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Find hotels near Historic Main Street, St. Louis from AED 309
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Compare 463 hotels close to Historic Main Street with room rates, reviews, and availability. Most hotels are fully refundable.

Country Inn & Suites by Radisson, St. Charles Historic District
Country Inn & Suites by Radisson, St. Charles Historic District
9.4 out of 10, Exceptional, (1001)
The price is AED 387
AED 445 total
includes taxes & fees
4 May - 5 May

Drury Plaza Hotel St. Louis St. Charles
Drury Plaza Hotel St. Louis St. Charles
9.6 out of 10, Exceptional, (1002)
The price is AED 404
AED 468 total
includes taxes & fees
4 May - 5 May

Ameristar Casino Resort and Spa
Ameristar Casino Resort and Spa
8.4 out of 10, Very Good, (1001)
The price is AED 621
AED 787 total
includes taxes & fees
4 May - 5 May

Hampton Inn & Suites St. Charles Old Town Area
Hampton Inn & Suites St. Charles Old Town Area
9.0 out of 10, Wonderful, (511)
The price is AED 383
AED 463 total
includes taxes & fees
25 May - 26 May

Comfort Suites St Charles - St Louis
Comfort Suites St Charles - St Louis
8.6 out of 10, Excellent, (892)
The price is AED 309
AED 355 total
includes taxes & fees
6 May - 7 May

Hollywood Casino & Hotel St. Louis
Hollywood Casino & Hotel St. Louis
8.4 out of 10, Very Good, (1883)
The price is AED 364
AED 477 total
includes taxes & fees
1 May - 2 May
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Hotels near Other St. Louis Attractions
Hotels near Other St. Louis Attractions
First Missouri State Capitol Historic Site
4/5(2 reviews)
You can learn about the history of St. Charles when you stop by First Missouri State Capitol Historic Site. Discover the top-notch restaurants and acclaimed theater scene in this family-friendly area.
Recent reviews of Historic Main Street hotels
Recent reviews of Historic Main Street hotels

Drury Plaza Hotel St. Louis St. Charles
5/5 Excellent
Pleasant stay
"Very friendly and helpful staff "
A verified traveler stayed at Drury Plaza Hotel St. Louis St. Charles
Posted 11 hours ago
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Hotels near popular St. Louis Attractions
- Hotels near First Missouri State Capitol Historic Site
- Hotels near Hollywood Casino Amphitheatre
- Hotels near Ameristar Casino St. Charles
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- Hotels near St Charles Convention Center
- Hotels near Hollywood Casino
- Hotels near Lindenwood University
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- Hotels near Family Arena
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- Hotels near The Factory
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- Hotels near Kokomo Joe's Family Fun Center
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Hotels in top St. Charles Historic District neighborhoods
Other Hotels near Historic Main Street, St. Charles Historic District
- St. Charles Hotels
- Maryland Heights Hotels
- Chesterfield Hotels
- O'Fallon Hotels
- Hazelwood Hotels
- Wentzville Hotels
- Fenton Hotels
- St. Peters Hotels
- Alton Hotels
- Ozarks Hotels
- Grafton Hotels
- Kirkwood Hotels
- Richmond Heights Hotels
- Bridgeton Hotels
- Eureka Hotels
- Southern Illinois Hotels
- Brentwood Hotels
- Granite City Hotels
- Florissant Hotels
- Wildwood Hotels
More Hotel Options in Historic Main Street
- Adventure Hotels
- Business Hotels
- Casinos
- Cheap Hotels
- Family Hotels
- Golf Hotels
- Historic Hotels
- Hotel Wedding Venues
- Hotel with a Concierge
- Hotels with Bars
- Hotels with Free Parking
- Hotels with Hot Tubs
- Hotels with WiFi
- Hotels with a Pool
- Hotels with an Indoor Pool
- Luxury Hotels
- Pet-friendly Hotels
- Resorts & Hotels with Spas
- Shopping Hotels
- Winery Hotels
Explore more hotels
- The Wild West Getaway- 204-1
- Charming Cottage on Main St. in Historic St. Charles! Jetted Tub, 2 Fireplaces!!
- The Historic Bricks on Main
- Western-Themed 2-Bedroom Hideout for Outlaws 204-2
- Walking distance to Historic Main Street, St. Charles, MO
- St. Charles Victorian Gem | Steps to Main Street
- The Lofts of North Main Street
- The Wild Rose Cottage in Historic Old St Charles
- Prime Loft of Main Street
- Main Street Balcony Apartment by StayLage!
- Stay on Historic Main!
- Amazing Renovated Historic Loft on Main Street