Find 4 Star Hotels in Defiance, MO from AED 465
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Compare Defiance 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Ameristar Casino Resort and Spa
Ameristar Casino Resort and Spa
8.4 out of 10, Very Good, (1004)
The price is AED 621
AED 787 total
includes taxes & fees
30 Apr - 1 May

Hilton St. Louis Frontenac
Hilton St. Louis Frontenac
8.8 out of 10, Excellent, (1005)
The price is AED 550
AED 641 total
includes taxes & fees
4 May - 5 May

DoubleTree by Hilton Hotel St. Louis - Chesterfield
DoubleTree by Hilton Hotel St. Louis - Chesterfield
8.6 out of 10, Excellent, (1000)
The price is AED 514
AED 597 total
includes taxes & fees
27 Apr - 28 Apr

DoubleTree by Hilton St. Louis - Westport
DoubleTree by Hilton St. Louis - Westport
8.2 out of 10, Very Good, (1002)
The price is AED 465
AED 540 total
includes taxes & fees
1 May - 2 May

The Inn at Elijah McLeans
The Inn at Elijah McLeans
9.2 out of 10, Wonderful, (109)
The price is AED 496
AED 565 total
includes taxes & fees
7 May - 8 May

Overlook Main St. in this 2 Bedroom Owners Suite!
Overlook Main St. in this 2 Bedroom Owners Suite!
9.8 out of 10, Exceptional, (24)

518: Wine Country Getaway by JZ Vacation Rentals
518: Wine Country Getaway by JZ Vacation Rentals
8.0 out of 10, Very Good, (1)
The price is AED 603
AED 1,311 total
includes taxes & fees
6 May - 7 May
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Trip time! Discover the wineries, parks, and history in Defiance.

Recent reviews of Defiance hotels
Recent reviews of Defiance hotels

Hilton St. Louis Frontenac
5/5 Excellent
"Great location with easy access to downtown St. Louis and local medical facilities. Parking is very convenient, and the staff is nice and courteous. However, the hotel rooms are somewhat run down and need a significant facelift."
A verified traveler stayed at Hilton St. Louis Frontenac
Posted 2 weeks ago
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Defiance Hotels by Star Rating
Stay near popular Defiance attractions
- Hotels near Historic Daniel Boone Home and Heritage Center
- Hotels near Chandler Hill Vineyards
- Hotels near August A. Busch Memorial Conservation Area
- Hotels near Sugar Creek Winery
- Hotels near Broemmelsiek Park
- Hotels near Yellow Farmhouse Winery
- Hotels near Six Flags St. Louis
- Hotels near Hollywood Casino Amphitheatre
- Hotels near Ameristar Casino St. Charles
- Hotels near Mississippi River
- Hotels near Westport Plaza
- Hotels near Magic House - St. Louis Children's Museum
- Hotels near St Charles Convention Center
- Hotels near Route 66 State Park
- Hotels near Purina Farms
- Hotels near Missouri River
- Hotels near Hollywood Casino
- Hotels near Historic Main Street
- Hotels near Lindenwood University
- Hotels near Family Arena
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Explore more hotels
- Hilton St. Louis Frontenac
- Drury Plaza Hotel St. Louis Chesterfield
- Baymont by Wyndham St. Charles
- Best Western Plus St. Louis West-Westport
- Holiday Inn St. Louis - Creve Coeur by IHG
- Hampton Inn St. Charles St. Peters
- Courtyard by Marriott St Louis Westport Plaza
- Embassy Suites by Hilton St. Louis St. Charles
- Drury Inn & Suites Southwest St. Louis
- Holiday Inn St. Louis West Six Flags by IHG
- Days Inn and Suites by Wyndham St. Louis/Westport Plaza
- Relax Inn Saint Charles
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- Sleep Inn & Suites O'Fallon MO - Technology Drive
- Country Inn & Suites by Radisson, St. Charles Historic District
- Country Inn & Suites by Radisson, St. Peters, MO
- Holiday Inn Express & Suites St. Louis - Chesterfield by IHG
- Comfort Suites St Charles - St Louis
- Holiday Inn Express St. Louis West - O'Fallon by IHG