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Compare 243 Vacation Homes in Defiance with updated reviews, rates, and availability.

The St. Charles Guest House, lovely historic home, fun for families and groups

10.0 out of 10, Exceptional, (120)
"Sisters and sisterinlaws who take trips together had a fabulous time! House is great, clean and decorated nicely. Loved walking to shopping. Loved Lewis & Clark restaurant, Magpies, and Bradden 1818."
The St. Charles Guest House, lovely historic home, fun for families and groups

1870's Luxury Guest Cottage, Historic Downtown St. Charles, Mo.

10.0 out of 10, Exceptional, (249)
"The property was perfect for our 2 day shopping trip. Only a half block from all the shops and restaurants. House is very unique and beautifully decorated."
1870's Luxury Guest Cottage, Historic Downtown St. Charles, Mo.

The Cardinal Nest A Cozy Cottage on Historic Main Street; Pet Friendly

9.8 out of 10, Exceptional, (38)
"Home was clean and all necessities of convenience were provided. Cozy stay!"
The Cardinal Nest A Cozy Cottage on Historic Main Street; Pet Friendly

Innsbrook Luxe Escape

10.0 out of 10, Exceptional, (59)
"The home is in a great location among the hills and lakes, but still close enough to shopping if you need to venture in. Beautifully decorated with Christmas cheer our children & grandchildren had lots of space to relax and enjoy each others company. Thank you for providing such an inviting atmosphere. "
Innsbrook Luxe Escape

Cozy Historic WashMo home

9.4 out of 10, Exceptional, (17)
"We had a great time for my moms birthday."
The price is AED 331
AED 812 total
includes taxes & fees
15 Jan - 16 Jan
Cozy Historic WashMo home

Blair's House in St. Charles - Long Stays Welcome

9.6 out of 10, Exceptional, (14)
"Convenient location. The size and layout of the house is comfortable and great for visiting! Nice kitchen and laundry room. The game room is Fantastic! A short drive to the Schnucks ( groceries) and Fratelli’s (Italian restaurant). Highly recommend!"
Blair's House in St. Charles - Long Stays Welcome

518: Wine Country Getaway by JZ Vacation Rentals

8.4 out of 10, Very Good, (6)
"The pictures in listing were accurate. Very clean and easy to check in and out. Beds were comfortable. The bathroom upstairs is very easy to share with several people. Close to downtown Washington. Would stay here again."
The price is AED 545
AED 1,222 total
includes taxes & fees
12 Jan - 13 Jan
518: Wine Country Getaway by JZ Vacation Rentals

1790's Renovated Barn, Main Street St. Charles, Hot Tub in private backyard!

10.0 out of 10, Exceptional, (205)
"This was a perfect, cozy retreat. Super clean, well-appointed, and just steps from old main street in Saint Charles. Impressive!"
1790's Renovated Barn, Main Street St. Charles, Hot Tub in private backyard!

The robin nest a cozy cottage on historic main street; pet Friendly

9.8 out of 10, Exceptional, (31)
"Excellent location, great communication with property manager and terrific unit!"
The robin nest a cozy cottage on historic main street; pet Friendly

Newly Updated Charming and Cozy Home near Historic Main Street in Frenchtown.

10.0 out of 10, Exceptional, (21)
"We had a great time with family and friends! The house was so cute and had everything we needed. Including coffee and tea started pods! "
Newly Updated Charming and Cozy Home near Historic Main Street in Frenchtown.

BACKYARD OASIS! Cozy and charming 60s Brick ranch with relaxing gazebo over pond

9.8 out of 10, Exceptional, (28)
"We had an enjoyable stay at this property. We prefer to prepare our meals and the kitchen had everything we needed, including plenty of counter space, to do just that! There is a coziness to the house, perfect size for any family. The view of the pond and gazebo from the kitchen window made washing dishes and food prep very memorable. The property mgt team was very responsive and flexible with our needs. We would definitely return to this house when our travels take us back to the area. "
BACKYARD OASIS! Cozy and charming 60s Brick ranch with relaxing gazebo over pond

Stunning 1890's Home - Sleeps 8!

10.0 out of 10, Exceptional, (44)
"Just the perfect amount of space for our family. Great location. Beautiful home"
Stunning 1890's Home - Sleeps 8!

Luxurious couples retreat just steps from Historic Main Street in St. Charles!

