Find hotels in Defiance, MO from AED 264

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Compare 822 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

TownePlace Suites by Marriott St. Louis Chesterfield

3.0 star property
8.8 out of 10, Excellent, (233)
"Check in was easy and fast. Thanks Angela!!"
The price is AED 415
AED 487 total
includes taxes & fees
4 May - 5 May
TownePlace Suites by Marriott St. Louis Chesterfield

Holiday Inn Express St. Louis West - O'Fallon by IHG

2.5 star property
8.4 out of 10, Very Good, (691)
"Very friendly staff"
The price is AED 364
AED 429 total
includes taxes & fees
27 Apr - 28 Apr
Holiday Inn Express St. Louis West - O'Fallon by IHG

Sleep Inn & Suites O'Fallon MO - Technology Drive

2.5 star property
8.8 out of 10, Excellent, (1000)
"It was a wonderful hotel experience."
The price is AED 311
AED 367 total
includes taxes & fees
27 Apr - 28 Apr
Sleep Inn & Suites O'Fallon MO - Technology Drive

Staybridge Suites O'Fallon Chesterfield by IHG

3.0 star property
8.4 out of 10, Very Good, (317)
"It was a very nice place"
The price is AED 389
AED 459 total
includes taxes & fees
30 Apr - 1 May
Staybridge Suites O'Fallon Chesterfield by IHG

Residence Inn by Marriott O'Fallon

3.0 star property
8.4 out of 10, Very Good, (420)
"Good job"
The price is AED 466
AED 550 total
includes taxes & fees
11 May - 12 May
Residence Inn by Marriott O'Fallon

Comfort Inn & Suites St. Louis - Chesterfield

2.5 star property
8.2 out of 10, Very Good, (1004)
"Rooms were very clean. However the front desk person was not friendly and very short with us. A lot of marijuana smell throughout the hotel. Breakfast was dissapointing."
The price is AED 307
AED 370 total
includes taxes & fees
27 Apr - 28 Apr
Comfort Inn & Suites St. Louis - Chesterfield

Hilton Garden Inn St. Louis/O'Fallon MO

3.0 star property
8.8 out of 10, Excellent, (679)
" "
The price is AED 549
AED 651 total
includes taxes & fees
2 May - 3 May
Hilton Garden Inn St. Louis/O'Fallon MO

The Wildwood Hotel

3.5 star property
9.0 out of 10, Wonderful, (1480)
"Lovely property, a real gem of a find. The room was spacious, clean and very quaint."
The price is AED 324
AED 392 total
includes taxes & fees
5 May - 6 May
The Wildwood Hotel

Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

2.5 star property
9.2 out of 10, Wonderful, (852)
"Very clean, good condition property. Pool and breakfast were very good."
The price is AED 468
AED 544 total
includes taxes & fees
4 May - 5 May
Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

Courtyard by Marriott St. Louis Chesterfield

3.0 star property
9.0 out of 10, Wonderful, (503)
"Great location for one night stay after show at The Factory. Hotel was busy but staff was keeping up and being super professional abd courteous under the pressure. "
The price is AED 466
AED 543 total
includes taxes & fees
4 May - 5 May
Courtyard by Marriott St. Louis Chesterfield

Hampton Inn & Suites St. Louis/Chesterfield

3.5 star property
8.6 out of 10, Excellent, (769)
"We had a wonderful two night stay. Room was clean and comfortable. "
The price is AED 356
AED 414 total
includes taxes & fees
4 May - 5 May
Hampton Inn & Suites St. Louis/Chesterfield

Holiday Inn St. Louis West Six Flags by IHG

3.0 star property
8.8 out of 10, Excellent, (1000)
"Right by the highway, easy access, fun, castle like atmosphere. "
The price is AED 512
AED 597 total
includes taxes & fees
27 Apr - 28 Apr
Holiday Inn St. Louis West Six Flags by IHG

Comfort Inn Near Six Flags St. Louis

2.5 star property
8.4 out of 10, Very Good, (787)
"It was nice, clean, and quiet. Will stay again. "
The price is AED 376
AED 430 total
includes taxes & fees
7 May - 8 May
Comfort Inn Near Six Flags St. Louis

Quality Inn Near Six Flags St. Louis

2.5 star property
8.4 out of 10, Very Good, (307)
"The gentleman that check us in was very helpful. We had booked a room that happened to put us in the second floor. But, my husband has had knee surgery and is not comfortable doing stairs. The gentleman found us a room on the first floor with an outside entrance. What could have been a rough experience turned out to be a great stay thanks to him!"
The price is AED 364
AED 416 total
includes taxes & fees
24 Apr - 25 Apr
Quality Inn Near Six Flags St. Louis

Americas Best Inn - Eureka

2.5 star property
6.2 out of 10, (120)
"Needs updating"
The price is AED 268
AED 313 total
includes taxes & fees
24 Apr - 25 Apr
Americas Best Inn - Eureka

