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Check prices for these dates

Next weekend
9 May - 11 May
In two weeks
16 May - 18 May
In one month
30 May - 1 Jun
In two months
27 Jun - 29 Jun

Compare 98 Apartments in Defiance with updated reviews, rates, and availability.

Prime Loft of Main Street
Smart TV

Prime Loft of Main Street

9.8 out of 10, Exceptional, (84)
"Fantastic place and location!"
The price is AED 474
AED 965 total
includes taxes & fees
5 May - 6 May
Prime Loft of Main Street
The Lofts of North Main Street
Dining

The Lofts of North Main Street

9.6 out of 10, Exceptional, (132)
"Great location for a visit to old at charles"
The price is AED 474
AED 965 total
includes taxes & fees
5 May - 6 May
The Lofts of North Main Street
Overlook Main St. in this 2 Bedroom Owners Suite!
Fridge, microwave, oven, stovetop

Overlook Main St. in this 2 Bedroom Owners Suite!

4.0 star property
9.8 out of 10, Exceptional, (24)
"Perfect place for a visit to St Charles! Hope to return and stay here again!"
Overlook Main St. in this 2 Bedroom Owners Suite!
The Wild West Getaway- 204-1
2 bedrooms, iron/ironing board, travel crib, WiFi

The Wild West Getaway- 204-1

7.8 out of 10, Good, (6)
"Just make sure you are fit and able to navigate steps. Great party place for the younger generation. The bar below has a nice back outside sitting area we were able to use. "
The Wild West Getaway- 204-1
Sunny SparkingClean King bed Apt- CreveCoeurPark
Smart TV, books, music library, computer monitors

Sunny SparkingClean King bed Apt- CreveCoeurPark

9.6 out of 10, Exceptional, (10)
"Good Stay"
The price is AED 353
AED 790 total
includes taxes & fees
21 May - 22 May
Sunny SparkingClean King bed Apt- CreveCoeurPark
Studio, sleeps 4, patio, short drive to Ski Resort, Six Flags & concert venues
Interior

Studio, sleeps 4, patio, short drive to Ski Resort, Six Flags & concert venues

2.0 star property
8.4 out of 10, Very Good, (9)
"Good location. 3 beds to accommodate our family. "
The price is AED 275
AED 533 total
includes taxes & fees
5 May - 6 May
Studio, sleeps 4, patio, short drive to Ski Resort, Six Flags & concert venues
Main Street Balcony Apartment by StayLage!
Interior

Main Street Balcony Apartment by StayLage!

9.4 out of 10, Exceptional, (30)
"Enjoyed staying here"
Main Street Balcony Apartment by StayLage!
Main Street Living! 2 Bedroom Unit right On Main!
Fridge, microwave, oven, stovetop

Main Street Living! 2 Bedroom Unit right On Main!

10.0 out of 10, Exceptional, (26)
"Apartment was great, very clean , comfortable beds, bathroom was a little on the small side . Awesome location "
The price is AED 595
AED 1,595 total
includes taxes & fees
19 May - 20 May
Main Street Living! 2 Bedroom Unit right On Main!
Swim, Fish, Hike, Horseback
Outdoor dining

Swim, Fish, Hike, Horseback

9.6 out of 10, Exceptional, (55)
"We rented the property to be in the area for the holiday. The house had plenty of sleeping spaces and linens. The kids were enjoyed seeing the horses on the property. "
Swim, Fish, Hike, Horseback
Cozy country setting 4 miles from route 66
Terrace/patio

Cozy country setting 4 miles from route 66

10.0 out of 10, Exceptional, (4)
"Really nice property! Country setting and nice big living area."
The price is AED 551
AED 876 total
includes taxes & fees
4 May - 5 May
Cozy country setting 4 miles from route 66
Stunning Modern Apartment with King Bed - 5 Mins to Creve Coeur Lake
Smart TV, books

