Find hotels in Serra Mesa, San Diego from AED 264
Change your mind
Book hotels with free cancellation
Be picky
Search almost a million properties worldwide
Go beyond your typical stay in Serra Mesa
Family friendly
Check prices for these dates
Discover 8,848 Serra Mesa hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Sycuan Casino Resort
Sycuan Casino Resort
9.2 out of 10, Wonderful, (1216)
The price is AED 282
AED 354 total
includes taxes & fees
19 May - 20 May

Days Inn by Wyndham San Diego-East/El Cajon
Days Inn by Wyndham San Diego-East/El Cajon
7.6 out of 10, Good, (1005)
The price is AED 312
AED 344 total
includes taxes & fees
14 May - 15 May

Best Western Plus La Mesa San Diego
Best Western Plus La Mesa San Diego
8.2 out of 10, Very Good, (1005)
The price is AED 423
AED 465 total
includes taxes & fees
12 May - 13 May

SpringHill Suites by Marriott Chula Vista Eastlake
SpringHill Suites by Marriott Chula Vista Eastlake
9.6 out of 10, Exceptional, (318)
The price is AED 628
AED 692 total
includes taxes & fees
11 May - 12 May

Ramada by Wyndham San Diego Poway Miramar
Ramada by Wyndham San Diego Poway Miramar
6.8 out of 10, (785)
The price is AED 314
AED 345 total
includes taxes & fees
11 May - 12 May

Sonesta ES Suites San Diego - Rancho Bernardo
Sonesta ES Suites San Diego - Rancho Bernardo
8.4 out of 10, Very Good, (1009)
The price is AED 400
AED 456 total
includes taxes & fees
11 May - 12 May
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Where to stay in Serra Mesa
Where to stay in Serra Mesa
Hotels in top San Diego neighborhoods Learn more about Serra Mesa

Downtown San Diego
2 out of top 10 points of interest in this area
4.5/5(8,497 area reviews)
Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.
Recent reviews of Serra Mesa hotels
Recent reviews of Serra Mesa hotels

San Diego Mission Bay Resort
5/5 Excellent
Friends Time
"Great location. Excellent restaurant! Friendly staff."
A verified traveler stayed at San Diego Mission Bay Resort
Posted 1 day ago
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Hotels in top San Diego neighborhoods
- Hotels in Downtown San Diego
- Hotels in Mission Beach
- Hotels in Pacific Beach
- Hotels in Gaslamp Quarter
- Hotels in Ocean Beach
- Hotels in Point Loma
- Hotels in Mission Valley
- Hotels in Old Town San Diego
- Hotels in Little Italy
- Hotels in East Village
- Hotels in Carmel Valley
- Hotels in North Park
- Hotels in Hillcrest
- Hotels in Point Loma Heights
- Hotels in Torrey Pines
- Hotels in Bay Park
- Hotels in Marina District
Hotels near popular San Diego Attractions
- Hotels near Stadium Golf Center & Batting Cages
- Hotels near San Diego Zoo
- Hotels near San Diego Convention Center
- Hotels near Mission Bay
- Hotels near Petco Park
- Hotels near San Ysidro Border Crossing
- Hotels near Mission Beach
- Hotels near Balboa Park
- Hotels near San Diego State University
- Hotels near Hotel Circle
More Accommodation Types in
- Vacation Homes in San Diego
- Apartments in San Diego
- Condo Rentals in San Diego
- Cottages in San Diego
- Villas in San Diego
- Guest Houses in San Diego
- Aparthotels in San Diego
- Resorts in San Diego
- Motels in San Diego
- Hostels in San Diego
- B&B in San Diego
- Cabin Rentals in San Diego
- RV Parks in San Diego
- Inns in San Diego
- Houseboats in San Diego
Serra Mesa Hotels by Star Rating
Explore more hotels
- Lafayette Hotel & Club
- Hilton San Diego Mission Valley
- Humphreys Half Moon Inn
- Wyndham Garden San Diego Near SeaWorld
- Palihotel San Diego Gaslamp Quarter
- Legacy Resort Hotel & Spa
- Sheraton San Diego Resort
- DoubleTree by Hilton San Diego - Del Mar
- Bahia Resort Hotel
- Handlery Hotel
- Comfort Inn Sea World Area
- The Guild Hotel, San Diego, A Tribute Portfolio Hotel by Marriott