Find Luxury Hotels in Santee, SC

    calendar shield illustration
    Change your mind
    Book hotels with free cancellation
    deals illustration
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration
    Be picky
    Search almost a million properties worldwide

Check availability on Santee Luxury Hotels

Tonight
1 May - 2 May
Tomorrow
2 May - 3 May
This weekend
2 May - 4 May
Next weekend
9 May - 11 May

Compare Santee Luxury Hotels room rates, reviews, and availability. Most hotels are fully refundable.

Red Roof Inn Santee
Exterior

Red Roof Inn Santee

2.0 star property
6.6 out of 10, (603)
"Great place for the price to stop for the night. "
The price is AED 246
AED 273 total
includes taxes & fees
1 Jun - 2 Jun
Red Roof Inn Santee
Comfort Inn & Suites Santee
Lobby

Comfort Inn & Suites Santee

2.5 star property
8.0 out of 10, Very Good, (981)
"Central location clean rooms, friendly staff."
The price is AED 403
AED 447 total
includes taxes & fees
13 May - 14 May
Comfort Inn & Suites Santee
Baymont by Wyndham Santee
Room, 2 Queen Beds, Non Smoking | Desk, blackout drapes, iron/ironing board, free WiFi

Baymont by Wyndham Santee

2.5 star property
8.0 out of 10, Very Good, (1292)
"Great price and rooms met my expectations "
The price is AED 294
AED 326 total
includes taxes & fees
4 May - 5 May
Baymont by Wyndham Santee
Ramada by Wyndham Santee I-95
Property amenity

Ramada by Wyndham Santee I-95

2.0 star property
6.2 out of 10, (521)
"The property needs some work but it was quiet and close to a few restaurants we could walk to."
The price is AED 309
AED 343 total
includes taxes & fees
5 May - 6 May
Ramada by Wyndham Santee I-95
Econo Lodge
Exterior

Econo Lodge

2.0 star property
6.4 out of 10, (307)
"Check in was easy."
The price is AED 250
AED 277 total
includes taxes & fees
15 May - 16 May
Econo Lodge
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Don't see what you're looking for?
See all available properties in Santee

Frequently asked questions

Are you looking for a luxury hotel for your stay in Santee?
Let Expedia help you arrange your flight to Columbia Metropolitan Airport (CAE) airport, and then choose from some places to stay that will deliver the luxury you seek. Amenities are important when you plan a trip, so we make it easy to find what you’d like to make your stay relaxing and comfortable. If you want an upscale hotel with a spa, an indoor pool, or luxury bedding, Expedia can help you find the best luxury hotel experience that Santee has to offer. During your visit, you might want to enjoy the restaurants and coffee shops which Santee is known for.
How many luxury hotels will I be able to find in Santee?
Lie in the lap of luxury during your getaway to Santee in one of Expedia’s 8 luxury hotels.
When can I expect good weather in Santee?
Planning for the weather is an important factor for making your trip to Santee a success, especially when you’re splurging. The hottest months are usually July and August with an average temp of 79°F, while the coldest months are January and February with an average of 52°F. Average annual precipitation for Santee is 55 inches.
What's there to see and do in Santee?
Enjoy all that Santee has to offer and visit Santee Cooper Country Club, Santee Outlets, and Santee State Park. If you have a little extra time during your trip, you might want to make a stop at Santee National Golf Club and Santee Town Hall.