Stunning Modern Apartment with King Bed - 5 Mins to Creve Coeur Lake

8.0 out of 10, Very Good, (1)
"Comfortable apartment for a short stay in St Louis. All you need for your stay. We appreciated the stocked coffee bar. "
Stunning Modern Apartment with King Bed - 5 Mins to Creve Coeur Lake
Wentzville One Bedroom Apartment by StayLage
TV

Wentzville One Bedroom Apartment by StayLage

9.8 out of 10, Exceptional, (7)
"The advertising was spot on. Much better to stay here than any hotel. Beautiful place, well maintained, easy check in and easy check out. Couldn't get any better!!"
The price is AED 413
AED 1,142 total
includes taxes & fees
6 May - 7 May
Wentzville One Bedroom Apartment by StayLage
Charming Duplex on Main
Fridge, microwave, stovetop, toaster

Charming Duplex on Main

10.0 out of 10, Exceptional, (11)
"Perfect location, very cute! Safe neighborhood"
The price is AED 456
AED 1,096 total
includes taxes & fees
19 May - 20 May
Charming Duplex on Main
Historic South Main Street Retreat – Cozy 1BR Duplex in the Heart of St. Charles
Fridge, microwave, oven, stovetop

Historic South Main Street Retreat – Cozy 1BR Duplex in the Heart of St. Charles

10.0 out of 10, Exceptional, (4)
"Good location, comfortable bed, new interior, well equipped. Very clean and organized!"
The price is AED 417
AED 1,035 total
includes taxes & fees
5 May - 6 May
Historic South Main Street Retreat – Cozy 1BR Duplex in the Heart of St. Charles
‘The Ruebling House’ Cozy Defiance Apartment!
Fridge, microwave, stovetop, dishwasher

‘The Ruebling House’ Cozy Defiance Apartment!

9.0 out of 10, Wonderful, (23)
"Loved our stay"
‘The Ruebling House’ Cozy Defiance Apartment!
1st Capitol Mansion - Suite 401
Private kitchen

1st Capitol Mansion - Suite 401

8.4 out of 10, Very Good, (7)
"Nice property and a great location to all the shops and restaurants that St. Charles has to offer. The place was clean and nicely updated. Will definitely stay here again!"
The price is AED 364
AED 921 total
includes taxes & fees
11 May - 12 May
1st Capitol Mansion - Suite 401
Studio on Historic Main by StayLage
1 bedroom, iron/ironing board, WiFi, bed sheets

Studio on Historic Main by StayLage

9.4 out of 10, Exceptional, (23)
"My wife and I stayed for her birthday weekend and had a great time. The property is located at the end of the strip so it was perfect to start the bar hoping. The apartment was very cozy and clean. Definitely recommend for the quick get a way!!"
The price is AED 357
AED 872 total
includes taxes & fees
19 May - 20 May
Studio on Historic Main by StayLage
Amazing Renovated Historic Loft on Main Street
Fridge, microwave, oven, stovetop

Amazing Renovated Historic Loft on Main Street

10.0 out of 10, Exceptional, (51)
"Great place to stay and fantastic host"
The price is AED 474
AED 965 total
includes taxes & fees
5 May - 6 May
Amazing Renovated Historic Loft on Main Street
Remodeled Kirkwood Guest house
Exterior

Remodeled Kirkwood Guest house

10.0 out of 10, Exceptional, (71)
"Really nice place. Private, clean, and comfortable. "
Remodeled Kirkwood Guest house
Private Basement Retreat w/ HOT TUB by StayLage
TV

Private Basement Retreat w/ HOT TUB by StayLage

8.4 out of 10, Very Good, (5)
"It is absolutely beautiful. The room is huge it's super clean the hot tub was so nice the little back patio is stunning we spent our honeymoon here and 10 out of 10 recommend here "
The price is AED 341
AED 991 total
includes taxes & fees
6 May - 7 May
Private Basement Retreat w/ HOT TUB by StayLage
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Other property types in Defiance

St. Charles 1860's Gem - Sleeps 6!
Fridge, microwave, oven, stovetop

St. Charles 1860's Gem - Sleeps 6!

