Photo by Cindy Keese

Find hotels in Seneca, SC from AED 215

  • Plan, book, stay with confidence

  • bex rewards loyalty icon
    Be picky
    Search almost a million properties worldwide
    payments icon
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    today icon
    Change your mind
    Book hotels with free cancellation

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating

Compare 1,550 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Best Western Seneca-Clemson

2.5 star property
8.4 out of 10, Very Good, (589)
"Always great service "
The price is AED 356
AED 392 total
includes taxes & fees
16 Jun - 17 Jun
Best Western Seneca-Clemson

Quality Inn Seneca US-123

2.5 star property
8.0 out of 10, Very Good, (589)
"Nice place for the price. I would stay here again. Looks newly renovated and was clean. Very comfy bed, pillows. Breakfast was basic but delicious. Staff was excellent. Very pleasant and professional. We enjoyed our short stay. "
The price is AED 294
AED 360 total
includes taxes & fees
24 May - 25 May
Quality Inn Seneca US-123

Hampton Inn & Suites Seneca-Clemson Area

2.5 star property
9.4 out of 10, Exceptional, (594)
"The staff is very helpful. "
The price is AED 446
AED 491 total
includes taxes & fees
8 Jun - 9 Jun
Hampton Inn & Suites Seneca-Clemson Area

Fairfield Inn & Suites Seneca Clemson Univ Area

2.5 star property
9.4 out of 10, Exceptional, (148)
"Clean rooms and friendly staff"
The price is AED 474
AED 521 total
includes taxes & fees
19 May - 20 May
Fairfield Inn & Suites Seneca Clemson Univ Area

Lakeside Lodge Clemson

2.5 star property
9.0 out of 10, Wonderful, (870)
"Absolutely beautiful property & the room was the best I've ever stayed! "
The price is AED 400
AED 494 total
includes taxes & fees
19 May - 20 May
Lakeside Lodge Clemson

Tru by Hilton Seneca Clemson

2.5 star property
9.2 out of 10, Wonderful, (714)
"Had such a nice stay- comfy rooms and convenient location to shopping & dining!"
The price is AED 372
AED 409 total
includes taxes & fees
25 May - 26 May
Tru by Hilton Seneca Clemson

Postcard Cabins Lake Hartwell

2.0 star property
10.0 out of 10, Exceptional, (7)
"My boyfriend and I decided to stay here on a whim last year and had to come back again on our way back to Philly! Easily our favorite place we’ve stayed in together, perfect spot to wind down after a lot of traveling."
The price is AED 327
AED 501 total
includes taxes & fees
1 Jun - 2 Jun
Postcard Cabins Lake Hartwell

Days Inn by Wyndham Seneca / Clemson Area

2.0 star property
6.8 out of 10, (678)
"Clean and comfortable. Good location. Close to Clemson University "
The price is AED 259
AED 285 total
includes taxes & fees
20 May - 21 May
Days Inn by Wyndham Seneca / Clemson Area

Hampton Inn Clemson-University Area

2.5 star property
8.8 out of 10, Excellent, (586)
"Comfortable bed, walkable to the lake. "
The price is AED 387
AED 430 total
includes taxes & fees
25 May - 26 May
Hampton Inn Clemson-University Area

The Abernathy of Clemson

4.0 star property
9.6 out of 10, Exceptional, (511)
"It was a great stay!"
The price is AED 608
AED 675 total
includes taxes & fees
29 May - 30 May
The Abernathy of Clemson

Clemson University's James F. Martin Inn

3.0 star property
9.6 out of 10, Exceptional, (876)
"One of the absolute best places we have ever stayed! "
The price is AED 547
AED 607 total
includes taxes & fees
19 May - 20 May
Clemson University's James F. Martin Inn

The Shepherd Hotel Downtown Clemson

4.0 star property
9.8 out of 10, Exceptional, (576)
"We love staying at The Shepherd "
The price is AED 621
AED 689 total
includes taxes & fees
19 May - 20 May
The Shepherd Hotel Downtown Clemson

Inn @ Clemson

2.5 star property
8.0 out of 10, Very Good, (1014)
"The Inn is a great place to stay, staff is super friendly and it's in a great location 👍 "
The price is AED 364
AED 404 total
includes taxes & fees
19 May - 20 May
Inn @ Clemson

Comfort Inn & Suites Clemson - University Area

2.5 star property
8.2 out of 10, Very Good, (1008)
"Good place to stay"
The price is AED 356
AED 395 total
includes taxes & fees
24 May - 25 May
Comfort Inn & Suites Clemson - University Area

Best Western Plus Clemson Hotel & Conference Center

2.5 star property
8.2 out of 10, Very Good, (1008)
"A great place to stay. Breakfast is very good, plus an on site bar/restaurant with plenty of tvs and good food."
The price is AED 372
AED 412 total
includes taxes & fees
20 May - 21 May
Best Western Plus Clemson Hotel & Conference Center

Holiday Inn Express & Suites Clemson by IHG

2.5 star property
9.0 out of 10, Wonderful, (887)
"Great hotel"
The price is AED 415
AED 461 total
includes taxes & fees
25 May - 26 May
Holiday Inn Express & Suites Clemson by IHG

