Photo by Geraldine Soh
Find hotels near Historic Main Street, St. Louis from AED 267
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Compare 463 hotels close to Historic Main Street with room rates, reviews, and availability. Most hotels are fully refundable.

Country Inn & Suites by Radisson, St. Charles Historic District
Country Inn & Suites by Radisson, St. Charles Historic District
9.4 out of 10, Exceptional, (1003)
The price is AED 418
AED 481 total
includes taxes & fees
20 Apr - 21 Apr

Drury Plaza Hotel St. Louis St. Charles
Drury Plaza Hotel St. Louis St. Charles
9.6 out of 10, Exceptional, (1003)
The price is AED 404
AED 468 total
includes taxes & fees
20 Apr - 21 Apr

Hampton Inn & Suites St. Charles Old Town Area
Hampton Inn & Suites St. Charles Old Town Area
9.2 out of 10, Wonderful, (507)
The price is AED 434
AED 521 total
includes taxes & fees
11 May - 12 May

Comfort Suites St Charles - St Louis
Comfort Suites St Charles - St Louis
8.6 out of 10, Excellent, (879)
The price is AED 309
AED 355 total
includes taxes & fees
20 Apr - 21 Apr

Embassy Suites by Hilton St. Louis St. Charles
Embassy Suites by Hilton St. Louis St. Charles
8.8 out of 10, Excellent, (1143)
The price is AED 509
AED 585 total
includes taxes & fees
20 Apr - 21 Apr

Tru by Hilton St. Charles St. Louis, MO
Tru by Hilton St. Charles St. Louis, MO
8.6 out of 10, Excellent, (684)
The price is AED 403
AED 467 total
includes taxes & fees
20 Apr - 21 Apr
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Hotels near Other St. Louis Attractions
Hotels near Other St. Louis Attractions
First Missouri State Capitol Historic Site
4/5(2 reviews)
You can learn about the history of St. Charles when you stop by First Missouri State Capitol Historic Site. Discover the top-notch restaurants and acclaimed theater scene in this family-friendly area.
Recent reviews of Historic Main Street hotels
Recent reviews of Historic Main Street hotels

Ameristar Casino Resort and Spa
5/5 Excellent
"Had to wait about an hour for an attendant to come to a machine so I could cash out. Otherwise great stay "
A verified traveler stayed at Ameristar Casino Resort and Spa
Posted 2 days ago
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Hotels near popular St. Louis Attractions
- Hotels near First Missouri State Capitol Historic Site
- Hotels near Hollywood Casino Amphitheatre
- Hotels near Ameristar Casino St. Charles
- Hotels near Mississippi River
- Hotels near Westport Plaza
- Hotels near Saint Louis Galleria Mall
- Hotels near St Charles Convention Center
- Hotels near Missouri River
- Hotels near Lindenwood University
- Hotels near Hollywood Casino
- Hotels near Family Arena
- Hotels near St. Louis Premium Outlets
- Hotels near The Loop
- Hotels near The Factory
- Hotels near Centene Community Ice Center
- Hotels near Katy Trail
- Hotels near Lou Fusz Soccer Complex
- Hotels near Chesterfield Sports Fusion
- Hotels near Fast Lane Classic Cars
- Hotels near Mid Rivers Mall
Hotels in top St. Charles Historic District neighborhoods
Other Hotels near Historic Main Street, St. Charles Historic District
- St. Charles Hotels
- Maryland Heights Hotels
- Chesterfield Hotels
- O'Fallon Hotels
- Hazelwood Hotels
- Fenton Hotels
- St. Peters Hotels
- Alton Hotels
- Wentzville Hotels
- Kirkwood Hotels
- Grafton Hotels
- Ozarks Hotels
- Richmond Heights Hotels
- Brentwood Hotels
- Eureka Hotels
- Southern Illinois Hotels
- Bridgeton Hotels
- Wildwood Hotels
- Florissant Hotels
- Granite City Hotels
More Hotel Options in Historic Main Street
- Adventure Hotels
- Business Hotels
- Casinos
- Cheap Hotels
- Family Hotels
- Golf Hotels
- Historic Hotels
- Hotel Wedding Venues
- Hotel with a Concierge
- Hotels with Bars
- Hotels with Free Parking
- Hotels with Hot Tubs
- Hotels with WiFi
- Hotels with a Pool
- Hotels with an Indoor Pool
- Luxury Hotels
- Pet-friendly Hotels
- Resorts & Hotels with Spas
- Shopping Hotels
- Winery Hotels
Explore more hotels
- The Wild West Getaway- 204-1
- Charming Cottage on Main St. in Historic St. Charles! Jetted Tub, 2 Fireplaces!!
- The Historic Bricks on Main
- Walking distance to Historic Main Street, St. Charles, MO
- Western-Themed 2-Bedroom Hideout for Outlaws 204-2
- St. Charles Victorian Gem | Steps to Main Street
- The Lofts of North Main Street
- 🌷RARE NEW TREASURE🌷2 Homes+Outdoor Gathering Area. Two Blocks From Main St.!!!
- Stay on Historic Main!
- The Wild Rose Cottage in Historic Old St Charles
- Best Western Plus The Charles Hotel
- Prime Loft of Main Street