Search Vacation Homes in Defiance

  • Plan, book, stay with confidence

  • bex rewards loyalty icon
    Be picky
    Search almost a million properties worldwide
    payments icon
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    today icon
    Change your mind
    Book hotels with free cancellation

Check prices for these dates

Next weekend
In two weeks
In one month
In two months

Compare Vacation Homes in Defiance with updated reviews, rates, and availability.

Spacious*Outdoor Space*Modern*Family*Groups*Modern*Artistic

9.8 out of 10, Exceptional, (36)
"Was in town for a family funeral. House was comfortable and conveniently located. Was very thankful to be able to bring our dog. Will definitely try to stay here again when in town. "
The price is AEDĀ 474
AEDĀ 1,256 total
includes taxes & fees
13 Feb - 14 Feb
Spacious*Outdoor Space*Modern*Family*Groups*Modern*Artistic

The St. Charles Guest House, lovely historic home, fun for families and groups

10.0 out of 10, Exceptional, (123)
"A group of our college friends met for a hockey game/birthday celebration! This home smelt clean the second you walked in the door and was the perfect location! Much thanks for a fabulous weekend! "
The St. Charles Guest House, lovely historic home, fun for families and groups

Newly Updated Charming and Cozy Home near Historic Main Street in Frenchtown.

10.0 out of 10, Exceptional, (22)
"Itā€™s was clean and a very nice place! The host was absolutely amazing! Would book again :)"
Newly Updated Charming and Cozy Home near Historic Main Street in Frenchtown.

Stunning 1890's Home - Sleeps 8!

10.0 out of 10, Exceptional, (47)
"This property was so beautiful. A short walk to St. Charles Main Street. My family was happy with this house and our host was very accommodating and easy to reach. Canā€™t wait to go back, definitely renting this again."
Stunning 1890's Home - Sleeps 8!

Cute spacious Ranch - very safe area - 4 BR 2B- big fenced yard -1800 sft

9.6 out of 10, Exceptional, (14)
"Easy to find, comfortable beds and nice to be able to park the car in the garage."
The price is AEDĀ 525
AEDĀ 1,143 total
includes taxes & fees
18 Feb - 19 Feb
Cute spacious Ranch - very safe area - 4 BR 2B- big fenced yard -1800 sft

1870's Luxury Guest Cottage, Historic Downtown St. Charles, Mo.

10.0 out of 10, Exceptional, (250)
"The property was perfect for our 2 day shopping trip. Only a half block from all the shops and restaurants. House is very unique and beautifully decorated."
1870's Luxury Guest Cottage, Historic Downtown St. Charles, Mo.

šŸŒŸ Adorable Historic šŸ  in the ā¤ļø of St. Charles šŸŒŸ

9.8 out of 10, Exceptional, (58)
"The house is charming, late 18th century, in a lovely neighborhood. Queen beds only accessible from one side due to being against walls on both levels. Additional towels required search, and limited for kitchen. Listing has occupancy as 7 - but insufficient 3 piece silverware for one full meal for that number, so washing required even if only 4 for 2 meals a day.. Kitchen cookware quite adequate but preparation bowls and storage boxes are limited. Charming holiday decorations, placemats,...
šŸŒŸ Adorable Historic šŸ  in the ā¤ļø of St. Charles šŸŒŸ

Luxurious couples retreat just steps from Historic Main Street in St. Charles!

10.0 out of 10, Exceptional, (81)
"Had a great weekend getaway"
Luxurious couples retreat just steps from Historic Main Street in St. Charles!

1790's Renovated Barn, Main Street St. Charles, Hot Tub in private backyard!

10.0 out of 10, Exceptional, (207)
"The property was adorable and super clean. Located just off Historical Main Street in Saint Charles. Loved the hot tub! perfect way to end a day of shopping"
1790's Renovated Barn, Main Street St. Charles, Hot Tub in private backyard!

