San Francisco

Panama City

Photo by Hideki Yamagata
Photo by Hideki Yamagata
Photo by ‎James Barrow
Photo by ‎James Barrow
Photo by Adrian Damian
Photo by Adrian Damian
Photo by Nóra Széll
Photo by Nóra Széll
Photo by Panama Roadrunner
Photo by Panama Roadrunner

Popular places to visit

Rainy day in Panama City but the charm of this city never ends. A beautiful rainbow over the city invites us to spend a bright day in paradise. #LifeAtExpedia

Multiplaza Pacific Mall

4.5/5(634 reviews)

During your trip to Panama City, you can enjoy retail therapy at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.

Multiplaza Pacific Mall
Cinta Costera

Cinta Costera

4.5/5(456 reviews)

Explore the great outdoors at Cinta Costera, a lovely green space in Panama City. While you're in the area, stroll along the seaside.

Cinta Costera
Cinta Costera a wonderful pedestrian walkway with a separate lane for bicyclists and skateboarders #OrbitzTravel

Avenida Balboa

4/5(554 reviews)

You can find the perfect gifts to bring home at Avenida Balboa during your trip to Panama City. While you're in the area, wander around the natural setting.

Avenida Balboa
This resort is the place to go on the happening Isla Flamenco. Inside you'll find a Duty Free store, a pick & mix candy buffet called Sweet Day, and several restaurants. Not to mention a stunning view of the Flamenco Marina & the Panama City skyline. Did you know that Fort Amador was actually a US army base, built to protect the Panama Canal? When the US pulled out

Fuerte Amador Resort & Marina

Explore the waterfront in Ancon with a trip to Fuerte Amador Resort & Marina. Check out the shops and top-notch restaurants in this vibrant area.

Fuerte Amador Resort & Marina
Panama

Miraflores Locks

4.5/5(783 reviews)

Learn about the local history of Ancon with a stop at Miraflores Locks. Visit the shops and casinos in this vibrant area.

Miraflores Locks
Summer time in Panama City, blue sky and sunny days to enjoy this city. #lifeatexpedia #PanamaCity #travel

Calle 50

You can find out about the history of Panama City with a trip to Calle 50. Discover the area's casinos, or seek out its local tours.

Calle 50

San Francisco Hotel Deals

JW Marriott Panama
JW Marriott Panama
5 out of 5
Calle Punta Colon, Punta Pacifica, Panama City, Panama
The price is AED 572 per night from May 10 to May 11
AED 572
AED 629 total
includes taxes & fees
10 May - 11 May
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, 4 outdoor pools, and 3 restaurants. Our guests praise the helpful staff and the property condition ...
8.8/10 Excellent! (1,001 reviews)
"Unique building and location good making easy Uber to wherever we needed. Front desk staff & customer relations ready to help whenever asked. Pool area lovely. View from pool and most areas of the hotel breathtaking. Room was nicely cleaned each day. Masi Restaurant service rather slow, if it wasn’t ..."

Reviewed on 7 April 2025

JW Marriott Panama
Sheraton Grand Panama
Sheraton Grand Panama
4 out of 5
Via Israel And 77th Street, Panama City, Panama
The price is AED 496 per night from Apr 25 to Apr 26
AED 496
AED 545 total
includes taxes & fees
25 Apr - 26 Apr
Stay at this 4-star spa resort in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the property condition ...
8.4/10 Very Good! (860 reviews)
5 Stars all the way
"This was simply put, an outstanding stay from start to finish. The staff were amazing, the room was clean, the housekeeping was always on time and helpful, just a wonderful experience for me and my 3 kids. We were on the club floor which was an extra special experience. These folks know what they ..."

