Find 5 Star Hotels in Panama City from AED 310
- Plan, book, stay with confidence
Be picky
Search almost a million properties worldwide
Change your mind
Book hotels with free cancellation
Check availability on Panama City 5 Star Hotels
Compare Panama City 5 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Hotel Riu Plaza Panama
Hotel Riu Plaza Panama
9.0 out of 10, Wonderful, (3813)
The price is AED 437
AED 481 total
includes taxes & fees
21 Apr - 22 Apr

W Panama
W Panama
8.8 out of 10, Excellent, (1002)
The price is AED 585
AED 643 total
includes taxes & fees
2 May - 3 May

Waldorf Astoria Panama
Waldorf Astoria Panama
9.0 out of 10, Wonderful, (1001)
The price is AED 840
AED 924 total
includes taxes & fees
19 Apr - 20 Apr

JW Marriott Panama
JW Marriott Panama
8.8 out of 10, Excellent, (1002)
The price is AED 673
AED 740 total
includes taxes & fees
2 May - 3 May

Bristol Panama, a Registry Collection Hotel
Bristol Panama, a Registry Collection Hotel
9.2 out of 10, Wonderful, (1001)
The price is AED 578
AED 635 total
includes taxes & fees
2 May - 3 May

Sofitel Legend Casco Viejo, Panama City
Sofitel Legend Casco Viejo, Panama City
9.8 out of 10, Exceptional, (423)
The price is AED 1,074
AED 1,182 total
includes taxes & fees
21 Apr - 22 Apr

The Westin Playa Bonita Panama
The Westin Playa Bonita Panama
8.0 out of 10, Very Good, (1002)
The price is AED 720
AED 792 total
includes taxes & fees
1 May - 2 May

Hilton Panama
Hilton Panama
8.8 out of 10, Excellent, (1001)
The price is AED 730
AED 803 total
includes taxes & fees
2 May - 3 May
Save an average of 15% on thousands of hotels when you're signed in
Explore similar 4-star hotels
Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Panama City.

Crowne Plaza Panama Airport by IHG
Ave. Domingo Diaz, Corregimineto De Tocumen Hacia El, Tocumen, Panama
The price is AED 433 per night from May 4 to May 5
AED 433
AED 537 total
includes taxes & fees
4 May - 5 May
8.4/10 Very Good! (2,083 reviews)
Still don't see what you're looking for?
See all properties in Panama City.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Learn more about Panama City
Experience Panama City: its casinos, cafes, and more!

Recent reviews of Panama City hotels
Recent reviews of Panama City hotels

Hotel Riu Plaza Panama
5/5 Excellent
"It is a modern and upscale accommodation located in the heart of Panama City's financial district that offers a blend of comfort and convenience, making it ideal for both business and leisure travelers. The well-equipped gym and the wide breakfast options were my personal favourites. Also, their omelets are 1000/10. Still think about it lol. Will definitely be back! "
A verified traveler stayed at Hotel Riu Plaza Panama
Posted 4 hours ago
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Panama City Hotels by Star Rating
Stay near popular Panama City attractions
- Hotels near Albrook Shopping Mall
- Hotels near Multiplaza Pacific Mall
- Hotels near Amador Causeway
- Hotels near Cinta Costera
- Hotels near Avenida Balboa
- Hotels near Via Espana
- Hotels near El Dorado Mall
- Hotels near Fuerte Amador Resort & Marina
- Hotels near Miraflores Locks
- Hotels near Panama Viejo
- Hotels near Iglesia del Carmen
- Hotels near Los Pueblos Commercial Center
- Hotels near ATLAPA Conventions Center
- Hotels near Calle 50
- Hotels near Uruguay Street
- Hotels near Crown Casino
- Hotels near Panama Canal Railway
- Hotels near Metropolitan Cathedral of Panama
- Hotels near Amador Convention Center
- Hotels near Multicentro Panama
More Hotel Options in Panama City
- Adults Only Resorts & Hotels in Panama City
- Adventure Hotels in Panama City
- All-inclusive Hotel in Panama City
- Beach Hotels in Panama City
- Boutique Hotels in Panama City
- Business Hotels in Panama City
- Casinos in Panama City
- Cheap Hotels in Panama City
- Family Hotels in Panama City
- Golf Hotels in Panama City
- Green Hotels in Panama City
- Historic Hotels in Panama City
- Hotel Wedding Venues in Panama City
- Hotel with a Concierge in Panama City
- Hotels with Bars in Panama City
- Hotels with Early Check-in in Panama City
- Hotels with Free Parking in Panama City
- Hotels with Hot Tubs in Panama City
- Hotels with WiFi in Panama City
- Hotels with a Pool in Panama City
- Hotels with an Indoor Pool in Panama City
- Hotels with smoking rooms in Panama City
- Luxury Hotels in Panama City
- Pet-friendly Hotels in Panama City
- Resorts & Hotels with Spas in Panama City
- Romantic Hotels in Panama City
- Shopping Hotels in Panama City
- Ski Hotels in Panama City
- Waterpark Hotels in Panama City
- Winery Hotels in Panama City
Explore more hotels
- Novotel Panama City
- Plaza Paitilla Inn Hotel
- TRYP by Wyndham Panamá Centro
- Hotel Ojos del Rio
- Waldorf Astoria Panama
- Las Americas Golden Tower Panama
- Hotel El Panama by Faranda Grand, a member of Radisson Individuals
- Sofitel Legend Casco Viejo, Panama City
- Holiday Inn Panama Distrito Financiero by IHG
- Hospedium Princess Hotel Panama
- Studio Coliving
- Bristol Panama, a Registry Collection Hotel
- Central Hotel Panama Casco Viejo
- Hilton Panama
- Sheraton Grand Panama
- American Trade Hotel
- Exe Oriental Panama
- Waymore Hotel Spa & Casino
- MARINN PLACE Financial District
- The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City