Find 5 Star Hotels in Lake Nona Medical City, FL from AED 342

  • Plan, book, stay with confidence

  • bex rewards loyalty icon
    Be picky
    Search almost a million properties worldwide
    payments icon
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    today icon
    Change your mind
    Book hotels with free cancellation

Compare Lake Nona Medical City 5 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Waldorf Astoria Orlando - An Official Walt Disney World® Hotel

5.0 star property
9.2 out of 10, Wonderful, (175)
"The Waldorf Astoria Orlando was an absolutely wonderful property… The food… The pool… The hotel overall is just incredible! The staff is wonderful. The rooms are absolutely gorgeous and very spacious… And the Resturant Bull & Bear is really wonderful!! My family and I have stayed in this hotel multiple times and we are never disappointed… I absolutely recommend this property"
The price is AED 1,378
AED 1,757 total
includes taxes & fees
24 Jan - 25 January 2025
Waldorf Astoria Orlando - An Official Walt Disney World® Hotel

Four Seasons Resort Orlando at WALT DISNEY WORLD® Resort

5.0 star property
9.6 out of 10, Exceptional, (813)
"The best property we have stayed at within continental United States!"
The price is AED 3,655
AED 4,111 total
includes taxes & fees
5 Jan - 6 January 2025
Four Seasons Resort Orlando at WALT DISNEY WORLD® Resort

Conrad Orlando

5.0 star property
9.4 out of 10, Exceptional, (154)
"Great service, great rooms, clean- would highly recommend! "
The price is AED 1,513
AED 1,909 total
includes taxes & fees
7 Jan - 8 January 2025
Conrad Orlando

Reunion Resort & Golf Club

5.0 star property
8.6 out of 10, Excellent, (1194)
"Excellent Choice "
The price is AED 847
AED 1,135 total
includes taxes & fees
9 Jan - 10 January 2025
Reunion Resort & Golf Club

The Ritz-Carlton Orlando, Grande Lakes

5.0 star property
9.2 out of 10, Wonderful, (1001)
"I wish I could give more stars. Worth every penny for service and ambience. Lovely room, grounds, service, meals, people, everything!"
The price is AED 2,347
AED 2,859 total
includes taxes & fees
23 Jan - 24 January 2025
The Ritz-Carlton Orlando, Grande Lakes

ette hotel

5.0 star property
9.8 out of 10, Exceptional, (240)
"Great hotel "
The price is AED 1,650
AED 1,872 total
includes taxes & fees
1 Jan - 2 January 2025
ette hotel

Encore Resort at Reunion

5.0 star property
8.4 out of 10, Very Good, (901)
"I loved it, we end up extending our stay. "
Encore Resort at Reunion

Splendid 5Bd Close to Disney at Storey Lake 4251

5.0 star property
9.2 out of 10, Wonderful, (5)
"Everything from the house to the property was amazing!!! the only downside is entering the property. cars were backed up for at least half a mile and it took a long time to get in every time we returned from an outing. My husband had an argument with the security guard because his pass was not scanning so he was told he could not come in. They really need to come up with a better check in system."
Splendid 5Bd Close to Disney at Storey Lake 4251

Family Friendly Four Bedroom w GameRoom @Disney 5145

5.0 star property
8.6 out of 10, Excellent, (4)
"Well if you don’t mind the roof being ripped off and putting a new one on, banging at 7:30 AM waking you up in a panic for 1/2 of your trip, having the master bedroom bd frame broken and in the closet and mattress on the floor, mold in bathrooms, filthy stained rugs & caution/danger tape wrapped across the front entrance and back patio then you will like the place, also not enough dishes glasses etc for ten people as promised, also “the game room” broken dart board and no air hockey! The people...
Family Friendly Four Bedroom w GameRoom @Disney 5145

5 Bedroom Single Family @ Storey Lake Resort Close to Disney 4759

5.0 star property
10.0 out of 10, Exceptional, (1)
5 Bedroom Single Family @ Storey Lake Resort Close to Disney 4759

Gorgeous 4 Bedroom w/ Pool Close to Disney 4836

5.0 star property
9.2 out of 10, Wonderful, (7)
"Everything was great, They stayed in constant communication with me but I never needed anything. The only problem was the walls were pretty dirty and damaged needed to be painted orher than that all was great for our girls weekend. I would stay again."
Gorgeous 4 Bedroom w/ Pool Close to Disney 4836

