Photo by Dr__Vlad

Find hotels in O Brien, FL from AED 220

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Compare 302 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Hampton Inn & Suites Alachua I-75

2.5 star property
9.6 out of 10, Exceptional, (379)
"Near the interstate, but otherwise very nice property"
The price is AED 521
AED 587 total
includes taxes & fees
10 Mar - 11 Mar
Hampton Inn & Suites Alachua I-75

Americas Best Value Inn Alachua

2.0 star property
4.6 out of 10, (527)
"Good location and good prices. "
The price is AED 263
AED 296 total
includes taxes & fees
31 Mar - 1 Apr
Americas Best Value Inn Alachua

Royal Inn

2.0 star property
7.2 out of 10, Good, (165)
"It's a very old hotel but economically priced and the front desk employee, maybe owner, was very friendly and quick. The bathroom definitely needs updating or a better clean. We chose not to shower due to looking like mold. It may have been a stain as the rest of the room was clean. "
The price is AED 286
AED 322 total
includes taxes & fees
4 Mar - 5 Mar
Royal Inn

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

3.5 star property
9.2 out of 10, Wonderful, (1002)
"The staff was friendly and efficient "
The price is AED 522
AED 587 total
includes taxes & fees
16 Mar - 17 Mar
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Vista Verde Farm Retreat

2.0 star property
The price is AED 567
AED 799 total
includes taxes & fees
18 Mar - 19 Mar
Vista Verde Farm Retreat

BlueGem Motel

2.0 star property
9.2 out of 10, Wonderful, (332)
"Pefect place"
The price is AED 414
AED 466 total
includes taxes & fees
4 Mar - 5 Mar
BlueGem Motel

Palms Garden Inn

2.0 star property
7.4 out of 10, Good, (519)
"Room was clean and everything worked properly. King-size bed was comfy AF. Zero issues."
The price is AED 246
AED 277 total
includes taxes & fees
10 Mar - 11 Mar
Palms Garden Inn

The Blanche

2.0 star property
9.0 out of 10, Wonderful, (112)
"Elegant lobby and stair ways. Rooms updated and clean and well appointed. Muy room was right next to the road and each vehicle and bar across the street was heard. Ran the fan and white noise machine to bloke the noise."
The price is AED 643
AED 723 total
includes taxes & fees
4 Mar - 5 Mar
The Blanche

Days Inn by Wyndham Lake City I-10

2.0 star property
6.8 out of 10, (1000)
"Good one night stop "
The price is AED 265
AED 299 total
includes taxes & fees
6 Mar - 7 Mar
Days Inn by Wyndham Lake City I-10

Postcard Cabins Gilchrist Springs

2.0 star property
10.0 out of 10, Exceptional, (7)
"Nice clean"
The price is AED 413
AED 454 total
includes taxes & fees
1 Apr - 2 Apr
Postcard Cabins Gilchrist Springs

Super 8 by Wyndham Lake City

2.0 star property
7.0 out of 10, Good, (595)
"Nice stay and light the free supper, and eggs in the morning, the Wister with some meat selection. People were friendly but my only complaint would be the thin walls between the guest rooms. I could hear my neighbor and his TV playing 24/7 over 3 days"
The price is AED 422
AED 475 total
includes taxes & fees
9 Mar - 10 Mar
Super 8 by Wyndham Lake City

Driftwood Inn

2.0 star property
7.8 out of 10, Good, (727)
"This was a bare bones hotel. The room was clean and the beds were comfortable. There was Wi-Fi and a tv, and not much else. If all you want is a comfortable bed, then this is the place for you. "
The price is AED 360
AED 405 total
includes taxes & fees
6 Mar - 7 Mar
Driftwood Inn

Regal Inn

2.5 star property
8.6 out of 10, Excellent, (470)
"The man who checked my friend and I in last night was very nice. He was kind and helpful this morning as well. Thank you!"
The price is AED 241
AED 271 total
includes taxes & fees
17 Mar - 18 Mar
Regal Inn

Courtyard By Marriott Lake City

3.0 star property
9.6 out of 10, Exceptional, (25)
"Beautiful place and super clean!"
The price is AED 393
AED 442 total
includes taxes & fees
16 Mar - 17 Mar
Courtyard By Marriott Lake City

Days Inn by Wyndham Lake City I-75

2.0 star property
7.2 out of 10, Good, (1005)
"My only complaints are the strong smell of cleaning product in the room and the constant on/off of the AC. Otherwise, we were just passing through on the way to Naples so it was fine."
The price is AED 269
AED 302 total
includes taxes & fees
10 Mar - 11 Mar
Days Inn by Wyndham Lake City I-75

