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Compare 822 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

TownePlace Suites by Marriott St. Louis Chesterfield
TownePlace Suites by Marriott St. Louis Chesterfield
8.8 out of 10, Excellent, (233)
The price is AED 415
AED 487 total
includes taxes & fees
4 May - 5 May

Holiday Inn Express St. Louis West - O'Fallon by IHG
Holiday Inn Express St. Louis West - O'Fallon by IHG
8.4 out of 10, Very Good, (691)
The price is AED 364
AED 429 total
includes taxes & fees
27 Apr - 28 Apr

Sleep Inn & Suites O'Fallon MO - Technology Drive
Sleep Inn & Suites O'Fallon MO - Technology Drive
8.8 out of 10, Excellent, (1000)
The price is AED 311
AED 367 total
includes taxes & fees
27 Apr - 28 Apr

Staybridge Suites O'Fallon Chesterfield by IHG
Staybridge Suites O'Fallon Chesterfield by IHG
8.4 out of 10, Very Good, (317)
The price is AED 389
AED 459 total
includes taxes & fees
30 Apr - 1 May

Residence Inn by Marriott O'Fallon
Residence Inn by Marriott O'Fallon
8.4 out of 10, Very Good, (420)
The price is AED 466
AED 550 total
includes taxes & fees
11 May - 12 May

Comfort Inn & Suites St. Louis - Chesterfield
Comfort Inn & Suites St. Louis - Chesterfield
8.2 out of 10, Very Good, (1004)
The price is AED 307
AED 370 total
includes taxes & fees
27 Apr - 28 Apr
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about Defiance
Trip time! Discover the wineries, parks, and history in Defiance.

More cheap stays in Defiance
More cheap stays in Defiance

Best Western Plus St. Louis West-Westport
12220 Dorsett Rd, Maryland Heights, MO
The price is AED 327 per night from Apr 29 to Apr 30
AED 327
AED 380 total
includes taxes & fees
29 Apr - 30 Apr
8/10 Very Good! (1,002 reviews)
Hotels in Defiance with star-rating
Hotels in Defiance with star-rating

4 Star Hotels
7 properties
Stay near popular Defiance attractions
Stay near popular Defiance attractions

Busch Stadium
4.5/5(1,469 reviews)
Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's acclaimed theater scene or attend a baseball game.
Recent reviews of Defiance hotels
Recent reviews of Defiance hotels

Hampton Inn St. Charles St. Peters
5/5 Excellent
"Very clean and excellent beds"
A verified traveler stayed at Hampton Inn St. Charles St. Peters
Posted 3 hours ago
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Stay near popular Defiance attractions
- Hotels near Historic Daniel Boone Home and Heritage Center
- Hotels near Chandler Hill Vineyards
- Hotels near August A. Busch Memorial Conservation Area
- Hotels near Sugar Creek Winery
- Hotels near Broemmelsiek Park
- Hotels near Yellow Farmhouse Winery
- Hotels near Six Flags St. Louis
- Hotels near Hollywood Casino Amphitheatre
- Hotels near Ameristar Casino St. Charles
- Hotels near Mississippi River
- Hotels near Westport Plaza
- Hotels near Magic House - St. Louis Children's Museum
- Hotels near St Charles Convention Center
- Hotels near Route 66 State Park
- Hotels near Purina Farms
- Hotels near Missouri River
- Hotels near Hollywood Casino
- Hotels near Historic Main Street
- Hotels near Lindenwood University
- Hotels near Family Arena
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Defiance Hotels by Brand
Other Hotels near Defiance, St. Louis
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Explore more hotels
- Hilton St. Louis Frontenac
- Drury Plaza Hotel St. Louis Chesterfield
- Baymont by Wyndham St. Charles
- Best Western Plus St. Louis West-Westport
- Holiday Inn St. Louis - Creve Coeur by IHG
- Hampton Inn St. Charles St. Peters
- Courtyard by Marriott St Louis Westport Plaza
- Embassy Suites by Hilton St. Louis St. Charles
- Drury Inn & Suites Southwest St. Louis
- Holiday Inn St. Louis West Six Flags by IHG
- Days Inn and Suites by Wyndham St. Louis/Westport Plaza
- Relax Inn Saint Charles