Photo by Dr__Vlad

Search Vacation Homes in O Brien

    calendar shield illustration
    Change your mind
    Book hotels with free cancellation
    deals illustration
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    bed illustration
    Be picky
    Search almost a million properties worldwide

Check prices for these dates

Next weekend
In two weeks
In one month
In two months

Compare 141 Vacation Homes in O Brien with updated reviews, rates, and availability.

Right on the River: Enjoy the Santa Fe + Ichetucknee Rivers from a Private Dock

9.8 out of 10, Exceptional, (204)
"We had such a great spring break at Confluence Cabin. The location is awesome, a perfect outdoor getaway. We appreciate all the kayaks and canoes. We saw tons of wildlife. The house was clean and really loved the well-stocked kitchen. We will back!"
Right on the River: Enjoy the Santa Fe + Ichetucknee Rivers from a Private Dock

Ginnie Springs Hidden Scuba Oasis Retreat! Only 1 minute from Ginnie Springs

9.8 out of 10, Exceptional, (10)
"Large kitchen. Great entertaining space. Well stocked. Quite property."
Ginnie Springs Hidden Scuba Oasis Retreat! Only 1 minute from Ginnie Springs

The Coppertop Inn on The Ichetucknee River Pets are Welcome 50 per pet fee

10.0 out of 10, Exceptional, (58)
"Coppertop Inn provided the perfect location for our experience. Floating the Ichetucknee once again and making new memories! The home has everything you need for fun in the water and comfortable lodging.Thank You once again for allowing our fur babies!"
The Coppertop Inn on The Ichetucknee River Pets are Welcome 50 per pet fee

Walking distance to Brewery and Restaurants ⭐️⭐️⭐️⭐️⭐️

9.8 out of 10, Exceptional, (32)
"We enjoyed the springs, nature walk, cedar key, downtown high springs ice cream. The home was clean and had everything we needed. Very comfortable. The outdoor deck was wonderful to sit in am with coffee and evenings to relax. We would stay again. Our host was also very kind and responded quickly. "
The price is AED 411
AED 1,059 total
includes taxes & fees
13 May - 14 May
Walking distance to Brewery and Restaurants ⭐️⭐️⭐️⭐️⭐️

Bunkhouse Farm Stay

10.0 out of 10, Exceptional, (131)
"Very nice!"
Bunkhouse Farm Stay

The Cozy Retreat

10.0 out of 10, Exceptional, (1)
"Overall amazing"
The Cozy Retreat

ICHETUCKNEE RIVER - Riverfront on the Crystal Clear Ichetucknee River

9.8 out of 10, Exceptional, (86)
"Great location on the river. Wonderful views from the house! Great for families and friends! Will definitely be back!"
ICHETUCKNEE RIVER - Riverfront on the Crystal Clear Ichetucknee River

Secluded and very unique OFF grid country home, 15 springs within an hour.

10.0 out of 10, Exceptional, (6)
"We had an amazing time at the property and the parks near by. The house itself is very unique and is very spacious. The bedrooms were all very clean, good size and comfy beds. The living room was a nice spot for the family to hangout together and watch a movie on the large tv. Kitchen was well stocked and had a really cool seating area for the family to enjoy a meal together. The porch/patio area was the spot to be in. It was a Perfect area for hanging out, playing pool and pingpong. The...
Secluded and very unique OFF grid country home, 15 springs within an hour.

Pet-Friendly Florida Escape w/ Patio & Fire Pit!

10.0 out of 10, Exceptional, (20)
"Great spot, close to the springs. Clean. Will stay again. Thanks! "
Pet-Friendly Florida Escape w/ Patio & Fire Pit!