Knights Inn Lake City

1.5 star property
5.4 out of 10, (597)
"Was a nice place don’t show up over 4 people they won’t let you stay there. "
The price is AED 220
AED 248 total
includes taxes & fees
4 Mar - 5 Mar
Knights Inn Lake City

Holiday Inn & Suites Lake City by IHG

3.0 star property
8.4 out of 10, Very Good, (1003)
"Super friendly and helpful staff!!! The interior of the hotel has that exposed balcony sort of thing - like at the Orlando airport. The rooms could use updating , but for me it’s the bed and the people working there that make all the difference! The bed was nice and the staff was exemplary! "
The price is AED 426
AED 479 total
includes taxes & fees
16 Mar - 17 Mar
Holiday Inn & Suites Lake City by IHG

Quality Inn Lake City

2.5 star property
7.8 out of 10, Good, (835)
"Excellent Customer Service Super clean and the location was perfect. Everything is near by, restaurants and stores. Best part it’s right off the freeway so it’s so convenient to hop back on the next day. I recommend this 100%. "
The price is AED 309
AED 348 total
includes taxes & fees
17 Mar - 18 Mar
Quality Inn Lake City

La Quinta Inn & Suite by Wyndham Lake City

2.5 star property
8.8 out of 10, Excellent, (1008)
"Very clean and quiet place. I’d book the hotel next time. "
The price is AED 371
AED 418 total
includes taxes & fees
9 Mar - 10 Mar
La Quinta Inn & Suite by Wyndham Lake City

Rodeway Inn Lake City I-75

2.0 star property
6.8 out of 10, (367)
"quite "
The price is AED 248
AED 279 total
includes taxes & fees
11 Mar - 12 Mar
Rodeway Inn Lake City I-75
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about O Brien

Explore attractions like Suwannee River and Ichetucknee River as you discover things to see and do in O Brien.

An amazing state Park 2 hours drive from Orlando. Swimming and snorkeling in this crystal clear water is allowed and i really recommend to do it! 🐟🐢
Photo by Dr__Vlad
Open Photo by Dr__Vlad

Frequently asked questions

Where is the best place to stay in O Brien?

La Quinta Inn & Suite by Wyndham Lake City, located 18.2 mi (29.3 km) from the heart of O Brien, is a top choice for your stay based on our traveler data. Other good choices for your visit to the area are Americas Best Value Inn Lake City and TownePlace Suites by Marriott Lake City. See all available top hotels, or vacation rentals in O Brien.

What's the top vacation rental in O Brien?

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!: Visitors give good reviews to this O Brien vacation home rental, which is located on the beach and has a patio, a garden, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. You and your friends and family can relax into your vacation with amenities like a selection of games. Some other homes for rent in O Brien include Pet-Friendly Florida Escape w/ Patio & Fire Pit! and MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY. See all vacation rentals in O Brien.

If I need to cancel my hotel reservation in O Brien, will I receive a refund?

Yes! You'll find that most hotel reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and get a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in O Brien.

Where can I learn more about changing or cancelling my trip to O Brien?

To access more information about picking new dates or cancelling your trip to O Brien, click here.

Where is the best hotel to stay near Ichetucknee Springs State Park?

Escape to Nature - 2 miles from Ichetucknee park is one of the top choices for your stay based on our traveler data, and this property features in-room kitchens and fireplaces. It's located 2.3 mi (3.8 km) from Ichetucknee Springs State Park. Another good choice is A Riverview of a Magical Sunrise every morning, located 5.6 mi (9.1 km) away.

What are some accommodations with pools in O Brien?

La Quinta Inn & Suite by Wyndham Lake City: Features on-the-go, an indoor pool, and free self parking. Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks! and Americas Best Value Inn Lake City are two additional hotels that feature an onsite pool. View all hotels with pools in O Brien.

What's the best hotel for staying near Gainesville Regional Airport (GNV)?

Hampton Inn & Suites Gainesville Downtown is one of the top choices for your stay and is a popular hotel, featuring free breakfast and an outdoor pool. It's located 3.7 mi (6 km) from Gainesville Regional Airport. Other good choices close to the airport include Sweetwater Branch Inn and Travelers Inn.

How is it to stay in O Brien?

Visitors to O Brien are sure to find plenty to explore and enjoy. In O Brien, there are 11 hotels and other accommodations to choose from. Find out more about O Brien.

What should I see while I'm in O Brien?

Natural beauty is on display at Suwannee River, Ichetucknee River, and Ichetucknee Springs State Park. You'll also find Wes Skiles Peacock Springs State Park and Lafayette Blue Springs State Park in the area. Check out what more to see and do in Expedia's O Brien guide.

What's the seasonal weather like in O Brien?

The hottest months are usually July and August with an average temp of 80°F, while the coldest months are January and February with an average of 58°F. Average annual precipitation for O Brien is 50 inches.