Luxury Hotels in Panama from AED 400
- Plan, book, stay with confidence
Be picky
Search almost a million properties worldwide
Change your mind
Book hotels with free cancellation
Check availability on Panama Luxury Hotels
Pick from 67 Panama Luxury Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

JW Marriott Panama
JW Marriott Panama
8.8 out of 10, Excellent, (1002)
The price is AED 1,172
AED 1,289 total
includes taxes & fees
1 Mar - 2 Mar

Bristol Panama, a Registry Collection Hotel
Bristol Panama, a Registry Collection Hotel
9.2 out of 10, Wonderful, (1002)
The price is AED 611
AED 672 total
includes taxes & fees
1 Mar - 2 Mar

Waldorf Astoria Panama
Waldorf Astoria Panama
9.0 out of 10, Wonderful, (1002)
The price is AED 998
AED 1,098 total
includes taxes & fees
1 Mar - 2 Mar

American Trade Hotel
American Trade Hotel
9.4 out of 10, Exceptional, (476)
The price is AED 1,117
AED 1,228 total
includes taxes & fees
4 Mar - 5 Mar

Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
8.8 out of 10, Excellent, (913)
The price is AED 621
AED 683 total
includes taxes & fees
2 Mar - 3 Mar

Hilton Panama
Hilton Panama
8.8 out of 10, Excellent, (1002)
The price is AED 791
AED 870 total
includes taxes & fees
1 Mar - 2 Mar

The Buenaventura Golf & Beach Resort Panama, Autograph Collection
The Buenaventura Golf & Beach Resort Panama, Autograph Collection
9.2 out of 10, Wonderful, (607)
The price is AED 889
AED 978 total
includes taxes & fees
26 Feb - 27 Feb

Las Americas Golden Tower Panama
Las Americas Golden Tower Panama
8.8 out of 10, Excellent, (1001)
The price is AED 459
AED 505 total
includes taxes & fees
2 Mar - 3 Mar
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Recent reviews of Panama hotels
Recent reviews of Panama hotels

Hilton Panama
5/5 Excellent
"The hotel was very nice, clean and luxurious.
There were Christmas celebrations going on at ground level and we heard nothing from our room.
Beautiful hotel. "
A verified traveler from Sherwood Park stayed at Hilton Panama
Posted 6 hours ago
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Top destinations for Luxury Hotels in Panama
More Hotel Options in Panama
- Hotels with WiFi in Panama
- Hotels with Free Parking in Panama
- Family Hotels in Panama
- Hotels with Bars in Panama
- Beach Hotels in Panama
- Hotels with a Pool in Panama
- Adventure Hotels in Panama
- Business Hotels in Panama
- Shopping Hotels in Panama
- Hotel with a Concierge in Panama
- Hotels with smoking rooms in Panama
- Historic Hotels in Panama
- Casinos in Panama
- Resorts & Hotels with Spas in Panama
- Pet-friendly Hotels in Panama
- Hotel Wedding Venues in Panama
- Cheap Hotels in Panama
- Romantic Hotels in Panama
- Hotels with Hot Tubs in Panama
- Golf Hotels in Panama
More Themes
- All-inclusive Hotel
- Hotels with Bars
- Beach Hotels
- Boutique Hotels
- Cheap Hotels
- Business Hotels
- Casinos
- Hotel with a Concierge
- Family Hotels
- Hotels with Free Parking
- Golf Hotels
- Historic Hotels
- Hotels with Hot Tubs
- Hotels with an Indoor Pool
- Apartment Hotel
- Hotels with a Lazy River
- Pet-friendly Hotels
- Hotels with a Pool
- Adventure Hotels
- Romantic Hotels
- Shopping Hotels
- Ski Hotels
- Hotels with smoking rooms
- Resorts & Hotels with Spas
- Green Hotels
- Waterpark Hotels
- Hotels with Waterslides
- Hotel Wedding Venues
- Hotels with WiFi
- Winery Hotels