Quaint rural downtown community close to springs, 3 rivers, biking & equestrian

9.0 out of 10, Wonderful, (41)
"Thanks"
Quaint rural downtown community close to springs, 3 rivers, biking & equestrian

Serene at the Springs - New Reno & Tesla Charger

10.0 out of 10, Exceptional, (6)
"Clean, nicely decorated, nice screen porch out back with a TV, comfortable beds. Would stay again."
The price is AED 408
AED 1,000 total
includes taxes & fees
27 Apr - 28 Apr
Serene at the Springs - New Reno & Tesla Charger

Beautiful 2 story house overlooking the water. Has arcade & Close to the springs

10.0 out of 10, Exceptional, (43)
"Kelly was so accommodating and lovely to communicate with, even before the trip began. The place is charming with far more room than you would think. Everything was clean, ready and easy to use. We’ll be back here for sure :)"
The price is AED 547
AED 990 total
includes taxes & fees
27 Apr - 28 Apr
Beautiful 2 story house overlooking the water. Has arcade & Close to the springs

Custom Built Home steps from the Santa Fe River

10.0 out of 10, Exceptional, (69)
"Thank you for everything "
Custom Built Home steps from the Santa Fe River

Peaceful property on the historic Suwannee River.

10.0 out of 10, Exceptional, (22)
"Our group loved everything about this beautiful riverside property, both inside and out. The location also served as a great base to easily visit a number of springs in the area. We had a wonderful time and look forward to coming back in the future."
Peaceful property on the historic Suwannee River.

Beautiful New House on 5 Acres close to springs

9.8 out of 10, Exceptional, (19)
"Just what we were looking for. Centrally located. Very peaceful. Owner was amazing at accommodating our needs. Great place. "
The price is AED 675
AED 1,423 total
includes taxes & fees
27 Apr - 28 Apr
Beautiful New House on 5 Acres close to springs

Located on the Santa Fe River perfect for boating & tubing on the Ichetucknee.

9.8 out of 10, Exceptional, (24)
"Was a fabulous time(except for rain) but we made the best of it and took advantage of staying in a beautiful and comfortable home. Was just our style! Can’t wait to come again!"
Located on the Santa Fe River perfect for boating & tubing on the Ichetucknee.

Hilltop House

9.6 out of 10, Exceptional, (14)
"Finding this cozy cottage covered in trees and it's shady porch was just what I needed to get away from the city. It is very centrally located to many springs and beautiful natural areas and works as a great home base. It only 2 blocks from Ft. White, but you feel like you are out in the country. I LOVED having the windows open and not having to worry who was looking in. Really enjoyed the stay, also fenced yard great for dogs."
Hilltop House

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!

10.0 out of 10, Exceptional, (18)
"Perfect place for the area. Very relaxing property."
Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!

Serene Live Oak Home w/ Fire Pit by River + SOSMP!

8.4 out of 10, Very Good, (7)
"We rented this home to attend the Suwannee Spring Festival with our Florida friends. The home was at a great location to do that and provided us with the quiet restful nights we were looking for during our vacation. We will definitely stay again."
Serene Live Oak Home w/ Fire Pit by River + SOSMP!

Sunrise Cottage

9.4 out of 10, Exceptional, (6)
"Sunrise cottage was exactly what we needed for one night's stay! Our pup was welcome too! Evrything was nice and clean. "
The price is AED 338
AED 722 total
includes taxes & fees
28 Apr - 29 Apr
Sunrise Cottage
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Don't see what you're looking for?
See all available properties in O Brien
Save an average of 15% on thousands of hotels when you're signed in

Other property types in O Brien

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!

10.0 out of 10, Exceptional, (18)
"Perfect place for the area. Very relaxing property."
Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!

Pet-Friendly Florida Escape w/ Patio & Fire Pit!

10.0 out of 10, Exceptional, (20)
"Great spot, close to the springs. Clean. Will stay again. Thanks! "
Pet-Friendly Florida Escape w/ Patio & Fire Pit!

MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY

9.6 out of 10, Exceptional, (54)
"Very relaxing "
The price is AED 731
AED 1,575 total
includes taxes & fees
29 Apr - 30 Apr
MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.