Find Resorts & Hotels with Spas in Mission District, CA

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Pick from 23 Mission District Resorts & Hotels with Spas and compare room rates, reviews, and availability. Most hotels are fully refundable.

Inn San Francisco
2.5 star property
9.6 out of 10, Exceptional, (502)
"All the staff and owner were very friendly and accommodating. The BnB was beautiful with lovely gardens. The breakfast had a large variety of fruits, pastries and quiche."
The price is AED 810
AED 920 total
includes taxes & fees
24 Nov - 25 Nov
Inn San Francisco
Noe's Nest Bed and Breakfast
3.5 star property
9.4 out of 10, Exceptional, (97)
"Lovely home and wonderful hospitality. Breakfast was delicious!!"
The price is AED 826
AED 961 total
includes taxes & fees
24 Nov - 25 Nov
Noe's Nest Bed and Breakfast
Union Hotel
2.0 star property
7.0 out of 10, Good, (251)
"The Hotel was clean, staff and Service was nice. The Hotel lays in an proberty with a lot of homeless people around. We hat a good and Safe stay. Perfect for a cheap stay. "
The price is AED 198
AED 231 total
includes taxes & fees
24 Nov - 25 Nov
Union Hotel
Parker Guest House San Francisco
3.5 star property
9.4 out of 10, Exceptional, (392)
"I stayed me night but I truly loved the atmosphere, the comfy room, and the beautiful garden. I’ll be back!"
The price is AED 731
AED 852 total
includes taxes & fees
2 Dec - 3 Dec
Parker Guest House San Francisco
Charming 1 bed 1bath - 1 block to Dolores Park
Charming 1 bed 1bath - 1 block to Dolores Park
Quiet One Bedroom Suite in The Mission near Castro
10.0 out of 10, Exceptional, (2)
"This was so convenient. A block and a half from our daughter, 3 blocks from BART. The place was very clean and well appointed. I knew it was a basement unit, but at first was surprised when entering through the garage and almost no natural light. We were using it primarily as a place to sleep so that wasn't an issue. Didn't use the advertised outdoor space--it wasn't great. However, for a clean, quiet, convenient place to stay, I recommend this. We will return."
The price is AED 643
AED 1,247 total
includes taxes & fees
3 Dec - 4 Dec
Quiet One Bedroom Suite in The Mission near Castro
Cute 1 bed 1 bath Apt in Sunny and Hip Mission District
9.4 out of 10, Exceptional, (16)
"I stayed at Brian’s place in the Mission for nine weeks and it was perfect. There are lots of great restaurants and shops on Valencia. Easy and safe to talk to and from the train that’s just a few blocks away. The property itself is fairly spacious, well equipped, and very clean. Brian was very prompt in his responses to any inquiry I had. At one point there was an issue with the dryer and he had someone out to fix it the very next day. I would definitely stay here again in the future!"
Cute 1 bed 1 bath Apt in Sunny and Hip Mission District
Amazing Roof Deck in the Mission! Walk to Tartine Manufacture
9.6 out of 10, Exceptional, (15)
"Lots of room to entertain. The apartment furnishing need a little help. Kitchen was well stocked with cookware etc. We used the upper deck a lot but cushions were lacking. Plants and planters were in disrepair. However we would love to stay here again. The sunny Mission was true to its name. We walked everywhere with no problem. Didn’t walk past 17th, 16th st etc.on purpose. Having lived in SF in the 70’s it’s not the same city, homeless everywhere, garbage etc all over the streets and...
Amazing Roof Deck in the Mission! Walk to Tartine Manufacture
Explore the City from the Beautiful, Victorian Liberty Hill
Explore the City from the Beautiful, Victorian Liberty Hill
Best Mission Location - 100 Walk Score
Best Mission Location - 100 Walk Score
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Looking to vacation at a spa hotel in Mission District?
Book one of our wonderful spa hotels and treat yourself from the moment you arrive. Check out the art galleries and bars in Mission District—your day trip starts here. Be sure to pay a visit to the museums during your stay. Spa hotels are the perfect way to break away from your routine and add a layer of luxury to your vacation.
How many spa hotels are there in Mission District?
Among Expedia’s 95 accommodation options in Mission District, there are 2 spa hotels.
What's there to see and do in Mission District?
Experience Mission District with a stop at Mission Dolores Park, Mission San Francisco de Asís, and Incline Gallery. If you have a little extra time during your trip, you might want to make a stop at Southern Exposure and Victoria Theatre.
What is a Mission District spa hotel?
Spa hotels in Mission District provide lodging and have an on-site spa which offers services such as massages as well as beauty treatments. Some also offer in-room treatments. Spa hotels are a must if you want to give yourself an extra treat while on vacation.