Days Inn by Wyndham Clemson

3.5 star property
7.0 out of 10, Good, (162)
"Very nice and resonable pricing."
The price is AED 294
AED 327 total
includes taxes & fees
19 May - 20 May
Days Inn by Wyndham Clemson

Rodeway Inn & Suites

2.0 star property
7.6 out of 10, Good, (159)
"Great place to stay "
The price is AED 265
AED 296 total
includes taxes & fees
17 Jun - 18 Jun
Rodeway Inn & Suites

Frank Howard 111 Farmhouse

3.0 star property
9.8 out of 10, Exceptional, (6)
"Perfect location and loved the interior"
The price is AED 305
AED 848 total
includes taxes & fees
19 May - 20 May
Frank Howard 111 Farmhouse

Clemson Memorabilia House

3.0 star property
9.8 out of 10, Exceptional, (7)
"Cute cottage and perfect location for visiting Clemson University. "
The price is AED 305
AED 848 total
includes taxes & fees
19 May - 20 May
Clemson Memorabilia House
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Learn more about Seneca

Escape to Seneca! Enjoy its sports, lake views, and coffee.

View from the dike in Clemson, SC. This trail is used by runners, bikers, and lots of dog walkers.
Photo by Cindy Keese
Open Photo by Cindy Keese

Frequently asked questions

Where is the best place for a stay in Seneca?

Tru by Hilton Seneca Clemson is ranked highly by Expedia customers. This hotel is a short 5-minute walk from Lake Hartwell, and it offers free breakfast and free parking. Traveler reviews also recommend Lakeside Lodge Clemson and Hampton Inn & Suites Seneca-Clemson Area as top choices for your visit. See all available top hotels, or vacation rentals in Seneca.

What's the top vacation rental in Seneca?

6 Bedrooms and 3 docks on a Lake Hartwell cove, 3 miles from Clemson by water.: Visitors give good reviews to this Seneca vacation home rental, which is located on a lake and has a fireplace, a balcony, and a barbecue grill to put you at ease in your new surroundings. It has 6 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. Kick off your shoes and enjoy yourself with a garden and a selection of games. Our travelers also rate Quiet cove, deep water, minutes to Clemson, pet friendly, easy path to the dock as a favorite home for rent in Seneca. See all vacation rentals in Seneca.

If I need to cancel my hotel reservation in Seneca, will I receive a refund?

Yes, the majority of hotel reservations are refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If your reservation is non-refundable, it might still be possible to cancel it and be given a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Seneca.

Where can I learn more about changing or cancelling my trip to Seneca?

To find more details about updating your trip to Seneca or cancelling it, click here.

What's the best place to stay for a family vacation to Seneca?

Fairfield Inn & Suites Seneca Clemson Univ Area is a hotel with an outdoor pool and free parking, and it's a top choice on Expedia for families. Attractions in the area like Ultimate Action Sports are also fun for the whole family. Find more child-friendly accommodations in Seneca.

What's the best LGBTQ-friendly place to stay in Seneca?

Tru by Hilton Seneca Clemson is a top LGBTQ-friendly hotel, and features free breakfast and free WiFi. Hampton Inn & Suites Seneca-Clemson Area is another good choice for your stay.

What's the best pet-friendly accommodation in Seneca?

Lakeside Lodge Clemson is a top hotel for people traveling with their pets, and offers a restaurant and a seasonal outdoor pool for its human guests. Other good choices to stay with your pet include Tru by Hilton Seneca Clemson and Quality Inn Seneca US-123. See more pet-friendly hotel accommodations in Seneca.

What are some hotels with pools in Seneca?

Lakeside Lodge Clemson: Hotel, 7-minute walk from Lake Hartwell. Features free self parking, a seasonal outdoor pool, and complimentary wireless internet access. Quality Inn Seneca US-123 and Fairfield Inn & Suites Seneca Clemson Univ Area are two additional hotels with an onsite pool. View all hotels with pools in Seneca.

What is the best accommodation for staying close to Greenville-Spartanburg International Airport (GSP)?

Wyndham Garden Greenville Airport is one of the top choices for your stay and is a popular 3-star hotel featuring free breakfast and a restaurant. It's located 3.8 mi (6.1 km) from Greenville-Spartanburg Intl. Airport. Other good options near the airport include Best Western Greenville Airport Inn and Extended Stay America - Greenville - Airport.

What is staying in Seneca like?

Visitors to Seneca are sure to enjoy the sporting events, lakeside setting, and university setting. Welcoming and scenic, this city also attracts tourists with its coffeehouses. In Seneca, there are 278 hotels and other accommodations to choose from. Find out more about Seneca.

What should I do while I'm visiting Seneca?

Cultural venues include The Gauntlet and Oconee Community Theatre. Natural beauty is on display at Keowee Reservoir, Lake Keowee, and Lake Hartwell. Exploring the waterfront is a great activity, and Keowee Key Golf Course is one place to visit. Check out what more to see and do in Expedia's Seneca guide.

What's the weather like in Seneca?

The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 46°F. Average annual precipitation for Seneca is 62 inches.