Photo by Hideki Yamagata
Find 5 Star Hotels in San Francisco from AED 300
- Plan, book, stay with confidence
Be picky
Search almost a million properties worldwide
Change your mind
Book hotels with free cancellation
Check availability on San Francisco 5 Star Hotels
Compare San Francisco 5 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Hotel Riu Plaza Panama
Hotel Riu Plaza Panama
9.0 out of 10, Wonderful, (3665)
The price is AED 442
AED 487 total
includes taxes & fees
27 Feb - 28 Feb

Waldorf Astoria Panama
Waldorf Astoria Panama
9.0 out of 10, Wonderful, (1002)
The price is AED 998
AED 1,098 total
includes taxes & fees
1 Mar - 2 Mar

W Panama
W Panama
8.8 out of 10, Excellent, (1002)
The price is AED 757
AED 833 total
includes taxes & fees
5 Mar - 6 Mar

Hilton Panama
Hilton Panama
8.8 out of 10, Excellent, (1003)
The price is AED 791
AED 870 total
includes taxes & fees
1 Mar - 2 Mar

JW Marriott Panama
JW Marriott Panama
8.8 out of 10, Excellent, (1003)
The price is AED 1,172
AED 1,289 total
includes taxes & fees
1 Mar - 2 Mar

The Westin Playa Bonita Panama
The Westin Playa Bonita Panama
8.0 out of 10, Very Good, (1002)
The price is AED 660
AED 726 total
includes taxes & fees
4 Mar - 5 Mar

Sofitel Legend Casco Viejo, Panama City
Sofitel Legend Casco Viejo, Panama City
9.8 out of 10, Exceptional, (395)
The price is AED 1,240
AED 1,364 total
includes taxes & fees
28 Feb - 1 Mar

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
9.6 out of 10, Exceptional, (549)
The price is AED 841
AED 925 total
includes taxes & fees
28 Feb - 1 Mar
Save an average of 15% on thousands of hotels when you're signed in
Explore similar 4-star hotels
Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in San Francisco.

Crowne Plaza Panama Airport, an IHG Hotel
Ave. Domingo Diaz, Corregimineto De Tocumen Hacia El, Tocumen, Panama
The price is AED 477 per night from Feb 23 to Feb 24
AED 477
AED 525 total
includes taxes & fees
23 Feb - 24 Feb
8.2/10 Very Good! (2,073 reviews)
Still don't see what you're looking for?
See all properties in San Francisco.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Recent reviews of San Francisco hotels
Recent reviews of San Francisco hotels

Hotel Riu Plaza Panama
5/5 Excellent
"This was a great place to stay in Panama City! I really liked how central the hotel was to everything in the city and how safe it was. Everyone was so friendly, and the hotel was very spacious and clean. The restaurant options at the hotel were lovely and the pool was great! "
A verified traveler stayed at Hotel Riu Plaza Panama
Posted 1 day ago
Explore a world of travel with Expedia
Explore a world of travel with Expedia
San Francisco Hotels by Star Rating
Hotels in San Francisco Neighborhoods
Stay near popular San Francisco attractions
- Hotels near Multiplaza Pacific Mall
- Hotels near Avenida Balboa
- Hotels near ATLAPA Conventions Center
- Hotels near Multicentro Panama
- Hotels near Hospital Punta Pacífica
- Hotels near Panama Canal Murals
- Hotels near Pacific Center
- Hotels near Omar Torrijos Recreational Park
- Hotels near Colonial Religious Art Museum
- Hotels near Albrook Shopping Mall
- Hotels near Cinta Costera
- Hotels near Amador Causeway
- Hotels near Via Espana
- Hotels near El Dorado Mall
- Hotels near Gamboa Rainforest Resort
- Hotels near Fuerte Amador Resort & Marina
- Hotels near Miraflores Locks
- Hotels near Veracruz Beach
- Hotels near Uruguay Street
- Hotels near Panama Viejo
More Hotel Options in San Francisco
- Adults Only Resorts & Hotels in San Francisco
- Adventure Hotels in San Francisco
- Beach Hotels in San Francisco
- Business Hotels in San Francisco
- Casinos in San Francisco
- Family Hotels in San Francisco
- Historic Hotels in San Francisco
- Hotel with a Concierge in San Francisco
- Hotels with Bars in San Francisco
- Hotels with Free Parking in San Francisco
- Hotels with WiFi in San Francisco
- Hotels with a Pool in San Francisco
- Hotels with smoking rooms in San Francisco
- Pet-friendly Hotels in San Francisco
- Resorts & Hotels with Spas in San Francisco
- Shopping Hotels in San Francisco
Explore more hotels
- San Francisco by Wynwood House
- Boutique Apartments Panamá Coco del Mar
- Hotel Riu Plaza Panama
- Dreams Playa Bonita Panama - All Inclusive
- Crowne Plaza Panama Airport, an IHG Hotel
- The Westin Playa Bonita Panama
- Waldorf Astoria Panama
- W Panama
- Marriott Panama Hotel
- AC Hotel by Marriott Panama City
- Novotel Panama City
- Waymore Hotel Spa & Casino
- The Executive Hotel
- Hilton Panama
- Hotel Ojos del Rio
- TRYP by Wyndham Panamá Centro
- Hospedium Princess Hotel Panama
- Principe Hotel and Suites
- MARINN PLACE Financial District
- Sofitel Legend Casco Viejo, Panama City