Photo by Linda Cronan

Find 4 Star Hotels in Medical Center District, TX from AED 315

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Compare Medical Center District 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Riverwalk Plaza
Lobby
Riverwalk Plaza
4.0 star property
8.2 out of 10, Very Good, (4266)
"Good location, friendly staff, room size was great. Valet service was easy to use and get my car back. Check in was easy and friendly staff. On the riverwalk. Overall great stay and if I’m back in San Antonio I’ll stay here again. "
The price is AED 360
AED 426 total
includes taxes & fees
15 Dec - 16 Dec
Riverwalk Plaza
Omni La Mansion del Rio
Terrace/patio
Omni La Mansion del Rio
4.0 star property
9.2 out of 10, Wonderful, (2363)
"Property was super clean and staff was super helpful. They even sent me cupcakes to my room for my birthday, free of charge, along with a birthday card signed by the staff. It made me feel welcome and I will definitely come back!"
The price is AED 684
AED 800 total
includes taxes & fees
24 Nov - 25 Nov
Omni La Mansion del Rio
Hotel Contessa
Living area
Hotel Contessa
4.0 star property
9.0 out of 10, Wonderful, (2907)
"Great view of the Riverwalk. "
The price is AED 633
AED 781 total
includes taxes & fees
24 Nov - 25 Nov
Hotel Contessa
Hotel Gibbs Downtown Riverwalk
Front of property
Hotel Gibbs Downtown Riverwalk
4.5 star property
9.0 out of 10, Wonderful, (3218)
"The staff was great, super nice. I purchased the room with Apple Pay because I lost my card and they still let me get a room with a cash deposit. A life saver for me and my son. "
The price is AED 315
AED 366 total
includes taxes & fees
24 Nov - 25 Nov
Hotel Gibbs Downtown Riverwalk
Canopy by Hilton San Antonio Riverwalk
Exterior
Canopy by Hilton San Antonio Riverwalk
4.0 star property
9.2 out of 10, Wonderful, (1410)
"The property is clean, convenient and in a great location to walk to restaurants and other entertainment. "
The price is AED 681
AED 790 total
includes taxes & fees
24 Nov - 25 Nov
Canopy by Hilton San Antonio Riverwalk
Hyatt Regency Hill Country Resort & Spa
Exterior
Hyatt Regency Hill Country Resort & Spa
4.0 star property
8.8 out of 10, Excellent, (1006)
"Enjoyed our stay to participate in the STCH Ministries golf tournament. "
The price is AED 646
AED 969 total
includes taxes & fees
24 Nov - 25 Nov
Hyatt Regency Hill Country Resort & Spa
Hotel Valencia Riverwalk
Exterior
Hotel Valencia Riverwalk
4.5 star property
9.4 out of 10, Exceptional, (1856)
"I think they can improve on setting expectations and delivering as promised. When an opportunity arises to turn it around, yak advantage. Sarah was amazing!"
The price is AED 578
AED 729 total
includes taxes & fees
1 Dec - 2 Dec
Hotel Valencia Riverwalk
InterContinental San Antonio Riverwalk, an IHG Hotel
Exterior
InterContinental San Antonio Riverwalk, an IHG Hotel
4.5 star property
9.8 out of 10, Exceptional, (154)
"The property was clean and beautifull! The staff very friendly and accomodating! The room was lovely and the beds were so comfortable comfortable "
The price is AED 519
AED 720 total
includes taxes & fees
18 Dec - 19 Dec
InterContinental San Antonio Riverwalk, an IHG Hotel
Hyatt Regency San Antonio Riverwalk
Pool
Hyatt Regency San Antonio Riverwalk
4.0 star property
9.0 out of 10, Wonderful, (1656)
"Very clean, family friendly and in an amazing location on the rivewalk! "
The price is AED 694
AED 950 total
includes taxes & fees
24 Nov - 25 Nov
Hyatt Regency San Antonio Riverwalk
The Maverick, powered by Placemakr - River Walk
Room
The Maverick, powered by Placemakr - River Walk
4.0 star property
8.6 out of 10, Excellent, (412)
"The Maverick is a gem right next to the Riverwalk…and above Voodoo Donuts! We got an upgrade to the penthouse which is the sweetest suite. Great rooftop patio with view of the Alamo, river, and skyline. Very modern decor, helpful staff, comfy beds, superb location. Free breakfast taco and coffee at nearby Revolucion was a nice bonus. "
The price is AED 407
AED 462 total
includes taxes & fees
1 Dec - 2 Dec
The Maverick, powered by Placemakr - River Walk
AC Hotel by Marriott San Antonio Riverwalk
Restaurant
AC Hotel by Marriott San Antonio Riverwalk
4.0 star property
8.8 out of 10, Excellent, (531)
"Liked the simplicity of the rooms, shower and bathroom layout. Nice to have a safe, mini fridge, iron in the room. Designers need to work on the following: Unintentional loud closing of doors by other guests. Most people aren't going to notice how they close the door so design a door that closes more quietly. Red light "off" indicator on tv and smoke detector light irritiating when trying to get to sleep."
The price is AED 465
AED 550 total
includes taxes & fees
19 Dec - 20 Dec
AC Hotel by Marriott San Antonio Riverwalk
Grand Hyatt San Antonio River Walk
Pool
Grand Hyatt San Antonio River Walk
4.0 star property
9.0 out of 10, Wonderful, (1064)
"Lovely front desk service "
The price is AED 694
AED 939 total
includes taxes & fees
28 Nov - 29 Nov
Grand Hyatt San Antonio River Walk
The St. Anthony, A Luxury Collection Hotel, San Antonio
Pool
The St. Anthony, A Luxury Collection Hotel, San Antonio
4.5 star property
8.8 out of 10, Excellent, (1001)
"Beautiful hotel, well kept, great suite "
The price is AED 643
AED 761 total
includes taxes & fees
25 Nov - 26 Nov
The St. Anthony, A Luxury Collection Hotel, San Antonio
The Westin Riverwalk, San Antonio
Exterior
The Westin Riverwalk, San Antonio
4.0 star property
8.8 out of 10, Excellent, (1004)
"Very clean "
The price is AED 674
AED 788 total
includes taxes & fees
19 Dec - 20 Dec
The Westin Riverwalk, San Antonio
Hilton Palacio Del Rio
Exterior
Hilton Palacio Del Rio
4.0 star property
8.6 out of 10, Excellent, (1002)
"Everything was good room is clean every day. Good location great staff."
Hilton Palacio Del Rio
JW Marriott San Antonio Hill Country Resort & Spa
Exterior
JW Marriott San Antonio Hill Country Resort & Spa
4.5 star property
8.8 out of 10, Excellent, (1003)
"Beautiful place "
The price is AED 1,135
AED 1,547 total
includes taxes & fees
15 Dec - 16 Dec
JW Marriott San Antonio Hill Country Resort & Spa
La Cantera Resort & Spa
Property grounds
La Cantera Resort & Spa
4.0 star property
8.8 out of 10, Excellent, (1003)
"Thank you we loved everything about this property!"
The price is AED 965
AED 1,252 total
includes taxes & fees
16 Dec - 17 Dec
La Cantera Resort & Spa
Mokara Hotel & Spa San Antonio
Rooftop pool
Mokara Hotel & Spa San Antonio
4.5 star property
9.6 out of 10, Exceptional, (1004)
"Amazing staff. They made the stay so special for my grandchildren. "
The price is AED 871
AED 1,008 total
includes taxes & fees
19 Nov - 20 Nov
Mokara Hotel & Spa San Antonio
Hilton San Antonio Hill Country
Terrace/patio
Hilton San Antonio Hill Country
4.0 star property
8.2 out of 10, Very Good, (1003)
"Quiet place. "
Hilton San Antonio Hill Country
Plaza San Antonio Hotel & Spa, Autograph Collection
Room
Plaza San Antonio Hotel & Spa, Autograph Collection
4.0 star property
9.2 out of 10, Wonderful, (286)
"This is a very beautiful property in downtown San Antonio. The restaurant was wonderful. The room was clean. The bed was comfortable. The people were very friendly. Staff was very kind and nice."
The price is AED 654
AED 769 total
includes taxes & fees
24 Nov - 25 Nov
Plaza San Antonio Hotel & Spa, Autograph Collection
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Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Medical Center District.
Thompson San Antonio - Riverwalk, by Hyatt

