Find Luxury Hotels in St. Charles, MO

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Check availability on St. Charles Luxury Hotels

Compare St. Charles Luxury Hotels room rates, reviews, and availability. Most hotels are fully refundable.

Ameristar Casino Resort and Spa
Exterior

Ameristar Casino Resort and Spa

4.5 star property
8.4 out of 10, Very Good, (1002)
"It was amazing!"
The price is AED 653
AED 824 total
includes taxes & fees
23 Feb - 24 Feb
Ameristar Casino Resort and Spa
Country Inn & Suites by Radisson, St. Charles Historic District
Exterior

Country Inn & Suites by Radisson, St. Charles Historic District

2.5 star property
9.4 out of 10, Exceptional, (1001)
"Cynnamon was outstanding"
The price is AED 418
AED 481 total
includes taxes & fees
23 Feb - 24 Feb
Country Inn & Suites by Radisson, St. Charles Historic District
Relax Inn Saint Charles
Lobby

Relax Inn Saint Charles

2.0 star property
6.4 out of 10, (780)
"These guys are amazing"
The price is AED 219
AED 251 total
includes taxes & fees
21 Feb - 22 Feb
Relax Inn Saint Charles
Baymont by Wyndham St. Charles
Room

Baymont by Wyndham St. Charles

2.5 star property
8.0 out of 10, Very Good, (1000)
"I "
The price is AED 256
AED 294 total
includes taxes & fees
24 Feb - 25 Feb
Baymont by Wyndham St. Charles
Embassy Suites by Hilton St. Louis St. Charles
Exterior

Embassy Suites by Hilton St. Louis St. Charles

3.5 star property
8.8 out of 10, Excellent, (1170)
"It was amazing. The staff was friendly and very professional "
The price is AED 481
AED 553 total
includes taxes & fees
23 Mar - 24 Mar
Embassy Suites by Hilton St. Louis St. Charles
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Are you looking for a luxury hotel for your stay in St. Charles?
During your visit, you might want to enjoy the casinos and shopping which St. Charles is known for.
What's the best luxury hotel in St. Charles?
Ameristar Casino Resort and Spa is a luxury hotel with 6 restaurants and 2 bars, and it’s a popular choice for Expedia travelers looking for an elegant place to stay.
How many luxury hotels can I expect to find in St. Charles?
Lie in the lap of luxury during your getaway to St. Charles in one of Expedia’s 6 luxury hotels.
When can I expect good weather in St. Charles?
Planning for the weather is an important factor for making your trip to St. Charles a success, especially when you’re splurging. The hottest months are usually July and August with an average temp of 75°F, while the coldest months are January and February with an average of 37°F. Average annual precipitation for St. Charles is 46 inches.
What's there to see and do in St. Charles?
When you’re in St. Charles, enjoy exploring the sights and attractions here including Historic Main Street, Katy Trail, and Lewis & Clark Boathouse and Nature Center. If you have a little extra time during your trip, you might want to make a stop at St Charles Convention Center and Ameristar Casino St. Charles.