Find Resorts & Hotels with Spas in Clayton, MO

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Pick from 6 Clayton Resorts & Hotels with Spas and compare room rates, reviews, and availability. Most hotels are fully refundable.

Hampton Inn & Suites Clayton/St. Louis-Galleria Area
Exterior
Hampton Inn & Suites Clayton/St. Louis-Galleria Area
3.0 star property
9.0 out of 10, Wonderful, (786)
"Very helpful and friendly staff. Best continental breakfast. "
The price is AED 465
AED 537 total
includes taxes & fees
5 Dec - 6 Dec
Hampton Inn & Suites Clayton/St. Louis-Galleria Area
The Ritz-Carlton, St. Louis
Banquet hall
The Ritz-Carlton, St. Louis
5.0 star property
9.2 out of 10, Wonderful, (519)
"Staff was not as willing to help as I would’ve expected based on my past experiences at other Ritz Carlton’s."
The price is AED 1,980
AED 2,306 total
includes taxes & fees
22 Dec - 23 Dec
The Ritz-Carlton, St. Louis
Le Méridien St. Louis Clayton
Room
Le Méridien St. Louis Clayton
4.0 star property
8.8 out of 10, Excellent, (539)
"very friendly very classy and a pop of color easy parking and amazing shower pressure "
The price is AED 555
AED 636 total
includes taxes & fees
24 Nov - 25 Nov
Le Méridien St. Louis Clayton
Clayton Plaza Hotel & Extended Stay
Exterior
Clayton Plaza Hotel & Extended Stay
3.5 star property
9.0 out of 10, Wonderful, (2902)
"It was overall a pleasant experience."
The price is AED 366
AED 415 total
includes taxes & fees
15 Dec - 16 Dec
Clayton Plaza Hotel & Extended Stay
Seven Gables, St. Louis West, a Tribute Portfolio Hotel
Property entrance
Seven Gables, St. Louis West, a Tribute Portfolio Hotel
3.5 star property
8.4 out of 10, Very Good, (551)
"The staff was terrific. "
The price is AED 529
AED 616 total
includes taxes & fees
8 Dec - 9 Dec
Seven Gables, St. Louis West, a Tribute Portfolio Hotel
Residence Inn By Marriott St. Louis Clayton
Exterior
Residence Inn By Marriott St. Louis Clayton
3.0 star property
9.2 out of 10, Wonderful, (128)
"It was nice and clean Continental breakfast was hot and good And the service was great"
The price is AED 591
AED 718 total
includes taxes & fees
6 Dec - 7 Dec
Residence Inn By Marriott St. Louis Clayton
King Bed, Comfy Environment, Cozy Space, Corporate Luxury
Living room of apartment offers comfort & a sleeper sofa.
King Bed, Comfy Environment, Cozy Space, Corporate Luxury
9.4 out of 10, Exceptional, (3)
"We thoroughly enjoyed our stay. The rooftop views are tremendous!"
King Bed, Comfy Environment, Cozy Space, Corporate Luxury
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Looking for a spa hotel in Clayton?
Book one of our lush spa hotels and pamper yourself from the moment you arrive. Travelers highly recommend the restaurants in Clayton. Be sure to pay a visit to the museums during your stay. Hotels with spas are the perfect way to break away from your daily routine and add a layer of luxury to your vacation.
How many spa hotels will I find in Clayton?
Among Expedia’s 10 accommodation options in Clayton, there are 3 spa hotels.
What's there to see and do in Clayton?
Enjoy all that Clayton has to offer when you visit Chapel of St. Timothy And St. Titus, Concordia Seminary, St. Louis Union Station, and Enterprise Center. If you have some spare time during your trip, you might want to check out Saint Louis Galleria Mall and The Loop.
What is a Clayton spa hotel?
Spa hotels in Clayton provide lodging and have an on-site spa offering services including therapies as well as beauty treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation, and relaxation.