Find hotels in Santa Clara, Panama City from AED 152
Change your mind
Book hotels with free cancellation
Be picky
Search almost a million properties worldwide
Go beyond your typical stay in Santa Clara
Apart hotel
Family friendly
Check prices for these dates
Discover 1,410 Santa Clara hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Crowne Plaza Panama Airport by IHG
Crowne Plaza Panama Airport by IHG
8.4 out of 10, Very Good, (2120)
The price is AED 437
AED 481 total
includes taxes & fees
5 May - 6 May

Central Hotel Panama Casco Viejo
Central Hotel Panama Casco Viejo
9.0 out of 10, Wonderful, (889)
The price is AED 961
AED 1,058 total
includes taxes & fees
13 May - 14 May

The Westin Playa Bonita Panama
The Westin Playa Bonita Panama
8.0 out of 10, Very Good, (1004)
The price is AED 599
AED 659 total
includes taxes & fees
20 May - 21 May

La Concordia Boutique Hotel
La Concordia Boutique Hotel
9.4 out of 10, Exceptional, (163)
The price is AED 598
AED 658 total
includes taxes & fees
7 May - 8 May

Dreams Playa Bonita Panama - All Inclusive
Dreams Playa Bonita Panama - All Inclusive
7.4 out of 10, Good, (1006)
The price is AED 900
AED 900 total
includes taxes & fees
9 May - 10 May

TRYP by Wyndham Panamá Centro
TRYP by Wyndham Panamá Centro
9.0 out of 10, Wonderful, (1005)
The price is AED 304
AED 334 total
includes taxes & fees
27 May - 28 May
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Where to stay in Santa Clara
Where to stay in Santa Clara
Hotels in top Panama City neighborhoods Learn more about Santa Clara

Casco Viejo
4.5/5(178 area reviews)
Unique features of Casco Viejo include the historic sites and bars. Make a stop by Metropolitan Cathedral of Panama or Palacio de las Garzas while you're exploring the area.
Recent reviews of Santa Clara hotels
Recent reviews of Santa Clara hotels

Principe Hotel and Suites
5/5 Excellent
"Great location for my stay"
A verified traveler from Telkwa stayed at Principe Hotel and Suites
Posted 22 hours ago
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Hotels in top Panama City neighborhoods
- Hotels in Casco Viejo
- Hotels in Bella Vista
- Hotels in El Cangrejo
- Hotels in San Francisco
- Hotels in Calidonia
- Hotels in San Felipe
- Hotels in Punta Paitilla
- Hotels in Costa del Este
- Hotels in Marbella
- Hotels in Punta Pacifica
- Hotels in Obarrio
- Hotels in Amador
- Hotels in Santa Ana
- Hotels in Juan Diaz
- Hotels in El Chorrillo
- Hotels in Bethania
- Hotels in Parque Lefevre
- Hotels in Balboa
- Hotels in Pueblo Nuevo
- Hotels in Curundu
Hotels near popular Panama City Attractions
- Hotels near Albrook Shopping Mall
- Hotels near Multiplaza Pacific Mall
- Hotels near Amador Causeway
- Hotels near Avenida Balboa
- Hotels near Cinta Costera
- Hotels near Via Espana
- Hotels near Fuerte Amador Resort & Marina
- Hotels near El Dorado Mall
- Hotels near Veracruz Beach
- Hotels near Gamboa Rainforest Resort
Hotels Close to Nearby Airports
Santa Clara Hotels by Star Rating
Santa Clara Hotels by Brand
Explore more hotels
- The Executive Hotel
- Ramada Plaza By Wyndham Panama Punta Pacífica
- Novotel Panama City
- Megapolis Hotel Panamá
- Principe Hotel and Suites
- TRYP by Wyndham Panamá Centro
- Decapolis Hotel Panama City
- Hotel Ojos del Rio
- Las Americas Golden Tower Panama
- Riande Aeropuerto Hotel & Casino
- Waldorf Astoria Panama
- Sofitel Legend Casco Viejo, Panama City