to us of things to check out and experience. House keeping was also very nice and readily happy to accommodate any requests for linen or a courtesy clean. The ONLY thing I have to say is the bed was hard and worn in the center. I slept rough all weekend, but the staffs friendliness outweighed the bad sleep."
The price is AED 452
AED 534 total
includes taxes & fees
7 Jan - 8 January 2025
Hyatt Place San Antonio - Riverwalk
Crockett Hotel
Lobby

Crockett Hotel

3.0 star property
8.8 out of 10, Excellent, (2209)
"Centrally located for the river walk and shopping at the Rivercenter mall"
The price is AED 400
AED 473 total
includes taxes & fees
5 Jan - 6 January 2025
Crockett Hotel
Canopy by Hilton San Antonio Riverwalk
Exterior

Canopy by Hilton San Antonio Riverwalk

4.0 star property
9.2 out of 10, Wonderful, (1411)
"It was a nice hotel for the price. Bar was good even though they charged a tip to the room even though I paid a tip in cash. Hotel said they will fix that so we shall see. Other than that, good. "
The price is AED 643
AED 774 total
includes taxes & fees
7 Jan - 8 January 2025
Canopy by Hilton San Antonio Riverwalk
Holiday Inn San Antonio - Riverwalk, an IHG Hotel
Exterior

Holiday Inn San Antonio - Riverwalk, an IHG Hotel

3.0 star property
8.4 out of 10, Very Good, (1018)
"I like that it was easy to check in"
The price is AED 279
AED 330 total
includes taxes & fees
5 Jan - 6 January 2025
Holiday Inn San Antonio - Riverwalk, an IHG Hotel
InterContinental San Antonio Riverwalk, an IHG Hotel
Exterior

InterContinental San Antonio Riverwalk, an IHG Hotel

4.5 star property
9.6 out of 10, Exceptional, (208)
"Loved it "
The price is AED 569
AED 798 total
includes taxes & fees
2 Jan - 3 January 2025
InterContinental San Antonio Riverwalk, an IHG Hotel
Grand Hyatt San Antonio River Walk
Pool

Grand Hyatt San Antonio River Walk

4.0 star property
9.0 out of 10, Wonderful, (1085)
"The property was nice, but too much construction so it was noisy. bathroom toilet was running all the time, but the stay was short so we did not complain"
The price is AED 584
AED 701 total
includes taxes & fees
12 Jan - 13 January 2025
Grand Hyatt San Antonio River Walk
Sonesta ES Suites San Antonio Downtown Alamo Plaza
Exterior

Sonesta ES Suites San Antonio Downtown Alamo Plaza

3.0 star property
8.2 out of 10, Very Good, (1350)
"Clean with very helpful staff. The breakfast was top level."
The price is AED 288
AED 340 total
includes taxes & fees
5 Jan - 6 January 2025
Sonesta ES Suites San Antonio Downtown Alamo Plaza
The St. Anthony, A Luxury Collection Hotel, San Antonio
Exterior

The St. Anthony, A Luxury Collection Hotel, San Antonio

4.5 star property
8.8 out of 10, Excellent, (1010)
"Excellent customer service!!!!!!"
The price is AED 823
AED 973 total
includes taxes & fees
17 Jan - 18 January 2025
The St. Anthony, A Luxury Collection Hotel, San Antonio
The Maverick, powered by Placemakr - River Walk
Room

The Maverick, powered by Placemakr - River Walk

4.0 star property
8.6 out of 10, Excellent, (482)
"The staff of The Maverick were exceptional. The rooms/apartments were very comfortable and clean. This hotel is so close to the river. Would definitely stay here again."
The price is AED 380
AED 444 total
includes taxes & fees
13 Jan - 14 January 2025
The Maverick, powered by Placemakr - River Walk
AC Hotel by Marriott San Antonio Riverwalk
Exterior

AC Hotel by Marriott San Antonio Riverwalk

4.0 star property
8.8 out of 10, Excellent, (584)
"This was an Amazing Hotel with great staff, great area the only complaint is the horrible parking "
The price is AED 419
AED 495 total
includes taxes & fees
2 Jan - 3 January 2025
AC Hotel by Marriott San Antonio Riverwalk
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

What is Medical Center District like?

Travelers are sure to enjoy a stay in San Antonio's Medical Center District neighborhood. Are you looking for Medical Center District travel tips? Be sure to check out USAA Corporate Office Headquarters and The San Antonio Art Institute while you're in the neighborhood.

What's a favorite place to stay in Medical Center District?

Based on Expedia customer reviews, Drury Inn & Suites San Antonio Northwest Medical Center is the highest ranked property in Medical Center District. This hotel offers free breakfast and an indoor pool. Other favorite options in the area include SpringHill Suites by Marriott San Antonio Medical Center/NW and Fairfield Inn & Suites by Marriott San Antonio Medical Center.

How many hotels will I be able to find in Medical Center District?

Expedia has 125 hotels and other accommodations in Medical Center District to choose from, making this an ideal home base for exploring the greater San Antonio area.

If I need to cancel my hotel reservation in Medical Center District, will I receive a refund?

Yes! You'll find that most hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and be given a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to view top deals in Medical Center District.

Where can I learn more about changing or cancelling my trip to Medical Center District?

For more information about changing or cancelling your trip to Medical Center District, go to https://www.expedia.com/service/.

What can I see and do in this San Antonio neighborhood?

A few attractions you might want to check out while you're in Medical Center District are USAA Corporate Office Headquarters and The San Antonio Art Institute. Wonderland of the Americas Mall and First Unitarian Universalist Church are also worth a visit when you're out sightseeing in San Antonio.