Clark Brick House w/ Pool - Historic St. Charles

9.8 out of 10, Exceptional, (82)
"The house was wonderful!"
Clark Brick House w/ Pool - Historic St. Charles

Cozy Historic WashMo home

9.4 out of 10, Exceptional, (21)
"We had a wonderful stay! The house was clean and well maintained. Hosts were responsive and the check in process was easy. Great central location. "
The price is AEDĀ 331
AEDĀ 801 total
includes taxes & fees
13 Feb - 14 Feb
Cozy Historic WashMo home

518: Wine Country Getaway by JZ Vacation Rentals

8.4 out of 10, Very Good, (6)
"The pictures in listing were accurate. Very clean and easy to check in and out. Beds were comfortable. The bathroom upstairs is very easy to share with several people. Close to downtown Washington. Would stay here again."
518: Wine Country Getaway by JZ Vacation Rentals

Blair's House in St. Charles - Long Stays Welcome

9.6 out of 10, Exceptional, (14)
"Convenient location. The size and layout of the house is comfortable and great for visiting! Nice kitchen and laundry room. The game room is Fantastic! A short drive to the Schnucks ( groceries) and Fratelliā€™s (Italian restaurant). Highly recommend!"
Blair's House in St. Charles - Long Stays Welcome

Historic*Unique*Downtown*Quiet*Bright*Cheerful*Getaway

9.6 out of 10, Exceptional, (31)
"We enjoyed our stay here at this property. Met our needs for a short stay in the St. Louis area. The kids enjoyed the games and little art area."
The price is AEDĀ 422
AEDĀ 1,131 total
includes taxes & fees
16 Feb - 17 Feb
Historic*Unique*Downtown*Quiet*Bright*Cheerful*Getaway

St. Charles 1860's Gem - Sleeps 6!

9.8 out of 10, Exceptional, (86)
"We enjoyed our stay! The place was clean and in a excellent location!"
The price is AEDĀ 422
AEDĀ 889 total
includes taxes & fees
16 Feb - 17 Feb
St. Charles 1860's Gem - Sleeps 6!

Innsbrook Luxe Escape

10.0 out of 10, Exceptional, (62)
"we rent this beautiful every January for a long weekend. As always, it was a great stay. Owner very responsive and house has everything needed. "
Innsbrook Luxe Escape

Charming Cottage on Main St. in Historic St. Charles! Jetted Tub, 2 Fireplaces!!

10.0 out of 10, Exceptional, (229)
"Such a beautiful home! We had a wonderful time over the holidays. The home was beautifully decorated. Highly recommended stay :)"
Charming Cottage on Main St. in Historic St. Charles! Jetted Tub, 2 Fireplaces!!

Central Luxe 5br Home - Hot Tub & Views - šŸ„‚ šŸ·

10.0 out of 10, Exceptional, (51)
"Our group of moms have come to this house that last two years to relax in the quiet after the holiday craziness! Plenty of places to sleep at night, and lounge during the day with our food and books. The hot tub is such a fun addition on a cold winter day! We will be back next year!"
The price is AEDĀ 1,102
AEDĀ 2,279 total
includes taxes & fees
13 Feb - 14 Feb
Central Luxe 5br Home - Hot Tub & Views - šŸ„‚ šŸ·

The robin nest a cozy cottage on historic main street; pet Friendly

9.8 out of 10, Exceptional, (32)
"Comfortable and convenient. Nice owner. "
The robin nest a cozy cottage on historic main street; pet Friendly

Madison House 1 -Walk to Main St

The price is AEDĀ 290
AEDĀ 823 total
includes taxes & fees
13 Feb - 14 Feb
Madison House 1 -Walk to Main St
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Don't see what you're looking for?
See all available properties in Defiance
Save an average of 15% on thousands of hotels when you're signed in

Other property types in Defiance

The St. Charles Guest House, lovely historic home, fun for families and groups

10.0 out of 10, Exceptional, (123)
"A group of our college friends met for a hockey game/birthday celebration! This home smelt clean the second you walked in the door and was the perfect location! Much thanks for a fabulous weekend! "
The St. Charles Guest House, lovely historic home, fun for families and groups

Spacious*Outdoor Space*Modern*Family*Groups*Modern*Artistic

9.8 out of 10, Exceptional, (36)
"Was in town for a family funeral. House was comfortable and conveniently located. Was very thankful to be able to bring our dog. Will definitely try to stay here again when in town. "
The price is AEDĀ 474
AEDĀ 1,256 total
includes taxes & fees
13 Feb - 14 Feb
Spacious*Outdoor Space*Modern*Family*Groups*Modern*Artistic

The Lofts of North Main Street

9.6 out of 10, Exceptional, (124)
"Great location for a visit to old at charles"
The price is AEDĀ 474
AEDĀ 969 total
includes taxes & fees
17 Feb - 18 Feb
The Lofts of North Main Street
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.