Find 5 Star Hotels in Clayton, MO

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Check availability on Clayton 5 Star Hotels

Tonight
4 Mar - 5 Mar
Tomorrow
5 Mar - 6 Mar
This weekend
7 Mar - 9 Mar
Next weekend
14 Mar - 16 Mar

Compare Clayton 5 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Four Seasons Hotel St Louis
Rooftop bar

Four Seasons Hotel St Louis

5.0 star property
9.4 out of 10, Exceptional, (987)
"Hotel is beautiful, staff was great! "
The price is AED 1,451
AED 1,696 total
includes taxes & fees
5 Mar - 6 Mar
Four Seasons Hotel St Louis
The Ritz-Carlton, St. Louis
Meeting facility

The Ritz-Carlton, St. Louis

5.0 star property
9.2 out of 10, Wonderful, (524)
"We like everything. This was our first trip to St Louis. The hotel and surroundings exceeded all our expectations. We booked 3 rooms and they got us all on the same floor. It was Christmas and the decorations and festivities were wonderful."
The price is AED 2,016
AED 2,349 total
includes taxes & fees
21 Mar - 22 Mar
The Ritz-Carlton, St. Louis
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Frequently asked questions

What are the best 5-star hotels in Clayton?
Treat yourself to a luxurious stay at The Ritz-Carlton, St. Louis. This is among the leading 5-star hotels in Clayton based on Expedia guest reviews. From its plush guest rooms to its premium amenities and services, you can count on impeccable quality from the moment you arrive.
How much does it cost to stay in a 5-star hotel in Clayton?
The amount you pay for a 5-star hotel in Clayton can vary according to when you prefer to travel and how long you plan to stay, among other factors. Take advantage of our price per night filter and other search tools to score the best deal on an indulgent stay.

  • Search for the lowest price per night

What makes a hotel 5 stars in Clayton?
Exceptional guest service is at the heart of every 5-star hotel in Clayton. From the moment you enter the lobby, staff cater to your every whim, whether recommending activities and tours or providing a nightly turn-down service. Additionally, hotels must feature superior amenities to be entitled to a 5-star rating. These can include luxury baths, a wellness center, swimming pools, fine dining kitchens and knowledgeable concierge.
Are there any 5-star all-inclusive resorts in Clayton?
Use Expedia’s filters to find a high-end getaway in Clayton where most of what you need is included in the price. Next, narrow your results for properties that have 5 stars and are categorized as “All inclusive.” The first thing on the schedule at these stays? Pure enjoyment and indulgence.
What are the top 5-star spa hotels in Clayton?
For a rejuvenating break in Clayton, you can’t beat The Ritz-Carlton, St. Louis. Check in to this 5-star spa escape and relax while experiencing its well-being programs and treatments.
Are there any 5-star vacation rentals in Clayton?
You won’t find any 5-star vacation rentals in Clayton on our site, but there are a few other top-rated properties worth looking into. Browse our vacation rentals in Clayton to find the ideal place for your stay.
Are there any 5-star hotels in downtown Clayton?
Check out The Ritz-Carlton, St. Louis. This 5-star hotel is an excellent option if you want to experience Clayton’s buzzing downtown scene.