Super 8 by Wyndham Eureka/Six Flags Nearby

2.0 star property
7.0 out of 10, Good, (1002)
"Room was clean, great customer service and very comfortable beds. "
The price is AED 264
AED 308 total
includes taxes & fees
28 Apr - 29 Apr
Super 8 by Wyndham Eureka/Six Flags Nearby

Hilton Garden Inn Chesterfield

3.0 star property
8.2 out of 10, Very Good, (740)
"Great stay great service"
The price is AED 428
AED 498 total
includes taxes & fees
4 May - 5 May
Hilton Garden Inn Chesterfield

AC Hotel by Marriott St. Louis Chesterfield

3.5 star property
9.0 out of 10, Wonderful, (161)
"The property was clean and the room was spacious and comfortable. The surrounding area was quiet and safe. There were dinning options only 3minutes away. "
The price is AED 569
AED 660 total
includes taxes & fees
4 May - 5 May
AC Hotel by Marriott St. Louis Chesterfield

DoubleTree by Hilton Hotel St. Louis - Chesterfield

4.0 star property
8.6 out of 10, Excellent, (1000)
"Breakfast place! "
The price is AED 514
AED 597 total
includes taxes & fees
27 Apr - 28 Apr
DoubleTree by Hilton Hotel St. Louis - Chesterfield

Drury Plaza Hotel St. Louis Chesterfield

3.0 star property
9.6 out of 10, Exceptional, (1002)
"Great service and very clean! Will stay there again."
The price is AED 477
AED 554 total
includes taxes & fees
28 Apr - 29 Apr
Drury Plaza Hotel St. Louis Chesterfield
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about Defiance

Trip time! Discover the wineries, parks, and history in Defiance.

Frequently asked questions

What's the best place to stay in Defiance?

Hollywood Casino & Hotel St. Louis, located 18.1 mi (29.2 km) from the heart of Defiance, is a top choice for your stay based on our traveler data. Other good choices for your stay in the area are Ameristar Casino Resort and Spa and The Wildwood Hotel. See all available top hotels, or vacation rentals in Defiance.

What's the top vacation rental in Defiance?

☆BackYard BBQ Hidden Gem☆Perfect Location~Groups /Pets Welcome: Visitors like this Defiance vacation home rental. It is located on a river and has a fireplace, a patio, and a barbecue grill to put you at ease in your new surroundings. It has 4 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. You can relax into your vacation with a private yard and a selection of games. See all vacation rentals in Defiance.

If I need to cancel my hotel reservation in Defiance, will I receive a refund?

Yes, the majority of hotel reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a reservation that's non-refundable, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.

Where can I learn more about changing or cancelling my trip to Defiance?

For more information about changing or cancelling your trip to Defiance, head over to our customer service page.

Where is the best hotel to stay with easy access to August A. Busch Memorial Conservation Area?

Sleep Inn & Suites O'Fallon MO - Technology Drive is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an indoor pool. It's located 2.6 mi (4.3 km) from August A. Busch Memorial Conservation Area. Other good options within a few miles include Hilton Garden Inn St. Louis/O'Fallon MO and Holiday Inn Express St. Louis West - O'Fallon, an IHG Hotel.

What about the best place to stay near Chandler Hill Vineyards?

One of the top choices for your stay is The Wildwood Hotel, located 10 mi (16.1 km) from Chandler Hill Vineyards, and this 3.5-star hotel offers free breakfast and an indoor pool.

What are some accommodations with pools in Defiance?

Ameristar Casino Resort and Spa: Hotel steps from Ameristar Casino St. Charles. Offers 6 restaurants, a seasonal outdoor pool, and a full-service spa. The Wildwood Hotel and Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham are two additional hotels that offer an onsite pool. View all hotels with pools in Defiance.

What's the best place to stay near Lambert-St. Louis International Airport (STL)?

Marriott St. Louis Airport is a popular 3.5-star hotel featuring a restaurant and an outdoor pool. It's located a short 0.3 mi (0.5 km) from Lambert-St. Louis Intl. Airport. Other good choices within close proximity to the airport include Pear Tree Inn Airport - St. Louis - St. Ann, MO and Drury Inn & Suites St. Louis Airport.

What's it like to stay in Defiance?

Visitors can enjoy all that Defiance has to offer including the wineries and parks. Top sights in the area include Enterprise Center, St. Louis Union Station, and Busch Stadium. In Defiance, there are 20 hotels and other accommodations to choose from. Find out more about Defiance.

What is there to see in Defiance?

Natural beauty is on display at August A. Busch Memorial Conservation Area, Missouri River, and Matson Hill Park Trailhead. A couple of additional sights to add to your agenda are Chandler Hill Vineyards and Sugar Creek Winery. Check out what more to see and do in Expedia's Defiance guide.

What's the seasonal weather like in Defiance?

The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 38°F. Average annual precipitation for Defiance is 48 inches.