Photo by Linda Cronan

Find 4 Star Hotels in Medical Center District, TX from AED 350

  • Plan, book, stay with confidence

    • bex rewards loyalty icon
    Be picky
    Search almost a million properties worldwide
    payments icon
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    Sign in
    today icon
    Change your mind
    Book hotels with free cancellation

Check availability on Medical Center District 4 Star Hotels

Tonight
30 Jan - 31 Jan
Tomorrow
31 Jan - 1 Feb
This weekend
31 Jan - 2 Feb
Next weekend
7 Feb - 9 Feb

Compare Medical Center District 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

The Westin Riverwalk, San Antonio
Exterior

The Westin Riverwalk, San Antonio

4.0 star property
8.8 out of 10, Excellent, (1066)
"Great place and centrally located to everything. "
The price is AED 699
AED 833 total
includes taxes & fees
23 Feb - 24 Feb
The Westin Riverwalk, San Antonio
Riverwalk Plaza
Lobby

Riverwalk Plaza

4.0 star property
8.2 out of 10, Very Good, (4612)
"The atmosphere was great. Location was good as well. Would definitely stay again"
The price is AED 350
AED 413 total
includes taxes & fees
23 Feb - 24 Feb
Riverwalk Plaza
Hotel Contessa
Living area

Hotel Contessa

4.0 star property
9.0 out of 10, Wonderful, (3021)
"Food, drinks, and live music were excellent. Friendly and approachable staff. Excellent location just off the main bustle of the river walk tourism. "
The price is AED 653
AED 831 total
includes taxes & fees
2 Feb - 3 Feb
Hotel Contessa
Omni La Mansion del Rio
Terrace/patio

Omni La Mansion del Rio

4.0 star property
9.4 out of 10, Exceptional, (2451)
"My birthday weekend and as always it was awesome experience "
The price is AED 690
AED 828 total
includes taxes & fees
16 Feb - 17 Feb
Omni La Mansion del Rio
Hyatt Regency Hill Country Resort & Spa
Exterior

Hyatt Regency Hill Country Resort & Spa

4.0 star property
8.8 out of 10, Excellent, (1002)
"5 star "
The price is AED 937
AED 1,331 total
includes taxes & fees
16 Feb - 17 Feb
Hyatt Regency Hill Country Resort & Spa
Hyatt Regency San Antonio Riverwalk
Pool

Hyatt Regency San Antonio Riverwalk

4.0 star property
9.0 out of 10, Wonderful, (1690)
"First time staying on the Riverwalk, very convenient! Our room (as well as the entire hotel) was very clean and the staff was so helpful and welcoming! "
The price is AED 819
AED 1,098 total
includes taxes & fees
2 Feb - 3 Feb
Hyatt Regency San Antonio Riverwalk
AC Hotel by Marriott San Antonio Riverwalk
Room

AC Hotel by Marriott San Antonio Riverwalk

4.0 star property
8.8 out of 10, Excellent, (632)
"perfect place to stay next to the river walk. I did not like the pillows. the valet service was awesome."
The price is AED 438
AED 518 total
includes taxes & fees
9 Feb - 10 Feb
AC Hotel by Marriott San Antonio Riverwalk
Grand Hyatt San Antonio River Walk
Pool

Grand Hyatt San Antonio River Walk

4.0 star property
9.0 out of 10, Wonderful, (1101)
"We were in town for a gymnastics meet and loved the convenience of walking to and from the meet from our room! Had a nice view of the Tower of the Americas from our room which was beautiful!"
The price is AED 713
AED 853 total
includes taxes & fees
7 Feb - 8 Feb
Grand Hyatt San Antonio River Walk
Element San Antonio Riverwalk
Exterior

Element San Antonio Riverwalk

4.0 star property
9.0 out of 10, Wonderful, (595)
"Great service and location"
The price is AED 497
AED 587 total
includes taxes & fees
7 Feb - 8 Feb
Element San Antonio Riverwalk
The Westin San Antonio North
Exterior

The Westin San Antonio North

4.0 star property
8.6 out of 10, Excellent, (1005)
"Was a great stay. "
The price is AED 403
AED 482 total
includes taxes & fees
16 Feb - 17 Feb
The Westin San Antonio North
Hotel Valencia Riverwalk
Exterior

Hotel Valencia Riverwalk

4.5 star property
9.4 out of 10, Exceptional, (1856)
"The hotel itself is charming and is very well maintained. The staff is super helpful and friendly. The property is in an excellent location - right on the riverwalk. However, the shower drain was clogged and the ice machine on the floor was out of order, This was the only reason why I did not give it a perfect 5 rating. Will that stop me from staying in this hotel when I come back? Absolutely not! I love everything else about it."
The price is AED 657
AED 843 total
includes taxes & fees
31 Jan - 1 Feb
Hotel Valencia Riverwalk
Canopy by Hilton San Antonio Riverwalk
Exterior