Reviewed on 6 April 2025

Sheraton Grand Panama
Plaza Paitilla Inn Hotel
Plaza Paitilla Inn Hotel
3.5 out of 5
Italy Avenue, Punta Paitilla, Winston Churchill Street, Panama City, Panama
Fully refundableReserve now, pay when you stay
The price is AED 435 per night from Apr 28 to Apr 29
AED 435
AED 489 total
includes taxes & fees
28 Apr - 29 Apr
Stay at this 3.5-star business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool ...
9.2/10 Wonderful! (2,001 reviews)
"I stayed here for a week in 2023, so-so experience. I felt the property had improved a great deal. Breakfast buffet is quite excellent with a wide variety of offerings. The small workout work had improved in the quality of its equipment. I liked that an early check (5 hours) cost me only $35. Definitely ..."

Reviewed on 13 April 2025

Plaza Paitilla Inn Hotel
Decapolis Hotel Panama City
Decapolis Hotel Panama City
4 out of 5
Avenida Balboa Con Multicentro, Panama City, Panama
The price is AED 344 per night from Apr 26 to Apr 27
AED 344
AED 378 total
includes taxes & fees
26 Apr - 27 Apr
Stay at this 4-star spa hotel in Panama City. Enjoy free breakfast, free WiFi, and free valet parking. Our guests praise the breakfast and the helpful staff ...
8.4/10 Very Good! (1,132 reviews)
"Everything was great really enjoyed my stay thank u guys so much for everything"

Reviewed on 10 April 2025

Decapolis Hotel Panama City
Ramada Plaza By Wyndham Panama Punta Pacífica
Ramada Plaza By Wyndham Panama Punta Pacífica
4 out of 5
Via Israel y Calle 71, San Francisco, Panama City, Panama
The price is AED 410 per night from May 1 to May 2
AED 410
AED 452 total
includes taxes & fees
1 May - 2 May
Stay at this 4-star business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,003 reviews)
"Lots to do in the area and quite central."

Reviewed on 11 April 2025

Ramada Plaza By Wyndham Panama Punta Pacífica
Megapolis Hotel Panamá
Megapolis Hotel Panamá
4.5 out of 5
Avenida Balboa, Panama City
The price is AED 467 per night from Apr 15 to Apr 16
AED 467
AED 513 total
includes taxes & fees
15 Apr - 16 Apr
Stay at this 4.5-star luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
8.2/10 Very Good! (845 reviews)
"Nuevamente una estadía más que satisfactoria, el hotel siempre cumple y supera la expectativas."

Reviewed on 12 April 2025

Megapolis Hotel Panamá
See all 1,372 properties in San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighborhoods around San Francisco

Summer time in Panama City, blue sky and sunny days to enjoy this city. #lifeatexpedia #PanamaCity #travel

Obarrio

4/5(91 area reviews)

Unique features of Obarrio include the casinos and coffeehouses. Make a stop by Calle 50 or Soho City Center while you're exploring the area.

Obarrio
Default Image

Punta Pacifica

Notable for its seaside views, restaurants, and casinos, Punta Pacifica is a sought-after destination for many travelers visiting Panama City. If you want to see some sights in the area, check out Avenida Balboa or Multiplaza Pacific Mall.

Punta Pacifica
Hard Rock Hotel Panama #StunningStructures

Punta Paitilla

Travelers come to Punta Paitilla for its abundant dining options, and you can see top attractions like Avenida Balboa and Multicentro Panama while you're in town.

Punta Paitilla
Default Image

Campo Alegre

4/5(368 area reviews)

If you're spending some time in Campo Alegre, Uruguay Street and Calle 50 are top sights worth seeing.

Campo Alegre
Default Image

Pueblo Nuevo

While Pueblo Nuevo might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like El Dorado Mall and Multiplaza Pacific Mall.

Pueblo Nuevo
Panama viejo

El Cangrejo

4/5(530 area reviews)

The abundant dining options and casinos are top of the list for many visitors to El Cangrejo. A stop by Crown Casino or Luxor Towers might round out your trip.

El Cangrejo

Search cruises