Find 4 Star Hotels in Upstate South Carolina, SC from AED 297
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Compare Upstate South Carolina 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

The Shepherd Hotel Downtown Clemson
The Shepherd Hotel Downtown Clemson
9.8 out of 10, Exceptional, (550)
The price is AED 621
AED 689 total
includes taxes & fees
11 May - 12 May

Grand Bohemian Lodge Greenville, Autograph Collection
Grand Bohemian Lodge Greenville, Autograph Collection
9.6 out of 10, Exceptional, (336)
The price is AED 988
AED 1,087 total
includes taxes & fees
11 May - 12 May

The Westin Poinsett Greenville
The Westin Poinsett Greenville
9.2 out of 10, Wonderful, (1003)
The price is AED 653
AED 739 total
includes taxes & fees
11 May - 12 May

Mint House Greenville - Downtown
Mint House Greenville - Downtown
9.4 out of 10, Exceptional, (649)
The price is AED 487
AED 550 total
includes taxes & fees
27 Apr - 28 Apr

Greenville Marriott
Greenville Marriott
8.6 out of 10, Excellent, (552)
The price is AED 465
AED 529 total
includes taxes & fees
11 May - 12 May

Hotel Hartness
Hotel Hartness
9.8 out of 10, Exceptional, (499)
The price is AED 638
AED 826 total
includes taxes & fees
27 Apr - 28 Apr

The Abernathy of Clemson
The Abernathy of Clemson
9.6 out of 10, Exceptional, (506)
The price is AED 657
AED 730 total
includes taxes & fees
5 May - 6 May

Mint House Greenville - West End
Mint House Greenville - West End
9.2 out of 10, Wonderful, (85)
The price is AED 592
AED 669 total
includes taxes & fees
25 May - 26 May
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Learn more about Upstate South Carolina
Experience the family-friendly area of Upstate South Carolina—live music, restaurants, and sights from Discovery Island Water Park to Frankie's Fun Park.

Photo by South Carolina Department of Parks, Recreation & Tourism
Open Photo by South Carolina Department of Parks, Recreation & Tourism
Recent reviews of Upstate South Carolina hotels
Recent reviews of Upstate South Carolina hotels

The Shepherd Hotel Downtown Clemson
5/5 Excellent
"Extremely clean space and beds are super comfortable. The location is convenient to the college and there are many shops and restaurants within walking distance. "
A verified traveler stayed at The Shepherd Hotel Downtown Clemson
Posted 2 days ago

Grand Bohemian Lodge Greenville, Autograph Collection
5/5 Excellent
"Great place, expensive but worth it "
A verified traveler stayed at Grand Bohemian Lodge Greenville, Autograph Collection
Posted 3 days ago
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Upstate South Carolina Hotels by Star Rating
Hotels in Upstate South Carolina Neighborhoods
Stay near popular Upstate South Carolina attractions
- Hotels near Clemson University
- Hotels near Falls Park on the Reedy
- Hotels near BMW Performance Center
- Hotels near Lake Jocassee
- Hotels near Haywood Mall
- Hotels near Bon Secours Wellness Arena
- Hotels near Prisma Health Greenville Memorial Hospital
- Hotels near Greenville Convention Center
- Hotels near The Peace Center
- Hotels near Bob Jones University
- Hotels near Wofford College
- Hotels near Anderson University
- Hotels near Fred W. Symmes Chapel
- Hotels near Devils Fork State Park
- Hotels near Fluor Field at the West End
- Hotels near Memorial Stadium
- Hotels near Converse College
- Hotels near Table Rock State Park
- Hotels near WestGate Mall
- Hotels near Tyger River Park
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More Accommodation Types in Upstate South Carolina
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Explore more hotels
- Wooded Cottage - 3 Mi to Clemson University
- The Shepherd Hotel Downtown Clemson
- Lakeside Lodge Clemson
- Holiday Inn Greenville - Woodruff Road by IHG
- Homewood Suites by Hilton Greenville Downtown
- Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd
- Quality Inn & Suites Greenville - Haywood Mall
- Wingate by Wyndham - Greenville-Airport
- Hyatt Place Greenville/Haywood
- Mint House Greenville - Downtown
- Inn @ Clemson
- Comfort Suites At WestGate Mall
- Spartanburg Marriott
- ECHO Suites Extended Stay by Wyndham Spartanburg
- Best Western Plus Spartanburg
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- Courtyard Greenville-Spartanburg by Marriott
- Holiday Inn Express Gaffney by IHG
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