Canopy by Hilton San Antonio Riverwalk

4.0 star property
9.2 out of 10, Wonderful, (1401)
"Great location on the River Walk. Very nice room. Hotel was very quiet but there was a little street noise even on the 15th floor. No more than expected on a weekend in a city. Room very solid and clean. Both hotel bars we visited were fun and the drinks were good. Overall, really nice place."
The price is AED 671
AED 808 total
includes taxes & fees
7 Feb - 8 Feb
Canopy by Hilton San Antonio Riverwalk
Hilton San Antonio Hill Country
Terrace/patio

Hilton San Antonio Hill Country

4.0 star property
8.2 out of 10, Very Good, (1005)
"Restaurant has limited hours "
The price is AED 350
AED 421 total
includes taxes & fees
10 Feb - 11 Feb
Hilton San Antonio Hill Country
Kimpton Santo, an IHG Hotel
Spa

Kimpton Santo, an IHG Hotel

4.5 star property
9.2 out of 10, Wonderful, (164)
"Great new property "
The price is AED 777
AED 928 total
includes taxes & fees
7 Feb - 8 Feb
Kimpton Santo, an IHG Hotel
The St. Anthony, A Luxury Collection Hotel, San Antonio
Room

The St. Anthony, A Luxury Collection Hotel, San Antonio

4.5 star property
8.8 out of 10, Excellent, (1002)
"Loved it!"
The price is AED 856
AED 1,012 total
includes taxes & fees
7 Feb - 8 Feb
The St. Anthony, A Luxury Collection Hotel, San Antonio
JW Marriott San Antonio Hill Country Resort & Spa
View from property

JW Marriott San Antonio Hill Country Resort & Spa

4.5 star property
8.8 out of 10, Excellent, (1005)
"Great experience at the property family friendly"
The price is AED 1,135
AED 1,547 total
includes taxes & fees
7 Feb - 8 Feb
JW Marriott San Antonio Hill Country Resort & Spa
InterContinental San Antonio Riverwalk, an IHG Hotel
Exterior

InterContinental San Antonio Riverwalk, an IHG Hotel

4.5 star property
9.4 out of 10, Exceptional, (248)
"The hotel was breat, the staff was amazing and in a great location. "
The price is AED 629
AED 870 total
includes taxes & fees
2 Feb - 3 Feb
InterContinental San Antonio Riverwalk, an IHG Hotel
La Cantera Resort & Spa
Property grounds

La Cantera Resort & Spa

4.0 star property
9.0 out of 10, Wonderful, (1004)
"I’m glad they have upgraded the hotel and rooms ! Much better ! "
The price is AED 1,172
AED 1,554 total
includes taxes & fees
7 Feb - 8 Feb
La Cantera Resort & Spa
San Antonio Marriott Rivercenter on the River Walk
Reception

San Antonio Marriott Rivercenter on the River Walk

4.0 star property
8.8 out of 10, Excellent, (1002)
"No complaints. Great stay. "
The price is AED 757
AED 1,010 total
includes taxes & fees
28 Feb - 1 Mar
San Antonio Marriott Rivercenter on the River Walk
Mokara Hotel & Spa San Antonio
Rooftop pool

Mokara Hotel & Spa San Antonio

4.5 star property
9.6 out of 10, Exceptional, (1001)
"Another wonderful stay at the Mokara! The hotel is gorgeous, the staff are wonderful, and the amenities are amazing. I love the views from the rooftop pool and the peace and quiet of the spa whirlpool and sauna. Fantastic room service food, too. The only issue with this visit was getting conflicting info from the spa staff about the different services' features and costs. Other than that, it was a perfect visit. We hope to come back soon!"
The price is AED 951
AED 1,127 total
includes taxes & fees
2 Feb - 3 Feb
Mokara Hotel & Spa San Antonio
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Frequently asked questions

What are the best 4-star hotels in Medical Center District?
The Westin San Antonio North is highly praised by Expedia guests. This 4-star hotel located around Medical Center District guarantees a warm and inviting atmosphere and plenty of handy amenities.
How much does it cost to stay in a 4-star hotel in Medical Center District?
We can help you quickly find the ideal 4-star hotel for your trip to Medical Center District. Use our handy filter tool to tailor your search by things like budget, amenities and star rating and get access to fabulous deals in a few clicks.

  • Search for the lowest price from AED 350

What's the difference between 5-star and 4-star hotels in Medical Center District?
Give yourself the luxury treatment during your Medical Center District escape by choosing a 4-star hotel. As well as featuring upmarket surroundings, these retreats are typically packed with amenities such as large beds, complimentary bathrobes and more. A 5-star hotel will go the extra mile to make your trip an even more lavish and unforgettable one. Concierge assistance, elegant furnishings and world-class dining are a few of the first-rate conveniences and services you’ll likely have access to.
Does Medical Center District have any 4-star all-inclusive resorts?
Finding your dream hotel in Medical Center District is as simple as entering your travel dates and selecting our “All inclusive” filter. Stay and play where almost everything is already taken care of like your meals, room, entertainment and activities, or go for a standard 4-star resort in or around this sought-after destination.