Find 4 Star Hotels in Upstate South Carolina, SC from AED 352

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Compare Upstate South Carolina 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

The Westin Poinsett Greenville
Breakfast area

The Westin Poinsett Greenville

4.0 star property
9.2 out of 10, Wonderful, (1002)
"Very clean and staff was extremely friendly Highly recommend "
The price is AED 621
AED 703 total
includes taxes & fees
29 Dec - 30 Dec
The Westin Poinsett Greenville
The Shepherd Hotel Downtown Clemson
Room

The Shepherd Hotel Downtown Clemson

4.0 star property
9.8 out of 10, Exceptional, (445)
"The staff were very kind. "
The price is AED 584
AED 648 total
includes taxes & fees
1 Jan - 2 January 2025
The Shepherd Hotel Downtown Clemson
Grand Bohemian Lodge Greenville, Autograph Collection
Exterior

Grand Bohemian Lodge Greenville, Autograph Collection

4.0 star property
9.6 out of 10, Exceptional, (268)
"It is a beautiful hotel. Great place to stay for a special occasion!"
The price is AED 1,021
AED 1,123 total
includes taxes & fees
12 Jan - 13 January 2025
Grand Bohemian Lodge Greenville, Autograph Collection
Hotel Hartness
Exterior

Hotel Hartness

4.0 star property
9.8 out of 10, Exceptional, (419)
"I have been traveling to the Clemson/Greenville area for over 20 years, and this is the first time I have stayed in a hotel with this level of service, quality, and beauty. This will be our new place to stay when traveling to SC. Stunning."
The price is AED 608
AED 793 total
includes taxes & fees
19 Jan - 20 January 2025
Hotel Hartness
The Abernathy of Clemson
Room

The Abernathy of Clemson

4.0 star property
9.6 out of 10, Exceptional, (478)
"Wonderful experience. Friendly staff and clean rooms. "
The price is AED 547
AED 607 total
includes taxes & fees
24 Dec - 25 Dec
The Abernathy of Clemson
Greenville Marriott
Exterior

Greenville Marriott

4.0 star property
8.6 out of 10, Excellent, (528)
"Airport shuttle, clean, impeccable service."
The price is AED 433
AED 492 total
includes taxes & fees
27 Dec - 28 Dec
Greenville Marriott
Mint House Greenville - Downtown
Room

Mint House Greenville - Downtown

4.0 star property
9.2 out of 10, Wonderful, (577)
"Great location!"
The price is AED 352
AED 398 total
includes taxes & fees
5 Jan - 6 January 2025
Mint House Greenville - Downtown
Mint House Greenville - West End
Exterior

Mint House Greenville - West End

4.0 star property
9.2 out of 10, Wonderful, (72)
"Best place to stay in Greenville for a private condominium like setting in lieu of a hotel. We have stayed at this location multiple times and would recommend. "
The price is AED 487
AED 550 total
includes taxes & fees
3 Jan - 4 January 2025
Mint House Greenville - West End
Liberty Hall Bed and Breakfast
Front of property

Liberty Hall Bed and Breakfast

4.0 star property
10.0 out of 10, Exceptional, (46)
"A great place to stay close to Clemson University..we were actually going to a party close by, so this worked perfectly for us..beautiful home and property; quiet and relaxing. The hosts are very friendly..breakfast was so delicious!! "
Liberty Hall Bed and Breakfast
The Station by Compo Hotels
Terrace/patio

The Station by Compo Hotels

4.0 star property
10.0 out of 10, Exceptional, (4)
"Definitely recommend!"
The price is AED 760
AED 1,053 total
includes taxes & fees
29 Dec - 30 Dec
The Station by Compo Hotels
Hotel Domestique
Front of property

Hotel Domestique

4.0 star property
9.6 out of 10, Exceptional, (28)
"We loved the welcoming staff, the hotel and convenient attached restaurant architecture and European feel. The 2nd floor room had large view windows opening to the balcony that were wonderful. The fireplace in the room and bottle of wine was such a nice touch - as was the convenient coffee bar just down the hall in the morning. And the food was amazing! We will definitely be back to enjoy the cold plunge, infrared sauna, workout room, jacuzzi and pool when it warms up a bit. Funny...
The price is AED 1,010
AED 1,111 total
includes taxes & fees
9 Jan - 10 January 2025
Hotel Domestique
Lake Hartwell Frank Howard Home Clemson
Front of property

Lake Hartwell Frank Howard Home Clemson

4.0 star property
The price is AED 452
AED 1,664 total
includes taxes & fees
5 Jan - 6 January 2025
Lake Hartwell Frank Howard Home Clemson
34 Allen St
Balcony

34 Allen St

4.0 star property
34 Allen St
140 Catlin Circle
Exterior

140 Catlin Circle

4.0 star property
140 Catlin Circle
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Frequently asked questions

What are the best 4-star hotels in Upstate South Carolina?
Greenville Marriott is rated highly by many Expedia guests. Located in Greer, Upstate South Carolina, this 4-star hotel features lots of amenities to help make your stay comfortable and convenient.
How much does it cost to stay in a 4-star hotel in Upstate South Carolina?
Expedia can help you quickly locate the perfect 4-star hotel for your getaway in Upstate South Carolina. Use our handy filter tool to tailor your search by things like amenities, budget and property star rating and get access to fabulous deals in a few clicks.

  • Search for the lowest price from AED 352

What's the difference between 5-star and 4-star hotels in Upstate South Carolina?
Offering a friendly guest experience and upmarket décor, 4-star hotels are a wonderful option for your Upstate South Carolina trip. These kinds of accommodations generally come with loads of handy amenities that make it simple to kick back and relax — think large beds, bathrobes, restaurants and pools. Or live the high life at a 5-star hotel designed to pamper with exclusive perks and amenities. Full-service health clubs, premium toiletries and fine dining are typically featured at these deluxe retreats.
Does Upstate South Carolina have any 4-star all-inclusive resorts?
Enjoy a relaxing vacation experience where just about everything is included in one upfront price by using our “All inclusive” filter. Staying within budget is a breeze when your room, food and many activities are already taken care of. Eager for more options? Check out the terrific offers on our standard 4-star hotels in and around Upstate South Carolina too.
Are there any 4-star hotels near Greenville-Spartanburg Intl. Airport (GSP)?
For those early departures or late-in-the-evening flights, Greenville Marriott is a great option. This 4-star retreat is about 8 kilometers from Greenville-Spartanburg Intl. Airport (GSP), one of the main airports in Upstate South Carolina.