9.8 out of 10, Exceptional, (94)
"Our second year in a row and we love this place! It is perfect for a girls trip."
The price is AED 422
AED 885 total
includes taxes & fees
5 May - 6 May
St. Charles 1860's Gem - Sleeps 6!
Value Suites Extended Stay - St Louis
Studio Suite, 1 King Bed | Desk, laptop workspace, blackout drapes, WiFi

Value Suites Extended Stay - St Louis

3.0 star property
7.0 out of 10, Good, (1110)
"We’ve stayed here twice before and have always been pleased with everything. Very good hotel close to what we need."
The price is AED 313
AED 664 total
includes taxes & fees
16 May - 17 May
Value Suites Extended Stay - St Louis
1830's Luxury Brick Cottage, Cozy Fireplace, right off the Cobblestone Streets!
Outdoor dining

1830's Luxury Brick Cottage, Cozy Fireplace, right off the Cobblestone Streets!

10.0 out of 10, Exceptional, (200)
"This property is within easy walking distance to ALL of historic downtown St Charles. It's obvious the owners take great care in keeping The Guest House in perfect condition, with every possible amenity provided. Very comfortable stay. We'll absolutely be back!"
1830's Luxury Brick Cottage, Cozy Fireplace, right off the Cobblestone Streets!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What's it like to stay at an apartment in Defiance?
You’ll find 10 apartments to choose from in Defiance for your stay.
Why choose an apartment versus a traditional hotel?
Often more spacious than a traditional hotel room, an apartment includes a kitchen for convenient home-cooked meals. Apartments are ideal for families who want the conveniences of home, and also for couples who want something in a quieter part of town.
What's a favorite apartment for a stay in Defiance?
Here are some of the top apartments in the area: The Lofts of North Main Street: Located in St. Charles, 19.2 mi/30.8 km from the heart of Defiance. Includes free WiFi, sofa beds, and Smart TVs. Access to onsite laundry facilities is available on site. Studio, sleeps 4, patio, short drive to Ski Resort, Six Flags & concert venues: Located 14.1 mi/22.7 km away in Ballwin. Amenities include Smart TVs. Access to onsite laundry facilities is available on site. Overlook Main St. in this 2 Bedroom Owners Suite!: Located in St. Charles, 18.5 mi/29.7 km away. Includes private patios, sofa beds, and Smart TVs. Access to onsite laundry facilities is available on site. Prime Loft of Main Street: Located 19.2 mi/30.9 km away in St. Charles. Free WiFi, sofa beds, and Smart TVs are included. Access to onsite laundry facilities is available on site. 1st Capitol Mansion - Suite 401: It’s situated in St. Charles, 18.7 mi/30.1 km from Defiance.
How many apartments will I be able to find in Defiance?
Expedia has 10 apartments to book in Defiance.
What can I expect from the weather during my trip to Defiance?
Weather is only one factor, but it can really affect your travel plans, especially if you’re planning an extended stay in Defiance. The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 38°F. Average annual precipitation for Defiance is 48 inches.
What are the must-see places to visit in Defiance?
August A. Busch Memorial Conservation Area and Missouri River are a couple of scenic spots to enjoy the outdoors, whereas Historic Daniel Boone Home and Heritage Center is one of the cultural attractions. While here, Chandler Hill Vineyards and Sugar Creek Winery are other places worth a visit.
What's the best way to get to and around Defiance?
Knowing a bit about the transportation options can save you time when you get to your destination. Fly into St. Louis, MO (SUS-Spirit of St. Louis), which is located 7.5 mi (12 km) from the heart of the city. You can also search for flights into St. Louis Lambert Intl. Airport (STL), which is 23.5 mi (37.8 km) away. If you’d like to explore around the area, you may want a rental car for your journey.