Find 5 Star Hotels in Lake Nona Medical City, FL from AED 340

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Check availability on Lake Nona Medical City 5 Star Hotels

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Compare Lake Nona Medical City 5 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Waldorf Astoria Orlando - An Official Walt Disney World® Hotel

5.0 star property
9.2 out of 10, Wonderful, (231)
"The rooms are very large and very clean. It was a very nice hotel."
The price is AED 1,412
AED 1,795 total
includes taxes & fees
6 Apr - 7 Apr
Waldorf Astoria Orlando - An Official Walt Disney World® Hotel

Conrad Orlando

5.0 star property
9.4 out of 10, Exceptional, (185)
"Everything was great from beginning to end . Amazing staff and service . Will be returning "
The price is AED 2,340
AED 2,816 total
includes taxes & fees
21 Apr - 22 Apr
Conrad Orlando

Four Seasons Resort Orlando at WALT DISNEY WORLD® Resort

5.0 star property
9.6 out of 10, Exceptional, (833)
"Great stay highly recommended "
The price is AED 4,389
AED 4,938 total
includes taxes & fees
27 Apr - 28 Apr
Four Seasons Resort Orlando at WALT DISNEY WORLD® Resort

Reunion Resort & Golf Club

5.0 star property
8.6 out of 10, Excellent, (1240)
"Beautiful place and location well kept and very clean. The location is perfect for getting away from it all and just relaxing. "
The price is AED 769
AED 1,047 total
includes taxes & fees
21 Apr - 22 Apr
Reunion Resort & Golf Club

The Ritz-Carlton Orlando, Grande Lakes

5.0 star property
9.2 out of 10, Wonderful, (1041)
"Streaming Prime Video didn’t work and we couldn’t cast to the TV. Do better. "
The price is AED 2,935
AED 3,529 total
includes taxes & fees
25 Apr - 26 Apr
The Ritz-Carlton Orlando, Grande Lakes

ette hotel

5.0 star property
9.8 out of 10, Exceptional, (279)
"Nice, clean boutique hotel. Close enough to theme park activities, but a great place to quietly relax and recuperate after a day of fun in the sun!! "
The price is AED 1,322
AED 1,501 total
includes taxes & fees
3 Apr - 4 Apr
ette hotel

Encore Resort and Water Park At Reunion by Rentyl

5.0 star property
8.4 out of 10, Very Good, (944)
"Me encantó todo desde el servicio la casa el resort el parque de agua y el staff muy atento siempre ayudarte sin duda volvería muchas veces más aquí "
Encore Resort and Water Park At Reunion by Rentyl

Splendid 5Bd Close to Disney at Storey Lake 4251

5.0 star property
9.6 out of 10, Exceptional, (9)
" Very beautiful and clean property. "
Splendid 5Bd Close to Disney at Storey Lake 4251

Margarita Porch Paradise

5.0 star property
10.0 out of 10, Exceptional, (2)
"The house was beautiful and comfortable for our family, we would have stayed longer! The resort is fun, plenty of stores and good restaurants. We will definitely come back. "
Margarita Porch Paradise

Amazing 4Bd Screened Pool Close to Disney 4572

5.0 star property
8.0 out of 10, Very Good, (1)
"It was a great location to go to Disney and other places. Some of the tv's did not work properly, had to change to English setting on main tv, no remote for the one bedroom upstairs, and the downstairs bedroom tv did nor work properly. Microwave light did not work. Had to connect the upstairs bathroom it was disconnected had to reconnect it. Not enough comfortable seating should have another small love seat in the living room. Overall it was a nice place."
Amazing 4Bd Screened Pool Close to Disney 4572

Family Vacation Home, Water Park+Endless Amenities

5.0 star property
8.8 out of 10, Excellent, (17)
"Awesome staff, super helpful. And the resort was amazing"
Family Vacation Home, Water Park+Endless Amenities

7 Bedroom Villa, Private Pool, Resort Amenities

5.0 star property
9.0 out of 10, Wonderful, (11)
"The house was beautiful. Most of the upstairs televisions did not work but overall it was great would recommend it to friends and family "
7 Bedroom Villa, Private Pool, Resort Amenities

Reunion Resort & Golf Club

5.0 star property
8.8 out of 10, Excellent, (12)
"Very clean. Wondering why parental controls were on cable tv channels."
Reunion Resort & Golf Club

Gorgeous 2Bd Apto Close to Disney @ Storey Lake 404 3191

5.0 star property
10.0 out of 10, Exceptional, (1)
Gorgeous 2Bd Apto Close to Disney @ Storey Lake 404 3191

Marvelous 4Bd with Pool at Storey Lake Resort 2601

5.0 star property
10.0 out of 10, Exceptional, (2)
Marvelous 4Bd with Pool at Storey Lake Resort 2601

Gorgeous Two Bedroom Apt Close to Disney 306 4721 @Storey Lake Resort

5.0 star property
8.4 out of 10, Very Good, (10)
"The complex was nice and very nice clean rooms, the water park was nice and huge. Definitely would visit again "
Gorgeous Two Bedroom Apt Close to Disney 306 4721 @Storey Lake Resort

Gorgeous 4 Bd w/ Pool @ Storey Lake Resort 2653

5.0 star property
10.0 out of 10, Exceptional, (1)
"Everything was excellent. I like the property was really cozy and nice. The only thing I didn’t like was that more concerned about when you leaving?"
Gorgeous 4 Bd w/ Pool @ Storey Lake Resort 2653

Gorgeous 4Bd with Pool @ Storey Lake Resort 4475

5.0 star property
8.8 out of 10, Excellent, (3)
Gorgeous 4Bd with Pool @ Storey Lake Resort 4475

Luxurious 5Bd Single Family w Pool&Jacuzzi @Encore Resort 7432

5.0 star property
10.0 out of 10, Exceptional, (1)
"I recommend this property to anyone wanting to have a family trip and enjoy themselves this place is beautiful and my kids loved everything about this location. We will be staying again."
Luxurious 5Bd Single Family w Pool&Jacuzzi @Encore Resort 7432

The Ritz-Carlton Residences Orlando, Grande Lakes

5.0 star property
The Ritz-Carlton Residences Orlando, Grande Lakes
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Lake Nona Medical City?
There are a range of pricing options for 5-star hotels in Lake Nona Medical City on Expedia. The amount you pay will depend on when you plan to travel, trip length and other factors. Compare all of the available accommodations for your chosen dates and make use of our pricing and other filters to lock in the ideal high-end stay.

  • Search for the lowest price per night from AED 340

What makes a hotel 5 stars in Lake Nona Medical City?
From high-end dining venues and all-day fitness centers to swimming pools and luxury bedding, the 5-star experience in Lake Nona Medical City is all about indulgence and comfort. But it calls for more than just upscale conveniences to get a 5-star rating. Stays also have to deliver superior guest-focused services like in-room massage treatments, laundry and dry cleaning and 24-hour room service.
Are there any 5-star all-inclusive resorts in Lake Nona Medical City?
Expedia’s filter tool is the quickest way to narrow down what you want. Select “All inclusive” and “5-star” to see the most upscale resorts in Lake Nona Medical City where your room, meals, activities and entertainment are included in the upfront price. At these getaways, your vacation is pure leisure from the moment you put down your suitcase.
Are there any 5-star vacation rentals in Lake Nona Medical City?
Our site doesn’t offer any 5-star vacation rentals in Lake Nona Medical City. However, you can still find some top-rated escapes where the only item on your agenda will be to kick back and enjoy yourself. Discover what’s available by searching through our vacation rentals in Lake Nona Medical City.