Photo by Linda Cronan

Find hotels in Medical Center District, San Antonio from AED 229

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Discover 4,156 Medical Center District hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Riverwalk Plaza
Lobby
Riverwalk Plaza
4.0 star property
8.2 out of 10, Very Good, (4276)
"good property - older and layout is weird but it was a fine stay"
The price is AED 360
AED 426 total
includes taxes & fees
15 Dec - 16 Dec
Riverwalk Plaza
Menger Hotel
Outdoor pool
Menger Hotel
3.5 star property
9.0 out of 10, Wonderful, (3081)
"Liked the historic nature of the hotel, very cool. Should be a 5 star hotel, dont know why it not rated higher. Great experience altogether!"
The price is AED 482
AED 559 total
includes taxes & fees
16 Dec - 17 Dec
Menger Hotel
Drury Plaza Hotel San Antonio Riverwalk
Exterior
Drury Plaza Hotel San Antonio Riverwalk
3.0 star property
9.4 out of 10, Exceptional, (2908)
"The Hotel was an amazing experience overall. It neighbors the historic Riverwalk and is literally an 8 minute walk to the Alamo and an 8-9 minute walk (if you choose to) to the H.E.B. market. Staff is excellent and very friendly. "
The price is AED 441
AED 521 total
includes taxes & fees
25 Nov - 26 Nov
Drury Plaza Hotel San Antonio Riverwalk
Omni La Mansion del Rio
Terrace/patio
Omni La Mansion del Rio
4.0 star property
9.2 out of 10, Wonderful, (2355)
"Beautiful property"
The price is AED 684
AED 800 total
includes taxes & fees
24 Nov - 25 Nov
Omni La Mansion del Rio
Hotel Valencia Riverwalk
Exterior
Hotel Valencia Riverwalk
4.5 star property
9.4 out of 10, Exceptional, (1853)
"Beautiful property!"
The price is AED 598
AED 748 total
includes taxes & fees
15 Dec - 16 Dec
Hotel Valencia Riverwalk
Hyatt Place San Antonio - Riverwalk
Room
Hyatt Place San Antonio - Riverwalk
3.0 star property
8.8 out of 10, Excellent, (1042)
"Nice breakfast every morning. Room was cleaned they day."
The price is AED 446
AED 515 total
includes taxes & fees
22 Nov - 23 Nov
Hyatt Place San Antonio - Riverwalk
Canopy by Hilton San Antonio Riverwalk
Exterior
Canopy by Hilton San Antonio Riverwalk
4.0 star property
9.2 out of 10, Wonderful, (1403)
"Great place to stay"
The price is AED 681
AED 793 total
includes taxes & fees
28 Nov - 29 Nov
Canopy by Hilton San Antonio Riverwalk
La Quinta Inn & Suites by Wyndham San Antonio Downtown
Exterior
La Quinta Inn & Suites by Wyndham San Antonio Downtown
2.5 star property
8.8 out of 10, Excellent, (2522)
"Nice place to stay when visiting San Antonio downtown.."
The price is AED 300
AED 346 total
includes taxes & fees
22 Dec - 23 Dec
La Quinta Inn & Suites by Wyndham San Antonio Downtown
Hotel Contessa
Living area
Hotel Contessa
4.0 star property
9.0 out of 10, Wonderful, (2904)
"Beautiful property directly on the Riverwalk. We are breakfast at the Ambler downstairs each morning. Delicious and affordable."
The price is AED 521
AED 651 total
includes taxes & fees
22 Dec - 23 Dec
Hotel Contessa
Hyatt Regency San Antonio Riverwalk
Pool
Hyatt Regency San Antonio Riverwalk
4.0 star property
9.0 out of 10, Wonderful, (1651)
"Location is perfect access to the riverwalk. Valet was phenomenal. "
The price is AED 585
AED 804 total
includes taxes & fees
26 Nov - 27 Nov
Hyatt Regency San Antonio Riverwalk
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
Pool
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
3.0 star property
7.6 out of 10, Good, (3194)
"Enjoyed the location."
The price is AED 327
AED 377 total
includes taxes & fees
24 Nov - 25 Nov
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
InterContinental San Antonio Riverwalk, an IHG Hotel
Exterior
InterContinental San Antonio Riverwalk, an IHG Hotel
4.5 star property
9.8 out of 10, Exceptional, (157)
"Great staff"
The price is AED 519
AED 720 total
includes taxes & fees
18 Dec - 19 Dec
InterContinental San Antonio Riverwalk, an IHG Hotel
The Maverick, powered by Placemakr - River Walk
Room
The Maverick, powered by Placemakr - River Walk
4.0 star property
8.6 out of 10, Excellent, (419)
"Great location! Close to so many wonderful restaurants and attractions. The room is small but nice, including a kitchenette and spacious bathroom.The only downside was the noise level from outside. If you choose to stay here bring earplugs! And park a block away at the Houston Garage for $10 a day!"
The price is AED 401
AED 456 total
includes taxes & fees
27 Nov - 28 Nov
The Maverick, powered by Placemakr - River Walk
Crockett Hotel
Pool
Crockett Hotel
3.0 star property
8.8 out of 10, Excellent, (2136)
"Staying at the Crockett was an excellent experience, well definitely be staying again. I went to the Iron Maiden concert and really made a good choice in staying there "
The price is AED 385
AED 441 total
includes taxes & fees
15 Dec - 16 Dec
Crockett Hotel
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
Front of property
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
2.5 star property
8.6 out of 10, Excellent, (2087)
"Everything was ok just the bed was uncomfortable "
The price is AED 229
AED 262 total
includes taxes & fees
9 Dec - 10 Dec
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
Homewood Suites by Hilton San Antonio Riverwalk/Downtown
Exterior
Homewood Suites by Hilton San Antonio Riverwalk/Downtown
3.0 star property
8.4 out of 10, Very Good, (1002)
"Very clean and nicely furnished. Plenty of room. Fantastic location! Will definitely stay here again."
The price is AED 403
AED 472 total
includes taxes & fees
15 Dec - 16 Dec
Homewood Suites by Hilton San Antonio Riverwalk/Downtown
Sonesta ES Suites San Antonio Downtown Alamo Plaza
Exterior
Sonesta ES Suites San Antonio Downtown Alamo Plaza
3.0 star property
8.2 out of 10, Very Good, (1365)
"Upon checking in, myself, the associates were friendly. I could smell how new everything was as well. Fresh remodel of entire property. This was a major plus. I went up to the room and the water was off for 3 hours, possibly due to them installing new water heaters. I guess this because when the water came back on it took a long time for the hot water to hit, but once it did, there was almost instant hot water the rest of my stay. When I went back down to set foot into the town, i was assisted...
The price is AED 288
AED 331 total
includes taxes & fees
24 Nov - 25 Nov
Sonesta ES Suites San Antonio Downtown Alamo Plaza
Grand Hyatt San Antonio River Walk
Pool
Grand Hyatt San Antonio River Walk
4.0 star property
9.0 out of 10, Wonderful, (1063)
"Ok"
The price is AED 526
AED 725 total
includes taxes & fees
22 Dec - 23 Dec
Grand Hyatt San Antonio River Walk
La Quinta Inn & Suites by Wyndham San Antonio Airport
Exterior
La Quinta Inn & Suites by Wyndham San Antonio Airport
2.5 star property
7.8 out of 10, Good, (2741)
"Nice convenient hotel."
The price is AED 276
AED 326 total
includes taxes & fees
1 Dec - 2 Dec
La Quinta Inn & Suites by Wyndham San Antonio Airport
Hotel Gibbs Downtown Riverwalk
Front of property
Hotel Gibbs Downtown Riverwalk
4.5 star property
9.0 out of 10, Wonderful, (3223)
"Great stay "
The price is AED 345
AED 403 total
includes taxes & fees
24 Nov - 25 Nov
Hotel Gibbs Downtown Riverwalk
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