10.0 out of 10, Exceptional, (79)
"My wife and I stayed here for two nights and enjoyed the property and surrounding area so much. The property was so cozy and inviting. We especially loved coming into the warm gas fire after exploring the shops that line the streets of St. Charles.The owners were also a pleasure to work with and they were very accommodating."
Luxurious couples retreat just steps from Historic Main Street in St. Charles!

Paradise Point by Innsbrook Vacations!

9.2 out of 10, Wonderful, (14)
"Good activities for the group bonding."
Paradise Point by Innsbrook Vacations!

Blair's House - Game Room - Long Stays Welcome

10.0 out of 10, Exceptional, (13)
"Wow! We picked the perfect house for our family to celebrate a very special weekend. The house was clean and well organized. The kitchen had everything I needed to do a mini early Thanksgiving dinner since our family is never all together for the holiday’s. My adult children, nieces and nephews loved the games in the basement! Some intense ping pong games took place. My older parents said the bed in the master bedroom slept better than their expensive one at home! I loved having this space...
Blair's House - Game Room - Long Stays Welcome

Charming 1800s Farmhouse in Historic St. Charles

10.0 out of 10, Exceptional, (2)
"Our son was married this past weekend. We chose this house based on proximity to the church, rehearsal dinner, other out of town guests and the wedding venue. Over nights were just right to accommodate our multigenerational family, a bedroom on first floor alleviated my parents from using the stairs. We did need to send guests through the down stairs bedroom to access the only first floor bathroom. Kitchen was well appointed, I cooked breakfast, lunch and dinner for our family, amd had some...
The price is AED 466
AED 2,054 total
includes taxes & fees
4 Feb - 5 Feb
Charming 1800s Farmhouse in Historic St. Charles

4 Bedroom Wentzville Adventure 3 King Bedrooms

The price is AED 294
AED 483 total
includes taxes & fees
31 Jan - 1 Feb
4 Bedroom Wentzville Adventure 3 King Bedrooms

Charming 3-bedroom house with WiFi, and fenced-in backyard in serene Byrnes Mill

2.0 star property
10.0 out of 10, Exceptional, (4)
"Though out stay was short it was amazing. Home was exactly as described and pictured. Host was so helpful with all questions we had. Not many homes welcome pets. Though we ended up not bringing ours it was so great to have had the option! Thank you so much for all the extras that you had for us as your guests. We definitely will be staying again! "
The price is AED 551
AED 966 total
includes taxes & fees
19 Jan - 20 Jan
Charming 3-bedroom house with WiFi, and fenced-in backyard in serene Byrnes Mill

Spacious Missouri Retreat w/ Pool, Gym & Game Room

9.0 out of 10, Wonderful, (12)
"Enjoyed our stay. Check in was easy and communication was excellent"
Spacious Missouri Retreat w/ Pool, Gym & Game Room

Clark Brick House w/ Pool - Historic St. Charles

9.8 out of 10, Exceptional, (82)
"Plenty of room to move around and play games. "
Clark Brick House w/ Pool - Historic St. Charles
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Other property types in Defiance

BACKYARD OASIS! Cozy and charming 60s Brick ranch with relaxing gazebo over pond

9.8 out of 10, Exceptional, (28)
"We had an enjoyable stay at this property. We prefer to prepare our meals and the kitchen had everything we needed, including plenty of counter space, to do just that! There is a coziness to the house, perfect size for any family. The view of the pond and gazebo from the kitchen window made washing dishes and food prep very memorable. The property mgt team was very responsive and flexible with our needs. We would definitely return to this house when our travels take us back to the area. "
BACKYARD OASIS! Cozy and charming 60s Brick ranch with relaxing gazebo over pond

The St. Charles Guest House, lovely historic home, fun for families and groups

10.0 out of 10, Exceptional, (120)
"Sisters and sisterinlaws who take trips together had a fabulous time! House is great, clean and decorated nicely. Loved walking to shopping. Loved Lewis & Clark restaurant, Magpies, and Bradden 1818."
The St. Charles Guest House, lovely historic home, fun for families and groups

The Lofts of North Main Street

9.6 out of 10, Exceptional, (120)
"Loved the vibe, location couldn’t have been better. The unit was clean and had everything we needed. "
The price is AED 400
AED 889 total
includes taxes & fees
21 Jan - 22 Jan
The Lofts of North Main Street
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.