Find Resorts & Hotels with Spas in Santee, SC

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Check availability on Santee Resorts & Hotels with Spas

Compare Santee Resorts & Hotels with Spas room rates, reviews, and availability. Most hotels are fully refundable.

Fairfield Inn & Suites by Marriott Santee
Exterior

Fairfield Inn & Suites by Marriott Santee

2.5 star property
9.8 out of 10, Exceptional, (1001)
"One of my favorite places to stay when we travel back and forth to Florida. It has everything we need. Great bathroom and shower and one of the few that actually has enough hooks. "
The price is AED 477
AED 530 total
includes taxes & fees
28 Jan - 29 Jan
Fairfield Inn & Suites by Marriott Santee
Hampton Inn Santee-I-95
Room

Hampton Inn Santee-I-95

2.5 star property
9.6 out of 10, Exceptional, (1002)
"The property and hotel was very clean and maintained. The staff was pleasant and informative. The area offered several dining options "
The price is AED 454
AED 504 total
includes taxes & fees
9 Feb - 10 Feb
Hampton Inn Santee-I-95
Baymont by Wyndham Santee
Exterior

Baymont by Wyndham Santee

2.5 star property
8.0 out of 10, Very Good, (1279)
"Highly recommend for pet owners, very convenient and super kind check in staff. "
The price is AED 275
AED 306 total
includes taxes & fees
23 Jan - 24 Jan
Baymont by Wyndham Santee
Ramada by Wyndham Santee I-95
Pool

Ramada by Wyndham Santee I-95

2.0 star property
6.2 out of 10, (508)
"Nice room staf was excellent and i love the bars plaing pools and food was amazing try chicken wings "
The price is AED 312
AED 346 total
includes taxes & fees
28 Jan - 29 Jan
Ramada by Wyndham Santee I-95
Holiday Inn Santee, an IHG Hotel
Exterior

Holiday Inn Santee, an IHG Hotel

3.0 star property
8.2 out of 10, Very Good, (828)
"Great location. Very close to many excellent restarants."
The price is AED 421
AED 468 total
includes taxes & fees
9 Feb - 10 Feb
Holiday Inn Santee, an IHG Hotel
Travelodge by Wyndham Santee
Exterior

Travelodge by Wyndham Santee

2.0 star property
7.0 out of 10, Good, (583)
"Very nice hotel "
The price is AED 220
AED 245 total
includes taxes & fees
23 Jan - 24 Jan
Travelodge by Wyndham Santee
Tru By Hilton Santee
Exterior

Tru By Hilton Santee

2.5 star property
9.0 out of 10, Wonderful, (304)
"Nice newer hotel just off the 95 great for a one night stop along the interstate. Staff was friendly. Rooms are small and there is noise from the highway."
The price is AED 404
AED 448 total
includes taxes & fees
2 Feb - 3 Feb
Tru By Hilton Santee
Red Roof Inn Santee
Room

Red Roof Inn Santee

2.0 star property
6.6 out of 10, (590)
"The only thing I didn't like was the refrigerator wasn't working other than that everything was okay."
The price is AED 246
AED 273 total
includes taxes & fees
23 Jan - 24 Jan
Red Roof Inn Santee
Super 8 by Wyndham Santee
Exterior

Super 8 by Wyndham Santee

2.0 star property
6.6 out of 10, (411)
"Close to exit. Easy checkin "
The price is AED 275
AED 306 total
includes taxes & fees
23 Jan - 24 Jan
Super 8 by Wyndham Santee
Lake Marion 2Bed/2Bath Deluxe!
Interior

Lake Marion 2Bed/2Bath Deluxe!

2.5 star property
Lake Marion 2Bed/2Bath Deluxe!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Looking for a spa hotel in Santee?
Book one of our fantastic spa hotels and treat yourself from the moment you arrive. Travelers recommend the gourmet restaurants in Santee. Be sure to enjoy activities like fishing and golfing during your stay. Hotels with spas are a great way to break out of your routine and add a layer of luxury to your vacation.
How many spa hotels will I find in Santee?
Among Expedia’s 36 accommodation options in Santee, there is 1 spa hotel.
What's there to see and do in Santee?
Enjoy all that Santee has to offer when you visit Santee Cooper Country Club, Santee National Golf Club, and Santee State Park. If you have a bit of extra time while you’re in the area, you might want to check out Lake Marion and Santee Outlets.
What is a Santee spa hotel?
Spa hotels in Santee provide lodging and have an on-site spa offering services such as facials and beauty treatments. Some also offer in-room treatments. Spa hotels are a must if you want to give yourself an extra treat while on vacation.