Find Resorts & Hotels with Spas in Clayton, MO

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Check availability on Clayton Resorts & Hotels with Spas

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Compare Clayton Resorts & Hotels with Spas room rates, reviews, and availability. Most hotels are fully refundable.

Hampton Inn & Suites Clayton/St. Louis-Galleria Area

3.0 star property
9.0 out of 10, Wonderful, (828)
"It was a great hotel! Will stay there again!"
The price is AED 491
AED 576 total
includes taxes & fees
27 Apr - 28 Apr
Hampton Inn & Suites Clayton/St. Louis-Galleria Area

The Ritz-Carlton, St. Louis

5.0 star property
9.2 out of 10, Wonderful, (526)
"good"
The price is AED 2,127
AED 2,477 total
includes taxes & fees
5 Apr - 6 Apr
The Ritz-Carlton, St. Louis

Le Méridien St. Louis Clayton

4.0 star property
8.8 out of 10, Excellent, (581)
"We had a great stay at Le Meridien! The kids were comfy. We loved the beds. It was clean and up-to-date. "
The price is AED 584
AED 686 total
includes taxes & fees
30 Mar - 31 Mar
Le Méridien St. Louis Clayton

Clayton Plaza Hotel & Extended Stay

3.5 star property
9.0 out of 10, Wonderful, (3046)
"Old hotel with newly updated rooms,people are friendly, service was good."
The price is AED 331
AED 386 total
includes taxes & fees
13 Apr - 14 Apr
Clayton Plaza Hotel & Extended Stay

Seven Gables, St. Louis West, a Tribute Portfolio Hotel

3.5 star property
8.4 out of 10, Very Good, (556)
"I had a very pleasant stay at the Seven Gables Inn. The room was big (213) and clean. Huge marble bath and heated toilet. Some of the hotel needs a paint job or renovation but the room was great. People friendly and made an extra effort. My colleague stayed in a different room half the size and was not happy so now I understand the mixed reviews on the site. Ask for room 213 or equivalent. "
The price is AED 481
AED 571 total
includes taxes & fees
30 Mar - 31 Mar
Seven Gables, St. Louis West, a Tribute Portfolio Hotel

Residence Inn By Marriott St. Louis Clayton

3.0 star property
9.2 out of 10, Wonderful, (149)
"Very large rooms….Good breakfast…."
The price is AED 606
AED 749 total
includes taxes & fees
20 Apr - 21 Apr
Residence Inn By Marriott St. Louis Clayton

King Bed, Comfy Environment, Cozy Space, Corporate Luxury

9.4 out of 10, Exceptional, (3)
"We thoroughly enjoyed our stay. The rooftop views are tremendous!"
King Bed, Comfy Environment, Cozy Space, Corporate Luxury
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Looking for a spa hotel in Clayton?
Book one of our lush spa hotels and pamper yourself from the moment you arrive. Travelers highly recommend the restaurants in Clayton. Be sure to pay a visit to the museums during your stay. Hotels with spas are the perfect way to break away from your daily routine and add a layer of luxury to your vacation.
How many spa hotels will I find in Clayton?
Among Expedia’s 10 accommodation options in Clayton, there are 3 spa hotels.
What's there to see and do in Clayton?
Enjoy all that Clayton has to offer when you visit Chapel of St. Timothy And St. Titus, Concordia Seminary, St. Louis Zoo, and St. Louis Union Station. If you have some spare time during your trip, you might want to check out Busch Stadium and Gateway Arch.
What is a Clayton spa hotel?
Spa hotels in Clayton provide lodging and have an on-site spa offering services including therapies as well as beauty treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation, and relaxation.