Thompson San Antonio - Riverwalk, by Hyatt

115 Lexington Avenue, San Antonio, TX
The price is AED 702 per night from Dec 15 to Dec 16
AED 702
AED 830 total
includes taxes & fees
15 Dec - 16 Dec
8.8/10 Excellent! (640 reviews)
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What are the best 4-star hotels in Medical Center District?
The Westin San Antonio North is highly praised by Expedia guests. This 4-star hotel located around Medical Center District guarantees a warm and inviting atmosphere and plenty of handy amenities.
How much does it cost to stay in a 4-star hotel in Medical Center District?
We can help you quickly find the ideal 4-star hotel for your trip to Medical Center District. Use our handy filter tool to tailor your search by things like budget, amenities and star rating and get access to fabulous deals in a few clicks.

  • Search for the lowest price from AED 702

What's the difference between 5-star and 4-star hotels in Medical Center District?
Give yourself the luxury treatment during your Medical Center District escape by choosing a 4-star hotel. As well as featuring upmarket surroundings, these retreats are typically packed with amenities such as large beds, complimentary bathrobes and more. A 5-star hotel will go the extra mile to make your trip an even more lavish and unforgettable one. Concierge assistance, elegant furnishings and world-class dining are a few of the first-rate conveniences and services you’ll likely have access to.
Does Medical Center District have any 4-star all-inclusive resorts?
Finding your dream hotel in Medical Center District is as simple as entering your travel dates and selecting our “All inclusive” filter. Stay and play where almost everything is already taken care of like your meals, room, entertainment and activities, or go for a standard 4-star resort in or around this sought-after destination.