Photo by Cindy Keese

Find Resorts & Hotels with Spas in Seneca, SC

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Pick from 73 Seneca Resorts & Hotels with Spas and compare room rates, reviews, and availability. Most hotels are fully refundable.

Lakeside Lodge Clemson
Outdoor pool

Lakeside Lodge Clemson

2.5 star property
9.0 out of 10, Wonderful, (750)
"Beautiful property!"
The price is AED 400
AED 494 total
includes taxes & fees
1 Dec - 2 Dec
Lakeside Lodge Clemson
Tru by Hilton Seneca Clemson
Exterior

Tru by Hilton Seneca Clemson

2.5 star property
9.2 out of 10, Wonderful, (642)
"Staff need training "
The price is AED 393
AED 433 total
includes taxes & fees
27 Dec - 28 Dec
Tru by Hilton Seneca Clemson
Quality Inn Seneca US-123
Room

Quality Inn Seneca US-123

2.5 star property
8.0 out of 10, Very Good, (553)
"Nice stay"
The price is AED 263
AED 325 total
includes taxes & fees
16 Dec - 17 Dec
Quality Inn Seneca US-123
Days Inn by Wyndham Seneca / Clemson Area
Exterior

Days Inn by Wyndham Seneca / Clemson Area

2.0 star property
6.8 out of 10, (646)
"My stay was very nice. The only thing was the tv was broken in rm 121. No worries, tough, as i was busy with family "
The price is AED 247
AED 271 total
includes taxes & fees
15 Dec - 16 Dec
Days Inn by Wyndham Seneca / Clemson Area
5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!
Rear of House (Lakeside)

5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!

10.0 out of 10, Exceptional, (81)
"We thoroughly enjoyed our stay in Seneca! My husband and I have 6 sons and we gather together for usually a long weekend every year. We chose Seneca for a new experience and the property was perfect for our crowd. Loved the open kitchen and huge living area. One of our sons is a gourmet cook, so he was able to be part of the family vibes as he prepped the dinner. We will probably be returning next year!!"
The price is AED 2,773
AED 5,770 total
includes taxes & fees
1 Dec - 2 Dec
5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!
What a family lake house should be! Natural Beauty w/ space for each to enjoy!!!
Dock room for 2 boats and 2 jet skis

What a family lake house should be! Natural Beauty w/ space for each to enjoy!!!

9.2 out of 10, Wonderful, (28)
"Overall, I highly recommend this place for anyone looking to unwind and enjoy some beautiful scenery. The house was exactly as described in the listing, which made our stay even more enjoyable. Waking up to those stunning views of the lake every morning was such a treat—it really set the perfect tone for our days. Communication with the owner was a breeze. They were super responsive and made sure we had everything we needed. Plus, the check-in and check-out process was incredibly easy, which...
What a family lake house should be! Natural Beauty w/ space for each to enjoy!!!
Best Western Seneca-Clemson
Exterior

Best Western Seneca-Clemson

2.5 star property
8.4 out of 10, Very Good, (555)
"Staff was friendly and helpful "
The price is AED 312
AED 343 total
includes taxes & fees
6 Dec - 7 Dec
Best Western Seneca-Clemson
Lakefront home w/covered dock*Pool table*Kayak/SUP*11mi to Clemson*Hot tub
Property grounds

Lakefront home w/covered dock*Pool table*Kayak/SUP*11mi to Clemson*Hot tub

10.0 out of 10, Exceptional, (41)
"Loved this home. Lots of room, great area, beautiful views. "
Lakefront home w/covered dock*Pool table*Kayak/SUP*11mi to Clemson*Hot tub
Serenity Bay, Keowee Lakefront Cabin, Covered Dock, Kayaks, Clean, Near Clemson
Comfortable seating on the lakefront deck, covered from the sun or rain.

Serenity Bay, Keowee Lakefront Cabin, Covered Dock, Kayaks, Clean, Near Clemson

10.0 out of 10, Exceptional, (194)
"Very nice, clean, well stocked and spacious. Relatively short drive to Clemson. Great place to stay!"
Serenity Bay, Keowee Lakefront Cabin, Covered Dock, Kayaks, Clean, Near Clemson
Lakefront Lake Keowee Home with flat lawn & private dock. 14 miles to Clemson!
Enjoy dining on back deck with friends and family with beautiful view of lake

Lakefront Lake Keowee Home with flat lawn & private dock. 14 miles to Clemson!

10.0 out of 10, Exceptional, (101)
"Perfect house to stay at if you are going to a Clemson game. Host was communicative and the house was adorable. We fished off the dock, roasted s’mores and watched lots of football. Would definitely rent again. "
Lakefront Lake Keowee Home with flat lawn & private dock. 14 miles to Clemson!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Looking for a spa hotel in Seneca?
Book one of our lush spa hotels and pamper yourself from the moment you arrive. Check out the lakeside setting in Seneca - worth a picture or two! Be sure to enjoy the coffeehouses during your stay. Hotels with spas are the perfect way to take a break from your routine and add a layer of luxury to your weekend away.
How many spa hotels will I find in Seneca?
Among Expedia’s 147 accommodation options in Seneca, there is 1 spa hotel.
What's there to see and do in Seneca?
Take in the sights and attractions that Seneca offers with a visit to Lake Keowee, Keowee Key Golf Course, and Lake Hartwell. If you have some spare time during your trip, you might want to check out Keowee Reservoir and Memorial Stadium.
What is a Seneca spa hotel?
Spa hotels in Seneca provide lodging and have an on-site spa offering services including couples massages as well as beauty treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation, and relaxation.