Find 4 Star Hotels in Defiance, MO from AED 434
- Plan, book, stay with confidence
Be picky
Search almost a million properties worldwide
Change your mind
Book hotels with free cancellation
Check availability on Defiance 4 Star Hotels
Compare Defiance 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Ameristar Casino Resort and Spa
Ameristar Casino Resort and Spa
8.4 out of 10, Very Good, (1144)
The price is AED 621
AED 787 total
includes taxes & fees
2 Apr - 3 Apr

Hilton St. Louis Frontenac
Hilton St. Louis Frontenac
8.8 out of 10, Excellent, (1059)
The price is AED 518
AED 603 total
includes taxes & fees
19 Apr - 20 Apr

DoubleTree by Hilton Hotel St. Louis - Chesterfield
DoubleTree by Hilton Hotel St. Louis - Chesterfield
8.6 out of 10, Excellent, (1049)
The price is AED 528
AED 612 total
includes taxes & fees
27 Apr - 28 Apr

DoubleTree by Hilton St. Louis - Westport
DoubleTree by Hilton St. Louis - Westport
8.2 out of 10, Very Good, (1033)
The price is AED 434
AED 503 total
includes taxes & fees
18 Apr - 19 Apr

The Inn at Elijah McLeans
The Inn at Elijah McLeans
9.0 out of 10, Wonderful, (107)
The price is AED 496
AED 565 total
includes taxes & fees
15 Apr - 16 Apr

Overlook Main St. in this 2 Bedroom Owners Suite!
Overlook Main St. in this 2 Bedroom Owners Suite!
9.8 out of 10, Exceptional, (23)

518: Wine Country Getaway by JZ Vacation Rentals
518: Wine Country Getaway by JZ Vacation Rentals
The price is AED 507
AED 1,208 total
includes taxes & fees
6 Apr - 7 Apr
Save an average of 15% on thousands of hotels when you're signed in
Learn more about Defiance
Trip time! Discover the wineries, parks, and history in Defiance.

Explore a world of travel with Expedia
Explore a world of travel with Expedia
Defiance Hotels by Star Rating
Stay near popular Defiance attractions
- Hotels near August A. Busch Memorial Conservation Area
- Hotels near Chandler Hill Vineyards
- Hotels near Historic Daniel Boone Home and Heritage Center
- Hotels near Sugar Creek Winery
- Hotels near Yellow Farmhouse Winery
- Hotels near Broemmelsiek Park
- Hotels near Six Flags St. Louis
- Hotels near Ameristar Casino St. Charles
- Hotels near Hollywood Casino Amphitheatre
- Hotels near Mississippi River
- Hotels near Westport Plaza
- Hotels near St Charles Convention Center
- Hotels near Hollywood Casino
- Hotels near Purina Farms
- Hotels near Magic House - St. Louis Children's Museum
- Hotels near Lindenwood University
- Hotels near Route 66 State Park
- Hotels near Missouri River
- Hotels near Family Arena
- Hotels near Historic Main Street
More Accommodation Types in Defiance
- Vacation Homes in Defiance
- Chalets in Defiance
- Apartments in Defiance
- Condo Rentals in Defiance
- Cottages in Defiance
- Cabin Rentals in Defiance
- B&B in Defiance
- Motels in Defiance
- Villas in Defiance
- Aparthotels in Defiance
- Guest Houses in Defiance
- Hostels in Defiance
- Inns in Defiance
- Lodges in Defiance
Explore more hotels
- Drury Plaza Hotel St. Louis St. Charles
- Best Western Plus St. Louis West-Westport
- Crowne Plaza St. Louis Airport by IHG
- Drury Plaza Hotel St. Louis Chesterfield
- Holiday Inn St. Louis - Creve Coeur by IHG
- Embassy Suites by Hilton St. Louis St. Charles
- Courtyard by Marriott St Louis Westport Plaza
- Holiday Inn St. Louis West Six Flags by IHG
- Hampton Inn St. Charles St. Peters
- Sleep Inn & Suites O'Fallon MO - Technology Drive
- Country Inn & Suites by Radisson, St. Charles Historic District
- Holiday Inn Express St. Louis West - O'Fallon by IHG
- Holiday Inn Express & Suites St. Louis - Chesterfield by IHG
- Hilton St. Louis Frontenac
- DoubleTree by Hilton Hotel St. Louis - Chesterfield
- Courtyard by Marriott St Louis Creve Coeur
- Drury Inn & Suites Southwest St. Louis
- Relax Inn Saint Charles
- Comfort Suites St Charles - St Louis
- Comfort Inn St Louis – Airport