Photo by Linda Cronan
Find 4 Star Hotels in Medical Center District, TX from AED 297
Change your mind
Book hotels with free cancellation
Be picky
Search almost a million properties worldwide
Check availability on Medical Center District 4 Star Hotels
Compare Medical Center District 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Riverwalk Plaza
Riverwalk Plaza
8.2 out of 10, Very Good, (5153)
The price is AED 320
AED 379 total
includes taxes & fees
26 May - 27 May

Grand Hyatt San Antonio River Walk
Grand Hyatt San Antonio River Walk
9.0 out of 10, Wonderful, (1155)
The price is AED 602
AED 831 total
includes taxes & fees
25 May - 26 May

Hotel Contessa
Hotel Contessa
9.0 out of 10, Wonderful, (3039)
The price is AED 651
AED 829 total
includes taxes & fees
20 May - 21 May

Hyatt Regency San Antonio Riverwalk
Hyatt Regency San Antonio Riverwalk
9.0 out of 10, Wonderful, (1741)
The price is AED 613
AED 855 total
includes taxes & fees
14 May - 15 May

The Westin Riverwalk, San Antonio
The Westin Riverwalk, San Antonio
8.8 out of 10, Excellent, (1191)
The price is AED 621
AED 740 total
includes taxes & fees
26 May - 27 May

Hotel Valencia Riverwalk
Hotel Valencia Riverwalk
9.4 out of 10, Exceptional, (1884)
The price is AED 559
AED 738 total
includes taxes & fees
26 May - 27 May

Canopy by Hilton San Antonio Riverwalk
Canopy by Hilton San Antonio Riverwalk
9.4 out of 10, Exceptional, (1483)
The price is AED 774
AED 931 total
includes taxes & fees
14 May - 15 May

Plaza San Antonio Hotel & Spa, Autograph Collection
Plaza San Antonio Hotel & Spa, Autograph Collection
9.2 out of 10, Wonderful, (451)
The price is AED 537
AED 746 total
includes taxes & fees
23 May - 24 May
Save an average of 15% on thousands of hotels when you're signed in
Explore similar 5-star hotels
Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Medical Center District.

Thompson San Antonio - Riverwalk, by Hyatt
115 Lexington Avenue, San Antonio, TX
The price is AED 760 per night from Jun 1 to Jun 2
AED 760
AED 1,024 total
includes taxes & fees
1 Jun - 2 Jun
9/10 Wonderful! (731 reviews)
Still don't see what you're looking for?
See all properties in Medical Center District.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Recent reviews of Medical Center District hotels
Recent reviews of Medical Center District hotels

Hotel Contessa
5/5 Excellent
"It was the perfect place for a Family Fiesta staycation! Location is prime for the Fiesta parades, NIOSA, La Semana Alegre and Fiesta San Fernando. Top notch service. A++"
A verified traveler stayed at Hotel Contessa
Posted 1 day ago
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Medical Center District Hotels by Star Rating
Hotels in Medical Center District Neighborhoods
Stay near popular Medical Center District attractions
- Hotels near USAA Corporate Office Headquarters
- Hotels near South Texas Medical Center
- Hotels near University of Texas Health and Science Center at San Antonio
- Hotels near CHRISTUS Santa Rosa Hospital - Medical Center
- Hotels near Oak Hills Country Club
- Hotels near The San Antonio Art Institute
- Hotels near River Walk
- Hotels near Six Flags Fiesta Texas
- Hotels near Lackland Air Force Base
- Hotels near Alamo
- Hotels near Henry B. González Convention Center
- Hotels near San Antonio Zoo and Aquarium
- Hotels near Alamodome
- Hotels near San Antonio River
- Hotels near Frost Bank Center
- Hotels near The Shops of La Cantera
Explore more hotels
- Hotel Contessa
- Hyatt Vacation Club at Wild Oak Ranch, San Antonio
- La Cantera Resort & Spa
- Days Inn by Wyndham San Antonio Alamo/Riverwalk
- Omni La Mansion del Rio
- Grand Hyatt San Antonio River Walk
- Sonesta ES Suites San Antonio Downtown Alamo Plaza
- Hyatt Regency Hill Country Resort & Spa
- JW Marriott San Antonio Hill Country Resort & Spa
- La Quinta Inn & Suites by Wyndham San Antonio Airport
- The Westin Riverwalk, San Antonio
- Hilton San Antonio Hill Country
- Red Roof Inn PLUS+ San Antonio Downtown - Riverwalk
- Canopy by Hilton San Antonio Riverwalk
- Crowne Plaza San Antonio Airport by IHG
- Aiden San Antonio Riverwalk
- Hyatt Regency San Antonio Riverwalk
- La Quinta Inn & Suites By Wyndham San Antonio At The Rim
- Thompson San Antonio - Riverwalk, by Hyatt
- InterContinental San Antonio Riverwalk by IHG