What is Medical Center District like?

Travelers are sure to enjoy a stay in San Antonio's Medical Center District neighborhood. Are you looking for Medical Center District travel tips? Be sure to check out USAA Corporate Office Headquarters and The San Antonio Art Institute while you're in the neighborhood.

What's a favorite place to stay in Medical Center District?

Based on Expedia customer reviews, Drury Inn & Suites San Antonio Northwest Medical Center is the highest ranked property in Medical Center District. This hotel offers free breakfast and an indoor pool. Other favorite options in the area include SpringHill Suites by Marriott San Antonio Medical Center/NW and Fairfield Inn & Suites by Marriott San Antonio Medical Center.

How many hotels will I be able to find in Medical Center District?

Expedia has 119 hotels and other accommodations in Medical Center District to choose from, making this an ideal home base for exploring the greater San Antonio area.

If I need to cancel my hotel reservation in Medical Center District, will I receive a refund?

Yes! You'll find that most hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and be given a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to view top deals in Medical Center District.

Where can I learn more about changing or cancelling my trip to Medical Center District?

For more information about changing or cancelling your trip to Medical Center District, go to https://www.expedia.com/service/.

What can I see and do in this San Antonio neighborhood?

A few attractions you might want to check out while you're in Medical Center District are USAA Corporate Office Headquarters and The San Antonio Art Institute. Wonderland of the Americas Mall and First Unitarian Universalist Church are also worth a visit when you're out sightseeing in San Antonio.