Gorgeous 4Bd with Pool @ Storey Lake Resort 4475

5.0 star property
9.0 out of 10, Wonderful, (2)
Gorgeous 4Bd with Pool @ Storey Lake Resort 4475

Luxurious 2 Bd Close to Disney @ Storey Lake 204 3131

5.0 star property
10.0 out of 10, Exceptional, (1)
"La propiedad es muy linda y cómoda , ideal para disfrutar en familia . La habitación de los niños hermosa decorada con Toy Story , a mis niños les encantó "
Luxurious 2 Bd Close to Disney @ Storey Lake 204 3131

Free Resort Access 4 Bedroom Near Disney with Themed Rooms

5.0 star property
9.2 out of 10, Wonderful, (31)
"Perfect location for 192, All Disney and Universal. 20 mins max. Pool fab, local restaurants and services perfect. Easy slept 2 families. Good facilities throughout the Villa. "
Free Resort Access 4 Bedroom Near Disney with Themed Rooms

Family Vacation Home, Water Park+Endless Amenities

5.0 star property
8.8 out of 10, Excellent, (17)
"Awesome staff, super helpful. And the resort was amazing"
Family Vacation Home, Water Park+Endless Amenities

Luxury 8Bd with Pool @ Sonoma Resort 2639

5.0 star property
2.0 out of 10, (1)
"The property had 8 bedrooms, only 2 were king size. All the beds are so low to the ground. The refrigerator was broken. The coffee table was broken. They charge a massive deposit. Then they send you an email after check out that they deducted money from your deposit and say that you have things damaged. I called the first day to tell them the defects and no one response. I wonder never recommend this place. "
Luxury 8Bd with Pool @ Sonoma Resort 2639

The Ritz-Carlton Residences Orlando, Grande Lakes

5.0 star property
The Ritz-Carlton Residences Orlando, Grande Lakes

Gorgeous 2Bd Apto Close to Disney @ Storey Lake 404 3191

5.0 star property
Gorgeous 2Bd Apto Close to Disney @ Storey Lake 404 3191

Marvelous 4Bd with Pool at Storey Lake Resort 2601

5.0 star property
10.0 out of 10, Exceptional, (2)
Marvelous 4Bd with Pool at Storey Lake Resort 2601

Gorgeous Two Bedroom Apt Close to Disney 306 4721 @Storey Lake Resort

5.0 star property
8.4 out of 10, Very Good, (9)
"The beds were comfortable. The condo was large. It also had TVs in every room with music playing when we arrived which was nice. They also supplied the first trash bags and soap and conditioner and shampoo. You would need to get started if you're staying for a week."
Gorgeous Two Bedroom Apt Close to Disney 306 4721 @Storey Lake Resort
Save an average of 15% on thousands of hotels when you're signed in

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Lake Nona Medical City.
Still don't see what you're looking for?
See all properties in Lake Nona Medical City.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Lake Nona Medical City?
There are a range of pricing options for 5-star hotels in Lake Nona Medical City on Expedia. The amount you pay will depend on when you plan to travel, trip length and other factors. Compare all of the available accommodations for your chosen dates and make use of our pricing and other filters to lock in the ideal high-end stay.

  • Search for the lowest price per night from AED 342

What makes a hotel 5 stars in Lake Nona Medical City?
From high-end dining venues and all-day fitness centers to swimming pools and luxury bedding, the 5-star experience in Lake Nona Medical City is all about indulgence and comfort. But it calls for more than just upscale conveniences to get a 5-star rating. Stays also have to deliver superior guest-focused services like in-room massage treatments, laundry and dry cleaning and 24-hour room service.
Are there any 5-star all-inclusive resorts in Lake Nona Medical City?
Expedia’s filter tool is the quickest way to narrow down what you want. Select “All inclusive” and “5-star” to see the most upscale resorts in Lake Nona Medical City where your room, meals, activities and entertainment are included in the upfront price. At these getaways, your vacation is pure leisure from the moment you put down your suitcase.
Are there any 5-star vacation rentals in Lake Nona Medical City?
Our site doesn’t offer any 5-star vacation rentals in Lake Nona Medical City. However, you can still find some top-rated escapes where the only item on your agenda will be to kick back and enjoy yourself. Discover what’s available by searching through our vacation rentals in Lake Nona Medical City.